WO2006093814A3 - Fgf growth factor analogs - Google Patents

Fgf growth factor analogs Download PDF

Info

Publication number
WO2006093814A3
WO2006093814A3 PCT/US2006/006488 US2006006488W WO2006093814A3 WO 2006093814 A3 WO2006093814 A3 WO 2006093814A3 US 2006006488 W US2006006488 W US 2006006488W WO 2006093814 A3 WO2006093814 A3 WO 2006093814A3
Authority
WO
WIPO (PCT)
Prior art keywords
growth factor
factor analogs
fgf growth
fibroblast growth
fgf
Prior art date
Application number
PCT/US2006/006488
Other languages
French (fr)
Other versions
WO2006093814A2 (en
Inventor
Paul O Zamora
Kazuyuki Takahashi
Louis A Pena
Xinhua Lin
Original Assignee
Biosurface Eng Tech Inc
Brookhaven Science Ass Llc
Paul O Zamora
Kazuyuki Takahashi
Louis A Pena
Xinhua Lin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosurface Eng Tech Inc, Brookhaven Science Ass Llc, Paul O Zamora, Kazuyuki Takahashi, Louis A Pena, Xinhua Lin filed Critical Biosurface Eng Tech Inc
Priority to EP06735950.5A priority Critical patent/EP1856146B1/en
Priority to ES06735950T priority patent/ES2738005T3/en
Priority to CA2599240A priority patent/CA2599240C/en
Priority to PL06735950T priority patent/PL1856146T3/en
Publication of WO2006093814A2 publication Critical patent/WO2006093814A2/en
Publication of WO2006093814A3 publication Critical patent/WO2006093814A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factors [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention provides a fibroblast growth factor heparin-binding analog of the formula: where Ri, R2, R3, R4, R5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.
PCT/US2006/006488 2005-02-25 2006-02-24 Fgf growth factor analogs WO2006093814A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP06735950.5A EP1856146B1 (en) 2005-02-25 2006-02-24 Fgf growth factor analogs
ES06735950T ES2738005T3 (en) 2005-02-25 2006-02-24 FGF growth factor analogues
CA2599240A CA2599240C (en) 2005-02-25 2006-02-24 Fgf growth factor analogs
PL06735950T PL1856146T3 (en) 2005-02-25 2006-02-24 Fgf growth factor analogs

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65686005P 2005-02-25 2005-02-25
US60/656,860 2005-02-25
US11/361,565 2006-02-23
US11/361,565 US8227411B2 (en) 2002-08-20 2006-02-23 FGF growth factor analogs

Publications (2)

Publication Number Publication Date
WO2006093814A2 WO2006093814A2 (en) 2006-09-08
WO2006093814A3 true WO2006093814A3 (en) 2009-04-16

Family

ID=36941659

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/006488 WO2006093814A2 (en) 2005-02-25 2006-02-24 Fgf growth factor analogs

Country Status (6)

Country Link
US (1) US8227411B2 (en)
EP (1) EP1856146B1 (en)
CA (1) CA2599240C (en)
ES (1) ES2738005T3 (en)
PL (1) PL1856146T3 (en)
WO (1) WO2006093814A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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US7166574B2 (en) * 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US7598224B2 (en) 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
DE602005023714D1 (en) 2004-02-20 2010-11-04 Biosurface Eng Tech Inc BONE MORPHOGENETIC PROTEIN-2 POSITIVE MODULATOR (BMP-2)
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
JP2009541358A (en) * 2006-06-22 2009-11-26 バイオサーフェス エンジニアリング テクノロジーズ，インク． Compositions and methods for delivering a BMP-2 amplification factor / co-activator to enhance bone formation
US20080255041A1 (en) * 2007-04-11 2008-10-16 Ebi, L.P. Treatment of annulus fibrosis defects
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WO2023220639A2 (en) * 2022-05-10 2023-11-16 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for improved memory in the aging

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Also Published As

Publication number Publication date
EP1856146A2 (en) 2007-11-21
WO2006093814A2 (en) 2006-09-08
PL1856146T3 (en) 2020-02-28
ES2738005T3 (en) 2020-01-17
CA2599240A1 (en) 2006-09-08
CA2599240C (en) 2018-05-01
EP1856146B1 (en) 2019-05-29
US20060199764A1 (en) 2006-09-07
US8227411B2 (en) 2012-07-24
EP1856146A4 (en) 2011-02-02

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