WO2007001159A1 - Integrated infusion container - Google Patents
Integrated infusion container Download PDFInfo
- Publication number
- WO2007001159A1 WO2007001159A1 PCT/KR2006/002522 KR2006002522W WO2007001159A1 WO 2007001159 A1 WO2007001159 A1 WO 2007001159A1 KR 2006002522 W KR2006002522 W KR 2006002522W WO 2007001159 A1 WO2007001159 A1 WO 2007001159A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- medicine
- container
- cap
- injection
- unitary
- Prior art date
Links
- 238000001802 infusion Methods 0.000 title description 2
- 239000003814 drug Substances 0.000 claims abstract description 170
- 229920003023 plastic Polymers 0.000 claims abstract description 55
- 239000004033 plastic Substances 0.000 claims abstract description 55
- 230000008878 coupling Effects 0.000 claims abstract description 43
- 238000010168 coupling process Methods 0.000 claims abstract description 43
- 238000005859 coupling reaction Methods 0.000 claims abstract description 43
- 238000002347 injection Methods 0.000 claims abstract description 39
- 239000007924 injection Substances 0.000 claims abstract description 39
- 239000007788 liquid Substances 0.000 claims abstract description 26
- 230000004927 fusion Effects 0.000 claims description 11
- 238000012856 packing Methods 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 7
- 230000000670 limiting effect Effects 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 4
- 238000005452 bending Methods 0.000 claims description 3
- 239000000243 solution Substances 0.000 abstract description 30
- 229920005989 resin Polymers 0.000 description 13
- 239000011347 resin Substances 0.000 description 13
- 210000003811 finger Anatomy 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- -1 polypropylene Polymers 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229920000092 linear low density polyethylene Polymers 0.000 description 2
- 239000004707 linear low-density polyethylene Substances 0.000 description 2
- 229920001684 low density polyethylene Polymers 0.000 description 2
- 239000004702 low-density polyethylene Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229920013716 polyethylene resin Polymers 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- SVSFIELZISOJDT-XRZFDKQNSA-N (6r,7r)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrochloride Chemical compound Cl.CN(C)CCN1N=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CC=3N=C(N)SC=3)[C@H]2SC1 SVSFIELZISOJDT-XRZFDKQNSA-N 0.000 description 1
- UPZFLZYXYGBAPL-UHFFFAOYSA-N 2-ethyl-2-methyl-1,3-dioxolane Chemical compound CCC1(C)OCCO1 UPZFLZYXYGBAPL-UHFFFAOYSA-N 0.000 description 1
- 239000004709 Chlorinated polyethylene Substances 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- KLOHDWPABZXLGI-YWUHCJSESA-M ampicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=CC=C1 KLOHDWPABZXLGI-YWUHCJSESA-M 0.000 description 1
- 229960001931 ampicillin sodium Drugs 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 239000003699 antiulcer agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- FLKYBGKDCCEQQM-WYUVZMMLSA-M cefazolin sodium Chemical compound [Na+].S1C(C)=NN=C1SCC1=C(C([O-])=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 FLKYBGKDCCEQQM-WYUVZMMLSA-M 0.000 description 1
- 229960003408 cefazolin sodium Drugs 0.000 description 1
- ADLFUPFRVXCDMO-LIGXYSTNSA-M ceftizoxime sodium Chemical compound [Na+].N([C@@H]1C(N2C(=CCS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 ADLFUPFRVXCDMO-LIGXYSTNSA-M 0.000 description 1
- 229960000636 ceftizoxime sodium Drugs 0.000 description 1
- 150000001782 cephems Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 description 1
- 229960001596 famotidine Drugs 0.000 description 1
- UHRBTBZOWWGKMK-DOMZBBRYSA-N flomoxef Chemical compound O([C@@H]1[C@@](C(N1C=1C(O)=O)=O)(NC(=O)CSC(F)F)OC)CC=1CSC1=NN=NN1CCO UHRBTBZOWWGKMK-DOMZBBRYSA-N 0.000 description 1
- 210000004247 hand Anatomy 0.000 description 1
- 229960002182 imipenem Drugs 0.000 description 1
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 229920006122 polyamide resin Polymers 0.000 description 1
- 229920005668 polycarbonate resin Polymers 0.000 description 1
- 239000004431 polycarbonate resin Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
- 229960000620 ranitidine Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 229920006163 vinyl copolymer Polymers 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
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- A61J1/14—Details; Accessories therefor
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- A61J1/2048—Connecting means
- A61J1/2065—Connecting means having aligning and guiding means
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- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1462—Containers with provisions for hanging, e.g. integral adaptations of the container
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
Definitions
- the present invention relates to a unitary medicine bottle for injection, more particularly, to a unitary medicine bottle having an integral structure where a medicine container is easily connected with a plastic container including a solution at a completely sterilized state so that powdered, freeze-dried or liquid medicine is mixed with the solution with one touch for a short time.
- the container including the dissolved medicine is coupled with the container including the solution using a coupling tool such as a double-ended needle or a coupling tube.
- the container including the dissolved medicine is inclined so that the medicine dissolved in the container is inserted into the container including the solution.
- a hollow cavity needle is attached toward the vial and a breaking materi al like a tube made of platic is attached toward the plastic container.
- the breaking material blocks a passage in the tube for holding a liquid from flowing.
- the more improved one than the above medicine bottle for injection includes a plastic container having a liquid passage with an enclosure at the uppermost and filled with a solution or a diluted solution in the medicine bottle for injection, a capsule connected with the plastic container, a medicine container connected by pricking its rubber stopper of which the inlet is closed with a needle and which is maintained in the capsule and a flue means for connecting the inside of the plastic container with the inside of the medicine container.
- the flue means includes a hollow cavity needle having a hub in the middle and blades at both ends, a control means for perforating a stopper of the medicine container by one blade of the cavity needle and an enclosure of the plastic container by the other blade of the cavity needle in a serial order so as to connect the plastic container with the medicine container.
- the above described medicine bottle for injection is improved in that a medicine container is connected with a plastic container including a solution, but a plurality of operations that the rubber stopper of a vial is pricked by a cavity needle and a breaking material is broken with a finger to open the passage require quite a long time.
- the above medicine bottle for injection is considered to be improved in that a medicine is mixed by connecting a medicine container with a plastic container including a solution, and a shortened time consumed for its operation.
- the medicine bottle for injection has a problem that a flue means needs a hollow osteoplasty needle having a hub in the middle and blades at both ends and a com- plicatedly shaped control means for controling a connecting order so that one blade of the osteoplasty needle pricks the stopper of a medicine container first and the other blade of it pricks the enclosure of the plastic container.
- the medicine bottle for injection consists of a number of parts, a manufacturing costs is high and the possibility of malfuntions is increased.
- An object of the present invention to solve the above problems is to provide a unitary medicine bottle for injection having an integral structure where a medicine container is easily connected with a plastic container including a solution at a completely sterilized state so that powdered, freeze-dried or liquid medicine is mixed with the solution with one touch for a short time.
- Another object of the present invention is to provide a unitary medicine bottle for injection which can accept all sizes of medicine containers.
- a unitary medicine bottle for injection comprising: a plastic container having a coupling member to be connected with a medicine container at one end and a releasing member for releasing a liquid medicine to be injected at the other end; a protection cap integrally formed with the coupling member to accept the medicine container; and a flue needle which moves forward in a direction of the medicine container and perforates a stopper of the medicine container and is inserted into the coupling member for connecting the plastic container with the medicine container.
- the coupling member is characterized by comprising a guide section for guiding the flue needle and a diaphargm for supporting in contact with the stopper of the medicine container.
- the coupling member is characterized by comprising a stopper for limiting forward movements of the flue needle.
- the protection cap is characterized by comprising a fixing cap which is one body with the coupling member, a moving cap which is interpolized or extrapolated in the fixing cap for changing its inner space and a moving flange which is integrally formed with the fixing flange at an end of the fixing cap and fixed on the moving cap to set a space for forming the moving cap and the fixing cap.
- the protection cap is characterized by comprising a fixing packing for holding the medicine container to be fixed.
- the protection cap is characterized by comprising a hanging means for hanging a medicine bottle.
- the flue needle is characterized being a cavity needle having at least one connection passages through which a liquid medicine flows.
- the flue needle is characterized in that an interrupting protuberance is formed at one side so that it stops at a predetermined position in the coupling member after it moved in order not to displace further.
- the flue needle is characterized in that a fixing protuberance is formed at one side so that it is not easily displaced from the initial state without an external force.
- the medicine container is formed of a glass or a plastic.
- the stopper of the medicine container is formed of rubber or plastic.
- the releasing member is characterized by comprising: an outlet fixed to the plastic container so that a liquid medicine is not leaked; a releasing extended rim mounted at an inner end of the outlet; a releasing cap covering an end of the outlet to expose only the center of the releasing extended rim; and a cover seal attached to the outside of the releasing cap for sealing the releasing extended rim.
- connection between a moving flange and a fixing flange, and the connection between the moving flange and the moving cap are made by a thermal fusion, a supersonic fusion or a sealing bending.
- a unitary medicine bottle for injection according to the present invention can be manufactured easily and in a low cost because a medicine container and a plastic container do not move each other, and the whole medicine container is compact and the number of the consisting parts is small.
- the medicine bottle has a structure where a sterilization process is easily and perfectly carried out in manufacturing an injecting agent. Furthermore, as a medicine container and a plastic container can be connected at a fixed state, it is possible to prevent a solution from being leaked or contaminated, in advance.
- the solution can be moved softly in a plastic container by using a flue needle being a cavity needle.
- the medicine in the medicine container and the solution can be mixed for a short time.
- the protection cap accepting the medicine container is constituted to comprise a fixing cap and a moving cap to accept all sizes of medicine containers in the medicine bottle of the present invention.
- FIG. 1 is a configurational view of a unitary medicine bottle for injection in accordance with the present invention.
- Fig. 2 is a cross-section of a stopper of a liquid medicine container.
- Fig. 3 is a configurational view of a plastic container shown in Fig. 1.
- FIG. 4 is a partial exploded view of a coupling member and a flue needle shown in
- Fig. 5 is a cross-section of a releasing extended rim.
- Fig. 6 is an exploded view of a protection cap.
- Fig. 7 is a cross-section of a packing.
- Fig. 8 is a partial exploded view of an initial state of an embodiment.
- Fig. 9 is a paritial exploded view of a displaced flue needle of an embodiment.
- a unitary medicine bottle for injection comprising: a plastic container having a coupling member to be connected with a medicine container at one end and a releasing member for releasing a liquid medicine to be injected at the other end; a protection cap integrally formed with the coupling member to accept the medicine container; and a flue needle which moves forward in a direction of the medicine container and perforates a stopper of the medicine container and is inserted into the coupling member connecting the plastic container with the medicine container.
- the coupling member is characterized by comprising a guide section for guiding the flue needle and a diaphargm for supporting in contact with the stopper of the medicine bottle.
- the coupling member is characterized by comprising a stopper for lim iting forward movements of the flue needle.
- the protection cap is characterized by comprising a fixing cap which is one body with the coupling member, a moving cap which is interpolized or extrapolated in the fixing cap for changing its inner space and a moving flange which is integrally formed with the fixing flange at an end of the fixing cap and fixed on the moving cap to set a space for forming the moving cap and the fixing cap.
- the protection cap is characterized by comprising a fixing packing for holding the medicine container to be fixed.
- the protection cap is characterized by comprising a hanging means for hanging a medicine bottle.
- the flue needle is a cavity needle having at least one passage through which a liquid medicine flows.
- the flue needle is characterized in that an interrupting protuberance is formed at one side so that it stops at a predetermined position in the coupling member after it moved not to be displaced further.
- the flue needle is characterized in that a fixing protuberance is formed at a side so that it is not easily displaced from the initial state without an external force.
- the medicine container is formed of a glass or a plastic.
- the stopper of the medicine container is formed of rubber or plastic.
- the releasing member is characterized by comprising: an outlet fixed to the plastic container so that a liquid medicine is not leaked; a releasing extended rim mounted at an inner end of the outlet; a releasing cap covering the end of the outlet to expose only the center of thr releasing extended rim; and a cover seal attached to the outside of the releasing cap for sealing the releasing extended rim.
- connection between a moving flange and a fixing flange, and the connection between the moving flange and the moving cap are made by a thermal fusion, a supersonic fusion or a sealing bending.
- FIG. 1 shows a unitary medicine bottle in accordance with the present invention, consisting of a plastic container (2), a protecting cap, a releasing member, a flue needle (11), the protecting cap being inserted by a medicine container (2).
- the medicine container (2) is disclosed and is formed of plastic or glass.
- the medicine container has a neck (7) at which a stopper (10) is formed to seal the contained medicine.
- the stopper (10) is hermetically sealed at the neck (7) of the medicine container (1) by an aluminum cover (not shown). Accordingly, the medicine filled in the medicine container (1) is protected at a completely sterilized state.
- the stopper (10) is inserted in the packing (8) to be conjugated between the medicine container (1) and the coupling member (4) in an aseptic condition.
- the stopper (10) is formed of rubber or plastic to have the same shape shown in
- the medicine included in the medicine container is used by pricking the stopper (10) with an injection needle or a flue needle of a medicine bottle, etc.
- the medicine in the medicine container is in a liquid or powdered state.
- the powdered medicine is dissolved to be used.
- the medicine inserted into the medicine container includes cephem series pre- antibiotics like Cefazolin Sodium, ceftizoxime sodium, Cefotiam HCL etc., penicillin series antibiotics like Ampicillin Sodium and penicillin soldium etc., carbapenum series antibiotics like imipenem, various antibiotics like mitomycine C and fluorourcil, antiulcer agents like Famotidine and hydrochloric acid Ranitidine, a thrombosis solvent like urokinase and flomoxef sodium.
- cephem series pre- antibiotics like Cefazolin Sodium, ceftizoxime sodium, Cefotiam HCL etc.
- penicillin series antibiotics like Ampicillin Sodium and penicillin soldium etc.
- carbapenum series antibiotics like imipenem
- various antibiotics like mitomycine C and fluorourcil
- antiulcer agents like Famotidine and hydrochloric acid Ranitidine
- a thrombosis solvent like ur
- the plastic container (2) is a synthetic resin pack used to contain a solution (3) like saline solution and may be formed of a material with affluent plasticity such as a low density polyethylene resin, a linear low density polyethylene resin, polypropylene resin, soft polyethylene resin, chlorinated polyethylene resin, chlorinated vinyl resin and ethylene acetic acid vinyl copolymer.
- a material with affluent plasticity such as a low density polyethylene resin, a linear low density polyethylene resin, polypropylene resin, soft polyethylene resin, chlorinated polyethylene resin, chlorinated vinyl resin and ethylene acetic acid vinyl copolymer.
- a polyolefin series resin like a low density polyethylene resin, a linear low density polyethylene resin and polypropylene resin because they are chemical resistant, has small effluents and cost-effective.
- the solutions to be contained in the plastic container (2) include solution including various electrolytes besides a saline solution, 5% dextrose solution and distilled water for injection.
- the plastic container (2) is equipped with a coupling member
- the coupling member (4) comprises a guide section (14) for guiding the flue needle (11) and a diaphragm (9) for supporting a stopper (10) of the medicine container (1).
- a flange (22) formed at the side of the coupling member (4) is used together with the seats of the flue needle (11) with the same method as injecting a liquid medicine.
- the flue needle (11) is pushed upward by pressing the seats with a thumb and placing an index finger and a middle finger on the flange (22).
- a pipe is formed inside the coupling member (4) so that the flue needle (11) can make linear movements and an annular conjugation protuberance (25) is formed at an outer end so that the packing (8) is integrally sealed with the coupling member (4).
- the diaphragm (9) of the coupling member (4) is formed in a dome to be closely adhered to a central portion of the stopper (10) of the medicine container (1).
- the diaphragm (9) has a thin layer which is easily perforated by the flue needle (11). If it is blocked, it plays a role in sealing the plastic container (2).
- a stopper (15) is formed at the bottom of the coupling member (4) to play a role in limiting a vertical movement distance of the flue needle (11).
- the flue needle (11) inserted in the coupling member (4) is a cavity needle with at least one passageway through which a liquid medicine flows, having the similar shape to a general injection syringe.
- the flue needle (11) has a seat which is pressed by a finger at one end.
- the flue needle (11) has a fixing protuberance (24) so that the flue needle (11) is not easily displaced from the initial state and an interrupting protuberance (23) at one side so that the flue needle (11) is stopped at a predetermined position inside the coupling member (4) and not to be displaced further.
- the flue needle (11) is applied by an external force, it is moved toward the diaphragm (9) along with the guide section (14) and disaplced by a predetermined distance and is stopped by the interrupting protuberance (23) and/or the stopper (15).
- the flue needle (11) moves forward and pricks the stopper (10) of the medicine container (1) and plays a role in connecting the inside of the medicine container (1) with the inside of the plastic container (2), maintaining the state that the stopper is perforated.
- the releasing member (12) consists of an outlet (21) which is closely attached with the plastic container (2) so that a liquid medicine is not leaked, a releasing extended rim (16) which is mounted inside an end of the outlet (21), a releasing cap (20) for exposing only the center of the releasing extended rim (16) by covering one end of the outlet (20) and a cover seal (19) attached to the outside of the releasing cap (20) to seal the releasing extended rim (16).
- the outlet (21) is thermally fused with the plastic container (2) to be sealed.
- the releasing extended rim (16) made of a rubber, etc. (shown in Fig. 6) is forced to place inside of the outlet (21).
- the cover seal (19) is attached to the outside of the releasing cap (20) by a thermal fusion or a supersonic fusion. Therefore, the medicine bottle for injection according to the present invention can be sealed at an asceptic state by attaching the cover seal (19).
- the protection cap is integrally formed with the coupling member (4) to include a medicine container (1).
- the protection cap includes a fixing cap (5) integrally formed with the coupling member (4), a moving cap (6) which is interpolated or extrapolated in the fixing cap (5) to change the interal space, and a moving flange (18) which is integrally connected with the fixing flange (17) formed at one end of the fixing cap (5) and fixed to the moving cap (6) to set a space formed by the moving cap (6) and the fixing cap (5).
- connection with the moving flange (18) and the fixing flange (17) and the connection with the moving flange (18) and the moving cap (6) are carried out by a thermal fusion or a supersonic fusion.
- the size of the internal space formed by the moving cap (6) and the fixing cap (5) is not limited, thus all sizes of medicine container (1) can use it.
- the medicine container (1) is mounted with the stopper (10) inserted in the packing (8) mounted inside the fixing cap (5), upside down.
- the packing (8) is formed to wrap the stopper (10) and has a hole in the center so that the diaphragm (9) of the coupling member (4) is inserted.
- the fixing cap (5) and the moving cap (6) are formed of a polyolefin series resin, a stylene series resin, an acryl series resin, a polycarbonate resin, polyamide resin, etc.
- the fixing cap (5) and the moving cap (6) can sterilze their insides easily by a ⁇ -ray and a ultraviolet ray or a peroxide processing, using a polypropylene resin which relatively penetrates an ultraviolet ray and a methylpentine resin.
- a hanging means (13) has a hook or a hanging hole formed at the upper side of the moving cap (6), thus an unitary medicine bottle according to the present invention is hung on a hanger to be stably kept.
- the plastic container (2) After the inside of medicine container (1) in connected with the inside of the plastic container (2), the plastic container (2) is pressurized with both hands slightly to send a part of solution into the medicine container (1), thus dissolving the medicine.
- a unitary medicine bottle for injection is shaken a few times so that the medicine in the medicine container (1) is dissolved fast.
- the liquid medicine dissolved in the medicine container (1) is returned back to the plastic container (2) by the operations of pressurizing or pressing the plastic container (2).
- the liquid medicine including the liquid medicine and the solution (3) which are mixed in the plastic container (2) is released from the releasing means (12) attached at one end of the plastic container (2).
- the cover seal (19) is removed from the releasing cap (20) and a set of medicine bottle for injection is coupled to the releasing extended rim (16), thus a liquid medicine is instilled.
- the unitary medicine bottle for injection according to the present invention does not move a medicine container and a plastic container each other. Therefore, as the medicine bottle is compact and the number of constitutional parts is small, it is possible to manufacture the unitary medicine bottle for injection easily and cost-effectively.
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2008000145A MX2008000145A (en) | 2005-06-28 | 2006-06-28 | Integrated infusion container. |
ES06769094T ES2413762T3 (en) | 2005-06-28 | 2006-06-28 | Bottle of unit medicine for injection |
EP06769094A EP1912613B1 (en) | 2005-06-28 | 2006-06-28 | Unitary medicine bottle for injection |
US11/994,186 US8128612B2 (en) | 2005-06-28 | 2006-06-28 | Integrated infusion container |
CN2006800302700A CN101242800B (en) | 2005-06-28 | 2006-06-28 | Integrated infusion container |
PL06769094T PL1912613T3 (en) | 2005-06-28 | 2006-06-28 | Unitary medicine bottle for injection |
BRPI0612571-9A BRPI0612571A2 (en) | 2005-06-28 | 2006-06-28 | integrated infusion container |
US13/400,852 US9421148B2 (en) | 2005-06-28 | 2012-02-21 | Integrated infusion container |
US15/080,210 US10258539B2 (en) | 2005-06-28 | 2016-03-24 | Integrated infusion container |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20050056511A KR100569223B1 (en) | 2005-06-28 | 2005-06-28 | Integrated infusion container |
KR10-2005-0056511 | 2005-06-28 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/994,186 A-371-Of-International US8128612B2 (en) | 2005-06-28 | 2006-06-28 | Integrated infusion container |
US13/400,852 Continuation US9421148B2 (en) | 2005-06-28 | 2012-02-21 | Integrated infusion container |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2007001159A1 true WO2007001159A1 (en) | 2007-01-04 |
Family
ID=37180387
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2006/002522 WO2007001159A1 (en) | 2005-06-28 | 2006-06-28 | Integrated infusion container |
Country Status (9)
Country | Link |
---|---|
US (3) | US8128612B2 (en) |
EP (1) | EP1912613B1 (en) |
KR (1) | KR100569223B1 (en) |
CN (1) | CN101242800B (en) |
BR (1) | BRPI0612571A2 (en) |
ES (1) | ES2413762T3 (en) |
MX (1) | MX2008000145A (en) |
PL (1) | PL1912613T3 (en) |
WO (1) | WO2007001159A1 (en) |
Families Citing this family (14)
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KR100569223B1 (en) * | 2005-06-28 | 2006-04-10 | 오기범 | Integrated infusion container |
US8216207B2 (en) | 2007-08-01 | 2012-07-10 | Hospira, Inc. | Medicament admixing system |
CN102283775B (en) * | 2011-09-14 | 2013-11-20 | 重庆莱美药业股份有限公司 | Soft bag with dual-needle medicament feeder |
ES2660483T3 (en) | 2011-10-03 | 2018-03-22 | Hospira, Inc. | System and procedure for mixing the contents of two containers |
WO2013126055A1 (en) * | 2012-02-22 | 2013-08-29 | Baxter International Inc. | Packaging assembly to prevent premature activation |
EP2962676B1 (en) * | 2014-07-02 | 2017-03-22 | Paolo Gobbi Frattini S.r.l. | Flexible package with a sealed sterile chamber for the reconstitution and administration of fluid medicinal or nutritional substances instillable into the body of a patient |
KR101601695B1 (en) | 2014-09-15 | 2016-03-09 | 신중화 | an ringer's solution link system for two-way needle |
KR101631551B1 (en) * | 2016-03-10 | 2016-06-21 | 주식회사 대웅제약 | Integrated type injection kit |
EP3476766B1 (en) * | 2016-06-28 | 2023-06-21 | Kyoto University | Frozen storage container and frozen storage container system |
CN106309125A (en) * | 2016-07-22 | 2017-01-11 | 湖南科伦制药有限公司 | Instant matching infusion container |
CN107157765B (en) * | 2017-05-27 | 2019-09-17 | 余庆县人民医院 | Pulvis and aqua mix infusion bag |
WO2019067891A1 (en) * | 2017-09-28 | 2019-04-04 | Colder Products Company | Fluid handling devices |
WO2020068031A1 (en) * | 2018-09-24 | 2020-04-02 | Oh Pharmaceutical Co., Ltd. | Infusion system |
CN113908313A (en) * | 2021-09-26 | 2022-01-11 | 德清勤丰电子科技有限公司 | Waterproof electronic thermometer |
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Also Published As
Publication number | Publication date |
---|---|
US20080269712A1 (en) | 2008-10-30 |
CN101242800B (en) | 2012-02-08 |
EP1912613B1 (en) | 2013-03-13 |
PL1912613T3 (en) | 2013-08-30 |
US20130218122A1 (en) | 2013-08-22 |
US20160199259A1 (en) | 2016-07-14 |
EP1912613A4 (en) | 2010-09-15 |
ES2413762T3 (en) | 2013-07-17 |
US8128612B2 (en) | 2012-03-06 |
US10258539B2 (en) | 2019-04-16 |
CN101242800A (en) | 2008-08-13 |
KR100569223B1 (en) | 2006-04-10 |
MX2008000145A (en) | 2008-04-29 |
EP1912613A1 (en) | 2008-04-23 |
US9421148B2 (en) | 2016-08-23 |
BRPI0612571A2 (en) | 2010-11-23 |
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