WO2005112984A3 - Apparatus and method for transdermal delivery of parathyroid hormone agents - Google Patents

Apparatus and method for transdermal delivery of parathyroid hormone agents Download PDF

Info

Publication number
WO2005112984A3
WO2005112984A3 PCT/US2005/009147 US2005009147W WO2005112984A3 WO 2005112984 A3 WO2005112984 A3 WO 2005112984A3 US 2005009147 W US2005009147 W US 2005009147W WO 2005112984 A3 WO2005112984 A3 WO 2005112984A3
Authority
WO
WIPO (PCT)
Prior art keywords
transdermal delivery
parathyroid hormone
hormone agents
microprojection member
epidermis
Prior art date
Application number
PCT/US2005/009147
Other languages
French (fr)
Other versions
WO2005112984A2 (en
Inventor
Mahmoud Ameri
Michel J N Cormier
Yuh-Fun Maa
Marika Kamberi
Peter Daddona
Original Assignee
Alza Corp
Mahmoud Ameri
Michel J N Cormier
Yuh-Fun Maa
Marika Kamberi
Peter Daddona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp, Mahmoud Ameri, Michel J N Cormier, Yuh-Fun Maa, Marika Kamberi, Peter Daddona filed Critical Alza Corp
Priority to ES05727716.2T priority Critical patent/ES2568259T3/en
Priority to JP2007513130A priority patent/JP5007427B2/en
Priority to EP05727716.2A priority patent/EP1744683B1/en
Priority to MXPA06013168A priority patent/MXPA06013168A/en
Priority to BRPI0509788-6A priority patent/BRPI0509788A/en
Priority to CA002566032A priority patent/CA2566032A1/en
Priority to AU2005244734A priority patent/AU2005244734A1/en
Publication of WO2005112984A2 publication Critical patent/WO2005112984A2/en
Publication of WO2005112984A3 publication Critical patent/WO2005112984A3/en
Priority to IL179197A priority patent/IL179197A0/en
Priority to NO20065720A priority patent/NO20065720L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Abstract

An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (30) (or system) that includes a plurality of microprojections (32) (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating (35) that is applied to the microprojection member.
PCT/US2005/009147 2004-05-13 2005-03-18 Apparatus and method for transdermal delivery of parathyroid hormone agents WO2005112984A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES05727716.2T ES2568259T3 (en) 2004-05-13 2005-03-18 Apparatus and method for transdermal administration of parathyroid hormone agents
JP2007513130A JP5007427B2 (en) 2004-05-13 2005-03-18 Apparatus and method for transdermal delivery of parathyroid hormone agents
EP05727716.2A EP1744683B1 (en) 2004-05-13 2005-03-18 Apparatus and method for transdermal delivery of parathyroid hormone agents
MXPA06013168A MXPA06013168A (en) 2004-05-13 2005-03-18 Apparatus and method for transdermal delivery of parathyroid hormone agents.
BRPI0509788-6A BRPI0509788A (en) 2004-05-13 2005-03-18 apparatus and method for transdermal delivery of parathyroid hormone agents
CA002566032A CA2566032A1 (en) 2004-05-13 2005-03-18 Apparatus and method for transdermal delivery of parathyroid hormone agents
AU2005244734A AU2005244734A1 (en) 2004-05-13 2005-03-18 Apparatus and method for transdermal delivery of parathyroid hormone agents
IL179197A IL179197A0 (en) 2004-05-13 2006-11-12 Apparatus and method for transdermal delivery of parathyroid hormone agents
NO20065720A NO20065720L (en) 2004-05-13 2006-12-12 Apparatus and method for transdermal delivery of parathyroid hormone agents.

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US57130404P 2004-05-13 2004-05-13
US60/571,304 2004-05-13
US58527604P 2004-07-01 2004-07-01
US60/585,276 2004-07-01
US64366005P 2005-01-12 2005-01-12
US60/643,660 2005-01-12

Publications (2)

Publication Number Publication Date
WO2005112984A2 WO2005112984A2 (en) 2005-12-01
WO2005112984A3 true WO2005112984A3 (en) 2006-04-20

Family

ID=35428853

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/009147 WO2005112984A2 (en) 2004-05-13 2005-03-18 Apparatus and method for transdermal delivery of parathyroid hormone agents

Country Status (12)

Country Link
US (4) US7556821B2 (en)
EP (1) EP1744683B1 (en)
JP (2) JP5007427B2 (en)
AR (1) AR048887A1 (en)
AU (1) AU2005244734A1 (en)
BR (1) BRPI0509788A (en)
CA (1) CA2566032A1 (en)
ES (1) ES2568259T3 (en)
IL (1) IL179197A0 (en)
MX (1) MXPA06013168A (en)
NO (1) NO20065720L (en)
WO (1) WO2005112984A2 (en)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2253549C (en) * 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
JP4659332B2 (en) * 2000-10-13 2011-03-30 アルザ・コーポレーシヨン Apparatus and method for perforating skin using microprojections
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
NZ525551A (en) * 2000-10-26 2005-09-30 Alza Corp Transdermal drug delivery devices having coated microprotrusions
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US20040062813A1 (en) * 2002-06-28 2004-04-01 Cormier Michel J. N. Transdermal drug delivery devices having coated microprotrusions
ES2377647T3 (en) 2003-10-31 2012-03-29 Alza Corporation Self-acting applicator for microprojection ordering
BRPI0509897A (en) * 2004-04-13 2007-08-07 Alza Corp apparatus and method for transdermal delivery of multiple vaccines
JP5007427B2 (en) * 2004-05-13 2012-08-22 アルザ コーポレイション Apparatus and method for transdermal delivery of parathyroid hormone agents
TW200626196A (en) * 2004-09-08 2006-08-01 Alza Corp Microprojection array with improved skin adhesion and compliance
CN101267896A (en) * 2005-09-12 2008-09-17 阿尔扎公司 Coatable transdermal delivery microprojection assembly
US7994129B2 (en) * 2005-11-10 2011-08-09 Michigan Technological University Methods of using black bear parathyroid hormone
WO2007061781A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
WO2007084247A2 (en) * 2005-12-28 2007-07-26 Alza Corporation Stable therapeutic formulations
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US20080039775A1 (en) * 2006-03-15 2008-02-14 Alza Corporation Apparatus and Method for Transdermal Delivery of Parathyroid Hormone Agents to Prevent or Treat Osteopenia
WO2007127811A2 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with grouped microprojections for high drug loading
US20070299388A1 (en) * 2006-04-25 2007-12-27 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
EP2069013A2 (en) 2006-10-02 2009-06-17 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
EP2146689B1 (en) 2007-04-16 2020-08-12 Corium, Inc. Solvent-cast microneedle arrays containing active
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
EP2307546A1 (en) * 2008-06-04 2011-04-13 Coda Therapeutics, Inc. Treatment of pain with gap junction modulation compounds
EP2383013A4 (en) * 2008-12-26 2012-11-28 Hisamitsu Pharmaceutical Co Microneedle device
US20100226966A1 (en) * 2009-03-03 2010-09-09 Daddona Peter E Method for transdermal controlled release drug delivery
US20100286600A1 (en) * 2009-05-08 2010-11-11 Bommannan D Bommi Transdermal patch device
JP2013508119A (en) 2009-10-26 2013-03-07 エムキネティクス， インコーポレイテッド Method and apparatus for electromagnetic stimulation of nerves, muscles and body tissues
AU2009356227A1 (en) 2009-12-07 2012-06-21 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
EP2540337B1 (en) 2010-02-24 2019-04-03 Hisamitsu Pharmaceutical Co., Inc. Micro-needle device and preparation method
JP6327852B2 (en) * 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド Methods and devices for transdermal delivery of parathyroid hormone using microprojection arrays
MX342898B (en) 2010-05-12 2016-10-18 Radius Health Inc * Therapeutic regimens.
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
EP2621901B1 (en) 2010-09-28 2015-07-29 Radius Health, Inc Selective androgen receptor modulators
WO2012075375A1 (en) * 2010-12-02 2012-06-07 Lanco Biosciences, Inc. Delivery of parathyroid hormones by microinjection systems
US20130323293A1 (en) 2011-02-24 2013-12-05 Takuya Umemoto Glp-1 analogue composition for microneedle devices
WO2012115207A1 (en) * 2011-02-24 2012-08-30 久光製薬株式会社 Biologically active nonaqueous composition for microneedle devices, and biologically active nonaqueous composition adhering to microneedle
CN103917242A (en) 2011-04-22 2014-07-09 半径健康公司 Method of drug delivery for PTH, PTHrP and related peptides
KR20150116468A (en) 2011-06-07 2015-10-15 아사히 가세이 파마 가부시키가이샤 Freeze-dried preparation containing high-purity pth and method for producing same
US10980865B2 (en) 2012-08-10 2021-04-20 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
US9173598B1 (en) * 2012-08-27 2015-11-03 Abdullah Khalid Al Rasheed Device for piercing the skin to obtain a blood sample and method of use
KR20150052092A (en) * 2012-08-30 2015-05-13 테이진 가부시키가이샤 Microneedle array coated with drug composition
MX2015008157A (en) 2012-12-21 2016-02-22 Corium Int Inc Microarray for delivery of therapeutic agent and methods of use.
JP6081215B2 (en) * 2013-02-13 2017-02-15 久光製薬株式会社 Coating and microneedle devices
KR101866005B1 (en) 2013-02-13 2018-06-08 히사미쓰 세이야꾸 가부시키가이샤 Microneedle-coating composition and microneedle device
KR101948972B1 (en) 2013-02-13 2019-02-15 히사미쓰 세이야꾸 가부시키가이샤 Microneedle coating composition and microneedle device
ES2921481T3 (en) 2013-03-12 2022-08-26 Corium Inc Microprojection applicators
CA2903763C (en) 2013-03-15 2021-11-16 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
EP2968118B1 (en) 2013-03-15 2022-02-09 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
EP2968751B1 (en) 2013-03-15 2022-11-30 Corium, Inc. Multiple impact microprojection applicators
WO2015017561A1 (en) 2013-07-30 2015-02-05 Zosano Pharma, Inc. Low-profile microneedle patch applicator
JP5728553B2 (en) 2013-10-18 2015-06-03 ユニ・チャーム株式会社 Non-woven fabric bulk recovery device and non-woven fabric bulk recovery method
JP5728552B2 (en) 2013-10-18 2015-06-03 ユニ・チャーム株式会社 Non-woven fabric bulk recovery device and non-woven fabric bulk recovery method
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
WO2016081616A2 (en) * 2014-11-18 2016-05-26 4P Therapeutics Transdermal patch formulations for delivery of water soluble drugs, peptides, proteins and oligosaccharides
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744239B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
BR112017023233A2 (en) 2015-04-29 2018-11-06 Radius Pharmaceuticals Inc methods for cancer treatment
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
EP4049651A1 (en) * 2015-10-09 2022-08-31 Kindeva Drug Delivery L.P. Zinc compositions for coated microneedle arrays
EP3414570B1 (en) * 2016-02-08 2020-04-01 Lunaphore Technologies SA Methods of sample cycle multiplexing and in situ imaging
US9918932B2 (en) 2016-02-19 2018-03-20 Zosano Pharma Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
US10568937B2 (en) * 2016-04-18 2020-02-25 Radius Health, Inc. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
KR102397890B1 (en) 2016-06-22 2022-05-12 일립시스 파마 리미티드 AR+ Breast Cancer Treatment Method
AU2018205285C1 (en) 2017-01-05 2023-08-24 Radius Pharmaceuticals, Inc. Polymorphic forms of RAD1901-2HCl
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
EP3672570A1 (en) 2017-08-23 2020-07-01 Zosano Pharma Corporation Method of rapidly achieving therapeutic concentrations of zolmitriptan for treatment of migraines and cluster headaches
WO2019059302A1 (en) * 2017-09-22 2019-03-28 旭化成ファーマ株式会社 Teriparatide-containing liquid pharmaceutical composition having excellent stability
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
CA3104395A1 (en) 2018-07-04 2020-01-09 Radius Pharmaceuticals, Inc. Polymorphic forms of rad1901-2hcl

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679647A (en) * 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
US6230051B1 (en) * 1996-06-18 2001-05-08 Alza Corporation Device for enhancing transdermal agent delivery or sampling

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE25637E (en) 1964-09-08 Means for vaccinating
US3123212A (en) 1964-03-03 Multiple disposable intracutaneous injector package
US2619962A (en) 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US2893392A (en) 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3072122A (en) 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3221739A (en) 1962-03-26 1965-12-07 Rosenthal Sol Roy Injection device
US3221740A (en) 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
BE795384A (en) 1972-02-14 1973-08-13 Ici Ltd DRESSINGS
US4086196A (en) 1975-03-28 1978-04-25 Armour Pharmaceutical Company Parathyroid hormone
IL78342A (en) 1985-04-04 1991-06-10 Gen Hospital Corp Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
SE8501990D0 (en) 1985-04-24 1985-04-24 Pharmacia Ab BELEGGNINGSFORFARANDE
US5420242A (en) 1986-10-22 1995-05-30 Kaare M. Gautvik Production of human parathyroid hormone from microorganisms
US4833125A (en) 1986-12-05 1989-05-23 The General Hospital Corporation Method of increasing bone mass
US5080646A (en) 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
KR970008118B1 (en) 1987-07-09 1997-05-21 엘테에스 로오만 테라피-지스테메 게엠베하 운트 콤파니 카게 Transdermal therapeutic system
US5527772A (en) 1987-10-20 1996-06-18 Holick; Michael F. Regulation of cell proliferation and differentiation using peptides
US5169382A (en) 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5147296A (en) 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5208041A (en) 1991-05-23 1993-05-04 Allelix Biopharmaceuticals Inc. Essentially pure human parathyroid hormone
WO1993011785A1 (en) 1991-12-09 1993-06-24 Asahi Kasei Kogyo Kabushiki Kaisha Stabilized parathyroid hormone composition
US5629019A (en) * 1992-02-27 1997-05-13 Alza Corporation Formulations with hydrophobic permeation enhancers
US5225098A (en) * 1992-03-20 1993-07-06 The Procter & Gamble Company Neutral pH freezer bar and process
US5382658A (en) 1992-04-03 1995-01-17 Allelix Biopharmaceuticals Inc. Stability-enhanced variants of parathyroid hormone
AU672790B2 (en) 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
IT1255723B (en) 1992-10-09 1995-11-13 USE OF PARATORMONE, ITS BIOLOGICALLY ACTIVE FRAGMENTS AND RELATED PEPTIDES, FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS USEFUL IN THE PREVENTION AND THERAPY OF ABORTION AND PRETERMONE BIRTH AND IN GENERAL FOR THE TREATMENT OF GESTATION
ATE146965T1 (en) * 1993-01-21 1997-01-15 Janssen Pharmaceutica Nv TOPICAL KETOCONAZOLE DRUG
JP3628713B2 (en) * 1993-06-07 2005-03-16 帝國製薬株式会社 Vaginal preparation containing physiologically active peptide
TW303299B (en) 1993-07-22 1997-04-21 Lilly Co Eli
DE4341444C2 (en) 1993-12-04 1996-03-14 Lohmann Therapie Syst Lts Active substance-containing plaster and process for its production
US5496801A (en) * 1993-12-23 1996-03-05 Allelix Biopharmaceuticals Inc. Parathyroid hormone formulation
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
CA2204777A1 (en) * 1994-11-15 1996-05-23 Steven Scott Porter Skin care compositions and methods
US5747456A (en) 1994-12-19 1998-05-05 Beth Israel Deaconess Medical Center Continuous low-dose administration of parathyroid hormone or its agonist
ATE203266T1 (en) 1995-01-14 2001-08-15 Jochen Daume HEAT TRANSFER CONCENTRATE, METHOD FOR THE PRODUCTION THEREOF AND ITS USE AND LATENT HEAT STORAGE
US5550134A (en) 1995-05-10 1996-08-27 Eli Lilly And Company Methods for inhibiting bone loss
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
US5599822A (en) 1995-06-06 1997-02-04 Eli Lilly And Company Methods for minimizing bone loss
ATE219374T1 (en) 1996-02-01 2002-07-15 Chugai Pharmaceutical Co Ltd MEDICATIONS FOR THE TREATMENT OR PREVENTION OF THROMBOCYTOPENIA
US5935607A (en) 1996-02-15 1999-08-10 Hadasit Medical Research Services And Development Company Ltd. Treatment of osteoporosis
US5916524A (en) 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US5738728A (en) 1996-07-26 1998-04-14 Bio Dot, Inc. Precision metered aerosol dispensing apparatus
US5741554A (en) 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US5743960A (en) 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
DE69734157T2 (en) 1996-07-31 2006-07-13 The General Hospital Corp., Boston PARATHYROIDHORMONE-RELATED PEPTIDE ANALOG
EP0934093B1 (en) 1996-09-17 2003-01-15 Deka Products Limited Partnership System for delivery of drugs by transport
AU6883398A (en) 1997-04-03 1998-10-22 Eli Lilly And Company Methods of treating bone loss
IL120943A (en) 1997-05-29 2004-03-28 Univ Ben Gurion Transdermal delivery system
EP1030658A1 (en) 1997-10-14 2000-08-30 Eli Lilly And Company Method of building and maintaining bone
US6770623B1 (en) 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
WO1999029364A1 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
DK1037686T3 (en) 1997-12-11 2006-01-02 Alza Corp Apparatus for enhancing transdermal flow of agents
WO1999029298A2 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
EP0922467A3 (en) * 1997-12-12 2000-05-24 Takeda Chemical Industries, Ltd. Iontophoretic drug delivery
WO1999031137A1 (en) 1997-12-18 1999-06-24 Eli Lilly And Company Crystalline teriparatide
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US20040033950A1 (en) 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
AR033639A1 (en) 1998-08-19 2004-01-07 Lilly Co Eli USE OF PARTIROID HORMONES TO PREPARE MEDICINES TO REDUCE THE RISK OF VERTEBRAL OR NON-VERTEBRAL OSEAS FRACTURES IN HUMAN BEINGS WITH RISK OF SUFFERING OR WHO HAVE OSTEOPOROSIS
WO2000012173A1 (en) * 1998-08-31 2000-03-09 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
CA2245903A1 (en) 1998-09-28 2000-03-28 Mcgill University Use of pex in the treatment of metabolic bone diseases
AU6510999A (en) 1998-10-07 2000-04-26 Board Of Trustees Of The University Of Arkansas, The Methods of screening for apoptosis-controlling agents for bone anabolic therapies and uses thereof
ATE384743T1 (en) 1998-11-25 2008-02-15 Gen Hospital Corp AMINOTERMINAL MODIFIED PARATHYROID HORMONE (PTH) ANALOGUE
US6884427B1 (en) 1999-02-08 2005-04-26 Aderans Research Institute, Inc. Filamentary means for introducing agents into tissue of a living host
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
ES2250187T3 (en) 1999-09-20 2006-04-16 Eli Lilly And Company USE OF THE PARTIROID HORMONE TO REDUCE THE RISK OF CANCER.
CA2387693A1 (en) 1999-09-20 2001-03-29 Eli Lilly And Company Method for monitoring treatment with a parathyroid hormone
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US20020095134A1 (en) 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US8465468B1 (en) * 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
KR100452972B1 (en) * 2000-05-16 2004-10-14 주식회사 삼양사 Hydrogel composition for transdermal drug
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US20050008683A1 (en) 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
JP4659332B2 (en) 2000-10-13 2011-03-30 アルザ・コーポレーシヨン Apparatus and method for perforating skin using microprojections
BR0114634A (en) 2000-10-13 2004-01-27 Alza Corp Micro Blade Array Impact Applicator
WO2002030300A2 (en) 2000-10-13 2002-04-18 Alza Corporation Microprotrusion member retainer for impact applicator
NZ525551A (en) 2000-10-26 2005-09-30 Alza Corp Transdermal drug delivery devices having coated microprotrusions
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002074173A1 (en) * 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
CN100349632C (en) * 2001-04-20 2007-11-21 阿尔扎公司 Microprojection array having beneficial agent contg coating
US20020193729A1 (en) 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US20030135201A1 (en) 2001-09-28 2003-07-17 Gonnelli Robert R. Microneedle with membrane
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
WO2003039331A2 (en) 2001-11-05 2003-05-15 Eli Lilly And Company Method for improving stability of a bone-connecting implant
US20030199810A1 (en) 2001-11-30 2003-10-23 Trautman Joseph Creagan Methods and apparatuses for forming microprojection arrays
DK1465535T3 (en) 2001-12-20 2008-04-07 Alza Corp Micro projections for piercing the skin with plug depth control
US7015262B2 (en) 2002-05-01 2006-03-21 Lifescan, Inc. Hydrophilic coatings for medical implements
US7906480B2 (en) 2002-05-23 2011-03-15 Michael Holick Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy
US20040062813A1 (en) 2002-06-28 2004-04-01 Cormier Michel J. N. Transdermal drug delivery devices having coated microprotrusions
CA2516547A1 (en) * 2002-09-30 2004-04-15 Alza Corporation Drug delivery device having coated microprojections incorporating vasoconstrictors
AR042815A1 (en) 2002-12-26 2005-07-06 Alza Corp ACTIVE AGENT SUPPLY DEVICE THAT HAS COMPOUND MEMBERS
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
JP5174347B2 (en) * 2003-06-30 2013-04-03 アルザ・コーポレーシヨン Method for coating microprojections penetrating skin
TW200518771A (en) 2003-06-30 2005-06-16 Alza Corp Formulations for coated microprojections containing non-volatile counterions
US20070177839A1 (en) * 2003-07-10 2007-08-02 Ab Skf Bearing unit with brazed or soldered connection
BRPI0412664A (en) 2003-07-15 2006-09-26 Ca Nat Research Council A method for treating a condition characterized by hyperproliferation of skin cells in an at-risk or at-risk individual and using a therapeutically effective amount of a human parathyroid hormone (hpth) cyclic analogue.
WO2005016441A1 (en) * 2003-08-04 2005-02-24 Alza Corporation Method and device for enhancing transdermal agent flux
CA2543084A1 (en) * 2003-10-24 2005-05-12 Alza Corporation Apparatus and method for enhancing transdermal drug delivery
BRPI0415967A (en) * 2003-10-28 2007-01-23 Alza Corp application of peptide polymer conjugates and therapeutic proteins through coated microprojections
ES2377647T3 (en) 2003-10-31 2012-03-29 Alza Corporation Self-acting applicator for microprojection ordering
MXPA06005510A (en) * 2003-11-13 2006-12-14 Johnson & Johnson Composition and apparatus for transdermal delivery.
EP1557176A1 (en) 2004-01-26 2005-07-27 Ferring B.V. Treatment of bone metastases by means of PTH receptor agonists
JP5007427B2 (en) * 2004-05-13 2012-08-22 アルザ コーポレイション Apparatus and method for transdermal delivery of parathyroid hormone agents
US20070213272A1 (en) 2004-07-14 2007-09-13 Katsuhiko Sato Transmucosal Administration Agent Containing Pth
JP5500773B2 (en) 2004-11-11 2014-05-21 ザ ジェネラル ホスピタル コーポレーション Activation of parathyroid hormone receptor and proliferation of stem and progenitor cells
CN101151061B (en) 2005-01-31 2011-05-25 阿尔扎公司 Coated microprojections having reduced variability and method for producing same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679647A (en) * 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
US6230051B1 (en) * 1996-06-18 2001-05-08 Alza Corporation Device for enhancing transdermal agent delivery or sampling

Also Published As

Publication number Publication date
IL179197A0 (en) 2007-03-08
US8361022B2 (en) 2013-01-29
US9295714B2 (en) 2016-03-29
US7556821B2 (en) 2009-07-07
US20100160895A1 (en) 2010-06-24
JP5309203B2 (en) 2013-10-09
MXPA06013168A (en) 2007-05-15
US8633159B2 (en) 2014-01-21
CA2566032A1 (en) 2005-12-01
US20050256045A1 (en) 2005-11-17
BRPI0509788A (en) 2007-10-23
US20100119568A1 (en) 2010-05-13
EP1744683A4 (en) 2010-09-29
NO20065720L (en) 2007-02-13
ES2568259T3 (en) 2016-04-28
AU2005244734A1 (en) 2005-12-01
WO2005112984A2 (en) 2005-12-01
EP1744683B1 (en) 2016-03-16
JP2007536988A (en) 2007-12-20
EP1744683A2 (en) 2007-01-24
AR048887A1 (en) 2006-06-07
JP5007427B2 (en) 2012-08-22
JP2012097087A (en) 2012-05-24
US20100152649A1 (en) 2010-06-17

Similar Documents

Publication Publication Date Title
WO2005112984A3 (en) Apparatus and method for transdermal delivery of parathyroid hormone agents
WO2007106597A3 (en) Method for the transdermal delivery of parathyroid hormone agents for treating osteopenia
WO2005102334A3 (en) Apparatus and method for transdermal delivery of fentany-based agents
WO2005069758A3 (en) Frequency assisted transdermal agent delivery method and system
WO2006020841A3 (en) Apparatus and method for transdermal delivery of natriuretic peptides
WO2005099751A3 (en) Apparatus and method for transdermal delivery of influenza vaccine
WO2005051455A3 (en) Ultrasound assisted transdermal vaccine delivery method and system
TW200618830A (en) Micorprojection apparatus and system with low infection potential
TW200600107A (en) Apparatus and method for transdermal delivery of multiple vaccines
WO2005042054A3 (en) Pretreatment method and system for enhancing transdermal drug delivery
WO2004060473A3 (en) Active agent delivery device having composite members
JP2018141023A (en) Microarray for delivery of therapeutic agent and methods of use
WO2004030743A3 (en) Drug delivery device having coated microprojections incorporating vasoconstrictors
WO2006023684A3 (en) Microprojection array patch for transdermal delivery of vascular endothelial growth factors
MXPA03003815A (en) Transdermal drug delivery devices having coated microprotrusions.
WO2007011788A3 (en) Skin penetrating device and method of use
WO2004105729A3 (en) Transdermal vaccine delivery device having coated microprotrusions
TW200613029A (en) System and method for drug delivery and microfluidic applications using microneedles
WO2005044985A3 (en) Delivery of polymer conjugates of therapeutic peptides and proteins via coated microporjections
EA200601129A1 (en) METHOD OF TREATMENT OF UNDESIRABLE EFFECT IN TRANSACTION DELIVERY OF THE MEDICINE (OPTIONS)
TW200605929A (en) Method and apparatus for reducing the incidence of tobacco use
WO2006089056A3 (en) Apparatus and method for transdermal delivery of erythropoetin-based agents
CA2569285A1 (en) Methods of device-assisted drug delivery
TW200602019A (en) Apparatus and method for transdermal delivery of parathyroid hormone agents
WO2006113796A3 (en) Microbial cellulose materials for use in transdermal drug delivery system

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2566032

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2007513130

Country of ref document: JP

Ref document number: 2005727716

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 179197

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: PA/a/2006/013168

Country of ref document: MX

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2005244734

Country of ref document: AU

WWW Wipo information: withdrawn in national office

Ref document number: DE

WWE Wipo information: entry into national phase

Ref document number: 551358

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 7005/DELNP/2006

Country of ref document: IN

ENP Entry into the national phase

Ref document number: 2005244734

Country of ref document: AU

Date of ref document: 20050318

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2005244734

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1020067026016

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2006/10412

Country of ref document: ZA

Ref document number: 200610412

Country of ref document: ZA

WWE Wipo information: entry into national phase

Ref document number: 200580023222.4

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2005727716

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020067026016

Country of ref document: KR

ENP Entry into the national phase

Ref document number: PI0509788

Country of ref document: BR