WO2006116157A3 - Dipeptidyl peptidase-iv inhibitors - Google Patents

Dipeptidyl peptidase-iv inhibitors Download PDF

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Publication number
WO2006116157A3
WO2006116157A3 PCT/US2006/015200 US2006015200W WO2006116157A3 WO 2006116157 A3 WO2006116157 A3 WO 2006116157A3 US 2006015200 W US2006015200 W US 2006015200W WO 2006116157 A3 WO2006116157 A3 WO 2006116157A3
Authority
WO
WIPO (PCT)
Prior art keywords
dpp
inhibitors
compounds
dipeptidyl peptidase
present
Prior art date
Application number
PCT/US2006/015200
Other languages
French (fr)
Other versions
WO2006116157A2 (en
WO2006116157A9 (en
Inventor
Heiko Kroth
Tim Feuerstein
Frank Richter
Juergen Boer
Michael Essers
Bert Nolte
Matthias Schneider
Matthias Hochguertel
Fritz-Frieder Frickel
Arthur Taveras
Christoph Steeneck
Original Assignee
Alantos Pharmaceuticals Inc
Heiko Kroth
Tim Feuerstein
Frank Richter
Juergen Boer
Michael Essers
Bert Nolte
Matthias Schneider
Matthias Hochguertel
Fritz-Frieder Frickel
Arthur Taveras
Christoph Steeneck
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36694223&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006116157(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to ES06758484.7T priority Critical patent/ES2477868T3/en
Priority to BRPI0608469-9A priority patent/BRPI0608469A2/en
Priority to EP06758484.7A priority patent/EP1888562B1/en
Priority to AP2007004234A priority patent/AP2007004234A0/en
Priority to JP2008507950A priority patent/JP4568361B2/en
Priority to EA200702208A priority patent/EA200702208A1/en
Priority to MX2007011453A priority patent/MX2007011453A/en
Application filed by Alantos Pharmaceuticals Inc, Heiko Kroth, Tim Feuerstein, Frank Richter, Juergen Boer, Michael Essers, Bert Nolte, Matthias Schneider, Matthias Hochguertel, Fritz-Frieder Frickel, Arthur Taveras, Christoph Steeneck filed Critical Alantos Pharmaceuticals Inc
Priority to AU2006239929A priority patent/AU2006239929B2/en
Priority to CA002599419A priority patent/CA2599419A1/en
Publication of WO2006116157A2 publication Critical patent/WO2006116157A2/en
Publication of WO2006116157A9 publication Critical patent/WO2006116157A9/en
Publication of WO2006116157A3 publication Critical patent/WO2006116157A3/en
Priority to TNP2007000244A priority patent/TNSN07244A1/en
Priority to IL186607A priority patent/IL186607A0/en
Priority to NO20075973A priority patent/NO20075973L/en
Priority to AU2010201511A priority patent/AU2010201511B2/en

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    • C—CHEMISTRY; METALLURGY
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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Abstract

The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.
PCT/US2006/015200 2005-04-22 2006-04-21 Dipeptidyl peptidase-iv inhibitors WO2006116157A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP2008507950A JP4568361B2 (en) 2005-04-22 2006-04-21 Dipeptidyl peptidase-IV inhibitor
CA002599419A CA2599419A1 (en) 2005-04-22 2006-04-21 Dipeptidyl peptidase-iv inhibitors
AU2006239929A AU2006239929B2 (en) 2005-04-22 2006-04-21 Dipeptidyl peptidase-IV inhibitors
AP2007004234A AP2007004234A0 (en) 2005-04-22 2006-04-21 Dipeptidyl peptidase-IV inhibitors
BRPI0608469-9A BRPI0608469A2 (en) 2005-04-22 2006-04-21 dipeptidyl peptidase-iv inhibitors
EA200702208A EA200702208A1 (en) 2005-04-22 2006-04-21 DIPEPTIDYLPEPTIDASE-IV INHIBITORS
MX2007011453A MX2007011453A (en) 2005-04-22 2006-04-21 Dipeptidyl peptidase-iv inhibitors.
ES06758484.7T ES2477868T3 (en) 2005-04-22 2006-04-21 Dipeptidyl peptidase-IV inhibitors
EP06758484.7A EP1888562B1 (en) 2005-04-22 2006-04-21 Dipeptidyl peptidase-iv inhibitors
TNP2007000244A TNSN07244A1 (en) 2005-04-22 2007-06-26 Dipeptidyl peptidase-iv inhibitors
IL186607A IL186607A0 (en) 2005-04-22 2007-10-11 Dipeptidyl peptidase-iv inhibitors
NO20075973A NO20075973L (en) 2005-04-22 2007-11-22 Dipeptidyl peptidase IV inhibitors
AU2010201511A AU2010201511B2 (en) 2005-04-22 2010-04-15 Dipeptidyl peptidase-IV inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67415105P 2005-04-22 2005-04-22
US60/674,151 2005-04-22

Publications (3)

Publication Number Publication Date
WO2006116157A2 WO2006116157A2 (en) 2006-11-02
WO2006116157A9 WO2006116157A9 (en) 2007-03-01
WO2006116157A3 true WO2006116157A3 (en) 2007-04-19

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Application Number Title Priority Date Filing Date
PCT/US2006/015200 WO2006116157A2 (en) 2005-04-22 2006-04-21 Dipeptidyl peptidase-iv inhibitors

Country Status (19)

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US (3) US7553861B2 (en)
EP (1) EP1888562B1 (en)
JP (2) JP4568361B2 (en)
KR (1) KR20080000665A (en)
CN (1) CN101277949A (en)
AP (1) AP2007004234A0 (en)
AU (2) AU2006239929B2 (en)
BR (1) BRPI0608469A2 (en)
CA (1) CA2599419A1 (en)
CR (1) CR9462A (en)
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