WO2006127901A3 - Optical fiber microscopy launch system and method - Google Patents

Optical fiber microscopy launch system and method Download PDF

Info

Publication number
WO2006127901A3
WO2006127901A3 PCT/US2006/020236 US2006020236W WO2006127901A3 WO 2006127901 A3 WO2006127901 A3 WO 2006127901A3 US 2006020236 W US2006020236 W US 2006020236W WO 2006127901 A3 WO2006127901 A3 WO 2006127901A3
Authority
WO
WIPO (PCT)
Prior art keywords
optical fiber
launch system
fiber microscopy
microscopy launch
sample slide
Prior art date
Application number
PCT/US2006/020236
Other languages
French (fr)
Other versions
WO2006127901A2 (en
Inventor
Guy G Kennedy
David M Warshaw
Original Assignee
Univ Vermont
Guy G Kennedy
David M Warshaw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vermont, Guy G Kennedy, David M Warshaw filed Critical Univ Vermont
Publication of WO2006127901A2 publication Critical patent/WO2006127901A2/en
Publication of WO2006127901A3 publication Critical patent/WO2006127901A3/en

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/36—Mechanical coupling means
    • G02B6/3616—Holders, macro size fixtures for mechanically holding or positioning fibres, e.g. on an optical bench
    • G02B6/3624—Fibre head, e.g. fibre probe termination
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/0001—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems
    • G02B6/0011—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being planar or of plate-like form
    • G02B6/0013—Means for improving the coupling-in of light from the light source into the light guide
    • G02B6/0023—Means for improving the coupling-in of light from the light source into the light guide provided by one optical element, or plurality thereof, placed between the light guide and the light source, or around the light source
    • G02B6/0028—Light guide, e.g. taper
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/26—Optical coupling means
    • G02B6/34—Optical coupling means utilising prism or grating
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/26—Optical coupling means
    • G02B6/262—Optical details of coupling light into, or out of, or between fibre ends, e.g. special fibre end shapes or associated optical elements
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/36—Mechanical coupling means
    • G02B6/3628—Mechanical coupling means for mounting fibres to supporting carriers
    • G02B6/3632—Mechanical coupling means for mounting fibres to supporting carriers characterised by the cross-sectional shape of the mechanical coupling means
    • G02B6/3644—Mechanical coupling means for mounting fibres to supporting carriers characterised by the cross-sectional shape of the mechanical coupling means the coupling means being through-holes or wall apertures
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/36—Mechanical coupling means
    • G02B6/3628—Mechanical coupling means for mounting fibres to supporting carriers
    • G02B6/3684—Mechanical coupling means for mounting fibres to supporting carriers characterised by the manufacturing process of surface profiling of the supporting carrier
    • G02B6/3696—Mechanical coupling means for mounting fibres to supporting carriers characterised by the manufacturing process of surface profiling of the supporting carrier by moulding, e.g. injection moulding, casting, embossing, stamping, stenciling, printing, or with metallic mould insert manufacturing using LIGA or MIGA techniques
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S385/00—Optical waveguides
    • Y10S385/901—Illuminating or display apparatus

Abstract

A launch system and method for microscopy having an optical fiber positioned proximate a sample slide with an optical fiber mounting element so as to deliver an EMR from a terminal end of the optical fiber across a surface of the sample slide to an opposing side surface at a desired incident angle.
PCT/US2006/020236 2005-05-25 2006-05-25 Optical fiber microscopy launch system and method WO2006127901A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68446505P 2005-05-25 2005-05-25
US60/684,465 2005-05-25

Publications (2)

Publication Number Publication Date
WO2006127901A2 WO2006127901A2 (en) 2006-11-30
WO2006127901A3 true WO2006127901A3 (en) 2009-04-16

Family

ID=37452840

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/020236 WO2006127901A2 (en) 2005-05-25 2006-05-25 Optical fiber microscopy launch system and method

Country Status (2)

Country Link
US (4) US7433563B2 (en)
WO (1) WO2006127901A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006127901A2 (en) * 2005-05-25 2006-11-30 The University Of Vermont And State Agricultural College Optical fiber microscopy launch system and method
WO2007034796A1 (en) * 2005-09-26 2007-03-29 National University Corporation Hamamatsu University School Of Medicine Microscope cell observing/inspecting system using a plurality of observation techniques
US20080197273A1 (en) * 2007-01-23 2008-08-21 Paul Andrew Mitchell Light Detection Apparatus
EP1950790A1 (en) * 2007-01-23 2008-07-30 Burle Technologies, Inc. Light Detection Apparatus
FR2912225B1 (en) * 2007-02-01 2009-10-23 Faurecia Interieur Ind Snc LIGHT INJECTION DEVICE, AND LARGE SOURCE SOURCE ELEMENT
US7995272B2 (en) * 2007-07-11 2011-08-09 Nicholas E Bratt Fixed focus microscope objective lens
FR2942047B1 (en) * 2009-02-09 2011-06-17 Commissariat Energie Atomique STRUCTURE AND METHOD FOR ALIGNING OPTICAL FIBER AND SUBMICRONIC WAVEGUIDE
US8064745B2 (en) * 2009-11-24 2011-11-22 Corning Incorporated Planar waveguide and optical fiber coupling
US9012872B1 (en) 2010-01-15 2015-04-21 Iowa State University Research Foundation, Inc. Auto-calibrated scanning-angle prism-type total internal reflection microscopy for nanometer-precision axial position determination and optional variable-illumination-depth pseudo total internal reflection microscopy
US20110280038A1 (en) * 2010-05-12 2011-11-17 Jeong Hwan J Systems for and methods of illumination at a high optical solid angle
DE102010029612B4 (en) * 2010-06-02 2017-12-21 Laser-Laboratorium Göttingen eV Coupling device for coupling light into a planar waveguide
WO2012051383A2 (en) * 2010-10-13 2012-04-19 Guy Kennedy An adjustable total internal reflectance microscopy (tirfm) illuminator apparatus
JP2012256663A (en) * 2011-06-08 2012-12-27 Nec Corp Optical amplifier and optical amplification method
KR20150037880A (en) 2012-07-30 2015-04-08 휴렛-팩커드 디벨롭먼트 컴퍼니, 엘.피. Optical coupling system and method for fabricating the same
JP6239479B2 (en) * 2014-09-30 2017-11-29 富士フイルム株式会社 Dark field microscope and illumination method
DE102015220303B4 (en) * 2015-10-19 2022-05-25 Carl Zeiss Microscopy Gmbh Microscope and microscopy methods
JP7209182B2 (en) * 2018-12-27 2023-01-20 スミダコーポレーション株式会社 Excitation light irradiation device and excitation light irradiation method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3967877A (en) * 1974-07-16 1976-07-06 International Business Machines (Ibm) Coupler for coupling optical energy transmitted by optical fiber to optical waveguide and method of manufacture
US3971621A (en) * 1973-03-01 1976-07-27 Ciba-Geigy Corporation Method and apparatus for generating a relieflike contrast at microscopic images of a transparent phase object
US4674846A (en) * 1985-07-11 1987-06-23 Robert Lippman Microscope slide system
US5249077A (en) * 1991-12-12 1993-09-28 Microvideo Instruments, Inc. Darkfield illuminator for a microscope slide

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3864019A (en) * 1973-11-15 1975-02-04 Bell Telephone Labor Inc Optical film-fiber coupler
DE19541233B4 (en) * 1994-11-17 2006-04-06 Carl Zeiss Object table for microscopes
US5598005A (en) * 1995-02-15 1997-01-28 The United States Of America As Represented By The Secretary Of The Commerce Non-destructive method for determining the extent of cure of a polymerizing material and the solidification of a thermoplastic polymer based on wavelength shift of fluroescence
EP0830586A1 (en) * 1995-05-26 1998-03-25 Optical Analytic Inc. Wide angle scattering detector
US6103535A (en) * 1996-05-31 2000-08-15 University Of Maryland Optical fiber evanescent field excited fluorosensor and method of manufacture
US6819484B2 (en) * 2001-11-06 2004-11-16 Olympus Optical Co., Ltd. Total internal reflection illumination apparatus and microscope using this total internal reflection illumination apparatus
DE10229935B4 (en) * 2002-07-04 2018-02-08 Carl Zeiss Microscopy Gmbh Microscope slide for coupling light into a microscope
WO2005031431A1 (en) 2003-09-25 2005-04-07 Leica Microsystems Cms Gmbh Microscope lens for total internal reflexion microscopy and microscope
US20050141843A1 (en) * 2003-12-31 2005-06-30 Invitrogen Corporation Waveguide comprising scattered light detectable particles
US20060186346A1 (en) * 2005-02-18 2006-08-24 Academia Sinica Method and system for reading microarrays
WO2006127901A2 (en) * 2005-05-25 2006-11-30 The University Of Vermont And State Agricultural College Optical fiber microscopy launch system and method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971621A (en) * 1973-03-01 1976-07-27 Ciba-Geigy Corporation Method and apparatus for generating a relieflike contrast at microscopic images of a transparent phase object
US3967877A (en) * 1974-07-16 1976-07-06 International Business Machines (Ibm) Coupler for coupling optical energy transmitted by optical fiber to optical waveguide and method of manufacture
US4674846A (en) * 1985-07-11 1987-06-23 Robert Lippman Microscope slide system
US5249077A (en) * 1991-12-12 1993-09-28 Microvideo Instruments, Inc. Darkfield illuminator for a microscope slide

Also Published As

Publication number Publication date
US7885498B2 (en) 2011-02-08
US20090028505A1 (en) 2009-01-29
US7616853B2 (en) 2009-11-10
WO2006127901A2 (en) 2006-11-30
US7711225B2 (en) 2010-05-04
US7433563B2 (en) 2008-10-07
US20090245731A1 (en) 2009-10-01
US20060280404A1 (en) 2006-12-14
US20100209048A1 (en) 2010-08-19

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