WO2005076773A3 - Microfabricated rubber microscope using soft solid immersion lenses - Google Patents

Microfabricated rubber microscope using soft solid immersion lenses Download PDF

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Publication number
WO2005076773A3
WO2005076773A3 PCT/US2004/026126 US2004026126W WO2005076773A3 WO 2005076773 A3 WO2005076773 A3 WO 2005076773A3 US 2004026126 W US2004026126 W US 2004026126W WO 2005076773 A3 WO2005076773 A3 WO 2005076773A3
Authority
WO
WIPO (PCT)
Prior art keywords
microscope
lenses
solid immersion
surface tension
rubber
Prior art date
Application number
PCT/US2004/026126
Other languages
French (fr)
Other versions
WO2005076773A2 (en
WO2005076773A9 (en
Inventor
Stephen R Quake
Yann Gambin
Oliver Legrand
Original Assignee
California Inst Of Techn
Stephen R Quake
Yann Gambin
Oliver Legrand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn, Stephen R Quake, Yann Gambin, Oliver Legrand filed Critical California Inst Of Techn
Publication of WO2005076773A2 publication Critical patent/WO2005076773A2/en
Publication of WO2005076773A9 publication Critical patent/WO2005076773A9/en
Publication of WO2005076773A3 publication Critical patent/WO2005076773A3/en

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/33—Immersion oils, or microscope systems or objectives for use with immersion fluids
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/0008—Microscopes having a simple construction, e.g. portable microscopes

Abstract

Soft lithography with surface tension control is used to microfabricate extremely efficient solid immersion lenses (SILs; 102, 104) out of rubber elastomeric material for use in microscope (100) type applications. In order to counteract the surface tension of the mold material in a negative mold that causes creep on a positive mold, material such as RTV is partially cured before use in order to allow the reticulation of polymer chains to change the viscosity of the uncured material in a controllable manner. In a specific embodiment, the techniques of soft lithography with surface tension control are used to make molded SILs out of the elastomer polydimethylsiloxane. The lenses achieve an NA in the range of 1.25. The principle of compound lens design is used to make the first compound solid immersion lens (102), which is corrected for higher light gathering ability and has a calculated NA=1.32. An important application of these lenses is integrated optics for microfluidic devices, specifically in a handheld rubber microscope (100) for microfluidic flow cytometry.
PCT/US2004/026126 2003-08-11 2004-08-11 Microfabricated rubber microscope using soft solid immersion lenses WO2005076773A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49441603P 2003-08-11 2003-08-11
US60/494,416 2003-08-11

Publications (3)

Publication Number Publication Date
WO2005076773A2 WO2005076773A2 (en) 2005-08-25
WO2005076773A9 WO2005076773A9 (en) 2005-10-06
WO2005076773A3 true WO2005076773A3 (en) 2006-08-31

Family

ID=34860151

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/026126 WO2005076773A2 (en) 2003-08-11 2004-08-11 Microfabricated rubber microscope using soft solid immersion lenses

Country Status (2)

Country Link
US (1) US7042649B2 (en)
WO (1) WO2005076773A2 (en)

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Also Published As

Publication number Publication date
WO2005076773A2 (en) 2005-08-25
US7042649B2 (en) 2006-05-09
US20050052754A1 (en) 2005-03-10
WO2005076773A9 (en) 2005-10-06

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