WO2005075973A3 - Acousto-mechanical detection systems and methods of use - Google Patents

Acousto-mechanical detection systems and methods of use Download PDF

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Publication number
WO2005075973A3
WO2005075973A3 PCT/US2004/042662 US2004042662W WO2005075973A3 WO 2005075973 A3 WO2005075973 A3 WO 2005075973A3 US 2004042662 W US2004042662 W US 2004042662W WO 2005075973 A3 WO2005075973 A3 WO 2005075973A3
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WO
WIPO (PCT)
Prior art keywords
target biological
acousto
sample material
sensor
methods
Prior art date
Application number
PCT/US2004/042662
Other languages
French (fr)
Other versions
WO2005075973A2 (en
Inventor
Chad J Carter
Moses M David
Larry H Dodge
M Benton Free
Samuel J Gason
John S Huizinga
Raymond P Johnston
Brinda B Lakshmi
Patrick A Mach
Larry G Martin
Mikhail L Pekurovsky
Mark S Schaberg
Jeffrey D Smith
Kenneth B Wood
Wenyuan Xu
Original Assignee
3M Innovative Properties Co
Chad J Carter
Moses M David
Larry H Dodge
M Benton Free
Samuel J Gason
John S Huizinga
Raymond P Johnston
Brinda B Lakshmi
Patrick A Mach
Larry G Martin
Mikhail L Pekurovsky
Mark S Schaberg
Jeffrey D Smith
Kenneth B Wood
Wenyuan Xu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co, Chad J Carter, Moses M David, Larry H Dodge, M Benton Free, Samuel J Gason, John S Huizinga, Raymond P Johnston, Brinda B Lakshmi, Patrick A Mach, Larry G Martin, Mikhail L Pekurovsky, Mark S Schaberg, Jeffrey D Smith, Kenneth B Wood, Wenyuan Xu filed Critical 3M Innovative Properties Co
Priority to CA002551957A priority Critical patent/CA2551957A1/en
Priority to EP04821309A priority patent/EP1700109A2/en
Priority to AU2004315032A priority patent/AU2004315032A1/en
Priority to JP2006547193A priority patent/JP4861191B2/en
Priority to US10/596,956 priority patent/US20070281369A1/en
Publication of WO2005075973A2 publication Critical patent/WO2005075973A2/en
Publication of WO2005075973A3 publication Critical patent/WO2005075973A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/022—Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
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    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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Abstract

Detection systems and methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g., a surface acoustic wave sensor such as, e.g., a shear horizontal surface acoustic wave sensor (e.g., a LSH-SAW sensor). A variety of techniques for modifying the effective mass of the target biological analytes in sample material are disclosed, including fractionating or disassembling the target biological analytes in the sample material (e.g., lysing the target biological analyte), adding a detectable mass to the target biological analyte or enhancing coupling of the target biological analyte (e.g., through the use of magnetic particles), exposing the sample material to a reagent that causes a change in at least detectable physical property in the sample material if the target biological analyte is present (e.g., a change in viscous, elastic, and/or viscoelastic properties), etc.
PCT/US2004/042662 2003-12-30 2004-12-17 Acousto-mechanical detection systems and methods of use WO2005075973A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002551957A CA2551957A1 (en) 2003-12-30 2004-12-17 Acousto-mechanical detection systems and methods of use
EP04821309A EP1700109A2 (en) 2003-12-30 2004-12-17 Acousto-mechanical detection systems and methods of use
AU2004315032A AU2004315032A1 (en) 2003-12-30 2004-12-17 Acousto-mechanical detection systems and methods of use
JP2006547193A JP4861191B2 (en) 2003-12-30 2004-12-17 Acousto-mechanical detector
US10/596,956 US20070281369A1 (en) 2003-12-30 2004-12-17 Acousto-Mechanical Detection Systems and Methods of Use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53316903P 2003-12-30 2003-12-30
US60/533,169 2003-12-30

Publications (2)

Publication Number Publication Date
WO2005075973A2 WO2005075973A2 (en) 2005-08-18
WO2005075973A3 true WO2005075973A3 (en) 2006-01-26

Family

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PCT/US2004/042455 WO2005064349A2 (en) 2003-12-30 2004-12-17 Detection cartridges, modules, systems and methods
PCT/US2004/042662 WO2005075973A2 (en) 2003-12-30 2004-12-17 Acousto-mechanical detection systems and methods of use

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Country Status (10)

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US (2) US20070281369A1 (en)
EP (4) EP1711805A2 (en)
JP (2) JP4861191B2 (en)
KR (1) KR20060127933A (en)
CN (3) CN1922482B (en)
AU (2) AU2004315032A1 (en)
BR (1) BRPI0417914A (en)
CA (2) CA2551957A1 (en)
WO (2) WO2005064349A2 (en)
ZA (1) ZA200606289B (en)

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