WO2006116637A3 - Raman spectroscopy for non-invasive glucose measurements - Google Patents
Raman spectroscopy for non-invasive glucose measurements Download PDFInfo
- Publication number
- WO2006116637A3 WO2006116637A3 PCT/US2006/016107 US2006016107W WO2006116637A3 WO 2006116637 A3 WO2006116637 A3 WO 2006116637A3 US 2006016107 W US2006016107 W US 2006016107W WO 2006116637 A3 WO2006116637 A3 WO 2006116637A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- raman spectroscopy
- glucose
- glucose measurements
- invasive glucose
- blood
- Prior art date
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract 5
- 239000008103 glucose Substances 0.000 title abstract 5
- 238000001069 Raman spectroscopy Methods 0.000 title abstract 3
- 238000005259 measurement Methods 0.000 title abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 238000001237 Raman spectrum Methods 0.000 abstract 1
- 238000004159 blood analysis Methods 0.000 abstract 1
- 238000002790 cross-validation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
Abstract
The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose trans cutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected trans cutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67525205P | 2005-04-27 | 2005-04-27 | |
US60/675,252 | 2005-04-27 |
Publications (2)
Publication Number | Publication Date |
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WO2006116637A2 WO2006116637A2 (en) | 2006-11-02 |
WO2006116637A3 true WO2006116637A3 (en) | 2007-03-01 |
Family
ID=36992565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/016107 WO2006116637A2 (en) | 2005-04-27 | 2006-04-27 | Raman spectroscopy for non-invasive glucose measurements |
Country Status (2)
Country | Link |
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US (1) | US8355767B2 (en) |
WO (1) | WO2006116637A2 (en) |
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Also Published As
Publication number | Publication date |
---|---|
US20070060806A1 (en) | 2007-03-15 |
US8355767B2 (en) | 2013-01-15 |
WO2006116637A2 (en) | 2006-11-02 |
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