WO2006017277A3 - Closed-loop neuromodulation for optimal control of neurological disease - Google Patents

Closed-loop neuromodulation for optimal control of neurological disease Download PDF

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Publication number
WO2006017277A3
WO2006017277A3 PCT/US2005/024675 US2005024675W WO2006017277A3 WO 2006017277 A3 WO2006017277 A3 WO 2006017277A3 US 2005024675 W US2005024675 W US 2005024675W WO 2006017277 A3 WO2006017277 A3 WO 2006017277A3
Authority
WO
WIPO (PCT)
Prior art keywords
neurological
nervous system
closed
optimal control
neurological disease
Prior art date
Application number
PCT/US2005/024675
Other languages
French (fr)
Other versions
WO2006017277A2 (en
Inventor
Daniel J Dilorenzo
Original Assignee
Bioneuronics Corp
Daniel J Dilorenzo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/340,326 external-priority patent/US6366813B1/en
Priority claimed from US10/718,248 external-priority patent/US7209787B2/en
Priority claimed from US10/753,205 external-priority patent/US7242984B2/en
Priority claimed from US10/818,333 external-priority patent/US7277758B2/en
Priority claimed from US10/858,899 external-priority patent/US7324851B1/en
Application filed by Bioneuronics Corp, Daniel J Dilorenzo filed Critical Bioneuronics Corp
Publication of WO2006017277A2 publication Critical patent/WO2006017277A2/en
Publication of WO2006017277A3 publication Critical patent/WO2006017277A3/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526Head electrodes
    • A61N1/0529Electrodes for brain stimulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526Head electrodes
    • A61N1/0529Electrodes for brain stimulation
    • A61N1/0531Brain cortex electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526Head electrodes
    • A61N1/0529Electrodes for brain stimulation
    • A61N1/0534Electrodes for deep brain stimulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36064Epilepsy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36067Movement disorders, e.g. tremor or Parkinson disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a 'nervous system component.' The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state and prevent neurological signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.
PCT/US2005/024675 1998-08-05 2005-07-12 Closed-loop neuromodulation for optimal control of neurological disease WO2006017277A2 (en)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US9541398P 1998-08-05 1998-08-05
US09/340,326 US6366813B1 (en) 1998-08-05 1999-06-25 Apparatus and method for closed-loop intracranical stimulation for optimal control of neurological disease
US10/008,576 US6819956B2 (en) 1998-08-05 2001-11-11 Optimal method and apparatus for neural modulation for the treatment of neurological disease, particularly movement disorders
US42769902P 2002-11-20 2002-11-20
US43679202P 2002-12-27 2002-12-27
US43828603P 2003-01-06 2003-01-06
US46014003P 2003-04-03 2003-04-03
US10/718,248 US7209787B2 (en) 1998-08-05 2003-11-20 Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US10/753,205 US7242984B2 (en) 1998-08-05 2004-01-06 Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US10/818,333 US7277758B2 (en) 1998-08-05 2004-04-05 Methods and systems for predicting future symptomatology in a patient suffering from a neurological or psychiatric disorder
US56248704P 2004-04-14 2004-04-14
US10/858,899 US7324851B1 (en) 1998-08-05 2004-06-01 Closed-loop feedback-driven neuromodulation
US10/889,844 2004-07-12
US10/889,844 US7231254B2 (en) 1998-08-05 2004-07-12 Closed-loop feedback-driven neuromodulation

Publications (2)

Publication Number Publication Date
WO2006017277A2 WO2006017277A2 (en) 2006-02-16
WO2006017277A3 true WO2006017277A3 (en) 2006-06-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/024675 WO2006017277A2 (en) 1998-08-05 2005-07-12 Closed-loop neuromodulation for optimal control of neurological disease

Country Status (2)

Country Link
US (1) US7231254B2 (en)
WO (1) WO2006017277A2 (en)

Families Citing this family (381)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6944501B1 (en) 2000-04-05 2005-09-13 Neurospace, Inc. Neurostimulator involving stimulation strategies and process for using it
US20020169485A1 (en) 1995-10-16 2002-11-14 Neuropace, Inc. Differential neurostimulation therapy driven by physiological context
US7209787B2 (en) 1998-08-05 2007-04-24 Bioneuronics Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US9415222B2 (en) 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
US9375573B2 (en) 1998-08-05 2016-06-28 Cyberonics, Inc. Systems and methods for monitoring a patient's neurological disease state
US8762065B2 (en) 1998-08-05 2014-06-24 Cyberonics, Inc. Closed-loop feedback-driven neuromodulation
US7747325B2 (en) 1998-08-05 2010-06-29 Neurovista Corporation Systems and methods for monitoring a patient's neurological disease state
US9042988B2 (en) 1998-08-05 2015-05-26 Cyberonics, Inc. Closed-loop vagus nerve stimulation
US7853329B2 (en) 1998-08-05 2010-12-14 Neurovista Corporation Monitoring efficacy of neural modulation therapy
US8914114B2 (en) 2000-05-23 2014-12-16 The Feinstein Institute For Medical Research Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
US20050119580A1 (en) 2001-04-23 2005-06-02 Eveland Doug C. Controlling access to a medical monitoring system
JP3831788B2 (en) * 2002-09-11 2006-10-11 独立行政法人情報通信研究機構 Activity muscle display
US8396565B2 (en) 2003-09-15 2013-03-12 Medtronic, Inc. Automatic therapy adjustments
US9050469B1 (en) 2003-11-26 2015-06-09 Flint Hills Scientific, Llc Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals
US7330760B2 (en) * 2004-03-16 2008-02-12 Medtronic, Inc. Collecting posture information to evaluate therapy
US7717848B2 (en) * 2004-03-16 2010-05-18 Medtronic, Inc. Collecting sleep quality information via a medical device
US7805196B2 (en) 2004-03-16 2010-09-28 Medtronic, Inc. Collecting activity information to evaluate therapy
US7395113B2 (en) * 2004-03-16 2008-07-01 Medtronic, Inc. Collecting activity information to evaluate therapy
US7881798B2 (en) 2004-03-16 2011-02-01 Medtronic Inc. Controlling therapy based on sleep quality
US8055348B2 (en) 2004-03-16 2011-11-08 Medtronic, Inc. Detecting sleep to evaluate therapy
US7491181B2 (en) 2004-03-16 2009-02-17 Medtronic, Inc. Collecting activity and sleep quality information via a medical device
US8308661B2 (en) 2004-03-16 2012-11-13 Medtronic, Inc. Collecting activity and sleep quality information via a medical device
WO2005089646A1 (en) 2004-03-16 2005-09-29 Medtronic, Inc. Sensitivity analysis for selecting therapy parameter sets
US7366572B2 (en) 2004-03-16 2008-04-29 Medtronic, Inc. Controlling therapy based on sleep quality
US7792583B2 (en) 2004-03-16 2010-09-07 Medtronic, Inc. Collecting posture information to evaluate therapy
US8725244B2 (en) * 2004-03-16 2014-05-13 Medtronic, Inc. Determination of sleep quality for neurological disorders
US20050209512A1 (en) * 2004-03-16 2005-09-22 Heruth Kenneth T Detecting sleep
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
US8135473B2 (en) 2004-04-14 2012-03-13 Medtronic, Inc. Collecting posture and activity information to evaluate therapy
US8180601B2 (en) 2006-03-09 2012-05-15 The Cleveland Clinic Foundation Systems and methods for determining volume of activation for deep brain stimulation
US7346382B2 (en) * 2004-07-07 2008-03-18 The Cleveland Clinic Foundation Brain stimulation models, systems, devices, and methods
US8209027B2 (en) 2004-07-07 2012-06-26 The Cleveland Clinic Foundation System and method to design structure for delivering electrical energy to tissue
WO2006019822A2 (en) * 2004-07-14 2006-02-23 Arizona Technology Enterprises Pacemaker for treating physiological system dysfunction
US7787671B2 (en) * 2004-07-16 2010-08-31 New York University Method, system and storage medium which includes instructions for analyzing anatomical structures
JP2008513082A (en) * 2004-09-20 2008-05-01 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Deep brain stimulation system
US9050455B2 (en) 2004-10-21 2015-06-09 Medtronic, Inc. Transverse tripole neurostimulation methods, kits and systems
US20070239230A1 (en) * 2004-12-17 2007-10-11 Medtronic, Inc. System and method for regulating cardiac triggered therapy to the brain
US10384053B2 (en) * 2004-12-17 2019-08-20 Functional Neuromodulation Inc. Inducing neurogenesis within a human brain
US7957793B2 (en) * 2004-12-22 2011-06-07 Wisconsin Alumni Research Foundation Methods for identifying neuronal spikes
CN101124012B (en) 2004-12-27 2012-09-05 范因斯坦医学研究院 Device for treating inflammatory disorders by electrical vagus nerve stimulation
US11207518B2 (en) 2004-12-27 2021-12-28 The Feinstein Institutes For Medical Research Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
US8788044B2 (en) 2005-01-21 2014-07-22 Michael Sasha John Systems and methods for tissue stimulation in medical treatment
US9314633B2 (en) 2008-01-25 2016-04-19 Cyberonics, Inc. Contingent cardio-protection for epilepsy patients
US8260426B2 (en) 2008-01-25 2012-09-04 Cyberonics, Inc. Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device
US8565867B2 (en) 2005-01-28 2013-10-22 Cyberonics, Inc. Changeable electrode polarity stimulation by an implantable medical device
US8187209B1 (en) * 2005-03-17 2012-05-29 Great Lakes Neurotechnologies Inc Movement disorder monitoring system and method
US20060228121A1 (en) * 2005-03-29 2006-10-12 General Electric Company Remote monitoring system and method
US7406351B2 (en) 2005-04-28 2008-07-29 Medtronic, Inc. Activity sensing for stimulator control
WO2006119046A1 (en) 2005-04-30 2006-11-09 Medtronic, Inc. Impedance-based stimulation adjustment
US8021299B2 (en) * 2005-06-01 2011-09-20 Medtronic, Inc. Correlating a non-polysomnographic physiological parameter set with sleep states
US20070073354A1 (en) * 2005-09-26 2007-03-29 Knudson Mark B Neural blocking therapy
US8165682B2 (en) * 2005-09-29 2012-04-24 Uchicago Argonne, Llc Surface acoustic wave probe implant for predicting epileptic seizures
US7957797B2 (en) * 2005-12-02 2011-06-07 Medtronic, Inc. Closed-loop therapy adjustment
US7853322B2 (en) * 2005-12-02 2010-12-14 Medtronic, Inc. Closed-loop therapy adjustment
US20070129769A1 (en) 2005-12-02 2007-06-07 Medtronic, Inc. Wearable ambulatory data recorder
US7957809B2 (en) * 2005-12-02 2011-06-07 Medtronic, Inc. Closed-loop therapy adjustment
WO2007075477A2 (en) * 2005-12-19 2007-07-05 University Of Florida Closed-loop state-dependent seizure prevention systems
US8868172B2 (en) 2005-12-28 2014-10-21 Cyberonics, Inc. Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders
US8725243B2 (en) 2005-12-28 2014-05-13 Cyberonics, Inc. Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US20090220425A1 (en) * 2006-01-19 2009-09-03 Drexel University Method to Quantitatively Measure Effect of Psychotropic Drugs on Sensory Discrimination
US7996079B2 (en) 2006-01-24 2011-08-09 Cyberonics, Inc. Input response override for an implantable medical device
US7657310B2 (en) * 2006-01-26 2010-02-02 Cyberonics, Inc. Treatment of reproductive endocrine disorders by vagus nerve stimulation
US8606360B2 (en) * 2006-03-09 2013-12-10 The Cleveland Clinic Foundation Systems and methods for determining volume of activation for spinal cord and peripheral nerve stimulation
US8209018B2 (en) * 2006-03-10 2012-06-26 Medtronic, Inc. Probabilistic neurological disorder treatment
EP1998849B1 (en) 2006-03-24 2014-12-24 Medtronic, Inc. Collecting gait information for evaluation and control of therapy
EP2026874B1 (en) 2006-03-29 2015-05-20 Dignity Health Vagus nerve stimulation system
US7480641B2 (en) * 2006-04-07 2009-01-20 Nokia Corporation Method, apparatus, mobile terminal and computer program product for providing efficient evaluation of feature transformation
US7869885B2 (en) 2006-04-28 2011-01-11 Cyberonics, Inc Threshold optimization for tissue stimulation therapy
US7962220B2 (en) 2006-04-28 2011-06-14 Cyberonics, Inc. Compensation reduction in tissue stimulation therapy
US8545378B2 (en) 2006-06-15 2013-10-01 The Trustees Of Columbia University In The City Of New York Systems and methods for inducing electric field pulses in a body organ
US7753836B2 (en) * 2006-06-15 2010-07-13 The Trustees Of Columbia University In The City Of New York Systems and methods for inducing electric field pulses in a body organ
US8116875B2 (en) * 2006-06-16 2012-02-14 Neuropoint Medical, Inc. Implantable neurostimulation systems
EP2034885A4 (en) 2006-06-23 2010-12-01 Neurovista Corp Minimally invasive monitoring systems and methods
US8644930B2 (en) * 2006-08-28 2014-02-04 Medtronic, Inc. Operational electrode impedance measurement for an implantable medical stimulator
EP2056928A1 (en) * 2006-08-28 2009-05-13 Medtronic, Inc. Operational electrode impedance measurement for an implantable medical stimulator
US7769443B2 (en) * 2006-09-06 2010-08-03 Giancarlo Barolat Implantable reel for coiling an implantable elongated member
US8688209B2 (en) * 2006-09-25 2014-04-01 Koninklijke Philips N.V. Device for ambulatory monitoring of brain activity
US7869867B2 (en) 2006-10-27 2011-01-11 Cyberonics, Inc. Implantable neurostimulator with refractory stimulation
US20080103572A1 (en) 2006-10-31 2008-05-01 Medtronic, Inc. Implantable medical lead with threaded fixation
US8295934B2 (en) 2006-11-14 2012-10-23 Neurovista Corporation Systems and methods of reducing artifact in neurological stimulation systems
US20080161712A1 (en) 2006-12-27 2008-07-03 Kent Leyde Low Power Device With Contingent Scheduling
US9898656B2 (en) 2007-01-25 2018-02-20 Cyberonics, Inc. Systems and methods for identifying a contra-ictal condition in a subject
DE102007003799A1 (en) * 2007-01-25 2008-07-31 Anm Adaptive Neuromodulation Gmbh Implant for stimulation of nerve cells
US20080183097A1 (en) 2007-01-25 2008-07-31 Leyde Kent W Methods and Systems for Measuring a Subject's Susceptibility to a Seizure
US8554337B2 (en) * 2007-01-25 2013-10-08 Giancarlo Barolat Electrode paddle for neurostimulation
US8036736B2 (en) 2007-03-21 2011-10-11 Neuro Vista Corporation Implantable systems and methods for identifying a contra-ictal condition in a subject
US20080255582A1 (en) * 2007-04-11 2008-10-16 Harris John F Methods and Template Assembly for Implanting an Electrode Array in a Patient
US7869884B2 (en) 2007-04-26 2011-01-11 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US7904175B2 (en) 2007-04-26 2011-03-08 Cyberonics, Inc. Trans-esophageal vagus nerve stimulation
US7962214B2 (en) 2007-04-26 2011-06-14 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US7974701B2 (en) 2007-04-27 2011-07-05 Cyberonics, Inc. Dosing limitation for an implantable medical device
US8549015B2 (en) 2007-05-01 2013-10-01 Giancarlo Barolat Method and system for distinguishing nociceptive pain from neuropathic pain
US9788744B2 (en) 2007-07-27 2017-10-17 Cyberonics, Inc. Systems for monitoring brain activity and patient advisory device
EP2190532A1 (en) * 2007-07-31 2010-06-02 M. Bret Schneider Device and method for hypertension treatment by non-invasive stimulation to vascular baroreceptors
US8027737B2 (en) * 2007-08-01 2011-09-27 Intelect Medical, Inc. Lead extension with input capabilities
AU2008297476B2 (en) 2007-09-13 2011-09-15 Cardiac Pacemakers, Inc. Systems for avoiding neural stimulation habituation
WO2009036306A1 (en) 2007-09-14 2009-03-19 Corventis, Inc. Adherent cardiac monitor with advanced sensing capabilities
EP2207590A1 (en) * 2007-09-26 2010-07-21 Medtronic, INC. Therapy program selection
US20090264789A1 (en) * 2007-09-26 2009-10-22 Medtronic, Inc. Therapy program selection
US8380314B2 (en) * 2007-09-26 2013-02-19 Medtronic, Inc. Patient directed therapy control
EP2211980B1 (en) 2007-10-10 2015-01-07 Sorin CRM SAS Neurostimulator and method for regulating the same
WO2009051638A1 (en) 2007-10-16 2009-04-23 Medtronic, Inc. Therapy control based on a patient movement state
US8214057B2 (en) 2007-10-16 2012-07-03 Giancarlo Barolat Surgically implantable electrodes
US20090105786A1 (en) * 2007-10-22 2009-04-23 University Of Washington Method and device for strengthening synaptic connections
EP2211708A1 (en) 2007-10-23 2010-08-04 Optima Neuroscience, Inc. System for seizure monitoring and detection
JP4488057B2 (en) * 2007-11-09 2010-06-23 セイコーエプソン株式会社 Active matrix device, electro-optical display device, and electronic apparatus
US8170658B2 (en) * 2007-12-05 2012-05-01 The Invention Science Fund I, Llc System for electrical modulation of neural conduction
US8989858B2 (en) * 2007-12-05 2015-03-24 The Invention Science Fund I, Llc Implant system for chemical modulation of neural activity
US8170659B2 (en) * 2007-12-05 2012-05-01 The Invention Science Fund I, Llc Method for thermal modulation of neural activity
US8195287B2 (en) * 2007-12-05 2012-06-05 The Invention Science Fund I, Llc Method for electrical modulation of neural conduction
US8180447B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method for reversible chemical modulation of neural activity
US20090149797A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System for reversible chemical modulation of neural activity
US8165669B2 (en) * 2007-12-05 2012-04-24 The Invention Science Fund I, Llc System for magnetic modulation of neural conduction
US8180446B2 (en) * 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method and system for cyclical neural modulation based on activity state
US8165668B2 (en) * 2007-12-05 2012-04-24 The Invention Science Fund I, Llc Method for magnetic modulation of neural conduction
US20090171168A1 (en) 2007-12-28 2009-07-02 Leyde Kent W Systems and Method for Recording Clinical Manifestations of a Seizure
US9259591B2 (en) 2007-12-28 2016-02-16 Cyberonics, Inc. Housing for an implantable medical device
US8337404B2 (en) 2010-10-01 2012-12-25 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8382667B2 (en) 2010-10-01 2013-02-26 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
CN101925377A (en) * 2008-01-25 2010-12-22 麦德托尼克公司 The detection of Sleep stages
US8571643B2 (en) 2010-09-16 2013-10-29 Flint Hills Scientific, Llc Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex
US9220889B2 (en) 2008-02-11 2015-12-29 Intelect Medical, Inc. Directional electrode devices with locating features
US8019440B2 (en) 2008-02-12 2011-09-13 Intelect Medical, Inc. Directional lead assembly
US8195298B2 (en) * 2008-02-15 2012-06-05 Andres M Lozano Method for treating neurological/psychiatric disorders with stimulation to the subcaudate area of the brain
US8204603B2 (en) 2008-04-25 2012-06-19 Cyberonics, Inc. Blocking exogenous action potentials by an implantable medical device
US9238135B2 (en) 2008-04-30 2016-01-19 Medtronic, Inc. Flagging of electrodes of an implantable medical device, controller, system and method therefore
US8838242B2 (en) 2008-04-30 2014-09-16 Medtronic, Inc. Pre-configuration of electrode measurement of an implantable medical device, system and method therefore
US8195294B2 (en) 2008-04-30 2012-06-05 Medtronic, Inc. Multi-stage testing of electrodes of implantable medical device, system and method
WO2009135092A2 (en) * 2008-04-30 2009-11-05 University Of Florida Research Foundation, Inc. Method and system for detecting epileptogenesis
EP2321002B1 (en) * 2008-05-15 2014-04-23 Intelect Medical Inc. Clinician programmer system and method for calculating volumes of activation
US9272153B2 (en) 2008-05-15 2016-03-01 Boston Scientific Neuromodulation Corporation VOA generation system and method using a fiber specific analysis
US8708934B2 (en) 2008-07-11 2014-04-29 Medtronic, Inc. Reorientation of patient posture states for posture-responsive therapy
US8401666B2 (en) 2008-07-11 2013-03-19 Medtronic, Inc. Modification profiles for posture-responsive therapy
US9050471B2 (en) 2008-07-11 2015-06-09 Medtronic, Inc. Posture state display on medical device user interface
US8688225B2 (en) 2008-07-11 2014-04-01 Medtronic, Inc. Posture state detection using selectable system control parameters
US8282580B2 (en) 2008-07-11 2012-10-09 Medtronic, Inc. Data rejection for posture state analysis
US8150531B2 (en) 2008-07-11 2012-04-03 Medtronic, Inc. Associating therapy adjustments with patient posture states
US9956412B2 (en) 2008-07-11 2018-05-01 Medtronic, Inc. Linking posture states for posture responsive therapy
US8504150B2 (en) 2008-07-11 2013-08-06 Medtronic, Inc. Associating therapy adjustments with posture states using a stability timer
US8644945B2 (en) 2008-07-11 2014-02-04 Medtronic, Inc. Patient interaction with posture-responsive therapy
EP2313148B1 (en) * 2008-07-30 2013-08-21 Ecole Polytechnique Fédérale de Lausanne Apparatus for optimized stimulation of a neurological target
US8280517B2 (en) 2008-09-19 2012-10-02 Medtronic, Inc. Automatic validation techniques for validating operation of medical devices
US9393418B2 (en) * 2011-06-03 2016-07-19 Great Lakes Neuro Technologies Inc. Movement disorder therapy system, devices and methods of tuning
US9662502B2 (en) 2008-10-14 2017-05-30 Great Lakes Neurotechnologies Inc. Method and system for tuning of movement disorder therapy devices
US8457747B2 (en) 2008-10-20 2013-06-04 Cyberonics, Inc. Neurostimulation with signal duration determined by a cardiac cycle
US8417344B2 (en) 2008-10-24 2013-04-09 Cyberonics, Inc. Dynamic cranial nerve stimulation based on brain state determination from cardiac data
US8396550B2 (en) * 2008-10-29 2013-03-12 Sorin Crm Sas Optimal cardiac pacing with Q learning
US8255057B2 (en) 2009-01-29 2012-08-28 Nevro Corporation Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions
CA2743575C (en) 2008-11-12 2017-01-31 Ecole Polytechnique Federale De Lausanne Microfabricated neurostimulation device
JP2012508624A (en) * 2008-11-13 2012-04-12 プロテウス バイオメディカル インコーポレイテッド Multiplexed multiple electrode nerve stimulator
US20100121407A1 (en) * 2008-11-13 2010-05-13 The Rockefeller University Neuromodulation having non-linear dynamics
US8644919B2 (en) 2008-11-13 2014-02-04 Proteus Digital Health, Inc. Shielded stimulation and sensing system and method
WO2010057063A2 (en) * 2008-11-13 2010-05-20 Proteus Biomedical, Inc. Pacing and stimulation system, device and method
JP2012510877A (en) * 2008-12-04 2012-05-17 ザ クリーブランド クリニック ファウンデーション System and method for defining a target volume for brain stimulation
US8849390B2 (en) 2008-12-29 2014-09-30 Cyberonics, Inc. Processing for multi-channel signals
US8588933B2 (en) 2009-01-09 2013-11-19 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
US20100191304A1 (en) 2009-01-23 2010-07-29 Scott Timothy L Implantable Medical Device for Providing Chronic Condition Therapy and Acute Condition Therapy Using Vagus Nerve Stimulation
US8774923B2 (en) 2009-03-22 2014-07-08 Sorin Crm Sas Optimal deep brain stimulation therapy with Q learning
US8827912B2 (en) 2009-04-24 2014-09-09 Cyberonics, Inc. Methods and systems for detecting epileptic events using NNXX, optionally with nonlinear analysis parameters
US8239028B2 (en) 2009-04-24 2012-08-07 Cyberonics, Inc. Use of cardiac parameters in methods and systems for treating a chronic medical condition
US9327070B2 (en) 2009-04-30 2016-05-03 Medtronic, Inc. Medical device therapy based on posture and timing
US8175720B2 (en) 2009-04-30 2012-05-08 Medtronic, Inc. Posture-responsive therapy control based on patient input
US8231555B2 (en) 2009-04-30 2012-07-31 Medtronic, Inc. Therapy system including multiple posture sensors
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US8886339B2 (en) 2009-06-09 2014-11-11 Setpoint Medical Corporation Nerve cuff with pocket for leadless stimulator
WO2010135425A1 (en) 2009-05-19 2010-11-25 The Trustees Of Columbia University In The City Of New York Systems and methods for inducing electric field pulses in a body organ
US8786624B2 (en) 2009-06-02 2014-07-22 Cyberonics, Inc. Processing for multi-channel signals
CA2772330A1 (en) 2009-08-27 2011-03-03 The Cleveland Clinic Foundation System and method to estimate region of tissue activation
US8207651B2 (en) 2009-09-16 2012-06-26 Tyco Healthcare Group Lp Low energy or minimum disturbance method for measuring frequency response functions of ultrasonic surgical devices in determining optimum operating point
US9770204B2 (en) 2009-11-11 2017-09-26 Medtronic, Inc. Deep brain stimulation for sleep and movement disorders
WO2014169145A1 (en) * 2013-04-10 2014-10-16 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
US9833621B2 (en) 2011-09-23 2017-12-05 Setpoint Medical Corporation Modulation of sirtuins by vagus nerve stimulation
CA2782710C (en) 2009-12-01 2019-01-22 Ecole Polytechnique Federale De Lausanne Microfabricated neurostimulation device and methods of making and using the same
EP3636314B1 (en) 2009-12-23 2021-09-08 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
US8579834B2 (en) 2010-01-08 2013-11-12 Medtronic, Inc. Display of detected patient posture state
US9956418B2 (en) 2010-01-08 2018-05-01 Medtronic, Inc. Graphical manipulation of posture zones for posture-responsive therapy
US9357949B2 (en) 2010-01-08 2016-06-07 Medtronic, Inc. User interface that displays medical therapy and posture data
US9149210B2 (en) 2010-01-08 2015-10-06 Medtronic, Inc. Automated calibration of posture state classification for a medical device
US9643019B2 (en) 2010-02-12 2017-05-09 Cyberonics, Inc. Neurological monitoring and alerts
US9002472B2 (en) * 2010-02-26 2015-04-07 Intelect Medical, Inc. Neuromodulation having non-linear dynamics
US20110213266A1 (en) 2010-03-01 2011-09-01 Williams Justin C Closed Loop Neural Activity Triggered Rehabilitation Device And Method
EP2552536B1 (en) 2010-04-01 2016-06-08 Ecole Polytechnique Fédérale de Lausanne (EPFL) Device for interacting with neurological tissue
US8831732B2 (en) 2010-04-29 2014-09-09 Cyberonics, Inc. Method, apparatus and system for validating and quantifying cardiac beat data quality
US8649871B2 (en) 2010-04-29 2014-02-11 Cyberonics, Inc. Validity test adaptive constraint modification for cardiac data used for detection of state changes
US8406868B2 (en) 2010-04-29 2013-03-26 Medtronic, Inc. Therapy using perturbation and effect of physiological systems
US8639327B2 (en) 2010-04-29 2014-01-28 Medtronic, Inc. Nerve signal differentiation in cardiac therapy
US8620425B2 (en) 2010-04-29 2013-12-31 Medtronic, Inc. Nerve signal differentiation in cardiac therapy
US8562536B2 (en) 2010-04-29 2013-10-22 Flint Hills Scientific, Llc Algorithm for detecting a seizure from cardiac data
US9566441B2 (en) 2010-04-30 2017-02-14 Medtronic, Inc. Detecting posture sensor signal shift or drift in medical devices
CA2802708A1 (en) 2010-06-14 2011-12-22 Boston Scientific Neuromodulation Corporation Programming interface for spinal cord neuromodulation
US8679009B2 (en) 2010-06-15 2014-03-25 Flint Hills Scientific, Llc Systems approach to comorbidity assessment
US10085689B1 (en) 2010-06-18 2018-10-02 Great Lakes NeuroTechnolgies Inc. Device and method for monitoring and assessment of movement disorder symptoms
US9272139B2 (en) 2010-07-01 2016-03-01 Marilyn J. Hamilton Universal closed-loop electrical stimulation system
US8641646B2 (en) 2010-07-30 2014-02-04 Cyberonics, Inc. Seizure detection using coordinate data
US9211411B2 (en) 2010-08-26 2015-12-15 Medtronic, Inc. Therapy for rapid eye movement behavior disorder (RBD)
US8416086B2 (en) 2010-08-31 2013-04-09 Ut-Battelle, Llc Methods for improved forewarning of condition changes in monitoring physical processes
US8562524B2 (en) 2011-03-04 2013-10-22 Flint Hills Scientific, Llc Detecting, assessing and managing a risk of death in epilepsy
US8684921B2 (en) 2010-10-01 2014-04-01 Flint Hills Scientific Llc Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis
US8562523B2 (en) 2011-03-04 2013-10-22 Flint Hills Scientific, Llc Detecting, assessing and managing extreme epileptic events
US10226209B2 (en) 2010-10-15 2019-03-12 Brain Sentinel, Inc. Method and apparatus for classification of seizure type and severity using electromyography
US8706223B2 (en) 2011-01-19 2014-04-22 Medtronic, Inc. Preventative vagal stimulation
US8718763B2 (en) 2011-01-19 2014-05-06 Medtronic, Inc. Vagal stimulation
US8725259B2 (en) 2011-01-19 2014-05-13 Medtronic, Inc. Vagal stimulation
US8781582B2 (en) 2011-01-19 2014-07-15 Medtronic, Inc. Vagal stimulation
US8781583B2 (en) 2011-01-19 2014-07-15 Medtronic, Inc. Vagal stimulation
US9504390B2 (en) 2011-03-04 2016-11-29 Globalfoundries Inc. Detecting, assessing and managing a risk of death in epilepsy
CA2828318A1 (en) 2011-03-29 2012-10-04 Boston Scientific Neuromodulation Corporation System and method for image registration
US9498162B2 (en) 2011-04-25 2016-11-22 Cyberonics, Inc. Identifying seizures using heart data from two or more windows
US9402550B2 (en) 2011-04-29 2016-08-02 Cybertronics, Inc. Dynamic heart rate threshold for neurological event detection
WO2012155189A1 (en) 2011-05-13 2012-11-22 National Ict Australia Ltd Method and apparatus for estimating neural recruitment - f
US10588524B2 (en) 2011-05-13 2020-03-17 Saluda Medical Pty Ltd Method and apparatus for measurement of neural response
US9872990B2 (en) 2011-05-13 2018-01-23 Saluda Medical Pty Limited Method and apparatus for application of a neural stimulus
WO2012155185A1 (en) 2011-05-13 2012-11-22 National Ict Australia Ltd Method and apparatus for measurement of neural response
EP2707096B1 (en) 2011-05-13 2018-08-22 Saluda Medical Pty Limited Apparatus for measurement of neural response
US9592389B2 (en) 2011-05-27 2017-03-14 Boston Scientific Neuromodulation Corporation Visualization of relevant stimulation leadwire electrodes relative to selected stimulation information
US20130172774A1 (en) 2011-07-01 2013-07-04 Neuropace, Inc. Systems and Methods for Assessing the Effectiveness of a Therapy Including a Drug Regimen Using an Implantable Medical Device
US8958615B2 (en) 2011-08-09 2015-02-17 Boston Scientific Neuromodulation Corporation System and method for weighted atlas generation
EP2741817B1 (en) 2011-08-09 2021-12-22 Boston Scientific Neuromodulation Corporation Control and/or quantification of target stimulation volume overlap and interface therefor
CA2844079A1 (en) 2011-08-09 2013-02-14 Boston Scientific Neuromodulation Corporation Voa generation system and method using a fiber specific analysis
WO2013023085A2 (en) 2011-08-09 2013-02-14 Boston Scientific Neuromodulation Corporation Systems and methods for stimulation-related volume analysis, creation, and sharing
EP2750758B1 (en) 2011-09-01 2020-06-17 Boston Scientific Neuromodulation Corporation System for targeted brain stimulation using electrical parameter maps
WO2013052180A2 (en) * 2011-10-05 2013-04-11 University Of Kansas Methods and associated neural prosthetic devices for bridging brain areas to improve function
US9549677B2 (en) 2011-10-14 2017-01-24 Flint Hills Scientific, L.L.C. Seizure detection methods, apparatus, and systems using a wavelet transform maximum modulus algorithm
US9081488B2 (en) 2011-10-19 2015-07-14 Boston Scientific Neuromodulation Corporation Stimulation leadwire and volume of activation control and display interface
US10123717B2 (en) * 2011-11-10 2018-11-13 Neuropace, Inc. Multimodal brain sensing lead
US9572983B2 (en) 2012-03-26 2017-02-21 Setpoint Medical Corporation Devices and methods for modulation of bone erosion
US9907959B2 (en) 2012-04-12 2018-03-06 Medtronic, Inc. Velocity detection for posture-responsive therapy
US10448839B2 (en) 2012-04-23 2019-10-22 Livanova Usa, Inc. Methods, systems and apparatuses for detecting increased risk of sudden death
US9737719B2 (en) 2012-04-26 2017-08-22 Medtronic, Inc. Adjustment of therapy based on acceleration
US9604067B2 (en) 2012-08-04 2017-03-28 Boston Scientific Neuromodulation Corporation Techniques and methods for storing and transferring registration, atlas, and lead information between medical devices
US9002760B2 (en) 2012-08-23 2015-04-07 Qualcomm Incorporated Neural system of adaptive behavior
EP2890454B1 (en) 2012-08-28 2017-11-08 Boston Scientific Neuromodulation Corporation Point-and-click programming for deep brain stimulation using real-time monopolar review trendlines
CA2882974C (en) 2012-08-31 2018-10-23 Alfred E. Mann Foundation For Scientific Research Feedback controlled coil driver for inductive power transfer
US9289603B1 (en) * 2012-09-10 2016-03-22 Great Lakes Neuro Technologies Inc. Movement disorder therapy system, devices and methods, and methods of remotely tuning
US9238142B2 (en) 2012-09-10 2016-01-19 Great Lakes Neurotechnologies Inc. Movement disorder therapy system and methods of tuning remotely, intelligently and/or automatically
US11844945B1 (en) * 2012-09-10 2023-12-19 Great Lakes Neurotechnologies Inc. Movement disorder therapy system, devices and methods of remotely tuning
US9211417B2 (en) 2012-09-10 2015-12-15 Great Lakes Neurotechnologies Inc Movement disorder therapy system, devices and methods, and intelligent methods of tuning
US9792412B2 (en) 2012-11-01 2017-10-17 Boston Scientific Neuromodulation Corporation Systems and methods for VOA model generation and use
EP2908904B1 (en) 2012-11-06 2020-09-23 Saluda Medical Pty Limited System for controlling electrical conditions of tissue
BR112015017042B1 (en) 2013-01-21 2022-03-03 Cala Health, Inc Device to treat tremor
US10220211B2 (en) 2013-01-22 2019-03-05 Livanova Usa, Inc. Methods and systems to diagnose depression
US9056195B2 (en) 2013-03-15 2015-06-16 Cyberonics, Inc. Optimization of cranial nerve stimulation to treat seizure disorderse during sleep
US9044614B2 (en) 2013-03-15 2015-06-02 Alfred E. Mann Foundation For Scientific Research High voltage monitoring successive approximation analog to digital converter
WO2014144029A2 (en) 2013-03-15 2014-09-18 Boston Scientific Neuromodulation Corporation Clinical response data mapping
AU2014232252B2 (en) 2013-03-15 2018-01-18 Alfred E. Mann Foundation For Scientific Research Current sensing multiple output current stimulators with fast turn on time
CA2910984A1 (en) 2013-05-03 2014-11-06 Alfred E. Mann Foundation For Scientific Research Implant recharger handshaking system and method
CN104602760B (en) 2013-05-03 2017-11-07 艾尔弗雷德·E·曼科学研究基金会 High reliability wire for embedded type device is welded
EP2991726B1 (en) 2013-05-03 2018-07-25 Alfred E. Mann Foundation for Scientific Research Multi-branch stimulation electrode for subcutaneous field stimulation
US9780596B2 (en) 2013-07-29 2017-10-03 Alfred E. Mann Foundation For Scientific Research Microprocessor controlled class E driver
CA2919525C (en) 2013-07-29 2021-07-20 Alfred E. Mann Foundation For Scientific Research High efficiency magnetic link for implantable devices
EP3827874A1 (en) 2013-11-14 2021-06-02 Boston Scientific Neuromodulation Corporation Systems and visualization tools for stimulation and sensing of neural systems with system-level interaction models
US11172864B2 (en) 2013-11-15 2021-11-16 Closed Loop Medical Pty Ltd Monitoring brain neural potentials
AU2014353891B2 (en) 2013-11-22 2020-02-06 Saluda Medical Pty Ltd Method and device for detecting a neural response in a neural measurement
US20170126068A1 (en) * 2014-04-08 2017-05-04 Phitek Systems Limited Improvement in, or relating to, passenger/entertainment systems
US9302109B2 (en) 2014-04-25 2016-04-05 Cyberonics, Inc. Cranial nerve stimulation to treat depression during sleep
US9585611B2 (en) 2014-04-25 2017-03-07 Cyberonics, Inc. Detecting seizures based on heartbeat data
WO2015168735A1 (en) 2014-05-05 2015-11-12 Saluda Medical Pty Ltd Improved neural measurement
CN106455985B (en) 2014-05-16 2019-09-17 阿莱瓦神经治疗股份有限公司 With the device and production and preparation method thereof of nerve fiber interaction
US11311718B2 (en) 2014-05-16 2022-04-26 Aleva Neurotherapeutics Sa Device for interacting with neurological tissue and methods of making and using the same
JP6606105B2 (en) 2014-06-02 2019-11-13 カラ ヘルス,インコーポレイテッド System and method for peripheral nerve stimulation for treating tremor
US9959388B2 (en) 2014-07-24 2018-05-01 Boston Scientific Neuromodulation Corporation Systems, devices, and methods for providing electrical stimulation therapy feedback
EP3838331A1 (en) 2014-07-25 2021-06-23 Saluda Medical Pty Limited Neural stimulation dosing
US10265528B2 (en) 2014-07-30 2019-04-23 Boston Scientific Neuromodulation Corporation Systems and methods for electrical stimulation-related patient population volume analysis and use
US10272247B2 (en) 2014-07-30 2019-04-30 Boston Scientific Neuromodulation Corporation Systems and methods for stimulation-related volume analysis, creation, and sharing with integrated surgical planning and stimulation programming
EP3180075A4 (en) 2014-08-15 2018-03-07 Axonics Modulation Technologies Inc. Integrated electromyographic clinician programmer for use with an implantable neurostimulator
US10682521B2 (en) 2014-08-15 2020-06-16 Axonics Modulation Technologies, Inc. Attachment devices and associated methods of use with a nerve stimulation charging device
JP6795491B2 (en) 2014-08-15 2020-12-02 アクソニクス モジュレーション テクノロジーズ インコーポレイテッド Implantable lead attachment structure for nerve stimulation to relieve bladder dysfunction and other symptoms
CN107073258B (en) 2014-08-15 2020-02-21 艾克索尼克斯调制技术股份有限公司 System and method for neural stimulation electrode configuration based on neural localization
US9700731B2 (en) 2014-08-15 2017-07-11 Axonics Modulation Technologies, Inc. Antenna and methods of use for an implantable nerve stimulator
CN107073257B (en) 2014-08-15 2020-04-10 艾克索尼克斯调制技术股份有限公司 EMG lead positioning and stimulation titration in a neurostimulation system for treating overactive bladder
CA2958197C (en) 2014-08-15 2023-09-26 Axonics Modulation Technologies, Inc. External pulse generator device and associated methods for trial nerve stimulation
US9403011B2 (en) 2014-08-27 2016-08-02 Aleva Neurotherapeutics Leadless neurostimulator
US9474894B2 (en) 2014-08-27 2016-10-25 Aleva Neurotherapeutics Deep brain stimulation lead
US9974959B2 (en) 2014-10-07 2018-05-22 Boston Scientific Neuromodulation Corporation Systems, devices, and methods for electrical stimulation using feedback to adjust stimulation parameters
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
WO2016077882A1 (en) 2014-11-17 2016-05-26 Saluda Medical Pty Ltd Method and device for detecting a neural response in neural measurements
EP3229890B1 (en) 2014-12-11 2020-05-27 Saluda Medical Pty Limited Implantable electrode positioning
US10500399B2 (en) 2014-12-11 2019-12-10 Saluda Medical Pty Ltd Method and device for feedback control of neural stimulation
CN107427675B (en) 2015-01-09 2021-10-26 艾克索尼克斯股份有限公司 Patient remote control and associated method for use with a neurostimulation system
AU2016205050B2 (en) 2015-01-09 2020-02-27 Axonics Modulation Technologies, Inc. Attachment devices and associated methods of use with a nerve stimulation charging device
US10918872B2 (en) 2015-01-19 2021-02-16 Saluda Medical Pty Ltd Method and device for neural implant communication
US11406833B2 (en) 2015-02-03 2022-08-09 Setpoint Medical Corporation Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
US10130813B2 (en) 2015-02-10 2018-11-20 Neuropace, Inc. Seizure onset classification and stimulation parameter selection
EP3777964A1 (en) 2015-02-16 2021-02-17 Newronika S.p.A. Apparatus for treating neurological disorders
US10335302B2 (en) 2015-02-24 2019-07-02 Elira, Inc. Systems and methods for using transcutaneous electrical stimulation to enable dietary interventions
US10765863B2 (en) 2015-02-24 2020-09-08 Elira, Inc. Systems and methods for using a transcutaneous electrical stimulation device to deliver titrated therapy
US10376145B2 (en) 2015-02-24 2019-08-13 Elira, Inc. Systems and methods for enabling a patient to achieve a weight loss objective using an electrical dermal patch
US10864367B2 (en) 2015-02-24 2020-12-15 Elira, Inc. Methods for using an electrical dermal patch in a manner that reduces adverse patient reactions
CN108271363B (en) 2015-02-24 2022-08-09 伊莱拉股份有限公司 System and method for achieving appetite regulation and/or improving dietary compliance using electrode patches
US9956393B2 (en) 2015-02-24 2018-05-01 Elira, Inc. Systems for increasing a delay in the gastric emptying time for a patient using a transcutaneous electro-dermal patch
US10154922B1 (en) 2015-02-24 2018-12-18 Elira, Inc. Systems and methods for enabling appetite modulation and/or improving dietary compliance using percutaneous electrical neurostimulation
US10850102B2 (en) 2015-03-20 2020-12-01 Medtronic Sg, Llc Method and apparatus for multimodal electrical modulation of pain
US11167139B2 (en) 2015-03-20 2021-11-09 Medtronic Sg, Llc Method and apparatus for multi modal electrical modulation of pain using composite electromagnetic fields
AU2016235457B2 (en) 2015-03-20 2021-01-07 Medtronic Sg, Llc Method and apparatus for multimodal electrical modulation of pain
AU2016245335B2 (en) 2015-04-09 2020-11-19 Saluda Medical Pty Ltd Electrode to nerve distance estimation
EP3282931A4 (en) 2015-04-17 2019-01-16 Brain Sentinel, Inc. Method of monitoring a patient for seizure activity
AU2016268259B2 (en) 2015-05-26 2019-01-31 Boston Scientific Neuromodulation Corporation Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation
US10780283B2 (en) 2015-05-26 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation
JP2018516150A (en) 2015-05-31 2018-06-21 サルーダ・メディカル・ピーティーワイ・リミテッド Cranial nerve activity monitoring
EP3302692A4 (en) 2015-05-31 2019-01-16 Saluda Medical Pty Limited Brain neurostimulator electrode fitting
AU2016269843B2 (en) 2015-06-01 2021-03-04 Closed Loop Medical Pty Ltd Motor fibre neuromodulation
CN107847730B (en) 2015-06-10 2021-03-16 卡拉健康公司 System and method for peripheral nerve stimulation to treat tremor with a detachable treatment and monitoring unit
US10542961B2 (en) 2015-06-15 2020-01-28 The Research Foundation For The State University Of New York System and method for infrasonic cardiac monitoring
WO2017003947A1 (en) 2015-06-29 2017-01-05 Boston Scientific Neuromodulation Corporation Systems and methods for selecting stimulation parameters by targeting and steering
EP3280490B1 (en) 2015-06-29 2021-09-01 Boston Scientific Neuromodulation Corporation Systems for selecting stimulation parameters based on stimulation target region, effects, or side effects
EP3113033B1 (en) 2015-06-29 2019-01-09 Sorin CRM SAS Stimulation therapy system, in particular of the vagus nerve, by implementing a state transition model
EP3111991B1 (en) 2015-06-29 2020-01-29 Sorin CRM SAS Stimulation therapy system, in particular for vagus nerve stimulation, by implementing a state transition model that is self-adaptable in accordance with physical or physiological levels
EP3111990B1 (en) 2015-06-29 2019-02-27 Sorin CRM SAS Stimulation therapy system, in particular for vagus nerve stimulation, by implementing a state transition model with prior learning
EP3111992B1 (en) 2015-06-29 2018-08-01 Sorin CRM SAS Stimulation therapy system, in particular for vagus nerve stimulation, by implementing a state transition model operating at multiple space or time resolutions
JP6946261B2 (en) 2015-07-10 2021-10-06 アクソニクス インコーポレイテッド Implantable nerve stimulators and methods with internal electronics without ASICs
US11058541B2 (en) 2015-09-04 2021-07-13 The Johns Hopkins University Low-profile intercranial device
US10596376B2 (en) * 2015-09-17 2020-03-24 Albany Medical College Stimulation of the ventral pallidum for the treatment of epilepsy
AU2016325450A1 (en) * 2015-09-21 2018-05-10 Boston Scientific Neuromodulation Corporation Automated program optimization
CN108348746B (en) 2015-09-23 2021-10-12 卡拉健康公司 System and method for peripheral nerve stimulation in fingers or hands to treat hand tremor
WO2017062378A1 (en) 2015-10-09 2017-04-13 Boston Scientific Neuromodulation Corporation System and methods for clinical effects mapping for directional stimulations leads
US11318310B1 (en) 2015-10-26 2022-05-03 Nevro Corp. Neuromodulation for altering autonomic functions, and associated systems and methods
US10596367B2 (en) 2016-01-13 2020-03-24 Setpoint Medical Corporation Systems and methods for establishing a nerve block
US10195423B2 (en) 2016-01-19 2019-02-05 Axonics Modulation Technologies, Inc. Multichannel clip device and methods of use
US9517338B1 (en) 2016-01-19 2016-12-13 Axonics Modulation Technologies, Inc. Multichannel clip device and methods of use
US11471681B2 (en) 2016-01-20 2022-10-18 Setpoint Medical Corporation Batteryless implantable microstimulators
EP3405255A4 (en) 2016-01-20 2019-10-16 Setpoint Medical Corporation Implantable microstimulators and inductive charging systems
US10695569B2 (en) 2016-01-20 2020-06-30 Setpoint Medical Corporation Control of vagal stimulation
US11344722B2 (en) 2016-01-21 2022-05-31 Cala Health, Inc. Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder
US10583304B2 (en) 2016-01-25 2020-03-10 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
JP6876363B2 (en) 2016-01-29 2021-05-26 アクソニクス モジュレーション テクノロジーズ インコーポレイテッド Methods and systems for frequency adjustment that optimize the charging of implantable neurostimulators
WO2017134587A1 (en) 2016-02-02 2017-08-10 Aleva Neurotherapeutics, Sa Treatment of autoimmune diseases with deep brain stimulation
US10376704B2 (en) 2016-02-12 2019-08-13 Axonics Modulation Technologies, Inc. External pulse generator device and associated methods for trial nerve stimulation
JP6979967B2 (en) 2016-04-05 2021-12-15 サルーダ・メディカル・ピーティーワイ・リミテッド Improved feedback control of neuromodulation
BR112018071375A2 (en) 2016-04-19 2019-02-05 Brain Sentinel Inc systems and methods for the characterization of seizures
US10716942B2 (en) 2016-04-25 2020-07-21 Boston Scientific Neuromodulation Corporation System and methods for directional steering of electrical stimulation
US10776456B2 (en) 2016-06-24 2020-09-15 Boston Scientific Neuromodulation Corporation Systems and methods for visual analytics of clinical effects
EP3474747A4 (en) 2016-06-24 2020-01-22 Saluda Medical Pty Ltd Neural stimulation for reduced artefact
IL264116B2 (en) 2016-07-08 2024-01-01 Cala Health Inc Systems and methods for stimulating n nerves with exactly n electrodes and improved dry electrodes
US10912648B2 (en) 2016-08-30 2021-02-09 Longeviti Neuro Solutions Llc Method for manufacturing a low-profile intercranial device and the low-profile intercranial device manufactured thereby
WO2018044881A1 (en) 2016-09-02 2018-03-08 Boston Scientific Neuromodulation Corporation Systems and methods for visualizing and directing stimulation of neural elements
US10780282B2 (en) 2016-09-20 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for steering electrical stimulation of patient tissue and determining stimulation parameters
CN109803719B (en) 2016-10-14 2023-05-26 波士顿科学神经调制公司 System and method for closed loop determination of stimulation parameter settings for an electrical simulation system
CN107440704A (en) 2016-11-26 2017-12-08 张霞玲 A kind of adjustable neurostimulation probe in direction
JP6834005B2 (en) 2017-01-03 2021-02-24 ボストン サイエンティフィック ニューロモデュレイション コーポレイション Systems and methods for selecting MRI-matched stimulus parameters
EP3519043B1 (en) 2017-01-10 2020-08-12 Boston Scientific Neuromodulation Corporation Systems and methods for creating stimulation programs based on user-defined areas or volumes
US10390766B2 (en) * 2017-01-16 2019-08-27 General Electric Company System and method for predicting an excitation pattern of a deep brain stimulation
US10624588B2 (en) 2017-01-16 2020-04-21 General Electric Company System and method for predicting an excitation pattern of a deep brain stimulation
US10625082B2 (en) 2017-03-15 2020-04-21 Boston Scientific Neuromodulation Corporation Visualization of deep brain stimulation efficacy
CA3058786A1 (en) 2017-04-03 2018-10-11 Cala Health, Inc. Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder
WO2018187090A1 (en) 2017-04-03 2018-10-11 Boston Scientific Neuromodulation Corporation Systems and methods for estimating a volume of activation using a compressed database of threshold values
US10265517B2 (en) 2017-06-30 2019-04-23 Hi Llc Reconfigurable biosignal processing architecture
EP3651849B1 (en) 2017-07-14 2023-05-31 Boston Scientific Neuromodulation Corporation Estimating clinical effects of electrical stimulation
US11596795B2 (en) 2017-07-31 2023-03-07 Medtronic, Inc. Therapeutic electrical stimulation therapy for patient gait freeze
US11173307B2 (en) 2017-08-14 2021-11-16 Setpoint Medical Corporation Vagus nerve stimulation pre-screening test
US10960214B2 (en) 2017-08-15 2021-03-30 Boston Scientific Neuromodulation Corporation Systems and methods for controlling electrical stimulation using multiple stimulation fields
US11723579B2 (en) 2017-09-19 2023-08-15 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement
US10729907B2 (en) 2017-10-20 2020-08-04 Neuropace, Inc. Systems and methods for clinical decision making for a patient receiving a neuromodulation therapy based on deep learning
US10596377B2 (en) 2017-11-30 2020-03-24 International Business Machines Corporation Seizure detection, prediction and prevention using neurostimulation technology and deep neural network
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
US11478603B2 (en) 2017-12-31 2022-10-25 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
US11589992B2 (en) 2018-01-09 2023-02-28 Longeviti Neuro Solutions Llc Universal low-profile intercranial assembly
EP3740274A4 (en) 2018-01-17 2021-10-27 Cala Health, Inc. Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation
CN108096703B (en) * 2018-02-02 2021-11-02 陕西智联脑控科技有限公司 Multi-channel transcranial electrical stimulation device and method thereof
IT201800002962A1 (en) 2018-02-22 2019-08-22 Newronika Srl APPARATUS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS USING ELECTROSTIMULATION AND METHOD OF PROCESSING THE NEUROLOGICAL SIGNAL COLLECTED BY THIS APP
JP2021513902A (en) 2018-02-22 2021-06-03 アクソニクス モジュレーション テクノロジーズ インコーポレイテッド Nerve Stimulation Leads and Usage for Experimental Nerve Stimulation
US10702692B2 (en) 2018-03-02 2020-07-07 Aleva Neurotherapeutics Neurostimulation device
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
WO2019210214A1 (en) 2018-04-27 2019-10-31 Boston Scientific Neuromodulation Corporation Systems for visualizing and programming electrical stimulation
US11944820B2 (en) 2018-04-27 2024-04-02 Saluda Medical Pty Ltd Neurostimulation of mixed nerves
EP3784331B1 (en) 2018-04-27 2023-01-18 Boston Scientific Neuromodulation Corporation Multi-mode electrical stimulation systems and methods of making and using
EP3849410A4 (en) 2018-09-14 2022-11-02 Neuroenhancement Lab, LLC System and method of improving sleep
US11260229B2 (en) 2018-09-25 2022-03-01 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
US11318309B2 (en) 2018-12-13 2022-05-03 Newronika S.P.A. Method and apparatus for treating Tourette Syndrome by brain stimulation
US11590352B2 (en) 2019-01-29 2023-02-28 Nevro Corp. Ramped therapeutic signals for modulating inhibitory interneurons, and associated systems and methods
US11481578B2 (en) 2019-02-22 2022-10-25 Neuropace, Inc. Systems and methods for labeling large datasets of physiological records based on unsupervised machine learning
US11642537B2 (en) 2019-03-11 2023-05-09 Axonics, Inc. Charging device with off-center coil
US11612750B2 (en) 2019-03-19 2023-03-28 Neuropace, Inc. Methods and systems for optimizing therapy using stimulation mimicking natural seizures
US11918811B2 (en) 2019-05-06 2024-03-05 Medtronic Sg, Llc Method and apparatus for multi modal or multiplexed electrical modulation of pain using composite electromagnetic fields
US11848090B2 (en) 2019-05-24 2023-12-19 Axonics, Inc. Trainer for a neurostimulator programmer and associated methods of use with a neurostimulation system
US11439829B2 (en) 2019-05-24 2022-09-13 Axonics, Inc. Clinician programmer methods and systems for maintaining target operating temperatures
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep
US11247056B2 (en) 2019-07-25 2022-02-15 Medtronic, Inc. Systems and methods for lead fault detection and reconfiguration
US11890468B1 (en) 2019-10-03 2024-02-06 Cala Health, Inc. Neurostimulation systems with event pattern detection and classification
WO2021138543A1 (en) 2019-12-31 2021-07-08 Medtronic, Inc. Brain stimulation and sensing
EP4153053A1 (en) 2020-05-21 2023-03-29 The Feinstein Institutes for Medical Research Systems and methods for vagus nerve stimulation
US20230123383A1 (en) * 2021-10-18 2023-04-20 Advanced Neuromodulation Systems, Inc. Systems and methods for providing neurostimulation therapy using multi-dimensional patient features

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6018682A (en) * 1998-04-30 2000-01-25 Medtronic, Inc. Implantable seizure warning system

Family Cites Families (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218638A (en) 1962-05-29 1965-11-16 William M Honig Wireless passive biological telemetry system
US3498287A (en) 1966-04-28 1970-03-03 Neural Models Ltd Intelligence testing and signal analyzing means and method employing zero crossing detection
US3575162A (en) 1968-12-23 1971-04-20 Kenneth R Gaarder Physiological monitors and method of using the same in treatment of disease
US3522811A (en) 1969-02-13 1970-08-04 Medtronic Inc Implantable nerve stimulator and method of use
US3837331A (en) 1972-10-24 1974-09-24 S Ross System and method for controlling the nervous system of a living organism
US3967616A (en) 1972-10-24 1976-07-06 Ross Sidney A Multichannel system for and a multifactorial method of controlling the nervous system of a living organism
US3850161A (en) 1973-04-09 1974-11-26 S Liss Method and apparatus for monitoring and counteracting excess brain electrical energy to prevent epileptic seizures and the like
US3882850A (en) 1973-05-09 1975-05-13 Howard Bailin Brain wave feedback instrument
US3863625A (en) 1973-11-02 1975-02-04 Us Health Epileptic seizure warning system
US3918461A (en) 1974-01-31 1975-11-11 Irving S Cooper Method for electrically stimulating the human brain
US3993046A (en) 1974-11-06 1976-11-23 Heriberto Fernandez Seizure suppression device
US4505275A (en) 1977-09-15 1985-03-19 Wu Chen Treatment method and instrumentation system
JPS587291B2 (en) 1977-10-08 1983-02-09 財団法人交通医学研究財団 Automatic brain wave determination device
JPS5573269A (en) 1978-11-28 1980-06-02 Matsushita Electric Ind Co Ltd Living body feedback device
US4201224A (en) 1978-12-29 1980-05-06 Roy John E Electroencephalographic method and system for the quantitative description of patient brain states
US4305402A (en) 1979-06-29 1981-12-15 Katims Jefferson J Method for transcutaneous electrical stimulation
US4279258A (en) 1980-03-26 1981-07-21 Roy John E Rapid automatic electroencephalographic evaluation
JPS57177735A (en) 1981-04-27 1982-11-01 Toyoda Chuo Kenkyusho Kk Telemeter type brain nanometer
USRE34015E (en) 1981-05-15 1992-08-04 The Children's Medical Center Corporation Brain electrical activity mapping
US4407299A (en) 1981-05-15 1983-10-04 The Children's Medical Center Corporation Brain electrical activity mapping
US4408616A (en) 1981-05-15 1983-10-11 The Children's Medical Center Corporation Brain electricaL activity mapping
US4421122A (en) 1981-05-15 1983-12-20 The Children's Medical Center Corporation Brain electrical activity mapping
US4793353A (en) 1981-06-30 1988-12-27 Borkan William N Non-invasive multiprogrammable tissue stimulator and method
US4612934A (en) 1981-06-30 1986-09-23 Borkan William N Non-invasive multiprogrammable tissue stimulator
US4566464A (en) 1981-07-27 1986-01-28 Piccone Vincent A Implantable epilepsy monitor apparatus
US4494950A (en) 1982-01-19 1985-01-22 The Johns Hopkins University Plural module medication delivery system
US4545388A (en) 1983-06-09 1985-10-08 Roy John E Self-normed brain state monitoring
US4702254A (en) 1983-09-14 1987-10-27 Jacob Zabara Neurocybernetic prosthesis
US5025807A (en) 1983-09-14 1991-06-25 Jacob Zabara Neurocybernetic prosthesis
US4867164A (en) 1983-09-14 1989-09-19 Jacob Zabara Neurocybernetic prosthesis
US4844075A (en) 1984-01-09 1989-07-04 Pain Suppression Labs, Inc. Transcranial stimulation for the treatment of cerebral palsy
US4579125A (en) 1984-01-23 1986-04-01 Cns, Inc. Real-time EEG spectral analyzer
US4590946A (en) 1984-06-14 1986-05-27 Biomed Concepts, Inc. Surgically implantable electrode for nerve bundles
US4573481A (en) 1984-06-25 1986-03-04 Huntington Institute Of Applied Research Implantable electrode array
US4768176A (en) 1984-07-06 1988-08-30 Kehr Bruce A Apparatus for alerting a patient to take medication
US4768177A (en) 1984-07-06 1988-08-30 Kehr Bruce A Method of and apparatus for alerting a patient to take medication
US4817628A (en) 1985-10-18 1989-04-04 David L. Zealear System and method for evaluating neurological function controlling muscular movements
US5167229A (en) 1986-03-24 1992-12-01 Case Western Reserve University Functional neuromuscular stimulation system
US5070873A (en) 1987-02-13 1991-12-10 Sigmedics, Inc. Method of and apparatus for electrically stimulating quadriceps muscles of an upper motor unit paraplegic
US4838272A (en) 1987-08-19 1989-06-13 The Regents Of The University Of California Method and apparatus for adaptive closed loop electrical stimulation of muscles
US4926865A (en) 1987-10-01 1990-05-22 Oman Paul S Microcomputer-based nerve and muscle stimulator
US5010891A (en) 1987-10-09 1991-04-30 Biometrak Corporation Cerebral biopotential analysis system and method
US5871472A (en) 1987-11-17 1999-02-16 Brown University Research Foundation Planting devices for the focal release of neuroinhibitory compounds
US4852573A (en) 1987-12-04 1989-08-01 Kennedy Philip R Implantable neural electrode
GB8729899D0 (en) 1987-12-22 1988-02-03 Royal Postgrad Med School Method & apparatus for analysing electro-encephalogram
US5343064A (en) 1988-03-18 1994-08-30 Spangler Leland J Fully integrated single-crystal silicon-on-insulator process, sensors and circuits
US4920979A (en) 1988-10-12 1990-05-01 Huntington Medical Research Institute Bidirectional helical electrode for nerve stimulation
US4878498A (en) 1988-10-14 1989-11-07 Somatics, Inc. Electroconvulsive therapy apparatus and method for automatic monitoring of patient seizures
US4873981A (en) 1988-10-14 1989-10-17 Somatics, Inc. Electroconvulsive therapy apparatus and method for automatic monitoring of patient seizures
US5016635A (en) 1988-11-29 1991-05-21 Sigmedics, Inc. Of Delaware Control of FNS via pattern variations of response EMG
US4955380A (en) 1988-12-15 1990-09-11 Massachusetts Institute Of Technology Flexible measurement probes
FR2645641B1 (en) 1989-04-10 1991-05-31 Bruno Comby METHOD AND DEVICE FOR MEASURING VIBRATION, IN PARTICULAR MICROSCOPIC SHAKING OF LIVING ORGANISMS
EP0399063B1 (en) 1989-05-22 1994-01-05 Pacesetter AB Implantable medical device to stimulate contraction in tissues with an adjustable stimulation intensity, and process for using same
US5292772A (en) 1989-09-26 1994-03-08 Carter-Wallace, Inc. Method for the prevention and control of epileptic seizure associated with Lennox-Gastaut syndrome
US4978680A (en) 1989-09-26 1990-12-18 Carter-Wallace, Inc. Method for the prevention and control of epileptic seizure
US5082861A (en) 1989-09-26 1992-01-21 Carter-Wallace, Inc. Method for the prevention and control of epileptic seizure associated with complex partial seizures
US4979511A (en) 1989-11-03 1990-12-25 Cyberonics, Inc. Strain relief tether for implantable electrode
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
US5361760A (en) 1989-11-07 1994-11-08 University Of Utah Research Foundation Impact inserter mechanism for implantation of a biomedical device
US5154172A (en) 1989-11-13 1992-10-13 Cyberonics, Inc. Constant current sources with programmable voltage source
US5186170A (en) 1989-11-13 1993-02-16 Cyberonics, Inc. Simultaneous radio frequency and magnetic field microprocessor reset circuit
US5179950A (en) 1989-11-13 1993-01-19 Cyberonics, Inc. Implanted apparatus having micro processor controlled current and voltage sources with reduced voltage levels when not providing stimulation
US5235980A (en) 1989-11-13 1993-08-17 Cyberonics, Inc. Implanted apparatus disabling switching regulator operation to allow radio frequency signal reception
US5031618A (en) 1990-03-07 1991-07-16 Medtronic, Inc. Position-responsive neuro stimulator
US5097835A (en) 1990-04-09 1992-03-24 Ad-Tech Medical Instrument Corporation Subdural electrode with improved lead connection
US5314458A (en) 1990-06-01 1994-05-24 University Of Michigan Single channel microstimulator
DE69209324T2 (en) 1991-01-09 1996-11-21 Medtronic Inc Servo control for muscles
US5263480A (en) 1991-02-01 1993-11-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5188104A (en) 1991-02-01 1993-02-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5190029A (en) 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
US5269303A (en) 1991-02-22 1993-12-14 Cyberonics, Inc. Treatment of dementia by nerve stimulation
US5222503A (en) 1991-04-24 1993-06-29 Beth Israel Hospital Association Ambulatory electroencephalography system
US5335657A (en) 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation
US5251634A (en) 1991-05-03 1993-10-12 Cyberonics, Inc. Helical nerve electrode
US5299569A (en) 1991-05-03 1994-04-05 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
US5215086A (en) 1991-05-03 1993-06-01 Cyberonics, Inc. Therapeutic treatment of migraine symptoms by stimulation
US5269302A (en) 1991-05-10 1993-12-14 Somatics, Inc. Electroconvulsive therapy apparatus and method for monitoring patient seizures
US5205285A (en) 1991-06-14 1993-04-27 Cyberonics, Inc. Voice suppression of vagal stimulation
US5222494A (en) 1991-07-31 1993-06-29 Cyberonics, Inc. Implantable tissue stimulator output stabilization system
US5231988A (en) 1991-08-09 1993-08-03 Cyberonics, Inc. Treatment of endocrine disorders by nerve stimulation
US5293879A (en) 1991-09-23 1994-03-15 Vitatron Medical, B.V. System an method for detecting tremors such as those which result from parkinson's disease
US5215089A (en) 1991-10-21 1993-06-01 Cyberonics, Inc. Electrode assembly for nerve stimulation
US5458117A (en) 1991-10-25 1995-10-17 Aspect Medical Systems, Inc. Cerebral biopotential analysis system and method
US5304206A (en) 1991-11-18 1994-04-19 Cyberonics, Inc. Activation techniques for implantable medical device
US5237991A (en) 1991-11-19 1993-08-24 Cyberonics, Inc. Implantable medical device with dummy load for pre-implant testing in sterile package and facilitating electrical lead connection
US5330515A (en) 1992-06-17 1994-07-19 Cyberonics, Inc. Treatment of pain by vagal afferent stimulation
US5376359A (en) 1992-07-07 1994-12-27 Glaxo, Inc. Method of stabilizing aerosol formulations
US5476494A (en) 1992-09-11 1995-12-19 Massachusetts Institute Of Technology Low pressure neural contact structure
US5311876A (en) 1992-11-18 1994-05-17 The Johns Hopkins University Automatic detection of seizures using electroencephalographic signals
US5342408A (en) 1993-01-07 1994-08-30 Incontrol, Inc. Telemetry system for an implantable cardiac device
US5392788A (en) 1993-02-03 1995-02-28 Hudspeth; William J. Method and device for interpreting concepts and conceptual thought from brainwave data and for assisting for diagnosis of brainwave disfunction
US5411540A (en) 1993-06-03 1995-05-02 Massachusetts Institute Of Technology Method and apparatus for preferential neuron stimulation
US5365939A (en) 1993-10-15 1994-11-22 Neurotrain, L.C. Method for evaluating and treating an individual with electroencephalographic disentrainment feedback
US5349962A (en) 1993-11-30 1994-09-27 University Of Washington Method and apparatus for detecting epileptic seizures
US5513649A (en) 1994-03-22 1996-05-07 Sam Technology, Inc. Adaptive interference canceler for EEG movement and eye artifacts
US5486999A (en) 1994-04-20 1996-01-23 Mebane; Andrew H. Apparatus and method for categorizing health care utilization
US5531778A (en) 1994-09-20 1996-07-02 Cyberonics, Inc. Circumneural electrode assembly
US5995868A (en) * 1996-01-23 1999-11-30 University Of Kansas System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject
US5824021A (en) * 1996-04-25 1998-10-20 Medtronic Inc. Method and apparatus for providing feedback to spinal cord stimulation for angina
US5716377A (en) * 1996-04-25 1998-02-10 Medtronic, Inc. Method of treating movement disorders by brain stimulation
US6094598A (en) * 1996-04-25 2000-07-25 Medtronics, Inc. Method of treating movement disorders by brain stimulation and drug infusion
US5683422A (en) * 1996-04-25 1997-11-04 Medtronic, Inc. Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation
US5735814A (en) * 1996-04-30 1998-04-07 Medtronic, Inc. Techniques of treating neurodegenerative disorders by brain infusion
US5711316A (en) * 1996-04-30 1998-01-27 Medtronic, Inc. Method of treating movement disorders by brain infusion
US5713923A (en) * 1996-05-13 1998-02-03 Medtronic, Inc. Techniques for treating epilepsy by brain stimulation and drug infusion
US5782798A (en) * 1996-06-26 1998-07-21 Medtronic, Inc. Techniques for treating eating disorders by brain stimulation and drug infusion
US6042579A (en) * 1997-04-30 2000-03-28 Medtronic, Inc. Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain
US5975085A (en) * 1997-05-01 1999-11-02 Medtronic, Inc. Method of treating schizophrenia by brain stimulation and drug infusion
US6128537A (en) * 1997-05-01 2000-10-03 Medtronic, Inc Techniques for treating anxiety by brain stimulation and drug infusion
US6597954B1 (en) * 1997-10-27 2003-07-22 Neuropace, Inc. System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes
US6354299B1 (en) * 1997-10-27 2002-03-12 Neuropace, Inc. Implantable device for patient communication
US6427086B1 (en) * 1997-10-27 2002-07-30 Neuropace, Inc. Means and method for the intracranial placement of a neurostimulator
US6016449A (en) * 1997-10-27 2000-01-18 Neuropace, Inc. System for treatment of neurological disorders
US6647296B2 (en) * 1997-10-27 2003-11-11 Neuropace, Inc. Implantable apparatus for treating neurological disorders
US6459936B2 (en) * 1997-10-27 2002-10-01 Neuropace, Inc. Methods for responsively treating neurological disorders
AU754269B2 (en) * 1998-01-12 2002-11-07 Ronald P. Lesser Technique for using brain heat flow management to treat brain disorders
US6006449A (en) * 1998-01-29 1999-12-28 Precision Products Group, Inc. Footwear having spring assemblies in the soles thereof
US6227203B1 (en) * 1998-02-12 2001-05-08 Medtronic, Inc. Techniques for controlling abnormal involuntary movements by brain stimulation and drug infusion
US6374140B1 (en) * 1998-04-30 2002-04-16 Medtronic, Inc. Method and apparatus for treating seizure disorders by stimulating the olfactory senses
US5938689A (en) * 1998-05-01 1999-08-17 Neuropace, Inc. Electrode configuration for a brain neuropacemaker
AU5900299A (en) * 1998-08-24 2000-03-14 Emory University Method and apparatus for predicting the onset of seizures based on features derived from signals indicative of brain activity
US6356784B1 (en) * 1999-04-30 2002-03-12 Medtronic, Inc. Method of treating movement disorders by electrical stimulation and/or drug infusion of the pendunulopontine nucleus
US6109269A (en) * 1999-04-30 2000-08-29 Medtronic, Inc. Method of treating addiction by brain infusion
US6176242B1 (en) * 1999-04-30 2001-01-23 Medtronic Inc Method of treating manic depression by brain infusion
US6161045A (en) * 1999-06-01 2000-12-12 Neuropace, Inc. Method for determining stimulation parameters for the treatment of epileptic seizures
US6304775B1 (en) * 1999-09-22 2001-10-16 Leonidas D. Iasemidis Seizure warning and prediction
DE60027459T2 (en) * 1999-12-07 2006-12-21 George Mason University ADAPTIVE MODULATION OF AN ELECTRIC FIELD FOR NEURAL SYSTEMS
US6473639B1 (en) * 2000-03-02 2002-10-29 Neuropace, Inc. Neurological event detection procedure using processed display channel based algorithms and devices incorporating these procedures
US6484132B1 (en) * 2000-03-07 2002-11-19 Lockheed Martin Energy Research Corporation Condition assessment of nonlinear processes
US6353754B1 (en) * 2000-04-24 2002-03-05 Neuropace, Inc. System for the creation of patient specific templates for epileptiform activity detection
US6442421B1 (en) * 2000-04-27 2002-08-27 Centre National De La Recherche Scientifique Method for the medical monitoring in real time of a patient from the analysis of electroencephalograms to characterize and differentiate between physiological or pathological conditions, and a method for anticipating epileptic seizures
JP2001356925A (en) * 2000-06-12 2001-12-26 Nec Corp Portable telephone set
US6402678B1 (en) * 2000-07-31 2002-06-11 Neuralieve, Inc. Means and method for the treatment of migraine headaches
US6591138B1 (en) * 2000-08-31 2003-07-08 Neuropace, Inc. Low frequency neurostimulator for the treatment of neurological disorders
US6488617B1 (en) * 2000-10-13 2002-12-03 Universal Hedonics Method and device for producing a desired brain state
US6534693B2 (en) * 2000-11-06 2003-03-18 Afmedica, Inc. Surgically implanted devices having reduced scar tissue formation
US6591137B1 (en) * 2000-11-09 2003-07-08 Neuropace, Inc. Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders
US6594524B2 (en) * 2000-12-12 2003-07-15 The Trustees Of The University Of Pennsylvania Adaptive method and apparatus for forecasting and controlling neurological disturbances under a multi-level control
US6547746B1 (en) * 2001-08-27 2003-04-15 Andrew A. Marino Method and apparatus for determining response thresholds
US7110820B2 (en) * 2002-02-05 2006-09-19 Tcheng Thomas K Responsive electrical stimulation for movement disorders
US20030195588A1 (en) * 2002-04-16 2003-10-16 Neuropace, Inc. External ear canal interface for the treatment of neurological disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6018682A (en) * 1998-04-30 2000-01-25 Medtronic, Inc. Implantable seizure warning system

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