WO2005113798A3 - Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining - Google Patents

Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining Download PDF

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Publication number
WO2005113798A3
WO2005113798A3 PCT/US2005/013045 US2005013045W WO2005113798A3 WO 2005113798 A3 WO2005113798 A3 WO 2005113798A3 US 2005013045 W US2005013045 W US 2005013045W WO 2005113798 A3 WO2005113798 A3 WO 2005113798A3
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WIPO (PCT)
Prior art keywords
cancer
injury
organ injury
diagnostic biomarkers
muscle rehabilitation
Prior art date
Application number
PCT/US2005/013045
Other languages
French (fr)
Other versions
WO2005113798A2 (en
Inventor
Ka-Wang Kevin Wang
Ronald Hayes
Ming-Chen Liu
Monika Oli
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Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida filed Critical Univ Florida
Priority to EP05779948A priority Critical patent/EP1747282B1/en
Priority to AU2005245785A priority patent/AU2005245785B2/en
Priority to JP2007508611A priority patent/JP4885122B2/en
Priority to CA2578680A priority patent/CA2578680C/en
Priority to AT05779948T priority patent/ATE512365T1/en
Publication of WO2005113798A2 publication Critical patent/WO2005113798A2/en
Publication of WO2005113798A3 publication Critical patent/WO2005113798A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
PCT/US2005/013045 2004-04-15 2005-04-15 Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining WO2005113798A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP05779948A EP1747282B1 (en) 2004-04-15 2005-04-15 Map-2 proteolytic breakdown products as diagnostic biomarkers for neural injury
AU2005245785A AU2005245785B2 (en) 2004-04-15 2005-04-15 Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining
JP2007508611A JP4885122B2 (en) 2004-04-15 2005-04-15 Proteolytic markers as diagnostic biomarkers for cancer, organ injury, and muscle rehabilitation / exercise overtraining
CA2578680A CA2578680C (en) 2004-04-15 2005-04-15 Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining
AT05779948T ATE512365T1 (en) 2004-04-15 2005-04-15 MAP-2 PROTEOLYTIC PRODUCTS AS DIAGNOSTIC BIOMARKERS FOR NEURAL INJURY

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56281904P 2004-04-15 2004-04-15
US60/562,819 2004-04-15

Publications (2)

Publication Number Publication Date
WO2005113798A2 WO2005113798A2 (en) 2005-12-01
WO2005113798A3 true WO2005113798A3 (en) 2008-10-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/013045 WO2005113798A2 (en) 2004-04-15 2005-04-15 Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining

Country Status (8)

Country Link
US (2) US7456027B2 (en)
EP (1) EP1747282B1 (en)
JP (1) JP4885122B2 (en)
AT (1) ATE512365T1 (en)
AU (1) AU2005245785B2 (en)
CA (1) CA2578680C (en)
ES (1) ES2367311T3 (en)
WO (1) WO2005113798A2 (en)

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Also Published As

Publication number Publication date
US8298835B2 (en) 2012-10-30
EP1747282A4 (en) 2009-11-11
US20050260697A1 (en) 2005-11-24
EP1747282B1 (en) 2011-06-08
ES2367311T3 (en) 2011-11-02
CA2578680C (en) 2011-06-14
ATE512365T1 (en) 2011-06-15
US20090317805A1 (en) 2009-12-24
AU2005245785B2 (en) 2011-04-07
AU2005245785A1 (en) 2005-12-01
US7456027B2 (en) 2008-11-25
JP2007535318A (en) 2007-12-06
JP4885122B2 (en) 2012-02-29
WO2005113798A2 (en) 2005-12-01
CA2578680A1 (en) 2005-12-01
EP1747282A2 (en) 2007-01-31
AU2005245785A2 (en) 2005-12-01

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