WO2006047198A3 - Composition and method for using a cytokine to treat restenosis - Google Patents

Composition and method for using a cytokine to treat restenosis Download PDF

Info

Publication number
WO2006047198A3
WO2006047198A3 PCT/US2005/037684 US2005037684W WO2006047198A3 WO 2006047198 A3 WO2006047198 A3 WO 2006047198A3 US 2005037684 W US2005037684 W US 2005037684W WO 2006047198 A3 WO2006047198 A3 WO 2006047198A3
Authority
WO
WIPO (PCT)
Prior art keywords
cytokine
composition
restenosis
treat restenosis
vascular
Prior art date
Application number
PCT/US2005/037684
Other languages
French (fr)
Other versions
WO2006047198A2 (en
Inventor
Douglas W Losordo
Raj Kishore
Original Assignee
Caritas St Elizabeth Medical C
Douglas W Losordo
Raj Kishore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caritas St Elizabeth Medical C, Douglas W Losordo, Raj Kishore filed Critical Caritas St Elizabeth Medical C
Publication of WO2006047198A2 publication Critical patent/WO2006047198A2/en
Publication of WO2006047198A3 publication Critical patent/WO2006047198A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/044—Proteins; Polypeptides; Degradation products thereof
    • A61L29/048—Other specific proteins or polypeptides not covered by A61L29/045 - A61L29/047
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances

Abstract

The present invention provides devices, including stents and vascular catheters, comprising interleukin-10, for the treatment of restenosis and intimal hyperplasia associated with acute vascular injury. Also provided are methods for treating restenosis and preventing vascular obstruction.
PCT/US2005/037684 2004-10-26 2005-10-17 Composition and method for using a cytokine to treat restenosis WO2006047198A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62248204P 2004-10-26 2004-10-26
US60/622,482 2004-10-26

Publications (2)

Publication Number Publication Date
WO2006047198A2 WO2006047198A2 (en) 2006-05-04
WO2006047198A3 true WO2006047198A3 (en) 2007-05-31

Family

ID=36228246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/037684 WO2006047198A2 (en) 2004-10-26 2005-10-17 Composition and method for using a cytokine to treat restenosis

Country Status (1)

Country Link
WO (1) WO2006047198A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020090388A1 (en) * 2000-12-01 2002-07-11 Humes H. David Intravascular drug delivery device and use therefor
US20020128599A1 (en) * 2000-10-26 2002-09-12 Cormier Michel J.N. Transdermal drug delivery devices having coated microprotrusions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020128599A1 (en) * 2000-10-26 2002-09-12 Cormier Michel J.N. Transdermal drug delivery devices having coated microprotrusions
US20020090388A1 (en) * 2000-12-01 2002-07-11 Humes H. David Intravascular drug delivery device and use therefor

Also Published As

Publication number Publication date
WO2006047198A2 (en) 2006-05-04

Similar Documents

Publication Publication Date Title
WO2006014270A3 (en) Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders
WO2004006906A3 (en) Methods for the treatment of neoplasms
WO2009148926A3 (en) Biosoluble coating comprising anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders
WO2004060318A3 (en) Drug-coated stents and methods of use therefor
WO2006023649A3 (en) Treatment of severe multiple sclerosis
WO2005027842A3 (en) Combinations of drugs for the treatment of neoplasms
MXPA04006731A (en) Drug delivery systems for the prevention and treatment of vascular diseases comprising rapamycin and derivatives thereof.
WO2005011734A3 (en) Composition of a vegf antagonist and an anti-proliferative agent and its use for the treatment of cancer
WO2004069201A3 (en) Compounds useful in coating stents to prevent and treat stenosis and restenosis
WO2006002399A3 (en) Biodegradable implantable medical devices, methods and systems
EP1811923A4 (en) Stepped balloon catheter for treating vascular bifurcations
WO2006024018A3 (en) Compositions for treating nociceptive pain
EP1635815A4 (en) Methods and compounds for the treatment of vascular stenosis
WO2006055871A3 (en) Treatment for multiple sclerosis
WO2002078684A3 (en) Carbon monoxide generating compounds for treatment of vascular, inflammatory and immune disorders
DK0786991T3 (en) Polyamine Compounds for the Treatment of Proliferative Vascular Diseases
WO2007047919A3 (en) Treatment of restenosis and stenosis with dasatinib
EP1642592A4 (en) Remedy for sarcoidosis and method of treating the same
WO2004098495A3 (en) Medical devices and methods for inhibiting proliferation of smooth muscle cells
WO2007087424A3 (en) Method of treating kcnq related disorders using organozinc compounds
WO2005011572A3 (en) Combination of drugs for the treatment of neoplasms
EP1744761A4 (en) Methods for treating or preventing restenosis and other vascular proliferative disorders
WO2004009773A3 (en) Methods and compositions for activating or inhibiting vegf-d and vegf-c
WO2010042343A3 (en) Combination local delivery using a stent
WO2004060444A3 (en) Device for maintaining catheter lumen patency

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BW BY BZ CA CH CN CO CR CU CZ DK DM DZ EC EE EG ES FI GB GD GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV LY MD MG MK MN MW MX MZ NA NG NO NZ OM PG PH PL PT RO RU SC SD SG SK SL SM SY TJ TM TN TR TT TZ UG US UZ VC VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SZ TZ UG ZM ZW AM AZ BY KG MD RU TJ TM AT BE BG CH CY DE DK EE ES FI FR GB GR HU IE IS IT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW MR NE SN TD TG

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 05817062

Country of ref document: EP

Kind code of ref document: A2