WO2006081270A8 - Electrokinetic concentration device and methods of use thereof - Google Patents

Electrokinetic concentration device and methods of use thereof

Info

Publication number
WO2006081270A8
WO2006081270A8 PCT/US2006/002550 US2006002550W WO2006081270A8 WO 2006081270 A8 WO2006081270 A8 WO 2006081270A8 US 2006002550 W US2006002550 W US 2006002550W WO 2006081270 A8 WO2006081270 A8 WO 2006081270A8
Authority
WO
WIPO (PCT)
Prior art keywords
methods
microchannel
concentration device
nanochannel
species
Prior art date
Application number
PCT/US2006/002550
Other languages
French (fr)
Other versions
WO2006081270A2 (en
WO2006081270A3 (en
Inventor
Jogyoon Han
Ying-Chih Wang
Original Assignee
Massachusetts Inst Technology
Jogyoon Han
Ying-Chih Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Jogyoon Han, Ying-Chih Wang filed Critical Massachusetts Inst Technology
Priority to JP2007553185A priority Critical patent/JP4785868B2/en
Priority to KR1020077019294A priority patent/KR101329445B1/en
Priority to CA2595840A priority patent/CA2595840C/en
Priority to EP06733869A priority patent/EP1848986A4/en
Priority to CN2006800096436A priority patent/CN101506647B/en
Priority to AU2006208124A priority patent/AU2006208124B2/en
Publication of WO2006081270A2 publication Critical patent/WO2006081270A2/en
Publication of WO2006081270A8 publication Critical patent/WO2006081270A8/en
Publication of WO2006081270A3 publication Critical patent/WO2006081270A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B7/00—Microstructural systems; Auxiliary parts of microstructural devices or systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Electrostatic Separation (AREA)

Abstract

The present invention provides a device and methods of use thereof in concentrating a species of interest and/or controlling liquid flow in a device. The methods, inter-alia, make use of a device comprising microchannels, which are linked to nanochannels, whereby induction of an electric field in the nanochannel results in ion depletion in the linkage region between the microchannel and nanochannel, and a space charge layer is formed within the microchannel, which provides an energy barrier for said species of interest which enables its concentration in a region in the microchannel.
PCT/US2006/002550 2005-01-25 2006-01-25 Electrokinetic concentration device and methods of use thereof WO2006081270A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2007553185A JP4785868B2 (en) 2005-01-25 2006-01-25 Electrokinetic concentrator and method of use
KR1020077019294A KR101329445B1 (en) 2005-01-25 2006-01-25 Electrokinetic concentration device and methods of use thereof
CA2595840A CA2595840C (en) 2005-01-25 2006-01-25 Electrokinetic concentration device and methods of use thereof
EP06733869A EP1848986A4 (en) 2005-01-25 2006-01-25 Electrokinetic concentration device and methods of use thereof
CN2006800096436A CN101506647B (en) 2005-01-25 2006-01-25 Electrokinetic concentration device and methods of use thereof
AU2006208124A AU2006208124B2 (en) 2005-01-25 2006-01-25 Electrokinetic concentration device and methods of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64651305P 2005-01-25 2005-01-25
US60/646,513 2005-01-25

Publications (3)

Publication Number Publication Date
WO2006081270A2 WO2006081270A2 (en) 2006-08-03
WO2006081270A8 true WO2006081270A8 (en) 2007-09-07
WO2006081270A3 WO2006081270A3 (en) 2009-04-30

Family

ID=36741015

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/002550 WO2006081270A2 (en) 2005-01-25 2006-01-25 Electrokinetic concentration device and methods of use thereof

Country Status (8)

Country Link
US (1) US7651600B2 (en)
EP (1) EP1848986A4 (en)
JP (1) JP4785868B2 (en)
KR (1) KR101329445B1 (en)
CN (1) CN101506647B (en)
AU (1) AU2006208124B2 (en)
CA (1) CA2595840C (en)
WO (1) WO2006081270A2 (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7293411B2 (en) * 2004-12-20 2007-11-13 Palo Alto Research Center Incorporated Energy scavengers which adjust their frequency by altering liquid distributions on a beam
US8163154B1 (en) 2006-09-29 2012-04-24 Sandia Corporation Method for voltage-gated protein fractionation
CA2700397A1 (en) * 2007-09-26 2009-04-02 Massachusetts Institute Of Technology Electrokinetic concentration device and methods of use thereof
US20090136948A1 (en) * 2007-10-31 2009-05-28 Jongyoon Han Nanoconfinement- based devices and methods of use thereof
US8343425B1 (en) * 2008-02-29 2013-01-01 Uchicago Argonne, Llc Multi-layer micro/nanofluid devices with bio-nanovalves
WO2009120642A1 (en) * 2008-03-26 2009-10-01 Massachusetts Institute Of Technology Methods for fabricating electrokinetic concentration devices
JP5323933B2 (en) * 2008-07-22 2013-10-23 マサチューセッツ インスティテュート オブ テクノロジー Pump supply switching and desalting of amplified dynamic current bodies
FR2936316B1 (en) * 2008-09-25 2015-05-01 Etat Francais Dga DEVICE FOR SELECTIVE PRECONCENTRATION / DETECTION OF CHARGED ANALYTES CONTAINED IN AN ELECTROLYTE AND ASSOCIATED METHOD.
WO2010056986A2 (en) 2008-11-14 2010-05-20 The Board Of Regents Of The University Of Texas System Nanochanneled device and related methods
KR101383004B1 (en) 2009-12-02 2014-04-08 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 Flow path device and sample processing device including same
US8603303B2 (en) * 2010-03-15 2013-12-10 International Business Machines Corporation Nanopore based device for cutting long DNA molecules into fragments
US8039250B2 (en) * 2010-03-15 2011-10-18 International Business Machines Corporation Piezoelectric-based nanopore device for the active control of the motion of polymers through the same
US20110288497A1 (en) * 2010-05-19 2011-11-24 Nanomedical Systems, Inc. Nano-Scale Coatings and Related Methods Suitable for In-Vivo Use
US8753492B2 (en) * 2010-06-17 2014-06-17 Massachusetts Institute Of Technology Method for enhancing current throughput in an electrochemical system
WO2011163215A1 (en) 2010-06-21 2011-12-29 Massachusetts Institute Of Technology Method and apparatus for desalination and purification
US8852407B2 (en) 2011-01-28 2014-10-07 International Business Machines Corporation Electron beam sculpting of tunneling junction for nanopore DNA sequencing
US20120193231A1 (en) 2011-01-28 2012-08-02 International Business Machines Corporation Dna sequencing using multiple metal layer structure with organic coatings forming transient bonding to dna bases
US8986524B2 (en) 2011-01-28 2015-03-24 International Business Machines Corporation DNA sequence using multiple metal layer structure with different organic coatings forming different transient bondings to DNA
US9220829B2 (en) 2011-03-09 2015-12-29 Zvi Herschman Implantable systems and methods for removing specific impurities from fluids such as blood
FR2984756B1 (en) * 2011-12-27 2014-02-21 Commissariat Energie Atomique NANO DEVICE AND MICRO FLUID FOR SEPARATING AND CONCENTRATING PARTICLES PRESENT IN A FLUID
KR101275994B1 (en) * 2012-01-03 2013-06-17 국립대학법인 울산과학기술대학교 산학협력단 Electrostatic bioaerosol concentrator
KR101248271B1 (en) * 2012-02-21 2013-03-27 광운대학교 산학협력단 Energy conversion device using micro-nano channel and fabrication method thereof
KR101314420B1 (en) * 2012-02-21 2013-10-04 광운대학교 산학협력단 Three-dimensional energy conversion device using micro-nano channel and fabrication method thereof
US10029915B2 (en) 2012-04-04 2018-07-24 International Business Machines Corporation Functionally switchable self-assembled coating compound for controlling translocation of molecule through nanopores
EP2875343B1 (en) * 2012-07-20 2018-03-14 Northeastern University Microfluidic-nanofluidic devices for detection and measurement of redox active substances
US9387488B2 (en) * 2012-11-13 2016-07-12 Academia Sinica Molecular entrapment and enrichment
CN103055966B (en) * 2012-12-26 2015-01-14 北京航空航天大学 Nanofluidic diode device based on branched alumina nano channel film
WO2014116756A1 (en) 2013-01-22 2014-07-31 University Of Washington Through Its Center For Commercialization Sequential delivery of fluid volumes and associated devices, systems and methods
US20160310942A1 (en) * 2013-01-22 2016-10-27 University Of Washington Pressure-based control of fluid volumes and associated devices, systems, and methods
US9046511B2 (en) 2013-04-18 2015-06-02 International Business Machines Corporation Fabrication of tunneling junction for nanopore DNA sequencing
US9188578B2 (en) 2013-06-19 2015-11-17 Globalfoundries Inc. Nanogap device with capped nanowire structures
US9182369B2 (en) 2013-06-19 2015-11-10 Globalfoundries Inc. Manufacturable sub-3 nanometer palladium gap devices for fixed electrode tunneling recognition
JP6151128B2 (en) * 2013-08-12 2017-06-21 株式会社東芝 Semiconductor micro-analysis chip and manufacturing method thereof
JP2015099031A (en) * 2013-11-18 2015-05-28 株式会社東芝 Semiconductor micro analysis chip and manufacturing method thereof
US9079002B1 (en) * 2014-02-07 2015-07-14 Texas Instruments Incorporated Ceramic nanochannel drug delivery device and method of formation
WO2015148609A2 (en) * 2014-03-26 2015-10-01 Li-Cor, Inc. Immunoassays using colloidal crystals
US10967372B2 (en) * 2014-04-16 2021-04-06 International Business Machines Corporation Electro-fluidic flow probe
KR101718951B1 (en) * 2016-06-30 2017-03-22 광운대학교 산학협력단 Biomolecular preconcentration device and fabrication method thereof
KR101924976B1 (en) * 2016-10-17 2019-02-27 서울대학교 산학협력단 Device and method for non-destructive separating and concentrating the substance
CN107011899B (en) * 2017-04-01 2023-06-20 华南理工大学 Device and method for preparing full-spectrum perovskite quantum dots by using external electric field
US20180319681A1 (en) * 2017-05-02 2018-11-08 United States Of America As Represented By The Secretary Of The Army Contactless Ion Concentration Method & Apparatus Using Nanoporous Membrane with Applied Potential
US10669572B2 (en) 2017-05-31 2020-06-02 University Of Notre Dame Du Lac Ultra-sensitive multi-target lateral flow molecular assay with field-induced precipitation
KR102168202B1 (en) * 2019-01-21 2020-10-20 울산과학기술원 Method of performing self-powered diffusiophoresis using the same
KR102168201B1 (en) * 2019-01-21 2020-10-20 울산과학기술원 Self-powered diffusiophoresis apparatus and method of performing self-powered diffusiophoresis using the same
US11426500B2 (en) 2019-05-17 2022-08-30 Zvi Herschman Systems and methods for removing specific impurities from fluids such as blood using a nanotube selector
KR102218278B1 (en) * 2019-11-08 2021-02-19 울산과학기술원 Apparatus for controlling the transport of materials in nanochannels by controlling humidity
US20210346844A1 (en) 2020-05-05 2021-11-11 Massachusetts Institute Of Technology Electrokinetic-Based Concentrator Device and Method
CN115569677A (en) * 2022-10-12 2023-01-06 燕山大学 Forward osmosis and electroosmotic flow integrated chip based on dual pump effect

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE9004756U1 (en) * 1990-04-27 1991-08-22 Ramsauer, Dieter, 5620 Velbert, De
US5374834A (en) * 1993-10-12 1994-12-20 Massachusetts Institute Of Technology Ionic liquid-channel charge-coupled device
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
WO1998000231A1 (en) * 1996-06-28 1998-01-08 Caliper Technologies Corporation High-throughput screening assay systems in microscale fluidic devices
US5869004A (en) * 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
US6951682B1 (en) * 1998-12-01 2005-10-04 Syntrix Biochip, Inc. Porous coatings bearing ligand arrays and use thereof
JP2000262871A (en) * 1999-01-11 2000-09-26 Kawamura Inst Of Chem Res Microporous membrane separation device and its production
US6326083B1 (en) * 1999-03-08 2001-12-04 Calipher Technologies Corp. Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety
JP2004513342A (en) * 2000-10-31 2004-04-30 カリパー・テクノロジーズ・コープ． Microfluidic methods, apparatus and systems for concentrating materials in situ
JP3695431B2 (en) * 2001-08-03 2005-09-14 日本電気株式会社 Separation apparatus and method of manufacturing separation apparatus
JP2004042012A (en) * 2001-10-26 2004-02-12 Nec Corp Separation apparatus, analysis system, separating method, and method of manufacturing the apparatus
JP4855680B2 (en) 2002-05-09 2012-01-18 ザ・ユニバーシティ・オブ・シカゴ Apparatus and method for transport and reaction by pressure driven plug
SE0203773D0 (en) * 2002-12-19 2002-12-19 Capture Device Ab Method and device for capturing charged molecules traveling in a flow stream
JP2005007352A (en) 2003-06-20 2005-01-13 Sharp Corp Separation method, separation device and detection device for particle
KR100971044B1 (en) * 2003-09-05 2010-07-16 칼리퍼 라이프 사이언시즈, 인크. Analyte injection system
JP4250523B2 (en) 2003-12-25 2009-04-08 株式会社東芝 Microreactor, analysis system, analysis method, reaction system, reaction method, separation system, separation method

Also Published As

Publication number Publication date
WO2006081270A2 (en) 2006-08-03
CA2595840A1 (en) 2006-08-03
CN101506647B (en) 2013-06-12
KR20080019573A (en) 2008-03-04
JP2008532733A (en) 2008-08-21
AU2006208124A1 (en) 2006-08-03
CA2595840C (en) 2013-12-10
JP4785868B2 (en) 2011-10-05
EP1848986A2 (en) 2007-10-31
EP1848986A4 (en) 2009-07-29
US20060180469A1 (en) 2006-08-17
CN101506647A (en) 2009-08-12
KR101329445B1 (en) 2013-11-14
WO2006081270A3 (en) 2009-04-30
AU2006208124B2 (en) 2011-09-15
US7651600B2 (en) 2010-01-26

Similar Documents

Publication Publication Date Title
WO2006081270A3 (en) Electrokinetic concentration device and methods of use thereof
Chang et al. Nanoscale electrokinetics and microvortices: How microhydrodynamics affects nanofluidic ion flux
Slouka et al. Microfluidic systems with ion-selective membranes
Son et al. Engineered nanofluidic preconcentration devices by ion concentration polarization
WO2006067715A3 (en) Method for controlling the flow of liquids containing biological material by inducing electro- or magneto-rheological effect
WO2007062303A3 (en) Ion mobility spectrometer
Nakano et al. Insulator-based dielectrophoresis with β-galactosidase in nanostructured devices
WO2008039579A3 (en) Inorganic nanotubes and devices fabricated therefrom
WO2007078833A3 (en) Reusable pcr amplification system and method
WO2007009092A3 (en) Method for improved accuracy of blood testing
WO2005084374A3 (en) Magnetic device for isolation of cells and biomolecules in a microfluidic environment
WO2007041692A3 (en) Microfluidic detection of analytes
WO2011037984A3 (en) Ion mobility sensor system
GB0521160D0 (en) Electrochemical microfluidic sensor and method of creation of its microchannels by embossing
WO2010041230A3 (en) Microfluidic integrated device for sample processing
EP2479289A3 (en) Method for methylation analysis
WO2010028140A3 (en) Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
WO2008052138A3 (en) Inline-injection microdevice and microfabricated integrated dna analysis system using same
DE602004025801D1 (en) DNA POLYMERASE FUSIONS AND ITS USES
MY147438A (en) Biological materials and uses thereof
WO2012122564A3 (en) Diagnostic and sample preparation devices and methods
WO2002029400A3 (en) Apparatuses and methods for field flow fractionation of particles using acoustic and other forces
WO2019136202A8 (en) System and methods for electrokinetic loading of sub-micron-scale reaction chambers
MX2007011411A (en) Rage/diaphanous interaction and related compositions and methods.
Sasaki Recent applications of AC electrokinetics in biomolecular analysis on microfluidic devices

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200680009643.6

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2595840

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2007553185

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2006208124

Country of ref document: AU

Ref document number: 1020077019294

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2006733869

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2006208124

Country of ref document: AU

Date of ref document: 20060125

Kind code of ref document: A