WO2006055554B1 - Light diffusing tip - Google Patents

Light diffusing tip

Info

Publication number
WO2006055554B1
WO2006055554B1 PCT/US2005/041347 US2005041347W WO2006055554B1 WO 2006055554 B1 WO2006055554 B1 WO 2006055554B1 US 2005041347 W US2005041347 W US 2005041347W WO 2006055554 B1 WO2006055554 B1 WO 2006055554B1
Authority
WO
WIPO (PCT)
Prior art keywords
scattering
housing
light
light diffusing
region
Prior art date
Application number
PCT/US2005/041347
Other languages
French (fr)
Other versions
WO2006055554A3 (en
WO2006055554A2 (en
Inventor
Ashok Gowda
Roger Mcnichols
Marc Gelnett
Matthew Fox
Original Assignee
Biotex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotex Inc filed Critical Biotex Inc
Priority to CA002587691A priority Critical patent/CA2587691A1/en
Priority to EP05849640A priority patent/EP1817618A4/en
Publication of WO2006055554A2 publication Critical patent/WO2006055554A2/en
Publication of WO2006055554A3 publication Critical patent/WO2006055554A3/en
Publication of WO2006055554B1 publication Critical patent/WO2006055554B1/en

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/241—Light guide terminations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/26—Optical coupling means
    • G02B6/262—Optical details of coupling light into, or out of, or between fibre ends, e.g. special fibre end shapes or associated optical elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities

Abstract

A light diffusing tip (23) is provided. The light diffusing tip (23) comprises a housing (28) and a monolithic light scattering medium disposed within the housing. The monolithic light scattering medium comprises a first scattering region (30) at a first position, the scattering region having a first scattering property and a second scattering region (31) at a second position, the second scattering region having a second scattering property different from the first scattering property, wherein the first scattering region (30) and the second scattering region (31) are coextensive along a substantial portion of a length of the housing (28). A light diffusing applicator also is provided. The light diffusing applicator comprises at least one optical waveguide (22), a first termination coupled to a first end of the at least one optical waveguide (22), the first termination to couple to a light source and a light diffusing tip coupled to a second end of the at least one optical waveguide (22).

Claims

AMENDED CLAIMS[received by the International Bureau on 1 December 2006 (01.12.2006)]
1. A light diffusing tip comprising: a housing; and a monolithic light scattering medium disposed within the housing and comprising: a first scattering region at a first position, the scattering region having a first scattering property; and a second scattering region at n second position, the second scattering region having a second scattering property different from the first scattering property; wherein the first scattering region and the second scattering region are coextensive along a substantial portion of a length of the housing.
2. The light diffusing tip of claim 1, whereio the first scattering property includes a first concentration of a first type of scattering particle aad the second scattering property includes a second concentration of the first type of scattering particle.
3. The light diffusing tip of claim 1, wherein the first scattering property includes a first type of scattering particle and the second light scattering property includes a second type of scattering particle.
4. The light diffusing tip of claim I, wherein a light scattering coefficient of the first scattering region is less than a light scattering coefficient of the second scattering region.
5. The light diffusing tip of claim 4, wherein the first scattering region is at a proximal end of the housing and the second scattering region is at a distal end of the housing and wherein a light scattering coefficient of the light diffusing tip at the substantial portion of the length of the housing increases with a distance from the proximal end of the housing.
6. The light diffusing tip of claim I, wherein a cross-section of the first scattering region and a cross-section of the second scattering region vary across the substantial portion of the length of the housing.
7. The light diffusing tip of claim 6, wherein the cross-section of the first scattering region increases across the substantial portion of the length of the housing and the cross-section of the second scattering region decreases across the substantial portion of the length of the housing.
8. The light diffusing tip of claim 1, wherein the first scattering region comprises an approximately conical shape across the substantial portion of the length of the housing.
9. The light diffusing tip of claim 8, wherein the approximately conical shape is substantially coaxial with a longitudinal axis of the housing,
10. The light diffusing tip of claim 8, wherein the approximately conical shape is offset from a longitudinal axis of the housing.
11. The light diffusing tip of claim 1 , wherein the first scattering region comprises an approximately non-linear profile across the substantial portion of the length of the housing,
12. The light diffusing tip of claim 1, further comprising a cap disposed at an end of the housing.
13. The light diffusing tip of claim 12, wherein me cap comprises at least one of a pointed cap, a rounded cap, a biocompatible cap, or a light-scattering cap.
14. The light diffusing tip of claim 1, further comprising a reflective material disposed at a surface of the housing.
15. The light diffusing tip of claim 1, further comprising a non-stick material disposed at an outer surface of the housing.
16. The light diffusing tip of claim 1, wherein the light scattering medium comprises light scattering particles suspended in a light transmissive material.
17. The light diffusing tip of claim 1, wherein the housing is coextensive with a tip of at least one optical waveguide.
18. The light diffusing tip of claim 17, wherein the housing is approximately tubular and having an outer diameter substantially equivalent to an outer diameter of an outer jacketing that shealhs the at least one optical waveguide,
19. A light diffusing tip comprising: a housing; a first scattering region disposed within the housing at a first position and having a substantially conical portion extending along a portion of a length of the housing, the first scattering region having a first scattering coefficient; and a second scattering region disposed within the housing at a second position and having at least a portion coextensive with the substantially conical portion of the first scattering region, the second scattering region having a second scattering coefficient different from the first scattering coefficient.
20. The light diffusing tip of claim 19, wherein the first scattering coefficient is less than the second scattering coefficient.
21. The light diffusi ng tip of claim 19, wherein the conical portion is substantially coaxial with a longitudinal axis of the housing.
22. The light diffusing tip of claim 19, wherein the conical portion is offset from a longitudinal axis of the housing.
23. The light diffusing tip of claim 19, further comprising a cap disposed at an end of the housing.
24. The light diffusing tip of claim 23, wherein the cap comprises at least one of a pointed cap, a rounded cap or a light-scattering cap.
25. The light diffusing tip of claim 19, further comprising a reflective material disposed at a surface of the housing.
26. The light diffusing tip of claim 19, further comprising a non-stick material disposed at an outer surface of the housing.
27. The light diffusing tip of claim 19, wherein the light scattering medium comprises light scattering particles suspended in a light transmissive material
28. The light diffusing tip of claim 19, wherein the housing is coextensive with a tip of at least one optical waveguide.
29. The light diffusing tip of claim 28, wherein the housing is approximately tubular and having an outer diameter substantially equivalent to an outer diameter of an outer jacketing that sheaths the at least one optical waveguide.
30. An apparatus comprising: at least one optical waveguide; a first termination coupled to a first end of the at least one optical waveguide, the first termination to couple to a light source; and a light diffusing tip coupled to a second end of the at least one optical waveguide, the light diffusing tip comprising: a housing; and a monolithic light scattering medium disposed within the housing and comprising: a first scattering region at a first position, the scattering τegion having a first scattering property; and a second scattering region at a second position, the second scattering region having a second scattering property different from the first scattering property; wherein the first scattering region and the second scattering region are coextensive along a substantial portion of a length of the housing.
31. The apparatus of claim 30, wherein the first scattering property includes a first concentration of a first type of scattering particle and the second scattering property includes a second concentration of toe first type of scattering particle.
32. The apparatus of claim 30, wherein the first scattering property includes a first type of scattering particle and the second light scattering property includes a second type of scattering particle.
33. The apparatus of claim 30, wherein a tight scattering coefficient of the first scattering region is less than a light scattering coefficient of the second scattering region.
34. The apparatus of claim 33, wherein the first scattering region is at a proximal end of the housing and the second position scattering region is at a distal end of the housing and wherein a light scattering coefficient of the light diffusing tip at the substantial portion of the length of the housing increases with a distance from the proximal end of the housing.
35. The apparatus of claim 30, wherein a cross-section of the first scattering region and a cross-section of the second scattering region vary across the substantial portion of the length of the housing,
36. The apparatus of claim 30, wherein the first scattering region comprises an approximately conical shape across the substantial portion of the length of the housing.
37. The apparatus of claim 36, wherein the approximately conical shape is substantially coaxial with a longitudinal axis of the housing.
38. The apparatus of claim 36, wherein the approximately conical shape is offset from a longitudinal axis of the housing.
39- The apparatus of claim 30, wherein the first scattering region comprises a non-linear profile across the substantial portion of the length of the housing.
40. The apparatus of claim 30, further comprising a cap disposed at an end of the housing.
41. The apparatus of claim 40, wherein the cap comprises at least one of a pointed cap, a rounded cap, a biocompatible cap, or a light-scattering cap,
42. The apparatus of claim 30, further comprising a reflective material disposed at a surface of the housing.
43. The apparatus of claim 30, further comprising a non-stick material disposed at an outer surface of th e housing.
44. The apparatus of claim 30, wherein the light scattering medium comprises light scattering particles suspended in a light traπsmissive material.
45. The apparatus of claim 30, wherein the housing is approximately tubular and having an outer diameter substantially equivalent to an outer diameter of an outer jacketing that sheaths the at least one optical waveguide.
46. A method comprising: providing a light applicator having a light diffusing tip coupled to a first end of an optical waveguide of the light applicator, the light difϊusing tip comprising a housing and a monolithic light scattering medium disposed within the housing, the light scattering medium including a first scattering region having a first scattering property and a second scattering region having a second scattering property different from the first scattering property, wherein the first scattering region and the second scattering region are coextensive along a substantial portion of a length of the housing; locating the light diffusing tip proximal to a bodily tissue; and providing light energy to the light diffusing tip via a second end of optical waveguide of the light applicator so as to irradiate the bodily tissue.
47, A method comprising: providing a housing; forming a monolithic light scattering medium within the housing, the monolithic light scattering medium including a first scattering region having a first scattering property and a second scattering region having a second scattering property different from the first scattering property, wherein the first scattering region and the second scattering region are coextensive along a substantial portion of a length of the housing,
48, The method of claim 47, wherein forming the monolithic light scattering medium comprises: inserting a first scattering material into a first end of the housing to form the first scattering region, the first scattering material having the first scattering property; and inserting a second scattering material into the housing so as to displace a portion of the first scattering region over a substantial portion of the length of the housing to form the second scattering region, the second scattering material having the second scattering property; and curing the first scattering material and the second scattering material to form a monolithic scattering medium.
49. The method of claim 48, wherein the second scattering material is inserted into the first end of the housing.
50. The method of claim 48, wherein the second scattering material is inserted into a second end of the housing.
51. The method of claim 48, wherein the first scattering material includes a first concentration of scattering particles suspended in a light transmissive material and the second scattering material includes a second concentration of scattering particles suspended in a light transmissive material.
52. The method of claim 48, wherein the first scattering material includes a first type of scattering particle suspended in a light transmissive material and the second scattering material includes a second type of scattering particle suspended in a light transmissive material.
53. The method of claim 48, wherein the housing is positioned horizontally while curing the first and second scattering materials.
54. The method of claim 48, wherein the housing is subjected to a centrifuge while curing the first and second scattering materials.
55. The method of claim 48, furfher comprising; inserting a portion of at least one optical waveguide into one of the first or Second scattering materials prior to curing.
56. The method of claim 48, tether comprising: inserting a portion of at least one optical waveguide into one of the first or second ends prior to inserting the first and second scattering materials.
57. The method of claim 47, further comprising: disposing a reflective material on at least a portion of a surface of the housing.
58. The method of claim 47, further comprising: disposing a non-stick material on at least a portion of an outer surface of the housing.
59. The light diffusing tip of claim 1 , wherein the monolithic light scattering medium exhibits a gradient in scattering coefficient both axially and radially.
60. The light diffusing tip of claim I, wherein Hie monolithic light scattering medium has a longitudinally and radially varying scattering property.
61. The light diffusing tip of claim 1, wherein an interface between the first scattering region and the second scattering region changes radially with longitudinal position.
PCT/US2005/041347 2004-11-16 2005-11-15 Light diffusing tip WO2006055554A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002587691A CA2587691A1 (en) 2004-11-16 2005-11-15 Light diffusing tip
EP05849640A EP1817618A4 (en) 2004-11-16 2005-11-15 Light diffusing tip

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/989,894 US7274847B2 (en) 2004-11-16 2004-11-16 Light diffusing tip
US10/989,894 2004-11-16

Publications (3)

Publication Number Publication Date
WO2006055554A2 WO2006055554A2 (en) 2006-05-26
WO2006055554A3 WO2006055554A3 (en) 2007-02-08
WO2006055554B1 true WO2006055554B1 (en) 2007-04-12

Family

ID=36386383

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/041347 WO2006055554A2 (en) 2004-11-16 2005-11-15 Light diffusing tip

Country Status (4)

Country Link
US (5) US7274847B2 (en)
EP (1) EP1817618A4 (en)
CA (1) CA2587691A1 (en)
WO (1) WO2006055554A2 (en)

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US7274847B2 (en) 2007-09-25
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US7609927B2 (en) 2009-10-27
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WO2006055554A2 (en) 2006-05-26
US20100016930A1 (en) 2010-01-21
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CA2587691A1 (en) 2006-05-26
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US20080267570A1 (en) 2008-10-30
US7412141B2 (en) 2008-08-12

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