WO2005074880B1 - Holistic composition and method for reducing skin pigmentation - Google Patents

Holistic composition and method for reducing skin pigmentation

Info

Publication number
WO2005074880B1
WO2005074880B1 PCT/US2005/000481 US2005000481W WO2005074880B1 WO 2005074880 B1 WO2005074880 B1 WO 2005074880B1 US 2005000481 W US2005000481 W US 2005000481W WO 2005074880 B1 WO2005074880 B1 WO 2005074880B1
Authority
WO
WIPO (PCT)
Prior art keywords
extract
inhibitor
composition
ascorbyl
ascorbic acid
Prior art date
Application number
PCT/US2005/000481
Other languages
French (fr)
Other versions
WO2005074880A1 (en
Inventor
Di Qu
John V Scimeca
Louise M Schneider
Jay R Dittmer
Ronald J Sharpe
Original Assignee
Access Business Group Int Llc
Di Qu
John V Scimeca
Louise M Schneider
Jay R Dittmer
Ronald J Sharpe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Access Business Group Int Llc, Di Qu, John V Scimeca, Louise M Schneider, Jay R Dittmer, Ronald J Sharpe filed Critical Access Business Group Int Llc
Priority to CN2005800034346A priority Critical patent/CN1913866B/en
Priority to JP2006551115A priority patent/JP2007519722A/en
Publication of WO2005074880A1 publication Critical patent/WO2005074880A1/en
Publication of WO2005074880B1 publication Critical patent/WO2005074880B1/en
Priority to US11/502,871 priority patent/US20070087448A1/en
Priority to HK07106004.4A priority patent/HK1100896A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Abstract

The present invention provides a holistic composition and method for reducing skin pigmentation.

Claims

Amended Claims. Article 19 (Received by the International Bureau on the 02 September 2005 (02/09/2005) ; original claim 1 has been amended) ϋlaims:
1. A composition for reducing pigmentation in skin comprising: a. at least five different pigmentation inhibitors with each inhibitor selected from a different one ofthe following six inhibitor categories: i. a tyrosinase production inhibitor, ii. a tyrosinase activity inhibitor, iii. a competitive inhibitor of melanin polymerization, iv. a component that inhibits the transfer of a melanosome to a keratinocyte, v. a component to alter the ratio of eumelanin to phaeomelaπin, and vi. a component to lighten the skin through exfoliation; b. at least four different cell protectants with each cell protectant selected from a different one of the following five cell protectant categories: i. a matrix metalloproteinase inhibitor, ii. an antioxidant, iii. a sun protectant, iv. a cell metabolism stimulant, and v. an inflammation inhibitor; and c. at least one functional ingredient penetration enhancer selected from the group consisting of a water soluble ingredient and an oil soluble ingredient.
2. The composition of claim 1 wherein the tyrosinase production inhibitor is hexapeptide-2.
3. The composition of claim 1 wherein the tyrosinase activity inhibitor is selected from the group consisting of ascorbic acid, derivatives of ascorbic acid, arctostaphylos uva ursi (bearberry) leaf extract, glycyrrhiza glabra (licorice) extract, sanguisorba offlcinalis (burnet) extract, scutellaria baicalensis root extract, morus alba (mulberry) extract, and mixtures thereof.
4. The composition of claim 1 wherein the competitive inhibitor of melanin polymerization is selected from the group consisting of cafeic acid extract, helianthus annus (sunflower) seed extract, and mixtures thereof.
5. The composition of claim 1 wherein the component to alter the ratio of eumelanin to phaeomelanin comprises a triticum vulgare (wheat) germ extract.
6. The composition of claim 1 wherein the component that inhibits the transfer of a melanosome to a keratinocyte comprises a botanical extract of lectiπ and triticum vulgare (wheat) germ extract.
7. The composition of claim 1 wherein the component to lighten the skin through exfoliation is selected from the group consisting of sodium ascorbyl phosphate, calcium ascorbyl phosphate, magnesium ascorbyl phosphate, avena sativa (oat) kernel extract, a glycoprotein, and mixtures thereof.
8. The composition of claim 1 wherein the matrix metalloproteinase inhibitor comprises solanum tuberosum (potato) extract.
9. The composition of claim 1 wherein the antioxidant is selected from the group consisting of ascorbic acid and derivatives of ascorbic acid, helianthus annus (sunflower) seed extract, citrus unshiu peel extract, citrus medica (lemon) extract, cucumis sativus (cucumber) fruit extract, glycyrrhiza glabra (licorice) extract, tocopherol and derivatives of tocopherol, and mixtures thereof.
10. The composition of claim 1 wherein the sun protectant is selected from the group consisting of octinoxate, titanium dioxide, and mixtures thereof.
11. The composition of claim 1 wherein the cell metabolism stimulant comprises one or more glycoproteins.
12. The composition of claim 1 wherein the inflammation inhibitor includes a post- inflammatory hyperpigmentation inhibitor.
13. The composition of claim 1 wherein the inflammation inhibitor is selected from the group consisting of an alpha glucan oligosaccharide, dipotassium glycyrrhizinate, glycyrrhiza glabra (licorice) extract, allantoiπ, avena sativa (oat) kernel extract, morus alba (mulberry) extract, cucumis sativus (cucumber) fruit extract, and mixtures thereof.
14. The composition of claim 1 wherein the water soluble penetration enhancer comprises ethoxydiglycol.
15. The composition of claim 1 wherein the oil soluble penetration enhancer comprises a PPG-12/SMDI Copolymer.
AMENDED SHEET (ARTICLE 19) 19
16. The composition of claim 9 wherein the ascorbic acid derivatives are selected from the group consisting of alkyl esters of L-ascorbic acid such as L-ascorbyl palmitate, L-ascorbyl isopalmitate, L-ascorbyl dipalmitate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate, L-ascorbyl myristate, L-ascorbyl isomyristate, L- ascorbyf 2-ethylhexanoate, L-ascorbyl di-2-ethylhexanoate, L-ascorbyl oleate and L- ascorbyl dioleate; phosphates of L-ascorbic acid such as L-ascorbyl-2-phosphate and L- ascorbyl-3-phosphate; sulfates of L-ascorbic acid such as L-ascorbyI-2-sulfate and L- acorbyl-3-sulfate; their salts with alkaline earth metals such as calcium, sodium and magnesium, and mixtures thereof.
17. A composition comprising: a. at least five different pigmentation inhibitors with each inhibitor selected from a different one of the following six inhibitor categories: i. a tyrosinase production inhibitor, ii. a tyrosinase activity inhibitor, iii. a competitive inhibitor of melanin polymerization, iv. a component that inhibits the transfer of a meianosome to a keratinocyte, v. a component to alter the ratio of eumelanin to phaeomelaniπ, and vi. a component to lighten the skin through exfoliation; b. at least four different cell protectants with each cell protectant sleeted from a different one ofthe following five cell protectant categories: a matrix metalloproteinase inhibitor, an antioxidant, iii, a sun protectant, iv. a cell metabolism stimulant, and v. an inflammation inhibitor; and c. at least one functional ingredient penetration enhancer selected from the group consisting of a water soluble ingredient and an oil soluble ingredient; for reducing pigmentation in skin.
AMENDED SHEET (ARTICLE 19) 20
18. The use according to claim 17 wherein the multiple pigmentation inhibitor is comprised of ingredients selected from the group consisting of hexapeptide-2, ascorbic acid, derivatives of ascorbic acid, arctostaphylos uva ursi (bearberry) leaf extract, glycyrrhizinate glabra (licorice) extract, sanguisorba officinalis (burnet) extract, scutellaria baicalensis root extract, morus alba (mulberry) extract, cafeic acid extract, helianthus aπnus (sunflower) seed extract, triticum vulgare (wheat) germ extract, botanical extract of lectin and triticum vulgare (wheat) germ, kojic acid, avena sativa (oat) kernel extract, glycoprotein, and mixtures thereof.
19. The use according to claim 17 wherein the cell protectant is comprised of ingredients selected from the group consisting of ascorbic acid and derivatives of ascorbic acid, helianthus annus (sunflower) seed extract, citrus unshiu peel extract, citrus medica (lemon) extract, cucumis sativus (cucumber) fruit extract, glycyrrhiza glabra (licorice) extract, tocopherol and derivatives of tocopherol, solanum tuberosum (potato) extract, octinoxate, titanium dioxide, one or more glycoproteins, alpha glucan oligosaccharide, dipotassium glycyrrhizinate, allantoin, avena sativa (oat) kernel extract, morus alba (mulberry) extract, and mixtures thereof.
20. The use according to claim 17 wherein the functional ingredient penetration enhancer is comprised of ingredients selected from the group consisting of ethoxydiglycol, a PPG-12/S DI copolymer, and mixtures thereof.
AMENDED SHEET (ARTICLE 19) 21
PCT/US2005/000481 2004-01-30 2005-01-07 Holistic composition and method for reducing skin pigmentation WO2005074880A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN2005800034346A CN1913866B (en) 2004-01-30 2005-01-07 Holistic composition and method for reducing skin pigmentation
JP2006551115A JP2007519722A (en) 2004-01-30 2005-01-07 Overall composition and method for reducing skin pigmentation
US11/502,871 US20070087448A1 (en) 2004-02-16 2006-08-11 Biological profiles and methods of use
HK07106004.4A HK1100896A1 (en) 2004-01-30 2007-06-06 Holistic composition and method for reducing skin pigmentation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/769,556 2004-01-30
US10/769,556 US7429391B2 (en) 2004-01-30 2004-01-30 Holistic composition and method for reducing skin pigmentation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/502,871 Continuation-In-Part US20070087448A1 (en) 2004-02-16 2006-08-11 Biological profiles and methods of use

Publications (2)

Publication Number Publication Date
WO2005074880A1 WO2005074880A1 (en) 2005-08-18
WO2005074880B1 true WO2005074880B1 (en) 2005-12-08

Family

ID=34808162

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/000481 WO2005074880A1 (en) 2004-01-30 2005-01-07 Holistic composition and method for reducing skin pigmentation

Country Status (7)

Country Link
US (1) US7429391B2 (en)
JP (1) JP2007519722A (en)
KR (1) KR20060130631A (en)
CN (1) CN1913866B (en)
HK (1) HK1100896A1 (en)
TW (1) TWI361084B (en)
WO (1) WO2005074880A1 (en)

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HK1100896A1 (en) 2007-10-05
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KR20060130631A (en) 2006-12-19
CN1913866A (en) 2007-02-14
CN1913866B (en) 2013-03-13
TWI361084B (en) 2012-04-01
US7429391B2 (en) 2008-09-30
WO2005074880A1 (en) 2005-08-18
JP2007519722A (en) 2007-07-19

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