WO2006133144A8 - Erythropoietin receptor peptide formulations and uses - Google Patents

Erythropoietin receptor peptide formulations and uses

Info

Publication number
WO2006133144A8
WO2006133144A8 PCT/US2006/021845 US2006021845W WO2006133144A8 WO 2006133144 A8 WO2006133144 A8 WO 2006133144A8 US 2006021845 W US2006021845 W US 2006021845W WO 2006133144 A8 WO2006133144 A8 WO 2006133144A8
Authority
WO
WIPO (PCT)
Prior art keywords
erythropoietin receptor
receptor peptide
peptide formulations
formulations
erythropoietin
Prior art date
Application number
PCT/US2006/021845
Other languages
French (fr)
Other versions
WO2006133144A2 (en
Inventor
Anne-Marie Duliege
Richard Stead
Kerstin Leuther
Kathryn Woodburn
Robert Barnett Naso
Original Assignee
Affymax Inc
Anne-Marie Duliege
Richard Stead
Kerstin Leuther
Kathryn Woodburn
Robert Barnett Naso
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2006255081A priority Critical patent/AU2006255081B2/en
Priority to JP2008514966A priority patent/JP2008542399A/en
Application filed by Affymax Inc, Anne-Marie Duliege, Richard Stead, Kerstin Leuther, Kathryn Woodburn, Robert Barnett Naso filed Critical Affymax Inc
Priority to CA002609401A priority patent/CA2609401A1/en
Priority to EA200702656A priority patent/EA014528B1/en
Priority to US11/916,416 priority patent/US7906485B2/en
Priority to BRPI0613233-2A priority patent/BRPI0613233A2/en
Priority to MX2007015303A priority patent/MX2007015303A/en
Priority to EP06784593A priority patent/EP1917023A4/en
Priority to NZ563433A priority patent/NZ563433A/en
Publication of WO2006133144A2 publication Critical patent/WO2006133144A2/en
Priority to US11/777,500 priority patent/US7919461B2/en
Priority to IL187354A priority patent/IL187354A0/en
Priority to NO20076634A priority patent/NO20076634L/en
Priority to KR1020087000166A priority patent/KR101262312B1/en
Publication of WO2006133144A8 publication Critical patent/WO2006133144A8/en
Priority to US12/178,583 priority patent/US8324159B2/en
Priority to US12/195,832 priority patent/US20090221510A1/en
Priority to US13/686,245 priority patent/US20130079283A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
    • A61K47/665—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells the pre-targeting system, clearing therapy or rescue therapy involving biotin-(strept) avidin systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
PCT/US2006/021845 2005-06-03 2006-06-05 Erythropoietin receptor peptide formulations and uses WO2006133144A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
MX2007015303A MX2007015303A (en) 2005-06-03 2006-06-05 Erythropoietin receptor peptide formulations and uses.
EP06784593A EP1917023A4 (en) 2005-06-03 2006-06-05 Erythropoietin receptor peptide formulations and uses
CA002609401A CA2609401A1 (en) 2005-06-03 2006-06-05 Erythropoietin receptor peptide formulations and uses
EA200702656A EA014528B1 (en) 2005-06-03 2006-06-05 Erythropoietin receptor peptide formulations and uses
US11/916,416 US7906485B2 (en) 2005-06-03 2006-06-05 Erythropoietin receptor peptide formulations and uses
BRPI0613233-2A BRPI0613233A2 (en) 2005-06-03 2006-06-05 compound to treat a patient having a disorder
JP2008514966A JP2008542399A (en) 2005-06-03 2006-06-05 Formulation and use of erythropoietin receptor peptides
AU2006255081A AU2006255081B2 (en) 2005-06-03 2006-06-05 Erythropoietin receptor peptide formulations and uses
NZ563433A NZ563433A (en) 2005-06-03 2006-06-05 Erythropoietin receptor peptide formulations and uses
US11/777,500 US7919461B2 (en) 2005-06-03 2007-07-13 Erythropoietin receptor peptide formulations and uses
IL187354A IL187354A0 (en) 2005-06-03 2007-11-13 Erythropoietin receptor peptide formulations and uses
NO20076634A NO20076634L (en) 2005-06-03 2007-12-21 Erythropoietin receptor peptide formulations and applications
KR1020087000166A KR101262312B1 (en) 2005-06-03 2008-01-03 Erythropoietin Receptor Peptide Formulations and Uses
US12/178,583 US8324159B2 (en) 2005-06-03 2008-07-23 Erythropoietin receptor peptide formulations and uses
US12/195,832 US20090221510A1 (en) 2005-06-03 2008-08-21 Erythropoietin receptor peptide formulations and uses
US13/686,245 US20130079283A1 (en) 2005-06-03 2012-11-27 Erythropoitein Receptor Peptide Formulations and Uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68765505P 2005-06-03 2005-06-03
US60/687,655 2005-06-03

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/446,593 Continuation-In-Part US7550433B2 (en) 2005-06-03 2006-06-02 Erythropoietin receptor peptide formulations and uses
US11/777,500 Continuation-In-Part US7919461B2 (en) 2005-06-03 2007-07-13 Erythropoietin receptor peptide formulations and uses

Publications (2)

Publication Number Publication Date
WO2006133144A2 WO2006133144A2 (en) 2006-12-14
WO2006133144A8 true WO2006133144A8 (en) 2008-04-17

Family

ID=37499033

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/021845 WO2006133144A2 (en) 2005-06-03 2006-06-05 Erythropoietin receptor peptide formulations and uses

Country Status (20)

Country Link
US (2) US7550433B2 (en)
EP (1) EP1917023A4 (en)
JP (2) JP2008542399A (en)
KR (2) KR20120119921A (en)
CN (1) CN101553242A (en)
AU (1) AU2006255081B2 (en)
BR (1) BRPI0613233A2 (en)
CA (1) CA2609401A1 (en)
CR (1) CR9570A (en)
EA (1) EA014528B1 (en)
GE (1) GEP20135981B (en)
IL (1) IL187354A0 (en)
MA (1) MA29557B1 (en)
MX (1) MX2007015303A (en)
NO (1) NO20076634L (en)
NZ (1) NZ563433A (en)
SG (1) SG162747A1 (en)
UA (1) UA92497C2 (en)
WO (1) WO2006133144A2 (en)
ZA (1) ZA200711020B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7919461B2 (en) * 2005-06-03 2011-04-05 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US7550433B2 (en) * 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US8324159B2 (en) * 2005-06-03 2012-12-04 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
DK2076290T3 (en) 2006-10-27 2017-01-23 Sunnybrook Health Sciences Center MULTIMERIC TIE 2 AGONISTS AND APPLICATIONS THEREOF IN STIMULATING ANGIOGENESIS
CA2676820A1 (en) * 2007-01-31 2008-08-07 Affymax, Inc. Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules
JP2010536858A (en) * 2007-08-22 2010-12-02 アフィーマックス・インコーポレイテッド Erythropoietin receptor peptide preparation and use
JP2009191056A (en) * 2008-02-15 2009-08-27 Affymax Inc Therapy of disorder mediated by anti-erythropoietin antibody using epo receptor agonist based on synthetic peptide
CN102838677B (en) * 2010-04-09 2014-10-22 苏州元基生物技术有限公司 Recombinant erythropoietin and preparation method thereof
CN103044539B (en) * 2010-04-09 2014-10-22 苏州元基生物技术有限公司 Reorganizational hemopoietin and preparation method thereof
CN102210872A (en) * 2011-05-30 2011-10-12 深圳翰宇药业股份有限公司 Polyethylene glycol modified peptide pharmaceutical formulation and preparation method thereof
CN103450348B (en) * 2012-05-29 2016-03-30 中国人民解放军军事医学科学院毒物药物研究所 A kind of Erythropoietin mimetic peptide, Preparation Method And The Use
CN104231067B (en) * 2013-06-07 2017-08-11 中国人民解放军军事医学科学院毒物药物研究所 Erythropoietin mimetic peptide chemical dimer and application thereof
CN105837681B (en) * 2015-01-13 2019-04-19 天津药物研究院 A kind of Erythropoietin mimetic peptide derivative, preparation method and use
CN106317217B (en) * 2015-06-26 2019-06-28 天津药物研究院有限公司 A kind of Erythropoietin mimetic peptide and its preparation method and application
CN106279398B (en) * 2015-06-26 2019-06-28 天津药物研究院有限公司 A kind of Erythropoietin mimetic peptide and its preparation method and application
CN105085653B (en) * 2015-08-26 2019-01-08 天津药物研究院有限公司 A kind of Erythropoietin mimetic peptide and its preparation method and application
CN105153293B (en) * 2015-08-26 2019-01-08 天津药物研究院有限公司 A kind of Erythropoietin mimetic peptide and its dimer and preparation method and application
CN105085654B (en) * 2015-08-26 2019-01-08 天津药物研究院有限公司 A kind of Erythropoietin mimetic peptide and its preparation method and application
CN105418754A (en) * 2015-09-30 2016-03-23 天津药物研究院有限公司 Hydroxyethyl starch modified hemopoietin mimic peptide and preparation thereof and application thereof
CN106608911B (en) * 2015-10-22 2020-01-07 天津药物研究院有限公司 Disulfide bond modified EPO (erythropoietin) peptidomimetic derivative and preparation method and application thereof
CN106608912B (en) * 2015-10-22 2019-09-20 天津药物研究院有限公司 A kind of EPO simulation peptide derivant and its preparation method and application that aliphatic dicarboxylic acid is coupled
CN106608913B (en) * 2015-10-22 2020-05-05 天津药物研究院有限公司 1, 2, 3-propanetriacid coupled EPO (erythropoietin) peptidomimetic derivative and preparation method and application thereof
CN105367629B (en) * 2015-11-09 2019-01-08 天津药物研究院有限公司 A kind of Erythropoietin mimetic peptide with and its preparation method and application

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
US4703008A (en) 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
KR850004274A (en) * 1983-12-13 1985-07-11 원본미기재 Method for preparing erythropoietin
US4677195A (en) * 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
AU610083B2 (en) 1986-08-18 1991-05-16 Clinical Technologies Associates, Inc. Delivery systems for pharmacological agents
US5080891A (en) * 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
US5006333A (en) * 1987-08-03 1991-04-09 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
WO1990008822A1 (en) 1989-02-03 1990-08-09 Genetics Institute, Inc. Erythropoietin receptor
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
DE69026306T2 (en) 1989-05-27 1996-10-17 Sumitomo Pharma Process for the production of polyethylene glycol derivatives and modified proteins.
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5292654A (en) * 1990-12-13 1994-03-08 Whitehead Institute For Biomedical Research Mutant EPO receptor and uses therefor
CA2082951C (en) 1991-03-15 1999-12-21 Robert M. Platz Pulmonary administration of granulocyte colony stimulating factor
ATE240740T1 (en) 1991-03-15 2003-06-15 Amgen Inc PEGYLATION OF POLYPEPTIDES
JPH06506217A (en) 1991-03-18 1994-07-14 エンゾン，インコーポレーテッド Hydrazine-containing conjugates of polypeptides or glycopolypeptides and polymers
DK0604552T3 (en) 1991-09-18 1997-08-04 Affymax Tech Nv Process for the synthesis of different assemblies of oligomers
US6153407A (en) * 1992-07-28 2000-11-28 Beth Israel Deaconess Medical Center Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics
US5614184A (en) * 1992-07-28 1997-03-25 New England Deaconess Hospital Recombinant human erythropoietin mutants and therapeutic methods employing them
US5888511A (en) * 1993-02-26 1999-03-30 Advanced Biotherapy Concepts, Inc. Treatment of autoimmune diseases, including AIDS
US5919455A (en) * 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5773569A (en) * 1993-11-19 1998-06-30 Affymax Technologies N.V. Compounds and peptides that bind to the erythropoietin receptor
US5830851A (en) * 1993-11-19 1998-11-03 Affymax Technologies N.V. Methods of administering peptides that bind to the erythropoietin receptor
US5580853A (en) * 1994-03-22 1996-12-03 New England Deaconess Hospital Modified polypeptides with increased biological activity
US5747446A (en) * 1994-03-22 1998-05-05 Beth Israel Deaconess Medical Center Modified polypeptides with increased biological activity
US5919758A (en) * 1994-03-22 1999-07-06 Beth Israel Deaconess Medical Center Modified polypeptides with altered biological activity
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
US5668110A (en) * 1995-06-07 1997-09-16 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
EA001220B1 (en) * 1995-06-07 2000-12-25 Глаксо Груп Лимитед Peptides or peptidemimetics bound to thrombopoietin receptor, pharmaceutical composition and method of treatment
US6251864B1 (en) * 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5683983A (en) * 1995-06-07 1997-11-04 Glaxo Group Limited Peptides and compounds that bind to the IL-5 receptor
US5767078A (en) * 1995-06-07 1998-06-16 Johnson; Dana L. Agonist peptide dimers
YU34196A (en) 1995-06-07 1999-03-04 Glaxo Group Limited Peptides and compounds that bind to a receptor
CA2223833C (en) 1995-06-07 2010-12-21 Nicholas C. Wrighton Compounds and peptides that bind to the erythropoietin receptor
US5677280A (en) * 1995-06-07 1997-10-14 Glaxo Group Limited Peptides and compounds that bind to the IL-5 receptor
US5654276A (en) * 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
US6346390B1 (en) * 1996-03-08 2002-02-12 Receptron, Inc. Receptor derived peptides involved in modulation of response to ligand binding
US6103879A (en) * 1996-06-21 2000-08-15 Axys Pharmaceuticals, Inc. Bivalent molecules that form an activating complex with an erythropoietin receptor
EP0964702B1 (en) * 1996-08-02 2006-10-04 Ortho-McNeil Pharmaceutical, Inc. Polypeptides having a single covalently bound n-terminal water-soluble polymer
US5932546A (en) * 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
JP2001504689A (en) * 1996-10-25 2001-04-10 ジー．ディー．サール アンド カンパニー Multifunctional chimeric hematopoietic receptor agonist
US6221608B1 (en) * 1997-01-22 2001-04-24 Ortho Pharmaceutical Corporation Methods for identifying erythropoietin receptor binding protein
JP4304757B2 (en) 1998-04-24 2009-07-29 株式会社デンソー ABS actuator
DK2316475T3 (en) * 1998-08-06 2017-11-20 Mountain View Pharmaceuticals Inc Isolated tetrameric uricase
PL220873B1 (en) 1998-08-06 2016-01-29 Mountain View Pharmaceuticals Uricase conjugate, pharmaceutical composition comprising thereof and the use thereof
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
EP1008355A1 (en) 1998-12-08 2000-06-14 Debio Recherche Pharmaceutique S.A. Method for identifying or analyzing polymer linkage sites on macromolecules using amino acid report binding
DE69914611T2 (en) * 1998-08-28 2004-12-23 Gryphon Therapeutics, Inc., South San Francisco METHOD FOR PRODUCING POLYAMIDE CHAINS OF EXACT LENGTH AND THEIR CONJUGATES WITH PROTEINS
DE69934425T2 (en) 1998-10-23 2007-09-27 Amgen Inc., Thousand Oaks THROMBOPOIETIN SUBSTITUTE
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
DE69929464T2 (en) * 1998-11-17 2006-09-07 Smithkline Beecham Corp. CYCLIC POLYAMINES FOR THE TREATMENT OF THROMBOCYTOPENIA
JO2291B1 (en) * 1999-07-02 2005-09-12 اف . هوفمان لاروش ايه جي Erythopintin derivatives
CZ299516B6 (en) * 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Erythropoietin glycoprotein conjugate, process for its preparation and use and pharmaceutical composition containing thereof
AUPQ873300A0 (en) * 2000-07-12 2000-08-03 Medvet Science Pty. Ltd. A binding motif of a receptor (2)
WO2001021180A1 (en) * 1999-09-24 2001-03-29 Smithkline Beecham Corporation Thrombopoietin mimetics
ES2254224T3 (en) * 1999-09-27 2006-06-16 Chugai Seiyaku Kabushiki Kaisha NEW PROTEIN OF THE HEMATOPOYETINE RECEIVER, NR12.
US6703480B1 (en) * 1999-11-24 2004-03-09 Palani Balu Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use
US6858630B2 (en) * 1999-12-06 2005-02-22 Smithkline Beecham Corporation Naphthimidazole derivatives and their use as thrombopoietin mimetics
EP1334118A4 (en) * 2000-03-21 2005-10-05 Wisconsin Alumni Res Found Methods and reagents for regulation of cellular responses in biological systems
US6777387B2 (en) * 2000-03-31 2004-08-17 Enzon Pharmaceuticals, Inc. Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same
DK1311285T4 (en) * 2000-05-15 2017-07-24 Hoffmann La Roche Liquid pharmaceutical composition containing an erythropoietin derivative
CN1318084C (en) 2000-05-26 2007-05-30 奥索-麦克尼尔药品公司 Neuroprotective peptides
US20020052317A1 (en) * 2000-08-02 2002-05-02 Loretta Itri Anti-viral and anti-tumor chemotherapy by administration of erythropoeitin
US7030218B2 (en) * 2000-09-08 2006-04-18 Gryphon Therapeutics Pseudo native chemical ligation
CN100528235C (en) * 2000-12-20 2009-08-19 霍夫曼-拉罗奇有限公司 Conjugates of erythropoietin
US7767643B2 (en) * 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
US6531121B2 (en) * 2000-12-29 2003-03-11 The Kenneth S. Warren Institute, Inc. Protection and enhancement of erythropoietin-responsive cells, tissues and organs
US20020183259A1 (en) 2001-02-20 2002-12-05 Choe Yun Hwang Terminally-branched polymeric linkers and polymeric conjugates containing the same
FR2823220B1 (en) * 2001-04-04 2003-12-12 Genodyssee NOVEL ERYTHROPOIETIN (EPO) POLYNUCLEOTIDES AND POLYPEPTIDES
US20020169128A1 (en) * 2001-04-09 2002-11-14 Geroge Sigounas Erythropoietin ameliorates chemotherapy-induced toxicity in vivo
CA2450985A1 (en) 2001-06-28 2003-01-09 Mountain View Pharmaceuticals, Inc. Polymer stabilized proteinases
US6784154B2 (en) * 2001-11-01 2004-08-31 University Of Utah Research Foundation Method of use of erythropoietin to treat ischemic acute renal failure
US7122189B2 (en) 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
US20050176627A1 (en) * 2002-09-09 2005-08-11 Anthony Cerami Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin
US20040062748A1 (en) 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US8129330B2 (en) * 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US7396913B2 (en) * 2002-10-14 2008-07-08 Abbott Laboratories Erythropoietin receptor binding antibodies
WO2004043457A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
GEP20084486B (en) 2002-12-26 2008-09-25 Mountain View Pharmaceuticals Polymer conjugates of interferon-beta with enhanced biological potency
AU2003303636B2 (en) * 2002-12-26 2010-08-05 Mountain View Pharmaceuticals, Inc. Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
EA010095B1 (en) 2003-05-12 2008-06-30 Афимакс, Инк. Novel peptides that bind to the erythropoietin receptor
EP1625156B1 (en) 2003-05-12 2012-09-19 Affymax, Inc. Peptides that bind to the erythropoietin receptor
NZ543934A (en) 2003-05-12 2008-06-30 Affymax Inc Novel spacer moiety for poly (ethylene glycol)-modified peptide-based compounds
US7550433B2 (en) * 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses

Also Published As

Publication number Publication date
GEP20135981B (en) 2013-12-10
EP1917023A4 (en) 2010-03-24
JP2008542399A (en) 2008-11-27
US20090136442A1 (en) 2009-05-28
KR101262312B1 (en) 2013-05-14
AU2006255081B2 (en) 2012-03-29
US7906485B2 (en) 2011-03-15
CA2609401A1 (en) 2006-12-14
AU2006255081A1 (en) 2006-12-14
EP1917023A2 (en) 2008-05-07
KR20080021115A (en) 2008-03-06
WO2006133144A2 (en) 2006-12-14
EA014528B1 (en) 2010-12-30
BRPI0613233A2 (en) 2010-12-28
US7550433B2 (en) 2009-06-23
CN101553242A (en) 2009-10-07
JP2013173763A (en) 2013-09-05
IL187354A0 (en) 2008-04-13
MX2007015303A (en) 2008-03-05
ZA200711020B (en) 2008-12-31
EA200702656A1 (en) 2008-12-30
NZ563433A (en) 2009-12-24
CR9570A (en) 2008-05-05
KR20120119921A (en) 2012-10-31
US20070104704A1 (en) 2007-05-10
MA29557B1 (en) 2008-06-02
SG162747A1 (en) 2010-07-29
NO20076634L (en) 2008-02-29
UA92497C2 (en) 2010-11-10

Similar Documents

Publication Publication Date Title
WO2006133144A8 (en) Erythropoietin receptor peptide formulations and uses
EP2129401B8 (en) Stable buffered formulations containing polypeptides
AU2007300221A8 (en) Stabilized antibody formulations and uses thereof
HK1114568A1 (en) Stable protein formulations
AU2006339063A8 (en) Macro-diacrylates and macro-polyacrylates
WO2006138675A9 (en) Her-2 peptides
EP2195002A4 (en) Erythropoietin receptor peptide formulations and uses
AU2005905904A0 (en) Leukocyte-binding polypeptides and uses thereof
AU2005905247A0 (en) Peptide fomulation
AU2005907097A0 (en) Improved guidance and kinematics
AU2006906424A0 (en) Improved sunscreen formulations
AU2005904785A0 (en) Hair slat - curler
AU2004904599A0 (en) Enhanced sunscreen formulation
AU2005902195A0 (en) Composition and uses thereof
AU2011205115B2 (en) Insulin-oligomer conjugates, formulations and uses thereof
AU2005906304A0 (en) Improved umbrella
AU2006236005A1 (en) Improved Umbrella
AU2005906820A0 (en) Umbrella construction
AU2005900853A0 (en) Peptide networks
AU2005903643A0 (en) Peptide Networks
AU2005905323A0 (en) Peptide networks
AU2005903196A0 (en) Pharmaceutical formulation
AU2004906317A0 (en) Arthrospira-based Compositions and Uses Thereof
AU2005907008A0 (en) X Beach
AU2005904360A0 (en) Improved sprinkler

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200680026991.4

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 11777500

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 187354

Country of ref document: IL

Ref document number: 563433

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2006255081

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 4475/KOLNP/2007

Country of ref document: IN

ENP Entry into the national phase

Ref document number: 2609401

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 12007502703

Country of ref document: PH

ENP Entry into the national phase

Ref document number: 2008514966

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: MX/a/2007/015303

Country of ref document: MX

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: CR2007-009570

Country of ref document: CR

WWE Wipo information: entry into national phase

Ref document number: 07131223

Country of ref document: CO

WWE Wipo information: entry into national phase

Ref document number: 2006784593

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 200702656

Country of ref document: EA

WWE Wipo information: entry into national phase

Ref document number: 10461

Country of ref document: GE

WWE Wipo information: entry into national phase

Ref document number: 1020087000166

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 11916416

Country of ref document: US

ENP Entry into the national phase

Ref document number: PI0613233

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20071203

WWE Wipo information: entry into national phase

Ref document number: 1020127022673

Country of ref document: KR