WO2006031614A3 - Reduced toxicity methotrexate formulations and methods for using the same - Google Patents

Reduced toxicity methotrexate formulations and methods for using the same Download PDF

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Publication number
WO2006031614A3
WO2006031614A3 PCT/US2005/032046 US2005032046W WO2006031614A3 WO 2006031614 A3 WO2006031614 A3 WO 2006031614A3 US 2005032046 W US2005032046 W US 2005032046W WO 2006031614 A3 WO2006031614 A3 WO 2006031614A3
Authority
WO
WIPO (PCT)
Prior art keywords
mtx
methods
toxicity
same
reduced toxicity
Prior art date
Application number
PCT/US2005/032046
Other languages
French (fr)
Other versions
WO2006031614A2 (en
Inventor
Patrick Fogarty
Original Assignee
Tosk Inc
Patrick Fogarty
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tosk Inc, Patrick Fogarty filed Critical Tosk Inc
Priority to US11/662,375 priority Critical patent/US20080312201A1/en
Publication of WO2006031614A2 publication Critical patent/WO2006031614A2/en
Publication of WO2006031614A3 publication Critical patent/WO2006031614A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Methods of using methotrexate (MTX) active agents in which reduced host toxicity is observed are provided. In the subject methods, an effective amount of an MTX active agent is administered to the host in conjunction with the administration of an MTX toxicity reducing agent of the present invention. Also provided are compositions for use in practicing the subject methods, e.g., pharmaceutical compositions having reduced toxicity, in which the MTX active agent is combined with an MTX toxicity reducing agent that reduces the level of undesired MTX toxicity while maintaining an effective MTX anti-proliferative activity. Also provided are methods of using the subject methods and compositions in the treatment of a variety of different disease conditions.
PCT/US2005/032046 2004-09-10 2005-09-08 Reduced toxicity methotrexate formulations and methods for using the same WO2006031614A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/662,375 US20080312201A1 (en) 2004-09-10 2005-09-08 Reduced Toxicity Methotrexate Formulations and Methods for Using the Same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60904604P 2004-09-10 2004-09-10
US60/609,046 2004-09-10

Publications (2)

Publication Number Publication Date
WO2006031614A2 WO2006031614A2 (en) 2006-03-23
WO2006031614A3 true WO2006031614A3 (en) 2006-07-06

Family

ID=36060557

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/032046 WO2006031614A2 (en) 2004-09-10 2005-09-08 Reduced toxicity methotrexate formulations and methods for using the same

Country Status (2)

Country Link
US (1) US20080312201A1 (en)
WO (1) WO2006031614A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9114102B2 (en) 2007-11-07 2015-08-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method of inhibiting ABCG2 and related treatments
US8470888B2 (en) 2008-01-03 2013-06-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Botryllamides and method of inhibiting PGP in a mammal afflicted with cancer

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US20040048871A1 (en) * 2002-09-09 2004-03-11 Rowe Vernon D. Use of high dose intravenous methotrexate, with leucovorin rescue, to treat early multiple sclerosis and other diseases of the central nervous system
US20040110687A1 (en) * 2002-02-26 2004-06-10 Roland Buelow Methods and compositions for treating gastrointestinal toxicity induced by cytoablative therapy

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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020127223A1 (en) * 1984-07-17 2002-09-12 Matsumura Kenneth N. Method for reducing side effects of a drug
US20020169128A1 (en) * 2001-04-09 2002-11-14 Geroge Sigounas Erythropoietin ameliorates chemotherapy-induced toxicity in vivo
US20040110687A1 (en) * 2002-02-26 2004-06-10 Roland Buelow Methods and compositions for treating gastrointestinal toxicity induced by cytoablative therapy
US20040048871A1 (en) * 2002-09-09 2004-03-11 Rowe Vernon D. Use of high dose intravenous methotrexate, with leucovorin rescue, to treat early multiple sclerosis and other diseases of the central nervous system

Also Published As

Publication number Publication date
US20080312201A1 (en) 2008-12-18
WO2006031614A2 (en) 2006-03-23

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