WO2006116157A3 - Dipeptidyl peptidase-iv inhibitors - Google Patents
Dipeptidyl peptidase-iv inhibitors Download PDFInfo
- Publication number
- WO2006116157A3 WO2006116157A3 PCT/US2006/015200 US2006015200W WO2006116157A3 WO 2006116157 A3 WO2006116157 A3 WO 2006116157A3 US 2006015200 W US2006015200 W US 2006015200W WO 2006116157 A3 WO2006116157 A3 WO 2006116157A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dpp
- inhibitors
- compounds
- dipeptidyl peptidase
- present
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AP2007004234A AP2007004234A0 (en) | 2005-04-22 | 2006-04-21 | Dipeptidyl peptidase-IV inhibitors |
AU2006239929A AU2006239929B2 (en) | 2005-04-22 | 2006-04-21 | Dipeptidyl peptidase-IV inhibitors |
MX2007011453A MX2007011453A (en) | 2005-04-22 | 2006-04-21 | Dipeptidyl peptidase-iv inhibitors. |
JP2008507950A JP4568361B2 (en) | 2005-04-22 | 2006-04-21 | Dipeptidyl peptidase-IV inhibitor |
CA002599419A CA2599419A1 (en) | 2005-04-22 | 2006-04-21 | Dipeptidyl peptidase-iv inhibitors |
EA200702208A EA200702208A1 (en) | 2005-04-22 | 2006-04-21 | DIPEPTIDYLPEPTIDASE-IV INHIBITORS |
ES06758484.7T ES2477868T3 (en) | 2005-04-22 | 2006-04-21 | Dipeptidyl peptidase-IV inhibitors |
EP06758484.7A EP1888562B1 (en) | 2005-04-22 | 2006-04-21 | Dipeptidyl peptidase-iv inhibitors |
BRPI0608469-9A BRPI0608469A2 (en) | 2005-04-22 | 2006-04-21 | dipeptidyl peptidase-iv inhibitors |
TNP2007000244A TNSN07244A1 (en) | 2005-04-22 | 2007-06-26 | Dipeptidyl peptidase-iv inhibitors |
IL186607A IL186607A0 (en) | 2005-04-22 | 2007-10-11 | Dipeptidyl peptidase-iv inhibitors |
NO20075973A NO20075973L (en) | 2005-04-22 | 2007-11-22 | Dipeptidyl peptidase IV inhibitors |
AU2010201511A AU2010201511B2 (en) | 2005-04-22 | 2010-04-15 | Dipeptidyl peptidase-IV inhibitors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67415105P | 2005-04-22 | 2005-04-22 | |
US60/674,151 | 2005-04-22 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2006116157A2 WO2006116157A2 (en) | 2006-11-02 |
WO2006116157A9 WO2006116157A9 (en) | 2007-03-01 |
WO2006116157A3 true WO2006116157A3 (en) | 2007-04-19 |
Family
ID=36694223
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/015200 WO2006116157A2 (en) | 2005-04-22 | 2006-04-21 | Dipeptidyl peptidase-iv inhibitors |
Country Status (19)
Country | Link |
---|---|
US (3) | US7553861B2 (en) |
EP (1) | EP1888562B1 (en) |
JP (2) | JP4568361B2 (en) |
KR (1) | KR20080000665A (en) |
CN (1) | CN101277949A (en) |
AP (1) | AP2007004234A0 (en) |
AU (2) | AU2006239929B2 (en) |
BR (1) | BRPI0608469A2 (en) |
CA (1) | CA2599419A1 (en) |
CR (1) | CR9462A (en) |
EA (1) | EA200702208A1 (en) |
ES (1) | ES2477868T3 (en) |
IL (1) | IL186607A0 (en) |
MA (1) | MA29387B1 (en) |
MX (1) | MX2007011453A (en) |
NO (1) | NO20075973L (en) |
TN (1) | TNSN07244A1 (en) |
WO (1) | WO2006116157A2 (en) |
ZA (1) | ZA200708179B (en) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
DE102004054054A1 (en) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for preparing chiral 8- (3-amino-piperidin-1-yl) -xanthines |
JP4568361B2 (en) * | 2005-04-22 | 2010-10-27 | アラントス・ファーマシューティカルズ・ホールディング・インコーポレーテッド | Dipeptidyl peptidase-IV inhibitor |
CA2625646A1 (en) * | 2005-10-25 | 2007-05-03 | Merck & Co., Inc. | Combination of a dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension |
EP1962827A4 (en) * | 2005-12-16 | 2011-02-16 | Merck Sharp & Dohme | Pharmaceutical compositions of combinations of dipeptidyl peptidase-4 inhibitors with metformin |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
CN103951667A (en) | 2006-05-04 | 2014-07-30 | 勃林格殷格翰国际有限公司 | Polymorphs |
PE20080251A1 (en) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | USES OF DPP IV INHIBITORS |
WO2008011518A2 (en) * | 2006-07-19 | 2008-01-24 | Diakine Therapeutics, Inc. | Encapsulation system |
AU2008210988B2 (en) * | 2007-02-01 | 2012-09-06 | Allocure, Inc. | Potentiation of stem cell homing and treatment of organ dysfunction or organ failure |
WO2008120813A1 (en) | 2007-04-03 | 2008-10-09 | Mitsubishi Tanabe Pharma Corporation | Combined use of dipeptidyl peptidase iv inhibitor compound and sweetener |
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JP2008538574A (en) | 2008-10-30 |
US20100009961A1 (en) | 2010-01-14 |
BRPI0608469A2 (en) | 2010-01-05 |
US20110112051A1 (en) | 2011-05-12 |
KR20080000665A (en) | 2008-01-02 |
ZA200708179B (en) | 2009-12-30 |
AU2010201511A1 (en) | 2010-05-06 |
JP5198494B2 (en) | 2013-05-15 |
JP2010150273A (en) | 2010-07-08 |
CA2599419A1 (en) | 2006-11-02 |
IL186607A0 (en) | 2008-01-20 |
WO2006116157A2 (en) | 2006-11-02 |
WO2006116157A9 (en) | 2007-03-01 |
EA200702208A1 (en) | 2008-04-28 |
EP1888562B1 (en) | 2014-06-18 |
JP4568361B2 (en) | 2010-10-27 |
CN101277949A (en) | 2008-10-01 |
EP1888562A2 (en) | 2008-02-20 |
MX2007011453A (en) | 2008-02-12 |
AP2007004234A0 (en) | 2007-12-31 |
NO20075973L (en) | 2008-01-21 |
CR9462A (en) | 2008-04-16 |
US20060270701A1 (en) | 2006-11-30 |
MA29387B1 (en) | 2008-04-01 |
AU2010201511B2 (en) | 2012-02-16 |
US7553861B2 (en) | 2009-06-30 |
AU2006239929B2 (en) | 2011-11-03 |
AU2006239929A1 (en) | 2006-11-02 |
US8076330B2 (en) | 2011-12-13 |
TNSN07244A1 (en) | 2008-11-21 |
ES2477868T3 (en) | 2014-07-18 |
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