WO2005106038A3 - Neural proteins as biomarkers for nervous system injury and other neural disorders - Google Patents

Neural proteins as biomarkers for nervous system injury and other neural disorders Download PDF

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Publication number
WO2005106038A3
WO2005106038A3 PCT/US2005/012746 US2005012746W WO2005106038A3 WO 2005106038 A3 WO2005106038 A3 WO 2005106038A3 US 2005012746 W US2005012746 W US 2005012746W WO 2005106038 A3 WO2005106038 A3 WO 2005106038A3
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WO
WIPO (PCT)
Prior art keywords
neural
biomarkers
nervous system
injury
proteins
Prior art date
Application number
PCT/US2005/012746
Other languages
French (fr)
Other versions
WO2005106038A2 (en
Inventor
Ronald Hayes
Ka-Wang Kevin Wang
Ming-Chen Liu
Monika Oli
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Univ Florida
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Publication date
Application filed by Univ Florida filed Critical Univ Florida
Priority to EP05736034A priority Critical patent/EP1745149A4/en
Priority to CA2578670A priority patent/CA2578670C/en
Priority to AU2005238446A priority patent/AU2005238446B2/en
Priority to JP2007508545A priority patent/JP4659025B2/en
Publication of WO2005106038A2 publication Critical patent/WO2005106038A2/en
Publication of WO2005106038A3 publication Critical patent/WO2005106038A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
PCT/US2005/012746 2004-04-15 2005-04-15 Neural proteins as biomarkers for nervous system injury and other neural disorders WO2005106038A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP05736034A EP1745149A4 (en) 2004-04-15 2005-04-15 Neural proteins as biomarkers for nervous system injury and other neural disorders
CA2578670A CA2578670C (en) 2004-04-15 2005-04-15 Neural proteins as biomarkers for nervous system injury and other neural disorders
AU2005238446A AU2005238446B2 (en) 2004-04-15 2005-04-15 Neural proteins as biomarkers for nervous system injury and other neural disorders
JP2007508545A JP4659025B2 (en) 2004-04-15 2005-04-15 Neuroproteins as biomarkers for nervous system injury and other neurological disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56294404P 2004-04-15 2004-04-15
US60/562,944 2004-04-15

Publications (2)

Publication Number Publication Date
WO2005106038A2 WO2005106038A2 (en) 2005-11-10
WO2005106038A3 true WO2005106038A3 (en) 2007-08-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/012746 WO2005106038A2 (en) 2004-04-15 2005-04-15 Neural proteins as biomarkers for nervous system injury and other neural disorders

Country Status (7)

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US (2) US7396654B2 (en)
EP (2) EP2207033B1 (en)
JP (1) JP4659025B2 (en)
AU (1) AU2005238446B2 (en)
CA (2) CA2955027A1 (en)
ES (1) ES2482142T3 (en)
WO (1) WO2005106038A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108267598A (en) * 2018-02-06 2018-07-10 河北省健海生物芯片技术有限责任公司 A kind of preparation method of protein chip for screening lung cancer

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1519194A1 (en) 2003-09-24 2005-03-30 Roche Diagnostics GmbH Use of gfap for identification of intracerebral hemorrhage
US7747308B2 (en) * 2004-02-06 2010-06-29 Wake Forest University Health Sciences Non-invasive systems and methods for the determination of cardiac injury using a characterizing portion of a voxel histogram
EP2314218B1 (en) * 2004-02-06 2017-02-01 Wake Forest University Health Sciences Non-invasive imaging for determining global tissue characteristics
JP4885122B2 (en) * 2004-04-15 2012-02-29 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド Proteolytic markers as diagnostic biomarkers for cancer, organ injury, and muscle rehabilitation / exercise overtraining
US8492107B2 (en) 2004-04-15 2013-07-23 University Of Florida Research Foundation, Inc. Neural proteins as biomarkers for nervous system injury and other neural disorders
EP2514837B1 (en) * 2004-06-25 2016-02-10 Washington University Markers for brain damage
US8048638B2 (en) 2005-04-01 2011-11-01 University Of Florida Research Foundation, Inc. Biomarkers of liver injury
CA2635198C (en) * 2005-04-01 2019-11-12 University Of Florida Research Foundation, Inc Biomarkers of liver injury
WO2007092159A2 (en) * 2006-02-02 2007-08-16 Wake Forest University Health Sciences Cardiac visualization systems for displaying 3-d images of cardiac voxel intensity distributions with optional physician interactive boundary tracing tools
EP1815863A1 (en) * 2006-02-03 2007-08-08 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Use of TLR3 agonists for the treatment of neurodegenerative disorders
EP1840574A1 (en) * 2006-03-30 2007-10-03 Institut Pasteur Use of the alpha chain of brain spectrin and fragments thereof, for diagnosing cerebral diseases
PT2021792E (en) 2006-05-09 2013-05-23 Univ British Columbia Dissolved protein arthritis markers
WO2007136617A2 (en) * 2006-05-18 2007-11-29 Walter Reed Army Institute Of Research (Wrair) Endothelial-monocyte activating polypeptide ii, a biomarker for use in diagnosis of brain injury
DE102006033294A1 (en) * 2006-07-17 2008-01-31 Evotec Technologies Gmbh Analytical method for chemical and / or biological samples
WO2008097618A1 (en) * 2007-02-06 2008-08-14 University Of Florida Research Foundation, Inc. Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury
US8518649B2 (en) * 2007-04-04 2013-08-27 {hacek over (S)}árka O. Southern Systems and methods for analyzing persistent homeostatic perturbations
JP2009052933A (en) * 2007-08-24 2009-03-12 Rakuno Gakuen Detecting method and diagnosing kit of prion disease
EP3192807A1 (en) 2007-11-27 2017-07-19 The University Of British Columbia 14-3-3 eta antibodies and uses thereof for the diagnosis and treatment of arthritis
WO2009094713A1 (en) * 2008-01-29 2009-08-06 Murdoch Childrens Research Institute Diagnosis and treatment of sensory defect
EP2245466A2 (en) * 2008-02-04 2010-11-03 Banyan Biomarkers, Inc. Process to diagnose or treat brain injury
US20140342381A1 (en) * 2008-08-11 2014-11-20 Banyan Biomarkers, Inc. Devices and methods for biomarker detection process and assay of neurological condition
ES2665245T3 (en) 2008-08-11 2018-04-25 Banyan Biomarkers, Inc. Biomarker detection process and neurological status test
JP6166016B2 (en) 2008-12-05 2017-07-19 シー２エヌ ダイアグノスティクス Method for measuring the concentration of biomolecules
BRPI1009573A2 (en) 2009-03-11 2017-07-18 Augurex Life Sciences Corp method for assessing an arthritic condition in a subject, kit for detecting the presence of an autoantibody, and method for determining the arthritis subtype in a patient.
CA2766057A1 (en) * 2009-06-19 2010-12-23 Banyan Biomarkers, Inc. Biomarker assay of neurological condition
WO2011011334A2 (en) * 2009-07-18 2011-01-27 Banyan Biomarkers, Inc. SYNERGISTIC BIOMARKER ASSAY OF NEUROLGICAL CONDITION USING S-100β
HUE040281T2 (en) 2009-09-14 2019-03-28 Banyan Biomarkers Inc Autoantibody markers for diagnosis of traumatic brain injury
CA2784919A1 (en) 2010-01-26 2011-07-26 Banyan Biomarkers, Inc. Compositions and methods relating to argininosuccinate synthetase
US20130029362A1 (en) * 2010-04-01 2013-01-31 Andreas Jeromin Markers and assays for detection of neurotoxicity
WO2011160096A2 (en) * 2010-06-17 2011-12-22 Banyan Biomarkers, Inc. Glial fibrillary acidic protein, autoantigens and autoantibodies thereto as biomarkers of neural injury or neurological disorder or condition
WO2012051519A2 (en) * 2010-10-14 2012-04-19 The Johns Hopkins University Biomarkers of brain injury
US9612306B2 (en) * 2010-11-26 2017-04-04 Brigham And Women's Hospital, Inc. Method for assessing repetitive head injuries with two-dimensional magnetic resonance spectroscopy
DK2683419T3 (en) 2011-03-11 2018-07-02 Vib Vzw Molecules and Methods for Inhibition and Detection of Proteins
WO2012155134A2 (en) 2011-05-12 2012-11-15 The Johns Hopkins University Assay reagents for a neurogranin diagnostic kit
WO2012170998A1 (en) 2011-06-10 2012-12-13 Cornell University Immobilized protein system for rapid and enhanced multiplexed diagnostics
US20120322682A1 (en) * 2011-06-20 2012-12-20 William Marsh Rice University Brain injury biomarker panel
KR101333207B1 (en) * 2011-07-13 2013-11-26 부산대학교 산학협력단 Genetic markers associated with endometriosis and use thereof
US20130046093A1 (en) 2011-08-18 2013-02-21 Korea Institute Of Science And Technology Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same
CA2846625A1 (en) * 2011-09-14 2013-03-21 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Processes and kits to detect and monitor for diagnostic biomarkers for post traumatic stress disorder (ptsd) and to differentiate between suicidal and non-suicidal form of the disorder
BR112014009536A2 (en) 2011-10-21 2017-04-18 Augurex Life Sciences Corp 14-3-3 xitrulinated derivatives and their uses in the diagnosis of rheumatoid arthritis
JP2015500472A (en) * 2011-12-02 2015-01-05 シー２エヌ ダイアグノスティクス Method for measuring the concentration of biomolecules
JP2015517801A (en) * 2012-03-05 2015-06-25 バーグ エルエルシー Compositions and methods for diagnosis and treatment of pervasive developmental disorders
JP6392202B2 (en) 2012-03-13 2018-09-19 ザ・ジョンズ・ホプキンス・ユニバーシティ Citrullinated brain and neuroproteins as biomarkers of brain injury or neurodegeneration
CN102735834B (en) * 2012-05-11 2014-09-03 中国兽医药品监察所 Enzyme-linked immunoassay kit for detecting phenylethanolamine A
JP5984559B2 (en) * 2012-07-31 2016-09-06 オリンパス株式会社 Necrotic cell region detection apparatus and method, and necrotic cell region detection program
EP2883052B8 (en) 2012-08-10 2019-03-13 Istituto Superiore di Sanità Biomarkers
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
EP3757226A3 (en) 2013-07-17 2021-05-05 The Johns Hopkins University A multi-protein biomarker assay for brain injury detection and outcome
US10082500B2 (en) 2013-08-22 2018-09-25 Franz Baudenbacher Device and method for detecting a target analyte
GB201319492D0 (en) * 2013-11-05 2013-12-18 Secr Defence Biomarkers for traumatic brain injury
MX2016014565A (en) * 2014-05-08 2017-05-23 Sangamo Biosciences Inc Methods and compositions for treating huntington's disease.
US20170254818A1 (en) * 2014-08-24 2017-09-07 The Board Of Regents Of The University Of Texas Sy Stem Cns-specific biomarkers for cns diseases or injuries
JP6916107B2 (en) 2014-09-11 2021-08-11 バーグ エルエルシー Bayesian Causal Network Model for Health Examination and Treatment Based on Patient Data
EP3029466A1 (en) * 2014-12-03 2016-06-08 Fundació Hospital Universitari Vall d' Hebron - Institut de Recerca Methods for differentiating ischemic stroke from hemorrhagic stroke
US10667737B2 (en) 2015-03-23 2020-06-02 International Business Machines Corporation Monitoring a person for indications of a brain injury
US10244971B2 (en) * 2015-05-12 2019-04-02 International Business Machines Corporation Mouthguard for analysis of biomarkers for traumatic brain injury
US20190137490A1 (en) * 2016-05-06 2019-05-09 Duke University Methods and kits for diagnosing and treating nervous system disease or injury
US20200309791A1 (en) * 2016-05-06 2020-10-01 Nanosomix, Inc. Synaptic protein biomarkers and differential diagnosis of alzheimer's disease and other neurodegenerative disorders
EP3519824A1 (en) * 2016-10-03 2019-08-07 Abbott Laboratories Improved methods of assessing uch-l1 status in patient samples
RU2648515C1 (en) * 2016-12-21 2018-03-26 Общество с ограниченной ответственностью "ДРД" Predicting the course and outcome of coma and post-coma unconscious states (including vegetative ones) with the help of blood tests
WO2018132791A1 (en) * 2017-01-16 2018-07-19 The Regents Of The University Of California Treatment of neurodegenerative conditions by disruption of rhes
JP7346300B2 (en) 2017-03-23 2023-09-19 アボット・ラボラトリーズ Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in human subjects using the early biomarker ubiquitin carboxy-terminal hydrolase L1
JP7344797B2 (en) 2017-04-15 2023-09-14 アボット・ラボラトリーズ Methods to aid in hyperacute diagnosis and determination of traumatic brain injury in human subjects using early biomarkers
CN110603449A (en) 2017-04-28 2019-12-20 雅培实验室 Method for determining traumatic brain injury using early biomarkers from at least two samples of the same human subject for aiding hyperacute diagnosis
WO2018218169A1 (en) 2017-05-25 2018-11-29 Abbott Laboratories Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers
US10849548B2 (en) 2017-05-30 2020-12-01 Abbott Laboratories Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin I and early biomarkers
WO2019010131A1 (en) 2017-07-03 2019-01-10 Abbott Laboratories Improved methods for measuring ubiquitin carboxy-terminal hydrolase l1 levels in blood
CN107748263A (en) * 2017-08-31 2018-03-02 北京臻惠康生物科技有限公司 The new application and kit of a kind of plasminogen
CA3067057A1 (en) 2017-12-09 2019-06-13 Abbott Laboratories Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (tbi), using glial fibrillary acidic protein (gfap) and/or ubiquitin carboxy-terminal hydrolase l1 (uch-l1)
JP7379165B2 (en) 2017-12-09 2023-11-14 アボット・ラボラトリーズ Methods for aiding in diagnosing and assessing traumatic brain injury in human subjects using a combination of GFAP and UCH-L1
WO2019169309A1 (en) * 2018-03-02 2019-09-06 Berger Russell Jay Methods, apparatuses and kits for rapid testing of traumatic brain injuries
US20200335315A1 (en) * 2019-04-22 2020-10-22 Amit, Inc. Method for generating data set for training a prediction model and apparatus comprising the prediciton model
KR102443101B1 (en) * 2020-12-23 2022-09-13 단국대학교 천안캠퍼스 산학협력단 Biomarker composition for predicting of neurodevelopmental disorders
US20220308053A1 (en) * 2021-03-29 2022-09-29 Euroimmun Medizinische Labordiagnostika Ag Method and reagents for the detection of an autoantibody
CN113584021A (en) * 2021-06-17 2021-11-02 中国人民解放军军事科学院军事医学研究院 Target lncRNA for microwave irradiation induced neuronal synaptic injury: MSTRG.31953.1
WO2023022269A1 (en) * 2021-08-20 2023-02-23 단국대학교 천안캠퍼스 산학협력단 Pharmaceutical composition for preventing or treating attention deficit/hyperactivity disorder
CN113970643B (en) * 2021-11-23 2023-06-30 北京大学人民医院 Application of reagent for detecting autoantibody of UCH-L1 epitope in preparation of SLE serum diagnosis related product
CN116879564A (en) * 2023-09-06 2023-10-13 暨南大学附属第一医院（广州华侨医院） Spinal cord injury biomarker based on proteomics and phosphorylated protein modification histology and application thereof

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US5231000A (en) * 1987-10-08 1993-07-27 The Mclean Hospital Antibodies to A4 amyloid peptide
IL91501A (en) 1988-09-02 1998-03-10 Dyax Corp Generation of a variegated library of mutant potential binding proteins and screening of said library for proteins with a desired binding activity
US5118606A (en) 1988-09-02 1992-06-02 The Regents Of The University Of California Methods for detecting cellular pathology by assaying spectrin and spectrin breakdown products
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5118937A (en) 1989-08-22 1992-06-02 Finnigan Mat Gmbh Process and device for the laser desorption of an analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
AU7247191A (en) 1990-01-11 1991-08-05 Molecular Affinities Corporation Production of antibodies using gene libraries
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
WO1992009690A2 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
DK1471142T3 (en) 1991-04-10 2009-03-09 Scripps Research Inst Heterodimeric receptor libraries using phagemids
WO1993003369A1 (en) * 1991-08-01 1993-02-18 Voorheis Paul H Diagnostic method for alzheimer's disease
ATE463573T1 (en) 1991-12-02 2010-04-15 Medimmune Ltd PRODUCTION OF AUTOANTIBODIES ON PHAGE SURFACES BASED ON ANTIBODIES SEGMENT LIBRARIES
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5792664A (en) 1992-05-29 1998-08-11 The Rockefeller University Methods for producing and analyzing biopolymer ladders
AU685055B2 (en) 1992-05-29 1998-01-15 Rockefeller University, The Method and product for the sequence determination of peptides using a mass spectrometer
ATE242485T1 (en) 1993-05-28 2003-06-15 Baylor College Medicine METHOD AND MASS SPECTROMETER FOR THE DESORPTION AND IONIZATION OF ANALYTES
WO1995015982A2 (en) 1993-12-08 1995-06-15 Genzyme Corporation Process for generating specific antibodies
ATE300610T1 (en) 1994-01-31 2005-08-15 Univ Boston LIBRARIES OF POLYCLONAL ANTIBODIES
US5536639A (en) 1994-03-25 1996-07-16 Cephalon, Inc. Methods for detecting calpain activation by detection of calpain activated spectrin breakdown products
US5516637A (en) 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
JP2978435B2 (en) 1996-01-24 1999-11-15 チッソ株式会社 Method for producing acryloxypropyl silane
US6048703A (en) 1996-11-15 2000-04-11 Cephalon, Inc. Methods for detecting cell apoptosis
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
IL138668A0 (en) 1998-04-03 2001-10-31 Phylos Inc Addressable protein arrays
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
AU4025300A (en) 1999-03-24 2000-10-09 Packard Bioscience Company Continuous porous matrix arrays
US6589746B1 (en) 1999-10-21 2003-07-08 University Of Cincinnati Method of detecting axonally-derived protein tau in patients with traumatic CNS injury
JP2003070498A (en) * 2001-07-19 2003-03-11 Pharma Design Inc Method for detecting abnormality of ubiquitin carboxy- terminal hydrolase l1 gene
US20030040660A1 (en) * 2001-08-27 2003-02-27 George Jackowski Method for diagnosing and distinguishing traumatic brain injury and diagnostic devices for use therein
JP2005538380A (en) * 2002-09-11 2005-12-15 ユニヴァーシティ オヴ フロリダ Analysis of nerve cell damage
EP2508608A1 (en) * 2003-06-09 2012-10-10 Alnylam Pharmaceuticals Inc. Method of treating neurodegenerative disease
JP4885122B2 (en) * 2004-04-15 2012-02-29 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド Proteolytic markers as diagnostic biomarkers for cancer, organ injury, and muscle rehabilitation / exercise overtraining
CA2635198C (en) * 2005-04-01 2019-11-12 University Of Florida Research Foundation, Inc Biomarkers of liver injury

Non-Patent Citations (18)

* Cited by examiner, † Cited by third party
Title
ANDRE V.M. ET AL.: "NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue", CEREB. CORT., vol. 14, June 2004 (2004-06-01), pages 634 - 646, XP003016152 *
BLENNOW K.: "Cerebrospinal fluid protein biomarkers for Alzheimer's Disease", THE JOUR. OF THE AMER. SOC. FOR EXPERIMENTAL NEURO. THERAPEUT., vol. 1, April 2004 (2004-04-01), pages 213 - 225, XP005871685 *
CUTLER N.R. ET AL.: "Review of the next generation of Alzheimer's Disease therapeutics: Challenges for drug development", PROG. NEURO. PSYCHOPHARMACOL. BIOL. PSYCHIAT., vol. 25, 2001, pages 27 - 57, XP002243957 *
DEKOSKY S.T. ET AL.: "Looking backward to move forward: early detection of neurodegenerative disorders", SCIENCE, vol. 302, 31 October 2004 (2004-10-31), pages 830 - 834, XP003016151 *
INDEN M. ET AL.: "Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats", J. PHARMACOL. SCIENCE, vol. 97, 2005, pages 203 - 211, XP003016157 *
OHTA M. ET AL.: "Clinical and analytical evaluation of an enzyme immunoassay for myelin basic protein in cerebrospinal fluid", CLIN. CHEM., vol. 46, September 2000 (2000-09-01), pages 1326 - 1330, XP003016153 *
PEARL P.L. ET AL.: "Clinical aspects of the disorders of GABA metabolism in children", CURR. OPIN. NEUROL., vol. 17, 2004, pages 107 - 113, XP008097550 *
SANCHEZ J.-C. ET AL.: "Cystatin C as a potential cerebrospinal fluid marker for the diagnosis of Creutzfeldt-Jakob disease", PROTEOMICS, vol. 4, 2004, pages 2229 - 2233, XP003016159 *
See also references of EP1745149A4 *
SMITH D.H. ET AL.: "Protein accumulation in traumatic brain injury", NEUROMOL. MED., vol. 4, 2003, pages 59 - 72, XP008097564 *
TAHERI S. ET AL.: "The role of Hypocretins (orexins) in sleep regulation and narcolepsy", ANN. REV. NEUROSCI., vol. 25, 2002, pages 283 - 313, XP003016154 *
TEUNISSEN C.E. ET AL.: "Biochemical markers related to Alzheimer's dementia is serum and cerebrospinal gluid", NEUROBIOL. AGING, vol. 23, 2002, pages 485 - 508, XP002406249 *
TOONEY P.A. ET AL.: "Neurons expressing calcium-binding proteins in the prefrontal cortex in schizophrenia", PROG. NEURO. PSYCHOPHARM. BIOL. PSYCHIAT., vol. 28, March 2004 (2004-03-01), pages 273 - 278, XP003016150 *
VAN EVERBROECK B. ET AL.: "A prospective study of CSF markers in 250 patients with possible Creutzfeldt-Jakob disease", J. NEUROL. NEUROSURG. PSYCHIAT., vol. 74, 2003, pages 1210 - 1214, XP003016156 *
WILSON K.E. ET AL.: "Functional genomics and proteomics: application in neurosciences", J. NEUROL. NEUROSURG. PSYCHIAT., vol. 75, 2004, pages 529 - 538, XP003016160 *
YOHRLING G.J. ET AL.: "Inhibition of tryptophan hydroxylase activity and decreased 5-HT1A receptor binding in a mouse modes of Huntington's Disease", J. NEUROCHEM., vol. 82, 2002, pages 1416 - 1423, XP003016158 *
ZAFFARONI M.: "Biological indicators of the neurodegenerative phase of multiple sclerosis", NEUROL. SCI., vol. 24, 2003, pages S279 - S282, XP008097562 *
ZHANG X. ET AL.: "Phenotypes of T cells infiltrating the eyes in autoimmune anterior Uveitis associated with EAE", INVEST. OPTHAL. VIS. SCIENCE, vol. 43, 2002, pages 1499 - 1508, XP003016155 *

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN108267598A (en) * 2018-02-06 2018-07-10 河北省健海生物芯片技术有限责任公司 A kind of preparation method of protein chip for screening lung cancer

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