WO2005067668A2 - Devices and methods for treatment of luminal tissue - Google Patents
Devices and methods for treatment of luminal tissue Download PDFInfo
- Publication number
- WO2005067668A2 WO2005067668A2 PCT/US2005/000646 US2005000646W WO2005067668A2 WO 2005067668 A2 WO2005067668 A2 WO 2005067668A2 US 2005000646 W US2005000646 W US 2005000646W WO 2005067668 A2 WO2005067668 A2 WO 2005067668A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- support
- balloon
- electrode
- electrodes
- furled
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/06—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating caused by chemical reaction, e.g. moxaburners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/08—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
- A61B2018/0022—Balloons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00482—Digestive system
- A61B2018/00488—Esophagus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00482—Digestive system
- A61B2018/00494—Stomach, intestines or bowel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/0066—Sensing and controlling the application of energy without feedback, i.e. open loop control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00702—Power or energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00761—Duration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00982—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B2018/044—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating the surgical action being effected by a circulating hot fluid
- A61B2018/046—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating the surgical action being effected by a circulating hot fluid in liquid form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B2018/1807—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using light other than laser radiation
Definitions
- the present invention relates generally to medical devices and methods. More particularly, the invention is directed to devices and methods for treating the esophagus and other interior tissue regions of the body.
- the human body has a number of internal body lumens or cavities located within, many of which have an inner lining or layer. These inner linings can be susceptible to disease. In some cases, surgical intervention can be required to remove the inner lining in order to prevent the spread of disease to otherwise healthy tissue located nearby.
- gastroesophageal reflux disease manifested by classic symptoms of heartburn and regurgitation of gastric and intestinal content.
- the causative agent for such problems may vary. Patients with severe forms of gastroesophageal reflux disease, no matter what the cause, can sometimes develop secondary damage of the esophagus due to the interaction of gastric or intestinal contents with esophageal cells not designed to experience such interaction.
- the esophagus is composed of three main tissue layers; a superficial mucosal layer lined by squamous epithelial cells, a middle submucosal layer and a deeper muscle layer.
- Barrett's esophagus has important clinical consequences, since the Barrett's columnar cells can, in some patients, become dysplastic and then progress to a certain type of deadly cancer of the esophagus.
- the presence of Barrett's esophagus is the main risk factor for the development of adenocarcinoma of the esophagus.
- U.S. Patent No. 6,112,123 describes a device and method for ablating tissue in the esophagus.
- the device and method do not adequately control the application of energy to effect ablation of tissue to a controlled depth.
- Patent publications of interest include US 2001/0041887; US 2002/0013581; US 2002/0143325 Al; US
- an electrode deployment device for treatment of tissue in a body lumen comprises a plurality of electrodes having a pre-selected electrode density arranged on the surface of a dimensionally stable support.
- An expansion member such as an inflatable balloon, selectively exposes a portion of the electrode surface while a remaining portion remains shielded.
- the support can be expanded to engage the needed area of electrodes against targeted luminal tissue while maintaining the electrode density.
- Electrode deployment devices and methods of the present invention may be used whenever uniform delivery of energy is desired to treat a controlled depth of tissue in a lumen or cavity of the body, especially where such body structures may vary in size. Therefore, the following description is provided for exemplary purposes and should not be construed to limit the scope of the invention.
- the support may be comprised of a flexible, non-distensible backing.
- the backing may comprise of a thin, rectangular sheet of a polymer material such as polyimide, polyester or other flexible thermoplastic or thermosetting polymer film, polymer covered materials, or other nonconductive materials.
- the backing may also be comprised of an electrically insulating polymer, with an electro-conductive material, such as copper, deposited onto a surface.
- an electrode pattern can be etched into the material to create an array of electrodes.
- the support is spirally furled about an axis of the expansion member.
- the electrode pattern may be aligned in axial or traverse direction across the backing, formed in a linear or non-linear parallel array or series of bipolar pairs, or other suitable pattern.
- the electrodes may be arranged to control the depth and pattern of treatment.
- the electrodes typically have a width from 0.1mm to 3mm, preferably from 0.1mm to 0.3mm, and are spaced apart by a distance in the range from 0.1 mm to 3mm, typically from 0.1mm to 0.3mm.
- the expandable member may comprise any material or configuration.
- the expansion member comprises an inflatable balloon that is tapered at both ends.
- a balloon-type expansion member may be elastic, or optionally comprise a non-distensible bladder having a shape and a size in its fully expanded form that will extend in an appropriate way to the tissue to be contacted.
- Additional embodiments may comprise a basket, plurality of struts, an expandable member with a furled and an unfurled state, one or more springs, foam, backing material that expands to an enlarged configuration when unrestrained, and the like.
- the support is furled around the balloon so that the electrode-exposed surface of the support unfurls as the balloon is inflated.
- the support may be coiled into a loop and placed around an expandable balloon, so that a first end of the support is furled around the balloon overlapping the second end of the support.
- Some embodiments further include one or more elastic members that are attached to the second end and another point on the support to keep the backing constrained until being unfurled. As the balloon expands, the elastic members allow the support to unfurl and further expose additional electrodes that had previously been shielded by the overlapping portion of the support.
- the support is attached at its first end to a balloon, and a second end is unattached and furled around the balloon overlapping the first end of the support. As the balloon expands, the support unfurls and exposes additional electrodes that had previously been shielded by the overlapping portion of the support.
- the support is attached at its midpoint to the surface of the balloon and the ends of the support are furled in opposite directions around the balloon.
- a first support is attached at its midpoint to an expandable balloon so that the ends of the first support furl around the balloon in opposite directions.
- a second support is also attached at its midpoint to the balloon opposite from the first support, the ends of the second support also being furled in opposite directions around the balloon and overlapping the ends of the first support.
- Some embodiments further include one or more elastic members coupled to the first and second supports. As the balloon expands, the elastic members allow the supports to unfurl with respect to each other and further expose additional electrodes of the first support that had previously been shielded by the overlapping portion of the second support.
- the support is spirally furled inside a container having a slot down its axis through which one end of the furled support can pass.
- the container may comprise of a tubular-shaped, semi-rigid material, such as a plastic.
- a balloon surrounds a portion of the outside surface of the container, avoiding the opening provided by the axial slot.
- the support is partially unfurled from the container, through the slot and around the circumference of the balloon until it again reaches the slot in the container where it is attached at one end.
- the support may be attached to the balloon at a location proximal to the slot.
- the support When the balloon expands, the support unfurls from the container, exposing additional electrodes to compensate for the increased surface area of the balloon, and maintaining the constant electrode density on the surface of the support.
- the support is folded into a plurality of pleats inside the container.
- the support is attached to a shaft and is furled around the shaft inside the container.
- the shaft for example, may comprise an elongate, handheld rod of a flexible material such as a metallic wire.
- the device may further include a torsion spring coupled to the shaft.
- the expansion member comprises a spiral spring.
- the spring for example, may comprise of a wire, series of wires, or strip or sheet of spring temper or superelastic memory material, such as 316 stainless steel or nitinol, that provides an unwinding force or constant stress or force while expanding from a compressed state.
- the support is attached to the outer surface of the spring support.
- the apparatus may further comprise a shaft that is coupled to the spring.
- the expansion member comprises a balloon having an adhesive applied to selected areas of the balloon's outside surface, so that the balloon can be folded over at one or more of the adhesive areas to form one or more creases. As the balloon expands, the creases expand to expose additional electrodes of the support that surrounds the balloon.
- an electrode deployment apparatus for treating tissue in a body lumen comprises: a shaft; a support attached at one end to the distal end of the shaft and spirally furled about the shaft; a balloon slidably received on the shaft axially proximal to the support, wherein the balloon and support are retained in a sheath so that they may be advanced past the sheath once the apparatus is positioned at a treatment area, and wherein the balloon is further advanced to the distal end of the shaft to expand the support.
- an electrode deployment apparatus comprising: a plurality of electrodes arranged on a surface of a support at a pre-selected electrode density; an expansion member coupled to expand the support to selectively expose a portion of the electrode surface while shielding a remaining portion and maintaining the electrode density; and a transesophageal catheter, wherein the expansion member is disposed at a distal end of the catheter.
- the apparatus may further comprise a RF power source coupled to the plurality of electrodes.
- the apparatus may also include a multiplexer and /or temperature sensor coupled to the plurality of electrodes.
- the apparatus might also have a control device coupled to the plurality of electrodes, the control device providing controlled positioning of the expandable member.
- an electrode deployment apparatus for treatment of tissue in a human esophagus includes: a plurality of electrodes arranged on a surface of a support at a pre-selected electrode density; and an expansion member coupled to expand the support to engage the electrode surface to a wall of the esophagus while maintaining the electrode density.
- the electrodes may be arranged in a parallel pattern, and have a spacing between them of up to 3mm.
- the support may comprise a non-distensible electrode backing.
- the expandable member may comprise an inflatable balloon.
- the support is furled at least partially around the balloon, so that the support unfurls as the balloon is inflated.
- the support may further be attached at one end to the surface of the balloon with the second end of the support being furled around the balloon.
- the support is attached at its midpoint to the surface of the balloon, a first and second end of the support furled in opposite directions around the balloon.
- the support may be sized so that the ends of the support do not overlap, thereby keeping the exposed area of electrodes constant during expansion of the balloon.
- a method for deploying electrodes to treat tissue in a body lumen comprises positioning an array of electrodes having a pre-selected electrode density within the body lumen, and exposing an area of the array sufficient to engage a wall of the lumen while maintaining the electrode density, wherein the size of the exposed area may vary depending on the size of the body lumen.
- positioning the array comprises transesophageally delivering the array to a treatment area within the esophagus.
- the array may be advanced via a catheter carrying the array through the esophagus.
- Some embodiments further include applying radiofrequency energy to tissue of the body lumen through the electrodes.
- such embodiments may also include applying bipolar radiofrequency energy through a multiplicity of bipolar electrode pairs in the array.
- the electrodes in the array may be parallel, and have a width in the range from 0.1 mm to 3 mm, and be spaced-apart by a distance in the range from 0.1 mm to 3 mm.
- the total radiofrequency energy delivered to the esophageal tissue will be in the range from 1 joules/cm 2 to 50 joules/cm 2 , usually being from 5 joules/cm 2 to 50 joules/cm .
- the array comprises a non-distensible, electrode support that is furled about an axis of the expansion member, wherein expanding comprises unfurling the support to selectively expose a portion of the available electrode area.
- unfurling comprises expanding an expansion member such as an inflatable balloon within the furled support.
- the above method for deploying electrodes to treat tissue in a body lumen further comprises: furling the support about an axis so that its ends overlap each other; coupling an elastic member to the support to retain the support from unfurling freely; placing the balloon within the circumference of the furled support; advancing the support assembly to a desired treatment region; and expanding the balloon to deploy the backing against a wall of the lumen.
- a method for deploying electrodes to treat tissue in a body lumen comprises: furling a support with an array of electrodes having a pre-selected density about the distal end of a shaft having a balloon slidably received on the shaft proximal to the support; positioning the balloon and support inside a sheath; positioning the sheath assembly near a treatment area; advancing the balloon and support past the sheath; advancing the balloon to the distal end of the shaft; positioning the balloon and support at the treatment area; and expanding the balloon to deploy the backing against the lumen.
- Figure 1 is a schematic view of portions of an upper digestive tract in a human.
- Figure 2 is a schematic view of a device of the invention, in a compressed mode, within an esophagus.
- Figure 3 is a schematic view of a device of the invention, in an expanded mode, within an esophagus.
- Figure 4 is a schematic view of another embodiment of a device of the invention.
- Figure 5 shows a top view and a bottom view of an electrode pattern of the device of Figure 4.
- Figure 6 shows the electrode patterns of the device of Figure 3.
- Figure 7 shows the electrode patterns that may be used with a device of the invention.
- Figure 8 is an enlarged cross-sectional view of a device of the invention in an expanded configuration.
- Figure 9 shows an enlarged cross-sectional view of the device of Figure 8 in a more expanded configuration.
- Figure 10 is an enlarged cross-sectional view of a device of the invention in an expanded configuration.
- Figure 11 is an enlarged cross-sectional view of the device of Figure 10 in a compressed configuration.
- Figure 12 shows an enlarged cross-sectional view of another embodiment of a device of the invention in an expanded configuration
- Figure 13 shows an enlarged cross-sectional view of yet another embodiment of a device of the invention in an expanded configuration.
- Figure 14A is a perspective cross-sectional view of another embodiment of a device of the invention in a compressed configuration.
- Figure 14B is a perspective cross-sectional view of the device of Figure 10 in a compressed configuration.
- Figure 15 shows enlarged cross-sectional views of several embodiments of a device of the invention in an expanded configuration.
- Figure 16 is an enlarged cross-sectional view of another embodiment of a device of the invention in an expanded configuration.
- Figure 17 shows an enlarged cross-sectional view of another embodiment of a device of the invention in an expanded configuration.
- Figure 18 is an enlarged cross-sectional view of yet another embodiment of a device of the invention in a partially expanded configuration.
- the present invention provides devices and methods for treating, at a controlled and uniform depth, the inner lining of a lumen or cavity within a patient. It will be appreciated that the present invention is applicable to a variety of different tissue sites and organs, including but not limited to the esophagus.
- a treatment apparatus including an energy delivery device comprising an expandable electrode array is provided. At least a portion of the delivery device is positioned at the tissue site, where the electrode array is expanded to contact the tissue surface. Sufficient energy is delivered from the electrode array to impart a desired therapeutic effect, such as ablation as described below, to a discreet layer of tissue.
- Certain disorders can cause the retrograde flow of gastric or intestinal contents from the stomach 12, into the esophagus 14, as shown by arrows A and B in Figure 1. Although the causation of these problems are varied, this retrograde flow may result in secondary disorders, such as Barrett's esophagus, which require treatment independent of and quite different from treatments appropriate for the primary disorder—such as disorders of the lower esophageal sphincter 16.
- Barrett's esophagus is an inflammatory disorder in which the stomach acids, bile acids and enzymes regurgitated from the stomach and duodenum enter into the lower esophagus causing damage to the esophageal mucosa.
- the present invention provides devices and methods for treating columnar epithelium of selected sites of the esophagus in order to mitigate more severe implications for the patient.
- the desired treatment effect is ablation of the tissue.
- ablation means thermal damage to the tissue causing tissue or cell necrosis.
- some therapeutic procedures may have a desired treatment effect that falls short of ablation, e.g. some level of agitation or damage that is imparted to the tissue to inure a desired change in the cellular makeup of the tissue, rather than necrosis of the tissue.
- a variety of different energy delivery devices can be utilized to create a treatment effect in a superficial layer of tissue, while preserving intact the function of deeper layers, as described hereafter.
- Cell or tissue necrosis can be achieved with the use of energy, such as radiofrequency energy, at appropriate levels to accomplish ablation of mucosal or submucosal level tissue, while substantially preserving muscularis tissue.
- energy such as radiofrequency energy
- Such ablation is designed to remove the columnar growths 20 from the portions of the esophagus 14 so affected.
- a treatment apparatus 10 constructed in accordance with the principles of the present invention, includes an elongated catheter sleeve 22, that is configured to be inserted into the body in any of various ways selected by the medical provider.
- Apparatus 10 may be placed, (i) endoscopically, e.g. through esophagus 14, (ii) surgically or (iii) by other means.
- the apparatus is delivered to the treatment area within the esophagus while in a non-expanded state.
- This low-profile configuration allows for ease-of-access to the treatment site without discomfort or complications to the patient.
- Proper treatment of the tissue site requires the apparatus to expand to the diameter of the esophagus, as illustrated in Figure 3. Once expanded, the apparatus can uniformly deliver treatment energy to the desired tissue site.
- catheter sleeve 22 can be inserted in the lumen of the endoscope, or catheter sleeve 22 can be positioned along the outside of the endoscope. Alternately, an endoscope may be used to visualize the pathway that catheter 22 should follow during placement. As well, catheter sleeve 22 can be inserted into esophagus 14 after removal of the endoscope
- Electrode support 24 is provided and can be positioned at a distal end 26 of catheter sleeve 22 to provide appropriate energy for ablation as desired.
- Electrode support 24 has a plurality of electrode area segments 32 attached to the surface of the support.
- the electrodes 32 can be configured in an array 30 of various patterns to facilitate a specific treatment by controlling the electrode size and spacing (electrode density).
- electrode support 24 is coupled to an energy source configured for powering array 30 at levels appropriate to provide the selectable ablation of tissue to a predetermined depth of tissue.
- the support 24 may comprise a flexible, non-distensible backing.
- the support 24 may comprise of a thin, rectangular sheet of polymer materials such as polyimide, polyester or other flexible thermoplastic or thermosetting polymer film.
- the support 24 may also comprise polymer covered materials, or other nonconductive materials.
- the backing may include an electrically insulating polymer, with an electro-conductive material, such as copper, deposited onto a surface so that an electrode pattern can be etched into the material to create an array of electrodes.
- Electrode support 24 can be operated at a controlled distance from, or in direct contact with the wall of the tissue site. This can be achieved by coupling electrode support 24 to an expandable member 28, which has a configuration that is expandable in the shape to conform to the dimensions of the expanded (not collapsed) inner lumen of the tissue site or structure, such as the human lower esophageal tract.
- Suitable expandable members 28 include but are not limited to a balloon, compliant balloon, balloon with a tapered geometry, basket, plurality of struts, an expandable member with a furled and an unfurled state, one or more springs, foam, bladder, backing material that expands to an expanded configuration when unrestrained, and the like.
- Expandable member 28 can also be utilized to place electrode support 24, as well as to anchor the position of electrode support 24. This can be achieved with expandable member 28 itself, or other devices that are coupled to member 28 including but not limited to an additional balloon, a plurality of struts, a bladder, and the like.
- electrode support 24 is utilized to regulate and control the amount of energy transferred to the tissue at a tissue site such as the inner wall of a lumen.
- Expandable member 28 can be bonded to a portion of catheter sleeve 22 at a point spaced from distal end 26.
- Electrode support 24 may be furled at least partially around the outside circumference of expandable member 28 so that when expansion member 28 expands, support 24 adapts to the changing circumference while maintaining a constant electrode density per unit area.
- Energy is transferred from the catheter sleeve 22 to the electrode support 24 on expandable member 28.
- U.S. Patent No. 5,713,942 incorporated herein by reference, in which an expandable balloon is connected to a power source, which provides radio frequency power having the desired characteristics to selectively heat the target tissue to a desired temperature.
- catheter sleeve 22 includes a cable that contains a plurality of electrical conductors surrounded by an electrical insulation layer, with an electrode support 24 positioned at distal end 26.
- a positioning and distending device can be coupled to catheter sleeve 22.
- the positioning and distending device can be configured and sized to contact and expand the walls of the body cavity in which it is placed, by way of example and without limitation, the esophagus.
- the positioning and distending device can be at different positions of electrode support 24, including but not limited to its proximal and/or distal ends, and also at its sides.
- electrode support 24 can be positioned so that energy is uniformly applied to all or a portion of the inner circumference of the lumen where treatment is desired. This can be accomplished by first positioning apparatus 10 to the treatment area in a compressed configuration with the electrode support 24 furled around the outside circumference of expandable member 28. Once the apparatus is advanced to the appropriate site, expandable member 28 is inflated, which unfurls electrode support 24 to engage the internal wall of the lumen. In some embodiments, additional electrode support may unfurl from slot 34, shown in greater detail as slot 166 in Figures 10 through 12, where the electrode support was previously shielded prior to expansion. The desired treatment energy may then be delivered to the tissue as necessary.
- the electrode support 24 uniformly engages the inner wall of the lumen with an array of electrodes 30 having a constant density so that the energy is uniformly applied to all or a portion of the circumference of the inner lumen of the esophagus or other tissue site
- One way to ensure that the energy is uniformly applied to the circumference of the inner lumen of the esophagus is the use of a vacuum or suction element to "pull" the esophageal wall, or other tissue site, against the outside circumference of expandable member 28.
- This suction element may be used alone to "pull" the esophageal wall into contact with electrode support 24, carried on or by catheter sleeve 22 without the use of expandable member 28, or in conjunction with expandable member 28 to ensure that the wall is in contact with electrode support 24 while carried on the outside of expandable member 28.
- This same result can be achieved with any of the electrode supports 24 utilized, and their respective forms of energy, with respect to expandable member 28 so that the energy is uniformly applied.
- Electrode support 24 can deliver a variety of different types of energy including but not limited to, radio frequency, microwave, ultrasonic, resistive heating, chemical, a heatable fluid, optical including without limitation, ultraviolet, visible, infrared, collimated or non collimated, coherent or incoherent, or other light energy, and the like. It will be appreciated that the energy, including but not limited to optical, can be used in combination with one or more sensitizing agents.
- the energy source may be manually controlled by the user and is adapted to allow the user to select the appropriate treatment time and power setting to obtain a controlled depth of ablation.
- the energy source can be coupled to a controller (not shown), which may be a digital or analog controller for use with the energy source, including but not limited to an RF source, or a computer with software.
- the computer controller When the computer controller is used it can include a CPU coupled through a system bus.
- the system may include a keyboard, a disk drive, or other non- volatile memory system, a display and other peripherals known in the art.
- a program memory and a data memory will also be coupled to the bus.
- the depth of treatment obtained with apparatus 10 can be controlled by the selection of appropriate treatment parameters by the user as described in the examples set forth herein.
- One important parameter in controlling the depth of treatment is the electrode density of the array 30. As the spacing between electrodes decreases, the depth of treatment of the affected tissue also decreases. Very close spacing of the electrodes assures that the current and resulting ohmic heating is limited to a very shallow depth so that injury and heating of the submucosal layer are minimized.
- each RF electrode For treatment of esophageal tissue using RF energy, it may be desirable to have a width of each RF electrode to be no more than, (i) 3 mm, (ii) 2 mm, (iii) 1 mm (iv) 0.5 mm or (v) 0.3 mm (vi) 0.1mm and the like. Accordingly, it may be desirable to have a spacing between adjacent RF electrodes to be no more than, (i) 3 mm, (ii) 2 mm, (iii) 1 mm (iv) 0.5 mm or (v) 0.3 mm (vi) 0.1mm and the like.
- the plurality of electrodes can be arranged in segments, with at least a portion of the segments being multiplexed. An RF electrode between adjacent segments can be shared by each of adjacent segments when multiplexed.
- the electrode patterns of the present invention may be varied depending on the length of the site to be treated, the depth of the mucosa and submucosa, in the case of the esophagus, at the site of treatment and other factors.
- the electrode pattern 30 may be aligned in an axial or traverse direction across the electrode support 24, or formed in a linear or nonlinear parallel matrix or series of bipolar pairs or monopolar electrode.
- One or more different patterns may be coupled to various locations of expandable member 28.
- an electrode array as illustrated in Figures 6(a) through 6(c), may comprise a pattern of bipolar axial interlaced finger electrodes 68, six bipolar rings 62 with 2 mm separation, or monopolar rectangles 65 with 1mm separation.
- Pattern 46 is a pattern of bipolar axial interlaced finger electrodes with 0.3 mm separation.
- Pattern 48 includes monopolar bands with 0.3 mm separation.
- Pattern 52 includes bipolar rings with 0.3 mm separation.
- Pattern 50 is electrodes in a pattern of undulating electrodes with 0.2548 mm separation.
- a probe sensor may also be used with the system of the present invention to monitor and determine the depth of ablation.
- one or more sensors can be included and associated with each electrode segment 32 in order to monitor the temperature from each segment and then control the energy delivery to that segment.
- the control can be by way of an open or closed loop feedback system.
- the electroconductive member can be configured to permit transmission of microwave energy to the tissue site.
- Treatment apparatus 10 can also include steerable and directional control devices, a probe sensor for accurately sensing depth of ablation, and the like.
- one embodiment of the invention comprises an electrode deployment device 100 having an electrode support 110 furled around the outside of an inflatable balloon 116 that is mounted on a catheter sleeve 118.
- Support 110 has an electrode array 112 etched on its surface, and is aligned between edges 120 that intersect the taper region located at the distal and proximal ends of balloon 116.
- Support 110 is attached at a first end 122 to balloon 116 with an adhesive.
- the second end 124 of the support is furled around the balloon, overlapping the first end 122.
- Figure 5 shows a bottom view 150 and a top view 152 of the electrode array 112 of support 110.
- the array 112 has 20 parallel bars, 0.25mm wide, separated by gaps of 0.3 mm.
- the bars on the circuit form twenty complete continuous rings around the circumference of balloon 116.
- Electrode array 112 can be etched from a laminate consisting of copper on both sides of a polyimide substrate. One end of each copper bar has a small plated through hole 128, which allows signals to be passed to these bars from 1 of 2 copper junction blocks 156 and 158, respectively, on the back of the laminate.
- One junction block 156 is connected to all of the even numbered bars, while the other junction block 158 is connected to all of the odd numbered bars.
- each junction block 156 and 158 is then wired to a bundle of AWG wires 134.
- the wiring is external to balloon 116, with the distal circuit wires affixed beneath the proximal circuit.
- these bundles 134 can be soldered to three litz wire bundles 136.
- One bundle 136 serves as a common conductor for both circuits while the other two bundles 136 are wired individually to each of the two circuits.
- the litz wires are encompassed with heat shrink tubing along the entire length of the catheter sleeve 118 of the device.
- each of these bundles 136 Upon emerging from the proximal end of the catheter sleeve, each of these bundles 136 is individually insulated with heat shrink tubing before terminating to a mini connector plug 138. Under this configuration, power can be delivered to either or both of the two bundles so that treatment can be administered to a specific area along the array.
- the y connector 142 at the proximal end of the catheter sleeve includes access ports for both the thru lumen 144 and the inflation lumen 146.
- the thru lumen spans the entire length of the balloon catheter and exits at tip 148 at the distal end of balloon 116.
- the inflation lumen 146 is coupled to balloon 116 so that the balloon can be inflated by delivery of a liquid, such as water, a gas, such as air, or the like.
- support 110 is tightly furled about deflated balloon 116 and placed with within a sheath (not shown). During deployment, this sheath is retracted along the shaft to expose support 110.
- an elastic member (not shown) may be coupled to the support 110 to keep the support furled around balloon 116 during deployment of apparatus 100.
- Apparatus 100 is designed for use with the RF energy methods as set forth herein.
- Electrode array 112 can be activated with approximately 300 watts of radio frequency power for the length of time necessary to deliver from 1 J/cm 2 to 50 J/cm 2 . To determine the appropriate level of energy, the diameter of the lumen is evaluated so that the total treatment area can be calculated.
- a typical treatment area will require total energy ranging from 1 J/cm to 50 J/cm ' [0074]
- An optimal time for effective treatment is less than 1 second, and preferably less than 0.5 second or 0.25 seconds. The lower bound on time may be limited by the ability of the RF power source to deliver high powers.
- RF powers of several hundred watts would be required in order to deliver the desired energy density in short periods of time. This may pose a practical limitation on the lower limit of time.
- an RF power source configured to deliver a very short, high power, pulse of energy could be utilized. Using techniques similar to those used for flash lamp sources, or other types of capacitor discharge sources, a very high power, short pulse of RF energy can be created. This would allow treatment times of a few milliseconds or less. While this type of approach is feasible, in practice a more conventional RF source with a power capability of several hundred watts may be preferred.
- the desired power and energy settings can be scaled as needed to deliver the same power and energy per unit area. These changes can be made either automatically or from user input to the RF power source. If different treatment depths are desired, the geometry of electrode array 112 can be modified to create either a deeper or more superficial treatment region. Making the electrodes of array 112 more narrow and spacing the electrodes closer together reduces the treatment depth. Making the electrodes of array 112 wider, and spacing the electrodes further apart, increases the depth of the treatment region. Non-uniform widths and spacings may be exploited to achieve various treatment effects.
- an electrode array is arranged on a support 160 comprising a flexible electrode backing that is axially furled inside a cylindrical container 162.
- Support 160 may comprise a non-distensible, rectangular-shaped thin sheet formed from a polymer material, such as polyimide.
- An expandable member 164 such as an elastic balloon, surrounds a portion of the outside surface of container 162, leaving access to an opening that is formed from an axial slot 166 down the center of container 162.
- One end of support 160 is partially unfurled through slot 166 of container 162, and around the circumference of the expandable member 164 until it again reaches slot 166 where it is attached to either expandable member 164 or container 162.
- FIG 11 illustrates the apparatus 200 of the present invention in its compressed configuration.
- expandable member 164 is incrementally deployed until the desired pressure is exerted on the inside wall of the lumen.
- the pressure to be exerted to do so should therefore be greater than the pressure exerted by such vessels, typically from 1 psig to 20 psig, usually from 5 psig to 10 psig.
- support 160 When the expandable member 164 is inflated, support 160 unfurls from the container 162, exposing additional electrodes to compensate for the increased surface area. Although the surface area of the electrode array increases, electrode density on the surface of support 160 remains constant. Energy, including but not limited to an RF signal, may then be delivered to the electrodes to facilitate a uniform treatment to a precise depth of tissue. After the treatment has been administered, the expandable member 164 is collapsed so that the apparatus 200 may be removed from the lumen, or reapplied elsewhere.
- Suitable expandable members 164 include but are not limited to a balloon, balloon with a tapered geometry, basket, plurality of struts, an expandable member with a furled and an unfurled state, one or more springs, foam, bladder, backing material that expands to an enlarged configuration when unrestrained, and the like.
- a balloon-type expansion member 164 may be elastic, or a non-distensible bladder having a shape and a size in its fully expanded form, which will extend in an appropriate way to the tissue to be contacted.
- container 162 may be centered within expansion member 164, such that expansion member 164 forms a "c" shape around container 162.
- electrode support 160 can be formed from an electrically insulating polymer, with an electroconductive material, such as copper, deposited onto a surface. An electrode pattern can then be etched into the material, and then the support can be attached to or furled around an outer surface of a balloon. Bay way of example and without limitation, the electrode pattern may be aligned in an axial or traverse direction across the support, formed in a linear or non- linear parallel matrix or series of bipolar pairs, or other suitable pattern as illustrated in Figures 5, 6 and 7.
- electrode support 160 is attached to a shaft 180, upon which support 160 is spirally coiled inside container 162.
- Shaft 180 rotates freely as the support is uncoiled from the expansion of balloon 164. After treatment has been administered, shaft 180 can be rotated in the opposite direction to recoil support 160 into the container, thereby facilitating removal of apparatus 162 from the lumen.
- Shaft 180 may also be coupled with a torsion spring (not shown) so that a retraction and/or constant torsional force is applied to the support 160 to keep the support snug against balloon 164 as it expands or compresses.
- Figure 13 illustrates another embodiment of the present invention utilizing a pleated electrode support.
- the electrode support 178 of apparatus 300 is repeatedly folded upon itself in an accordion- like pattern and attached at a first end 182 to the inside wall of container 162.
- the support 178 passes through slot 166 of the container and around balloon 164 to the inside wall of slot 166 where it is attached at its second end.
- balloon 164 is expanded, the pleats of support 178 unfold, deploying the previously shielded electrodes to accommodate the increase in surface area of the balloon.
- Figures 14A and 14B show an electrode deployment device 400 wherein electrode support 160 is attached to and spirally furled about the distal end of shaft 180.
- An expandable balloon 164 is positioned on shaft 180 proximal to support 160, and is mounted on shaft 180 so that it can freely slide axially along the shaft.
- Support 160 is retained in a compressed state by sheath 184, which shields both the support and balloon 164 from the interior walls of the lumen while the device 400 is advanced to the treatment region.
- the catheter assembly 186 is advanced out of the sheath 184, causing the electrode support 160 to slightly expand.
- the balloon 164 is then advanced to the distal end of the shaft 180 so that it is surrounded by the inside circumference of the support 160.
- Balloon 164 is then expanded to match the inside diameter of the treatment region, further exposing additional electrodes on the support as it unfurls to accommodate the increase in surface area of the balloon.
- FIGs 15A-C illustrate additional embodiments of the electrode support 160 of the present invention.
- support 160 is attached at a first end 168 to a expandable balloon 164.
- the second end 170 of the support 160 is furled around the balloon, overlapping the first end 168.
- support 160 is attached at its midpoint 172 to expandable balloon 164, the ends of the support furling around the balloon in opposite directions such that the first end 168 is overlapped by the second end 170.
- the support 160 unfurls and further exposes additional electrodes that had previously been shielded by the overlapping portion of the support.
- Figure 15C illustrates another embodiment of the present invention utilizing two separate electrode array supports.
- a first support 160 is attached at its midpoint 172 to an expandable balloon 164, the ends of the first support furling around the balloon in opposite directions.
- a second support 174 is also attached at its midpoint 176 to the balloon 164 opposite from the first support 160, the ends of the second support 174 also being furled in opposite directions around the balloon and overlapping the ends of the first support 160.
- One or more elastic members (not shown) are attached to the ends of the second support and another point on the first support. As the balloon is expanded, the elastic members allow the supports to unfurl with respect to each other and further expose additional electrodes of the first support that had previously been shielded by the overlapping portion of the second support.
- Figure 8 illustrates another embodiment where the support 160 is furled around balloon 164 in a non-overlapping configuration.
- support 160 is attached at one end 168 to the balloon 164 and the second end 170 is furled around the circumference of the balloon until it reaches the first attached end, where it terminates.
- balloon 164 expands, the ends of the support expand with it, forming a gap 188 between each end that increases with the increasing circumference of the balloon.
- the electrode surface area remains constant when the balloon is expanding. However, a portion of the circumference will be void of a treatment surface due to the gap in the electrode support.
- the non- overlapping support 160 may also comprise one or more supports that are attached at their midpoint 172, such that ends 168 and 170 form gap 188 when the balloon 164 is expanded.
- one or more elastic members are attached to the support to prevent the support from prematurely unfurling.
- elastic member 190 is attached to one end of electrode support 160 and to another point on the support free of electrodes.
- the elastic member 190 keeps the furled support 160 at a basic diameter smaller than that of the lumen to be treated.
- An expandable balloon 164 is then inserted within the inner diameter of support 160, and the assembly 600 is advanced to the treatment site where balloon 164 is expanded to engage the inner surface of the lumen.
- the elastic member 190 allows the support to unfurl and further expose additional electrodes while also keeping the free end of support 160 from shifting out of alignment with the remainder of the array.
- elastic member 190 After treatment has been administered, elastic member 190 recompresses support 160 while balloon 164 deflates, returning support 160 to a reduced diameter to facilitate removal of the assembly 600 from the lumen.
- Figure 16 shows an electrode deployment device 500 wherein electrode support 160 is attached to a spiral spring 188.
- Spring 188 may include, but is not limited to a wire, series of wires, or strip or sheet of a spring temper or superelastic material that provides a retraction and/or a constant stress or force while compressed, such as a 316 stainless steel or nitinol. It should be noted however, that any material suitable as a retraction and/or a constant force spring may be used.
- Spring 188 is attached at one end to a shaft 180. To facilitate treatment, the spring 188 and support are coiled about shaft 180 and placed inside a sheath (not shown).
- FIG. 18 illustrates another embodiment of the present invention utilizing an adhesive to compress a pre-selected electrode array.
- Apparatus 700 includes a flexible electrode support 160 that is folded into a loop and attached at its ends. The edges of a portion of support 160 are coated with an adhesive 192 in a region where the adhesive will not cover the conductive elements of the electrode. The support 160 is creased upon itself at the adhesive regions to form one or more folds 194 of unexposed electrodes.
- the adhesive 192 that is applied will preferably not form a strong bond, but rather have a low adhesive quality so that a reasonable amount of deployment force will allow the bond to pull apart and deploy and expose only the amount of electrode area required to have complete circumferential contact with the lumen.
- An expansion balloon 164 is positioned within the looped support 160. The apparatus 700 is then advanced to a treatment region, and the balloon 164 is inflated. As balloon 164 expands, the pressure on the support increases, forcing the folds 194 to separate and incrementally expose additional electrodes on the support. The diameter of the apparatus 700 increases until the proper engagement with the lumen wall is achieved.
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/754,444 | 2004-01-09 | ||
US10/754,444 US7150745B2 (en) | 2004-01-09 | 2004-01-09 | Devices and methods for treatment of luminal tissue |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005067668A2 true WO2005067668A2 (en) | 2005-07-28 |
WO2005067668A3 WO2005067668A3 (en) | 2006-04-27 |
Family
ID=34794726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/000646 WO2005067668A2 (en) | 2004-01-09 | 2005-01-06 | Devices and methods for treatment of luminal tissue |
Country Status (2)
Country | Link |
---|---|
US (6) | US7150745B2 (en) |
WO (1) | WO2005067668A2 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012016320A1 (en) * | 2010-08-03 | 2012-02-09 | Medtronic Cryocath Lp | Cryogenic medical mapping and treatment device |
CN102688092B (en) * | 2007-07-06 | 2015-04-22 | 柯惠有限合伙公司 | Ablation in the gastrointestinal tract to achieve hemostasis and eradicate lesions with a propensity for bleeding |
CN104546118A (en) * | 2013-10-25 | 2015-04-29 | 柯惠有限合伙公司 | Unfurling electrode devices with the multiple longitudinal electrode segments |
EP2865349A1 (en) * | 2013-10-25 | 2015-04-29 | Covidien LP | Unfurling electrode devices with the multiple longitudinal electrode segments |
US9113911B2 (en) | 2012-09-06 | 2015-08-25 | Medtronic Ablation Frontiers Llc | Ablation device and method for electroporating tissue cells |
US9345540B2 (en) | 2013-03-15 | 2016-05-24 | Medtronic Ablation Frontiers Llc | Contact specific RF therapy balloon |
US9387031B2 (en) | 2011-07-29 | 2016-07-12 | Medtronic Ablation Frontiers Llc | Mesh-overlayed ablation and mapping device |
WO2017024056A1 (en) * | 2015-08-03 | 2017-02-09 | Boston Scientific Scimed, Inc. | Systems and methods for mapping and ablation in the bladder |
US9763733B2 (en) | 2013-10-25 | 2017-09-19 | Covidien Lp | Unfurling electrode devices with the multiple longitudinal electrode segments |
US10149716B2 (en) | 2015-02-02 | 2018-12-11 | Covidien Lp | Self-sizing catheter features to prevent over-tightening of the electrode |
US10278776B2 (en) | 2004-01-09 | 2019-05-07 | Covidien Lp | Devices and methods for treatment of luminal tissue |
US10368934B2 (en) | 2015-01-14 | 2019-08-06 | Covidien Lp | Arrangement of multi-channel bipolar electrode zones to minimize leakage and edge effects |
Families Citing this family (168)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6464697B1 (en) * | 1998-02-19 | 2002-10-15 | Curon Medical, Inc. | Stomach and adjoining tissue regions in the esophagus |
US6740082B2 (en) * | 1998-12-29 | 2004-05-25 | John H. Shadduck | Surgical instruments for treating gastro-esophageal reflux |
US20040215235A1 (en) | 1999-11-16 | 2004-10-28 | Barrx, Inc. | Methods and systems for determining physiologic characteristics for treatment of the esophagus |
AU780278B2 (en) | 1999-11-16 | 2005-03-10 | Covidien Lp | System and method of treating abnormal tissue in the human esophagus |
US20040215296A1 (en) * | 1999-11-16 | 2004-10-28 | Barrx, Inc. | System and method for treating abnormal epithelium in an esophagus |
US20060095032A1 (en) | 1999-11-16 | 2006-05-04 | Jerome Jackson | Methods and systems for determining physiologic characteristics for treatment of the esophagus |
JP2004500207A (en) | 2000-03-06 | 2004-01-08 | ティシューリンク・メディカル・インコーポレーテッド | Fluid delivery system and electrosurgical instrument controller |
US8048070B2 (en) | 2000-03-06 | 2011-11-01 | Salient Surgical Technologies, Inc. | Fluid-assisted medical devices, systems and methods |
US6558385B1 (en) | 2000-09-22 | 2003-05-06 | Tissuelink Medical, Inc. | Fluid-assisted medical device |
US6689131B2 (en) | 2001-03-08 | 2004-02-10 | Tissuelink Medical, Inc. | Electrosurgical device having a tissue reduction sensor |
US7811282B2 (en) | 2000-03-06 | 2010-10-12 | Salient Surgical Technologies, Inc. | Fluid-assisted electrosurgical devices, electrosurgical unit with pump and methods of use thereof |
US7756583B2 (en) | 2002-04-08 | 2010-07-13 | Ardian, Inc. | Methods and apparatus for intravascularly-induced neuromodulation |
US8347891B2 (en) | 2002-04-08 | 2013-01-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen |
US8475455B2 (en) | 2002-10-29 | 2013-07-02 | Medtronic Advanced Energy Llc | Fluid-assisted electrosurgical scissors and methods |
US20040226556A1 (en) | 2003-05-13 | 2004-11-18 | Deem Mark E. | Apparatus for treating asthma using neurotoxin |
US7727232B1 (en) | 2004-02-04 | 2010-06-01 | Salient Surgical Technologies, Inc. | Fluid-assisted medical devices and methods |
JP4564046B2 (en) * | 2004-02-25 | 2010-10-20 | エルベ エレクトロメディツィン ゲーエムベーハー | A device for interstitial coagulation of tissue |
AU2014202911B2 (en) * | 2005-10-04 | 2016-02-11 | Covidien Lp | Methods and systems for determining physiologic characteristics for treatment of the esophagus |
US7997278B2 (en) | 2005-11-23 | 2011-08-16 | Barrx Medical, Inc. | Precision ablating method |
AU2006318617B2 (en) * | 2005-11-23 | 2012-07-05 | Covidien Lp | Precision ablating device |
US8702694B2 (en) | 2005-11-23 | 2014-04-22 | Covidien Lp | Auto-aligning ablating device and method of use |
US7959627B2 (en) | 2005-11-23 | 2011-06-14 | Barrx Medical, Inc. | Precision ablating device |
US10499937B2 (en) | 2006-05-19 | 2019-12-10 | Recor Medical, Inc. | Ablation device with optimized input power profile and method of using the same |
US20070299433A1 (en) * | 2006-06-27 | 2007-12-27 | C2 Therapeutics | Barrett's Esophagus Cryogenic Ablation System |
US8641711B2 (en) | 2007-05-04 | 2014-02-04 | Covidien Lp | Method and apparatus for gastrointestinal tract ablation for treatment of obesity |
US20080312644A1 (en) | 2007-06-14 | 2008-12-18 | Boston Scientific Scimed, Inc. | Cryogenic balloon ablation instruments and systems |
US8032222B2 (en) * | 2007-06-19 | 2011-10-04 | Loushin Michael K H | Device for electrically and mechanically stimulating a compartment in a body |
US8784338B2 (en) | 2007-06-22 | 2014-07-22 | Covidien Lp | Electrical means to normalize ablational energy transmission to a luminal tissue surface of varying size |
US8251992B2 (en) | 2007-07-06 | 2012-08-28 | Tyco Healthcare Group Lp | Method and apparatus for gastrointestinal tract ablation to achieve loss of persistent and/or recurrent excess body weight following a weight-loss operation |
US8646460B2 (en) | 2007-07-30 | 2014-02-11 | Covidien Lp | Cleaning device and methods |
US8273012B2 (en) * | 2007-07-30 | 2012-09-25 | Tyco Healthcare Group, Lp | Cleaning device and methods |
US10022250B2 (en) | 2007-12-12 | 2018-07-17 | Intact Vascular, Inc. | Deployment device for placement of multiple intraluminal surgical staples |
US9375327B2 (en) | 2007-12-12 | 2016-06-28 | Intact Vascular, Inc. | Endovascular implant |
US7896911B2 (en) | 2007-12-12 | 2011-03-01 | Innovasc Llc | Device and method for tacking plaque to blood vessel wall |
US10166127B2 (en) | 2007-12-12 | 2019-01-01 | Intact Vascular, Inc. | Endoluminal device and method |
US9603730B2 (en) | 2007-12-12 | 2017-03-28 | Intact Vascular, Inc. | Endoluminal device and method |
US8128677B2 (en) | 2007-12-12 | 2012-03-06 | Intact Vascular LLC | Device and method for tacking plaque to a blood vessel wall |
US8483831B1 (en) | 2008-02-15 | 2013-07-09 | Holaira, Inc. | System and method for bronchial dilation |
US8469919B2 (en) * | 2008-02-19 | 2013-06-25 | Boston Scientific Scimed, Inc. | Apparatus and methods for uniformly distributing coolant within a cryo-ablation device |
WO2009120694A2 (en) * | 2008-03-24 | 2009-10-01 | The Regents Of The University Of Michigan Office Of Technology Transfer | Non-contact infrared fiber-optic device for monitoring esophageal temperature to prevent thermal injury during radiofrequency catheter ablation or cryoablation |
EP2662046B1 (en) | 2008-05-09 | 2023-03-15 | Nuvaira, Inc. | Systems and assemblies for treating a bronchial tree |
US9028445B2 (en) | 2008-05-12 | 2015-05-12 | Frank W. Ingle | Apparatus and method for chilling cryo-ablation coolant and resulting cryo-ablation system |
EP2291132B1 (en) | 2008-05-15 | 2015-09-23 | Boston Scientific Scimed, Inc. | Apparatus for cryogenically ablating tissue and adjusting cryogenic ablation regions |
US9288886B2 (en) | 2008-05-30 | 2016-03-15 | Colorado State University Research Foundation | Plasma-based chemical source device and method of use thereof |
JP2011521735A (en) | 2008-05-30 | 2011-07-28 | コロラド ステート ユニバーシティ リサーチ ファンデーション | System, method and apparatus for generating plasma |
US8994270B2 (en) | 2008-05-30 | 2015-03-31 | Colorado State University Research Foundation | System and methods for plasma application |
US8097926B2 (en) | 2008-10-07 | 2012-01-17 | Mc10, Inc. | Systems, methods, and devices having stretchable integrated circuitry for sensing and delivering therapy |
US8389862B2 (en) | 2008-10-07 | 2013-03-05 | Mc10, Inc. | Extremely stretchable electronics |
US9123614B2 (en) | 2008-10-07 | 2015-09-01 | Mc10, Inc. | Methods and applications of non-planar imaging arrays |
US8372726B2 (en) | 2008-10-07 | 2013-02-12 | Mc10, Inc. | Methods and applications of non-planar imaging arrays |
WO2010042653A1 (en) * | 2008-10-07 | 2010-04-15 | Mc10, Inc. | Catheter balloon having stretchable integrated circuitry and sensor array |
US8886334B2 (en) | 2008-10-07 | 2014-11-11 | Mc10, Inc. | Systems, methods, and devices using stretchable or flexible electronics for medical applications |
US9795442B2 (en) | 2008-11-11 | 2017-10-24 | Shifamed Holdings, Llc | Ablation catheters |
CA2743140A1 (en) | 2008-11-11 | 2010-05-20 | Shifamed, Llc | Low profile electrode assembly |
WO2010082993A2 (en) * | 2008-12-11 | 2010-07-22 | Mc10, Inc. | Systems, methods, and devices using stretchable or flexible electronics for medical applications |
US20100160906A1 (en) * | 2008-12-23 | 2010-06-24 | Asthmatx, Inc. | Expandable energy delivery devices having flexible conductive elements and associated systems and methods |
EP2376011B1 (en) * | 2009-01-09 | 2019-07-03 | ReCor Medical, Inc. | Apparatus for treatment of mitral valve insufficiency |
US20100256630A1 (en) * | 2009-04-07 | 2010-10-07 | Angiodynamics, Inc. | Irreversible electroporation (ire) for esophageal disease |
US8795304B2 (en) | 2009-06-18 | 2014-08-05 | Cardiovascular Systems, Inc. | Atherectomy device, system and method having a bi-directional distal expandable ablation element |
CN102481433B (en) | 2009-06-24 | 2014-12-31 | 施菲姆德控股有限责任公司 | Steerable medical delivery devices and methods of use |
US9723122B2 (en) | 2009-10-01 | 2017-08-01 | Mc10, Inc. | Protective cases with integrated electronics |
CN107049479B (en) | 2009-10-27 | 2020-10-16 | 努瓦拉公司 | Delivery device with coolable energy emitting assembly |
US8222822B2 (en) | 2009-10-27 | 2012-07-17 | Tyco Healthcare Group Lp | Inductively-coupled plasma device |
US8911439B2 (en) | 2009-11-11 | 2014-12-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
KR101820542B1 (en) | 2009-11-11 | 2018-01-19 | 호라이라 인코포레이티드 | Systems, apparatuses, and methods for treating tissue and controlling stenosis |
JP2013521995A (en) | 2010-03-24 | 2013-06-13 | シファメド・ホールディングス・エルエルシー | Endovascular tissue destruction |
CA2794902A1 (en) | 2010-03-31 | 2011-10-06 | Colorado State University Research Foundation | Liquid-gas interface plasma device |
CA2794895A1 (en) | 2010-03-31 | 2011-10-06 | Colorado State University Research Foundation | Liquid-gas interface plasma device |
US20120116378A1 (en) * | 2010-04-26 | 2012-05-10 | Minerva Surgical, Inc. | Endometrial ablation with a device that conforms to symmetric or asymmetric uterine cavities |
CN103118620B (en) | 2010-05-12 | 2015-09-23 | 施菲姆德控股有限责任公司 | The electrode assemblie of low profile |
US9655677B2 (en) | 2010-05-12 | 2017-05-23 | Shifamed Holdings, Llc | Ablation catheters including a balloon and electrodes |
AU2011332014B2 (en) | 2010-11-27 | 2016-12-22 | Securus Medical Group, Inc. | Ablation and temperature measurement devices |
WO2012099974A2 (en) | 2011-01-19 | 2012-07-26 | Fractyl Laboratories, Inc. | Devices and methods for the treatment of tissue |
US10278774B2 (en) | 2011-03-18 | 2019-05-07 | Covidien Lp | Selectively expandable operative element support structure and methods of use |
CN103517731B (en) | 2011-04-08 | 2016-08-31 | 柯惠有限合伙公司 | For removing iontophoresis formula drug delivery system and the method for renal sympathetic nerve and iontophoresis formula drug delivery |
TW201242570A (en) | 2011-04-25 | 2012-11-01 | Medtronic Ardian Luxembourg | Apparatus and methods related to constrained deployment of cryogenic balloons for limited cryogenic ablation of vessel walls |
WO2012151396A2 (en) | 2011-05-03 | 2012-11-08 | Shifamed Holdings, Llc | Steerable delivery sheaths |
US8909316B2 (en) | 2011-05-18 | 2014-12-09 | St. Jude Medical, Cardiology Division, Inc. | Apparatus and method of assessing transvascular denervation |
EP2712491B1 (en) | 2011-05-27 | 2019-12-04 | Mc10, Inc. | Flexible electronic structure |
US10271973B2 (en) | 2011-06-03 | 2019-04-30 | Intact Vascular, Inc. | Endovascular implant |
US9757050B2 (en) | 2011-08-05 | 2017-09-12 | Mc10, Inc. | Catheter balloon employing force sensing elements |
WO2013022853A1 (en) | 2011-08-05 | 2013-02-14 | Mc10, Inc. | Catheter balloon methods and apparatus employing sensing elements |
WO2013028381A1 (en) | 2011-08-19 | 2013-02-28 | Cook Medical Technologies Llc | Cap for attachment to an endoscope |
CN103732170B (en) | 2011-08-19 | 2016-09-21 | 库克医学技术有限责任公司 | Ablation cap |
CN103889348B (en) | 2011-08-25 | 2016-10-12 | 柯惠有限合伙公司 | For treating the system of cavity tissue, apparatus and method |
DE102011085616A1 (en) | 2011-11-02 | 2013-05-02 | Celon Ag Medical Instruments | Electrosurgical probe and electrosurgery device |
CA2856732A1 (en) | 2011-12-09 | 2013-06-13 | Metavention, Inc. | Therapeutic neuromodulation of the hepatic system |
WO2013112768A1 (en) | 2012-01-25 | 2013-08-01 | Intact Vascular, Inc. | Endoluminal device and method |
IL296643A (en) | 2012-02-27 | 2022-11-01 | Fractyl Health Inc | Heat ablation systems, devices and methods for the treatment of tissue |
US8961550B2 (en) | 2012-04-17 | 2015-02-24 | Indian Wells Medical, Inc. | Steerable endoluminal punch |
AU2013249043B2 (en) | 2012-04-19 | 2017-04-27 | Fractyl Health, Inc. | Tissue expansion devices, system and methods |
US10610294B2 (en) | 2012-04-22 | 2020-04-07 | Newuro, B.V. | Devices and methods for transurethral bladder partitioning |
US9883906B2 (en) | 2012-04-22 | 2018-02-06 | Newuro, B.V. | Bladder tissue modification for overactive bladder disorders |
WO2013160772A2 (en) | 2012-04-22 | 2013-10-31 | Omry Ben-Ezra | Bladder tissue modification for overactive bladder disorders |
US9408662B2 (en) | 2012-05-07 | 2016-08-09 | Cook Medical Technologies Llc | Sphincterotome having expandable tines |
US9226402B2 (en) | 2012-06-11 | 2015-12-29 | Mc10, Inc. | Strain isolation structures for stretchable electronics |
KR20150031324A (en) | 2012-07-05 | 2015-03-23 | 엠씨10, 인크 | Catheter device including flow sensing |
US9295842B2 (en) | 2012-07-05 | 2016-03-29 | Mc10, Inc. | Catheter or guidewire device including flow sensing and use thereof |
US10786305B2 (en) | 2012-07-30 | 2020-09-29 | Northwestern University | Radiofrequency probe for circumferential ablation of a hollow cavity |
EP3714826A1 (en) * | 2012-07-30 | 2020-09-30 | Fractyl Laboratories, Inc. | Electrical energy ablation systems and devices for the treatment of tissue |
EP2882362B1 (en) | 2012-08-09 | 2024-01-03 | Fractyl Health, Inc. | Ablation systems, devices and methods for the treatment of tissue |
US9526570B2 (en) | 2012-10-04 | 2016-12-27 | Cook Medical Technologies Llc | Tissue cutting cap |
EP2903626A4 (en) | 2012-10-05 | 2016-10-19 | Fractyl Lab Inc | Methods, systems and devices for performing multiple treatments on a patient |
US9171794B2 (en) | 2012-10-09 | 2015-10-27 | Mc10, Inc. | Embedding thin chips in polymer |
EP2906960A4 (en) | 2012-10-09 | 2016-06-15 | Mc10 Inc | Conformal electronics integrated with apparel |
US9364277B2 (en) | 2012-12-13 | 2016-06-14 | Cook Medical Technologies Llc | RF energy controller and method for electrosurgical medical devices |
US9204921B2 (en) | 2012-12-13 | 2015-12-08 | Cook Medical Technologies Llc | RF energy controller and method for electrosurgical medical devices |
US9398933B2 (en) | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
US9532826B2 (en) | 2013-03-06 | 2017-01-03 | Covidien Lp | System and method for sinus surgery |
US9555145B2 (en) | 2013-03-13 | 2017-01-31 | Covidien Lp | System and method for biofilm remediation |
US9055950B2 (en) * | 2013-03-15 | 2015-06-16 | Chemo S.A. France | Method and system for delivering a tissue treatment using a balloon-catheter system |
CA2908517A1 (en) | 2013-04-08 | 2014-10-16 | Apama Medical, Inc. | Cardiac ablation catheters and methods of use thereof |
US10349824B2 (en) | 2013-04-08 | 2019-07-16 | Apama Medical, Inc. | Tissue mapping and visualization systems |
US10098694B2 (en) | 2013-04-08 | 2018-10-16 | Apama Medical, Inc. | Tissue ablation and monitoring thereof |
US9706647B2 (en) | 2013-05-14 | 2017-07-11 | Mc10, Inc. | Conformal electronics including nested serpentine interconnects |
EP3003461B1 (en) | 2013-06-04 | 2019-05-01 | Fractyl Laboratories, Inc. | Systems and devices for reducing the luminal surface area of the gastrointestinal tract |
CA2920485A1 (en) | 2013-08-05 | 2015-02-12 | Mc10, Inc. | Flexible temperature sensor including conformable electronics |
CN105705093A (en) | 2013-10-07 | 2016-06-22 | Mc10股份有限公司 | Conformal sensor systems for sensing and analysis |
JP6603660B2 (en) | 2013-11-22 | 2019-11-06 | フラクティル ラボラトリーズ インコーポレイテッド | System, device and method for generating treatment constraints in the gastrointestinal tract |
WO2015077559A1 (en) | 2013-11-22 | 2015-05-28 | Mc10, Inc. | Conformal sensor systems for sensing and analysis of cardiac activity |
CA2935372C (en) | 2014-01-06 | 2023-08-08 | Mc10, Inc. | Encapsulated conformal electronic systems and devices, and methods of making and using the same |
US10485118B2 (en) | 2014-03-04 | 2019-11-19 | Mc10, Inc. | Multi-part flexible encapsulation housing for electronic devices and methods of making the same |
WO2015142674A1 (en) | 2014-03-15 | 2015-09-24 | Rioux Robert F | System and method for marginal tissue ablation |
US10959774B2 (en) | 2014-03-24 | 2021-03-30 | Fractyl Laboratories, Inc. | Injectate delivery devices, systems and methods |
US10709490B2 (en) | 2014-05-07 | 2020-07-14 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter assemblies comprising a direct heating element for renal neuromodulation and associated systems and methods |
US9844641B2 (en) | 2014-07-16 | 2017-12-19 | Fractyl Laboratories, Inc. | Systems, devices and methods for performing medical procedures in the intestine |
EP3169260B1 (en) | 2014-07-16 | 2019-09-25 | Fractyl Laboratories, Inc. | System for treating diabetes and related diseases and disorders |
US11185367B2 (en) | 2014-07-16 | 2021-11-30 | Fractyl Health, Inc. | Methods and systems for treating diabetes and related diseases and disorders |
CN106659873B (en) * | 2014-07-28 | 2020-08-18 | 智能医疗系统有限公司 | Controlled furling balloon assembly |
US9899330B2 (en) | 2014-10-03 | 2018-02-20 | Mc10, Inc. | Flexible electronic circuits with embedded integrated circuit die |
US10297572B2 (en) | 2014-10-06 | 2019-05-21 | Mc10, Inc. | Discrete flexible interconnects for modules of integrated circuits |
USD781270S1 (en) | 2014-10-15 | 2017-03-14 | Mc10, Inc. | Electronic device having antenna |
EP3226783B1 (en) | 2014-12-03 | 2024-01-10 | PAVmed Inc. | Systems for percutaneous division of fibrous structures |
US9375336B1 (en) | 2015-01-29 | 2016-06-28 | Intact Vascular, Inc. | Delivery device and method of delivery |
US9433520B2 (en) | 2015-01-29 | 2016-09-06 | Intact Vascular, Inc. | Delivery device and method of delivery |
CN107530004A (en) | 2015-02-20 | 2018-01-02 | Mc10股份有限公司 | The automatic detection and construction of wearable device based on personal situation, position and/or orientation |
WO2016140961A1 (en) | 2015-03-02 | 2016-09-09 | Mc10, Inc. | Perspiration sensor |
WO2016160694A1 (en) | 2015-03-27 | 2016-10-06 | Shifamed Holdings, Llc | Steerable medical devices, systems, and methods of use |
AU2016253129A1 (en) | 2015-04-24 | 2017-10-26 | Shifamed Holdings, Llc | Steerable medical devices, systems, and methods of use |
EP3685782B1 (en) | 2015-04-29 | 2021-11-03 | Innoblative Designs, Inc. | Cavitary tissue ablation |
US10653332B2 (en) | 2015-07-17 | 2020-05-19 | Mc10, Inc. | Conductive stiffener, method of making a conductive stiffener, and conductive adhesive and encapsulation layers |
US10709384B2 (en) | 2015-08-19 | 2020-07-14 | Mc10, Inc. | Wearable heat flux devices and methods of use |
EP3356003A4 (en) | 2015-10-01 | 2019-04-03 | Mc10, Inc. | Method and system for interacting with a virtual environment |
EP3359031A4 (en) | 2015-10-05 | 2019-05-22 | Mc10, Inc. | Method and system for neuromodulation and stimulation |
AU2016335755B2 (en) | 2015-10-07 | 2021-07-01 | Mayo Foundation For Medical Education And Research | Electroporation for obesity or diabetes treatment |
ES2779627T3 (en) | 2015-10-29 | 2020-08-18 | Innoblative Designs Inc | Spherical Screen Tissue Ablation Devices |
EP3373794B1 (en) | 2015-11-09 | 2022-01-05 | Kalila Medical, Inc. | Steering assemblies for medical devices |
EP3376936B1 (en) | 2015-11-16 | 2024-01-03 | Boston Scientific Scimed, Inc. | Energy delivery devices |
US10531907B2 (en) | 2015-11-20 | 2020-01-14 | Covidien Lp | Devices, systems, and methods for treating ulcerative colitis and other inflammatory bowel diseases |
US10993824B2 (en) | 2016-01-01 | 2021-05-04 | Intact Vascular, Inc. | Delivery device and method of delivery |
JP6630836B2 (en) | 2016-02-02 | 2020-01-15 | イノブレイティブ デザインズ, インコーポレイテッド | Cavity tissue ablation system |
US10673280B2 (en) | 2016-02-22 | 2020-06-02 | Mc10, Inc. | System, device, and method for coupled hub and sensor node on-body acquisition of sensor information |
EP3420732B8 (en) | 2016-02-22 | 2020-12-30 | Medidata Solutions, Inc. | System, devices, and method for on-body data and power transmission |
WO2017151431A1 (en) | 2016-03-01 | 2017-09-08 | Innoblative Designs, Inc. | Resecting and coagulating tissue |
EP3445230B1 (en) | 2016-04-19 | 2024-03-13 | Medidata Solutions, Inc. | Method and system for measuring perspiration |
US10105179B2 (en) | 2016-05-02 | 2018-10-23 | Affera, Inc. | Catheter sensing and irrigating |
US10524859B2 (en) | 2016-06-07 | 2020-01-07 | Metavention, Inc. | Therapeutic tissue modulation devices and methods |
US10447347B2 (en) | 2016-08-12 | 2019-10-15 | Mc10, Inc. | Wireless charger and high speed data off-loader |
WO2018075389A1 (en) | 2016-10-17 | 2018-04-26 | Innoblative Designs, Inc. | Treatment devices and methods |
WO2018144090A2 (en) | 2016-11-08 | 2018-08-09 | Innoblative Designs, Inc. | Electrosurgical tissue and vessel sealing device |
US11660218B2 (en) | 2017-07-26 | 2023-05-30 | Intact Vascular, Inc. | Delivery device and method of delivery |
WO2019023328A1 (en) | 2017-07-26 | 2019-01-31 | Innoblative Designs, Inc. | Minimally invasive articulating assembly having ablation capabilities |
US20190192220A1 (en) * | 2017-12-27 | 2019-06-27 | Medlumics S.L. | Ablation Catheter with a Patterned Textured Active Area |
DE102019102841A1 (en) | 2019-02-05 | 2020-08-06 | Olympus Winter & Ibe Gmbh | Detachable insulating insert for use in a resectoscope |
DE102019102839A1 (en) | 2019-02-05 | 2020-08-06 | Olympus Winter & Ibe Gmbh | Irrigation fluid for resection |
EP3998973A4 (en) * | 2019-07-16 | 2023-07-26 | Galvanize Therapeutics, Inc. | Treatment of the reproductive tract with pulsed electric fields |
US20230414274A1 (en) * | 2020-11-13 | 2023-12-28 | Pulse Biosciences, Inc. | Nanosecond pulsing to treat a body lumen |
USD1014762S1 (en) | 2021-06-16 | 2024-02-13 | Affera, Inc. | Catheter tip with electrode panel(s) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5462545A (en) * | 1994-01-31 | 1995-10-31 | New England Medical Center Hospitals, Inc. | Catheter electrodes |
US6006755A (en) * | 1994-06-24 | 1999-12-28 | Edwards; Stuart D. | Method to detect and treat aberrant myoelectric activity |
US6123703A (en) * | 1998-09-19 | 2000-09-26 | Tu; Lily Chen | Ablation catheter and methods for treating tissues |
US6258118B1 (en) * | 1998-11-25 | 2001-07-10 | Israel Aircraft Industries Ltd. | Removable support device |
US6964661B2 (en) * | 2003-04-02 | 2005-11-15 | Boston Scientific Scimed, Inc. | Endovenous ablation mechanism with feedback control |
Family Cites Families (439)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US552832A (en) | 1896-01-07 | Instrument for treatment of strictures by electrolysis | ||
US1798902A (en) * | 1928-11-05 | 1931-03-31 | Edwin M Raney | Surgical instrument |
US2751608A (en) | 1953-09-17 | 1956-06-26 | George R Lucas | Hide away bed gates |
US3517128A (en) | 1968-02-08 | 1970-06-23 | James R Hines | Surgical expanding arm dilator |
US3924628A (en) | 1972-12-01 | 1975-12-09 | William Droegemueller | Cyrogenic bladder for necrosing tissue cells |
US3901241A (en) | 1973-05-31 | 1975-08-26 | Al Corp Du | Disposable cryosurgical instrument |
DE2513868C2 (en) * | 1974-04-01 | 1982-11-04 | Olympus Optical Co., Ltd., Tokyo | Bipolar electrodiathermy forceps |
US4196724A (en) * | 1978-01-31 | 1980-04-08 | Frecker William H | Tongue locking device |
US4311154A (en) | 1979-03-23 | 1982-01-19 | Rca Corporation | Nonsymmetrical bulb applicator for hyperthermic treatment of the body |
US4304239A (en) | 1980-03-07 | 1981-12-08 | The Kendall Company | Esophageal probe with balloon electrode |
WO1981003271A1 (en) | 1980-05-13 | 1981-11-26 | American Hospital Supply Corp | A multipolar electrosurgical device |
DK238080A (en) | 1980-06-03 | 1981-12-04 | P Pless | GIANT STIMULATION PROBLEMS FOR ELECTRIC STIMULATION OF THE HEART |
JPS5755573A (en) * | 1980-09-18 | 1982-04-02 | Olympus Optical Co Ltd | Cassette storing device |
US4565200A (en) * | 1980-09-24 | 1986-01-21 | Cosman Eric R | Universal lesion and recording electrode system |
US4411266A (en) | 1980-09-24 | 1983-10-25 | Cosman Eric R | Thermocouple radio frequency lesion electrode |
US4460298A (en) * | 1981-06-03 | 1984-07-17 | Illinois Tool Works Inc. | Self retaining threaded screw grommet |
US4407298A (en) | 1981-07-16 | 1983-10-04 | Critikon Inc. | Connector for thermodilution catheter |
US5421819A (en) | 1992-08-12 | 1995-06-06 | Vidamed, Inc. | Medical probe device |
US5385544A (en) * | 1992-08-12 | 1995-01-31 | Vidamed, Inc. | BPH ablation method and apparatus |
US5370675A (en) | 1992-08-12 | 1994-12-06 | Vidamed, Inc. | Medical probe device and method |
US5435805A (en) | 1992-08-12 | 1995-07-25 | Vidamed, Inc. | Medical probe device with optical viewing capability |
US5542915A (en) | 1992-08-12 | 1996-08-06 | Vidamed, Inc. | Thermal mapping catheter with ultrasound probe |
JPS5957650A (en) | 1982-09-27 | 1984-04-03 | 呉羽化学工業株式会社 | Probe for heating body cavity |
EP0105677B1 (en) | 1982-09-27 | 1986-12-10 | Kureha Kagaku Kogyo Kabushiki Kaisha | Endotract antenna device for hyperthermia |
CA1244889A (en) | 1983-01-24 | 1988-11-15 | Kureha Chemical Ind Co Ltd | Device for hyperthermia |
JPS6055966A (en) | 1983-09-05 | 1985-04-01 | オリンパス光学工業株式会社 | Medical electrode apparatus |
US4601296A (en) | 1983-10-07 | 1986-07-22 | Yeda Research And Development Co., Ltd. | Hyperthermia apparatus |
US4674481A (en) * | 1983-10-31 | 1987-06-23 | Board Of Regents, The University Of Texas System | RF electromagnetic field generation apparatus for regionally-focused hyperthermia |
US4705041A (en) | 1984-07-06 | 1987-11-10 | Kim Il G | Dilator for Sphincter of Oddi |
US5019075A (en) | 1984-10-24 | 1991-05-28 | The Beth Israel Hospital | Method and apparatus for angioplasty |
JPH0644105B2 (en) | 1985-01-14 | 1994-06-08 | オリンパス光学工業株式会社 | Endoscope |
US4658836A (en) * | 1985-06-28 | 1987-04-21 | Bsd Medical Corporation | Body passage insertable applicator apparatus for electromagnetic |
FR2586141B1 (en) * | 1985-08-06 | 1987-11-20 | Thomson Csf | SENSITIVE THYRISTOR WITH INTEGRATED TRIGGER-CATHODE DECOUPLING |
AT385894B (en) * | 1985-10-04 | 1988-05-25 | Basem Dr Nashef | TUBULAR PROBE |
US4709698A (en) | 1986-05-14 | 1987-12-01 | Thomas J. Fogarty | Heatable dilation catheter |
JPH0311011Y2 (en) | 1986-06-27 | 1991-03-18 | ||
US4740207A (en) * | 1986-09-10 | 1988-04-26 | Kreamer Jeffry W | Intralumenal graft |
US5231995A (en) * | 1986-11-14 | 1993-08-03 | Desai Jawahar M | Method for catheter mapping and ablation |
US5365926A (en) | 1986-11-14 | 1994-11-22 | Desai Jawahar M | Catheter for mapping and ablation and method therefor |
US5215103A (en) | 1986-11-14 | 1993-06-01 | Desai Jawahar M | Catheter for mapping and ablation and method therefor |
US4765331A (en) | 1987-02-10 | 1988-08-23 | Circon Corporation | Electrosurgical device with treatment arc of less than 360 degrees |
US4901737A (en) * | 1987-04-13 | 1990-02-20 | Toone Kent J | Method and therapeutic apparatus for reducing snoring |
US5888743A (en) | 1987-04-24 | 1999-03-30 | Das; Kiron M. | In vitro method for diagnosing benign Barrett's Epithelium |
US4943290A (en) | 1987-06-23 | 1990-07-24 | Concept Inc. | Electrolyte purging electrode tip |
JPH088933B2 (en) * | 1987-07-10 | 1996-01-31 | 日本ゼオン株式会社 | Catheter |
JPS6446056U (en) * | 1987-09-17 | 1989-03-22 | ||
US4860744A (en) | 1987-11-02 | 1989-08-29 | Raj K. Anand | Thermoelectrically controlled heat medical catheter |
FR2624747A1 (en) * | 1987-12-18 | 1989-06-23 | Delsanti Gerard | REMOVABLE ENDO-ARTERIAL DEVICES FOR REPAIRING ARTERIAL WALL DECOLLEMENTS |
US5588432A (en) | 1988-03-21 | 1996-12-31 | Boston Scientific Corporation | Catheters for imaging, sensing electrical potentials, and ablating tissue |
US5372138A (en) | 1988-03-21 | 1994-12-13 | Boston Scientific Corporation | Acousting imaging catheters and the like |
US4907589A (en) * | 1988-04-29 | 1990-03-13 | Cosman Eric R | Automatic over-temperature control apparatus for a therapeutic heating device |
DE3821544C2 (en) | 1988-06-25 | 1994-04-28 | H Prof Dr Med Just | Dilatation catheter |
US4947842A (en) | 1988-09-22 | 1990-08-14 | Medical Engineering And Development Institute, Inc. | Method and apparatus for treating tissue with first and second modalities |
US4906203A (en) * | 1988-10-24 | 1990-03-06 | General Motors Corporation | Electrical connector with shorting clip |
US4955377A (en) * | 1988-10-28 | 1990-09-11 | Lennox Charles D | Device and method for heating tissue in a patient's body |
US5151100A (en) * | 1988-10-28 | 1992-09-29 | Boston Scientific Corporation | Heating catheters |
US4966597A (en) | 1988-11-04 | 1990-10-30 | Cosman Eric R | Thermometric cardiac tissue ablation electrode with ultra-sensitive temperature detection |
DE3838840C2 (en) | 1988-11-17 | 1997-02-20 | Leibinger Gmbh | High frequency coagulation device for surgical purposes |
WO1990007303A1 (en) * | 1989-01-06 | 1990-07-12 | Angioplasty Systems, Inc. | Electrosurgical catheter for resolving atherosclerotic plaque |
US5779698A (en) | 1989-01-18 | 1998-07-14 | Applied Medical Resources Corporation | Angioplasty catheter system and method for making same |
CA1332905C (en) | 1989-03-10 | 1994-11-08 | John A. Murchie | Method and apparatus for treatment of snoring |
US5458571A (en) | 1989-03-17 | 1995-10-17 | Merit Medical Systems, Inc. | System and method for monitoring, displaying and recording balloon catheter condition interval data |
US4930521A (en) * | 1989-03-17 | 1990-06-05 | Metzger William T | Variable stiffness esophageal catheter |
US5125928A (en) | 1989-04-13 | 1992-06-30 | Everest Medical Corporation | Ablation catheter with selectively deployable electrodes |
US4976711A (en) | 1989-04-13 | 1990-12-11 | Everest Medical Corporation | Ablation catheter with selectively deployable electrodes |
US4979948A (en) | 1989-04-13 | 1990-12-25 | Purdue Research Foundation | Method and apparatus for thermally destroying a layer of an organ |
US5078717A (en) * | 1989-04-13 | 1992-01-07 | Everest Medical Corporation | Ablation catheter with selectively deployable electrodes |
US5057107A (en) | 1989-04-13 | 1991-10-15 | Everest Medical Corporation | Ablation catheter with selectively deployable electrodes |
US5151085A (en) | 1989-04-28 | 1992-09-29 | Olympus Optical Co., Ltd. | Apparatus for generating ultrasonic oscillation |
DE3915636C1 (en) | 1989-05-12 | 1990-04-26 | Sass, Wolfgang, Dr. | |
US5006119A (en) * | 1989-05-25 | 1991-04-09 | Engineering & Research Associates, Inc. | Hollow core coaxial catheter |
US5084044A (en) * | 1989-07-14 | 1992-01-28 | Ciron Corporation | Apparatus for endometrial ablation and method of using same |
US5056532A (en) * | 1989-07-25 | 1991-10-15 | Medtronic, Inc. | Esophageal pacing lead |
AU6042690A (en) | 1989-08-01 | 1991-03-11 | Claudio D'orazi | Percutaneous mechanical dilating catheter for cardiac valves and blood vessels |
US5010895A (en) * | 1989-08-03 | 1991-04-30 | Empi, Inc. | Expandable vaginal electrode |
US5057105A (en) | 1989-08-28 | 1991-10-15 | The University Of Kansas Med Center | Hot tip catheter assembly |
WO1991003207A1 (en) | 1989-09-08 | 1991-03-21 | Boston Scientific Corporation | Physiologic low stress angioplasty |
US5045056A (en) * | 1989-09-15 | 1991-09-03 | Behl Robert S | Method and device for thermal ablation of hollow body organs |
US5117828A (en) * | 1989-09-25 | 1992-06-02 | Arzco Medical Electronics, Inc. | Expandable esophageal catheter |
US5035696A (en) | 1990-02-02 | 1991-07-30 | Everest Medical Corporation | Electrosurgical instrument for conducting endoscopic retrograde sphincterotomy |
US5205287A (en) * | 1990-04-26 | 1993-04-27 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
US5122137A (en) | 1990-04-27 | 1992-06-16 | Boston Scientific Corporation | Temperature controlled rf coagulation |
US5236413B1 (en) | 1990-05-07 | 1996-06-18 | Andrew J Feiring | Method and apparatus for inducing the permeation of medication into internal tissue |
US5190540A (en) * | 1990-06-08 | 1993-03-02 | Cardiovascular & Interventional Research Consultants, Inc. | Thermal balloon angioplasty |
US5163938A (en) | 1990-07-19 | 1992-11-17 | Olympus Optical Co., Ltd. | High-frequency surgical treating device for use with endoscope |
US5083565A (en) * | 1990-08-03 | 1992-01-28 | Everest Medical Corporation | Electrosurgical instrument for ablating endocardial tissue |
US5100423A (en) * | 1990-08-21 | 1992-03-31 | Medical Engineering & Development Institute, Inc. | Ablation catheter |
US5428658A (en) * | 1994-01-21 | 1995-06-27 | Photoelectron Corporation | X-ray source with flexible probe |
WO1992004934A1 (en) * | 1990-09-14 | 1992-04-02 | American Medical Systems, Inc. | Combined hyperthermia and dilation catheter |
EP0503019B1 (en) | 1990-10-03 | 1996-03-27 | TRUFFER, Ernest | Snoring prevention device |
US5256138A (en) | 1990-10-04 | 1993-10-26 | The Birtcher Corporation | Electrosurgical handpiece incorporating blade and conductive gas functionality |
US5088979A (en) * | 1990-10-11 | 1992-02-18 | Wilson-Cook Medical Inc. | Method for esophageal invagination and devices useful therein |
US5190541A (en) * | 1990-10-17 | 1993-03-02 | Boston Scientific Corporation | Surgical instrument and method |
WO1992010142A1 (en) | 1990-12-10 | 1992-06-25 | Howmedica Inc. | A device and method for interstitial laser energy delivery |
US5197863A (en) * | 1990-12-28 | 1993-03-30 | The Nash Engineering Company | Bearing fluid distribution systems for liquid ring pumps with rotating lobe liners |
US5094233A (en) * | 1991-01-11 | 1992-03-10 | Brennan Louis G | Turbinate sheath device |
US5368557A (en) | 1991-01-11 | 1994-11-29 | Baxter International Inc. | Ultrasonic ablation catheter device having multiple ultrasound transmission members |
US5720293A (en) | 1991-01-29 | 1998-02-24 | Baxter International Inc. | Diagnostic catheter with memory |
US5370901A (en) | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
US5156151A (en) | 1991-02-15 | 1992-10-20 | Cardiac Pathways Corporation | Endocardial mapping and ablation system and catheter probe |
AU660444B2 (en) | 1991-02-15 | 1995-06-29 | Ingemar H. Lundquist | Torquable catheter and method |
US5345936A (en) | 1991-02-15 | 1994-09-13 | Cardiac Pathways Corporation | Apparatus with basket assembly for endocardial mapping |
US5409453A (en) | 1992-08-12 | 1995-04-25 | Vidamed, Inc. | Steerable medical probe with stylets |
US5465717A (en) | 1991-02-15 | 1995-11-14 | Cardiac Pathways Corporation | Apparatus and Method for ventricular mapping and ablation |
US5160334A (en) | 1991-04-30 | 1992-11-03 | Utah Medical Products, Inc. | Electrosurgical generator and suction apparatus |
US5275610A (en) * | 1991-05-13 | 1994-01-04 | Cook Incorporated | Surgical retractors and method of use |
US5542928A (en) | 1991-05-17 | 1996-08-06 | Innerdyne, Inc. | Method and device for thermal ablation having improved heat transfer |
AU1899292A (en) * | 1991-05-24 | 1993-01-08 | Ep Technologies Inc | Combination monophasic action potential/ablation catheter and high-performance filter system |
FI93607C (en) | 1991-05-24 | 1995-05-10 | John Koivukangas | Cutting Remedy |
US5383917A (en) * | 1991-07-05 | 1995-01-24 | Jawahar M. Desai | Device and method for multi-phase radio-frequency ablation |
US5171299A (en) | 1991-08-02 | 1992-12-15 | Baxter International Inc. | Balloon catheter inflation pressure and diameter display apparatus and method |
AU667055B2 (en) | 1991-09-26 | 1996-03-07 | Hans Bar | Medico-technical process and means for measuring blood irrigation of organs |
US5275608A (en) * | 1991-10-16 | 1994-01-04 | Implemed, Inc. | Generic endoscopic instrument |
US5976129A (en) | 1991-10-18 | 1999-11-02 | Desai; Ashvin H. | Endoscopic surgical instrument |
US5363861A (en) | 1991-11-08 | 1994-11-15 | Ep Technologies, Inc. | Electrode tip assembly with variable resistance to bending |
ATE241938T1 (en) | 1991-11-08 | 2003-06-15 | Boston Scient Ltd | ABLATION ELECTRODE WITH INSULATED TEMPERATURE MEASUREMENT ELEMENT |
US5275162A (en) * | 1991-11-08 | 1994-01-04 | Ep Technologies, Inc. | Valve mapping catheter |
US5328467A (en) | 1991-11-08 | 1994-07-12 | Ep Technologies, Inc. | Catheter having a torque transmitting sleeve |
US5257451A (en) | 1991-11-08 | 1993-11-02 | Ep Technologies, Inc. | Method of making durable sleeve for enclosing a bendable electrode tip assembly |
EP0566731A4 (en) | 1991-11-08 | 1995-02-22 | Ep Technologies | Radiofrequency ablation with phase sensitive power detection. |
US5383874A (en) | 1991-11-08 | 1995-01-24 | Ep Technologies, Inc. | Systems for identifying catheters and monitoring their use |
US5197964A (en) * | 1991-11-12 | 1993-03-30 | Everest Medical Corporation | Bipolar instrument utilizing one stationary electrode and one movable electrode |
US5197963A (en) | 1991-12-02 | 1993-03-30 | Everest Medical Corporation | Electrosurgical instrument with extendable sheath for irrigation and aspiration |
US5192297A (en) * | 1991-12-31 | 1993-03-09 | Medtronic, Inc. | Apparatus and method for placement and implantation of a stent |
US6355032B1 (en) * | 1995-06-07 | 2002-03-12 | Arthrocare Corporation | Systems and methods for selective electrosurgical treatment of body structures |
US5902272A (en) * | 1992-01-07 | 1999-05-11 | Arthrocare Corporation | Planar ablation probe and method for electrosurgical cutting and ablation |
US6053172A (en) | 1995-06-07 | 2000-04-25 | Arthrocare Corporation | Systems and methods for electrosurgical sinus surgery |
US5275169A (en) * | 1992-01-15 | 1994-01-04 | Innovation Associates | Apparatus and method for determining physiologic characteristics of body lumens |
US5242441A (en) | 1992-02-24 | 1993-09-07 | Boaz Avitall | Deflectable catheter with rotatable tip electrode |
US5263493A (en) | 1992-02-24 | 1993-11-23 | Boaz Avitall | Deflectable loop electrode array mapping and ablation catheter for cardiac chambers |
US5480644A (en) * | 1992-02-28 | 1996-01-02 | Jsf Consultants Ltd. | Use of injectable biomaterials for the repair and augmentation of the anal sphincters |
US5281216A (en) * | 1992-03-31 | 1994-01-25 | Valleylab, Inc. | Electrosurgical bipolar treating apparatus |
WO1993020886A1 (en) | 1992-04-13 | 1993-10-28 | Ep Technologies, Inc. | Articulated systems for cardiac ablation |
WO1993020768A1 (en) | 1992-04-13 | 1993-10-28 | Ep Technologies, Inc. | Steerable microwave antenna systems for cardiac ablation |
US5281217A (en) * | 1992-04-13 | 1994-01-25 | Ep Technologies, Inc. | Steerable antenna systems for cardiac ablation that minimize tissue damage and blood coagulation due to conductive heating patterns |
US5314466A (en) | 1992-04-13 | 1994-05-24 | Ep Technologies, Inc. | Articulated unidirectional microwave antenna systems for cardiac ablation |
US5562720A (en) | 1992-05-01 | 1996-10-08 | Vesta Medical, Inc. | Bipolar/monopolar endometrial ablation device and method |
US5277201A (en) * | 1992-05-01 | 1994-01-11 | Vesta Medical, Inc. | Endometrial ablation apparatus and method |
US5443470A (en) | 1992-05-01 | 1995-08-22 | Vesta Medical, Inc. | Method and apparatus for endometrial ablation |
US5255679A (en) | 1992-06-02 | 1993-10-26 | Cardiac Pathways Corporation | Endocardial catheter for mapping and/or ablation with an expandable basket structure having means for providing selective reinforcement and pressure sensing mechanism for use therewith, and method |
US5281218A (en) * | 1992-06-05 | 1994-01-25 | Cardiac Pathways Corporation | Catheter having needle electrode for radiofrequency ablation |
US5324284A (en) | 1992-06-05 | 1994-06-28 | Cardiac Pathways, Inc. | Endocardial mapping and ablation system utilizing a separately controlled ablation catheter and method |
US5254126A (en) | 1992-06-24 | 1993-10-19 | Ethicon, Inc. | Endoscopic suture punch |
US5411025A (en) | 1992-06-30 | 1995-05-02 | Cordis Webster, Inc. | Cardiovascular catheter with laterally stable basket-shaped electrode array |
WO1994002077A2 (en) * | 1992-07-15 | 1994-02-03 | Angelase, Inc. | Ablation catheter system |
US5672153A (en) | 1992-08-12 | 1997-09-30 | Vidamed, Inc. | Medical probe device and method |
US5549644A (en) | 1992-08-12 | 1996-08-27 | Vidamed, Inc. | Transurethral needle ablation device with cystoscope and method for treatment of the prostate |
US5470308A (en) | 1992-08-12 | 1995-11-28 | Vidamed, Inc. | Medical probe with biopsy stylet |
US5720718A (en) | 1992-08-12 | 1998-02-24 | Vidamed, Inc. | Medical probe apparatus with enhanced RF, resistance heating, and microwave ablation capabilities |
US5456662A (en) | 1993-02-02 | 1995-10-10 | Edwards; Stuart D. | Method for reducing snoring by RF ablation of the uvula |
US5556377A (en) | 1992-08-12 | 1996-09-17 | Vidamed, Inc. | Medical probe apparatus with laser and/or microwave monolithic integrated circuit probe |
US5542916A (en) * | 1992-08-12 | 1996-08-06 | Vidamed, Inc. | Dual-channel RF power delivery system |
US5514131A (en) | 1992-08-12 | 1996-05-07 | Stuart D. Edwards | Method for the ablation treatment of the uvula |
US5486161A (en) * | 1993-02-02 | 1996-01-23 | Zomed International | Medical probe device and method |
US5484400A (en) * | 1992-08-12 | 1996-01-16 | Vidamed, Inc. | Dual channel RF delivery system |
US5772597A (en) | 1992-09-14 | 1998-06-30 | Sextant Medical Corporation | Surgical tool end effector |
US5293869A (en) * | 1992-09-25 | 1994-03-15 | Ep Technologies, Inc. | Cardiac probe with dynamic support for maintaining constant surface contact during heart systole and diastole |
US5309910A (en) * | 1992-09-25 | 1994-05-10 | Ep Technologies, Inc. | Cardiac mapping and ablation systems |
US5313943A (en) | 1992-09-25 | 1994-05-24 | Ep Technologies, Inc. | Catheters and methods for performing cardiac diagnosis and treatment |
US5401272A (en) * | 1992-09-25 | 1995-03-28 | Envision Surgical Systems, Inc. | Multimodality probe with extendable bipolar electrodes |
US5471982A (en) | 1992-09-29 | 1995-12-05 | Ep Technologies, Inc. | Cardiac mapping and ablation systems |
US5416020A (en) | 1992-09-29 | 1995-05-16 | Bio-Technical Resources | Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid |
US5334196A (en) | 1992-10-05 | 1994-08-02 | United States Surgical Corporation | Endoscopic fastener remover |
WO1994007446A1 (en) | 1992-10-05 | 1994-04-14 | Boston Scientific Corporation | Device and method for heating tissue |
US5305696A (en) * | 1992-10-05 | 1994-04-26 | Mendenhall Robert Lamar | Process and system for treating contaminated particulate soil compositions |
US5415657A (en) | 1992-10-13 | 1995-05-16 | Taymor-Luria; Howard | Percutaneous vascular sealing method |
US5360432A (en) | 1992-10-16 | 1994-11-01 | Shturman Cardiology Systems, Inc. | Abrasive drive shaft device for directional rotational atherectomy |
US5342357A (en) | 1992-11-13 | 1994-08-30 | American Cardiac Ablation Co., Inc. | Fluid cooled electrosurgical cauterization system |
WO1994010924A1 (en) * | 1992-11-13 | 1994-05-26 | American Cardiac Ablation Co., Inc. | Fluid cooled electrosurgical probe |
US5348554A (en) | 1992-12-01 | 1994-09-20 | Cardiac Pathways Corporation | Catheter for RF ablation with cooled electrode |
US5409483A (en) * | 1993-01-22 | 1995-04-25 | Jeffrey H. Reese | Direct visualization surgical probe |
DE4303882C2 (en) | 1993-02-10 | 1995-02-09 | Kernforschungsz Karlsruhe | Combination instrument for separation and coagulation for minimally invasive surgery |
US5636634A (en) | 1993-03-16 | 1997-06-10 | Ep Technologies, Inc. | Systems using guide sheaths for introducing, deploying, and stabilizing cardiac mapping and ablation probes |
US5330488A (en) | 1993-03-23 | 1994-07-19 | Goldrath Milton H | Verres needle suturing kit |
US5403311A (en) * | 1993-03-29 | 1995-04-04 | Boston Scientific Corporation | Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue |
US5336222A (en) * | 1993-03-29 | 1994-08-09 | Boston Scientific Corporation | Integrated catheter for diverse in situ tissue therapy |
US5375594A (en) | 1993-03-29 | 1994-12-27 | Cueva; Roberto A. | Removable medical electrode system |
CA2136988A1 (en) | 1993-04-07 | 1994-10-13 | Mir A. Imran | Apparatus and method for ventricular mapping and ablation |
US5365945A (en) | 1993-04-13 | 1994-11-22 | Halstrom Leonard W | Adjustable dental applicance for treatment of snoring and obstructive sleep apnea |
US5716410A (en) * | 1993-04-30 | 1998-02-10 | Scimed Life Systems, Inc. | Temporary stent and method of use |
US6832996B2 (en) | 1995-06-07 | 2004-12-21 | Arthrocare Corporation | Electrosurgical systems and methods for treating tissue |
ATE284650T1 (en) | 1993-06-10 | 2005-01-15 | Mir A Imran | URETHRAL DEVICE FOR ABLATION USING HIGH FREQUENCY |
US5533958A (en) * | 1993-06-17 | 1996-07-09 | Wilk; Peter J. | Intrapericardial assist device and associated method |
US5800334A (en) * | 1993-06-17 | 1998-09-01 | Wilk; Peter J. | Intrapericardial assist device and associated method |
US5860974A (en) * | 1993-07-01 | 1999-01-19 | Boston Scientific Corporation | Heart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft |
DE4323585A1 (en) | 1993-07-14 | 1995-01-19 | Delma Elektro Med App | Bipolar high-frequency surgical instrument |
US5738096A (en) * | 1993-07-20 | 1998-04-14 | Biosense, Inc. | Cardiac electromechanics |
US5400783A (en) * | 1993-10-12 | 1995-03-28 | Cardiac Pathways Corporation | Endocardial mapping apparatus with rotatable arm and method |
US5582609A (en) | 1993-10-14 | 1996-12-10 | Ep Technologies, Inc. | Systems and methods for forming large lesions in body tissue using curvilinear electrode elements |
WO1995010322A1 (en) * | 1993-10-15 | 1995-04-20 | Ep Technologies, Inc. | Creating complex lesion patterns in body tissue |
US5797903A (en) | 1996-04-12 | 1998-08-25 | Ep Technologies, Inc. | Tissue heating and ablation systems and methods using porous electrode structures with electrically conductive surfaces |
WO1995010320A1 (en) | 1993-10-15 | 1995-04-20 | Ep Technologies, Inc. | Device for lengthening cardiac conduction pathways |
US5433739A (en) | 1993-11-02 | 1995-07-18 | Sluijter; Menno E. | Method and apparatus for heating an intervertebral disc for relief of back pain |
US5458597A (en) | 1993-11-08 | 1995-10-17 | Zomed International | Device for treating cancer and non-malignant tumors and methods |
US5472441A (en) | 1993-11-08 | 1995-12-05 | Zomed International | Device for treating cancer and non-malignant tumors and methods |
US5536267A (en) | 1993-11-08 | 1996-07-16 | Zomed International | Multiple electrode ablation apparatus |
US5599345A (en) * | 1993-11-08 | 1997-02-04 | Zomed International, Inc. | RF treatment apparatus |
US5507743A (en) * | 1993-11-08 | 1996-04-16 | Zomed International | Coiled RF electrode treatment apparatus |
US5683384A (en) | 1993-11-08 | 1997-11-04 | Zomed | Multiple antenna ablation apparatus |
CA2176149C (en) | 1993-11-10 | 2001-02-27 | Richard S. Jaraczewski | Electrode array catheter |
US5730127A (en) | 1993-12-03 | 1998-03-24 | Avitall; Boaz | Mapping and ablation catheter system |
WO1995020345A1 (en) * | 1994-01-28 | 1995-08-03 | Ep Technologies, Inc. | Minimizing blood contact in cardiac tissue measurements |
US5423812A (en) * | 1994-01-31 | 1995-06-13 | Ellman; Alan G. | Electrosurgical stripping electrode for palatopharynx tissue |
US5403310A (en) | 1994-02-04 | 1995-04-04 | Fischer; Nathan R. | Instrument for electro-surgical excisor for the transformation zone of the uterine cervix and method of using same |
US5517989A (en) * | 1994-04-01 | 1996-05-21 | Cardiometrics, Inc. | Guidewire assembly |
US5458596A (en) | 1994-05-06 | 1995-10-17 | Dorsal Orthopedic Corporation | Method and apparatus for controlled contraction of soft tissue |
US6405732B1 (en) | 1994-06-24 | 2002-06-18 | Curon Medical, Inc. | Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors |
US6056744A (en) | 1994-06-24 | 2000-05-02 | Conway Stuart Medical, Inc. | Sphincter treatment apparatus |
US5800429A (en) | 1994-06-24 | 1998-09-01 | Somnus Medical Technologies, Inc. | Noninvasive apparatus for ablating turbinates |
US6092528A (en) * | 1994-06-24 | 2000-07-25 | Edwards; Stuart D. | Method to treat esophageal sphincters |
US5505730A (en) * | 1994-06-24 | 1996-04-09 | Stuart D. Edwards | Thin layer ablation apparatus |
US5823197A (en) | 1994-06-24 | 1998-10-20 | Somnus Medical Technologies, Inc. | Method for internal ablation of turbinates |
US5681308A (en) * | 1994-06-24 | 1997-10-28 | Stuart D. Edwards | Ablation apparatus for cardiac chambers |
US6009877A (en) * | 1994-06-24 | 2000-01-04 | Edwards; Stuart D. | Method for treating a sphincter |
US6044846A (en) * | 1994-06-24 | 2000-04-04 | Edwards; Stuart D. | Method to treat esophageal sphincters |
US5575788A (en) | 1994-06-24 | 1996-11-19 | Stuart D. Edwards | Thin layer ablation apparatus |
EP0768842A4 (en) | 1994-06-27 | 1998-05-13 | Ep Technologies | Systems and methods for sensing temperature within the body |
ATE207651T1 (en) * | 1994-07-12 | 2001-11-15 | Photoelectron Corp | X-RAY DEVICE FOR DOSING A PREDETERMINED FLOW OF RADIATION TO INNER SURFACES OF BODY CAVIES |
US5566221A (en) | 1994-07-12 | 1996-10-15 | Photoelectron Corporation | Apparatus for applying a predetermined x-radiation flux to an interior surface of a body cavity |
US5454782A (en) | 1994-08-11 | 1995-10-03 | Perkins; Rodney C. | Translumenal circumferential energy delivery device |
JP2802244B2 (en) | 1994-08-29 | 1998-09-24 | オリンパス光学工業株式会社 | Endoscope sheath |
US5609151A (en) * | 1994-09-08 | 1997-03-11 | Medtronic, Inc. | Method for R-F ablation |
US5524622A (en) | 1994-09-20 | 1996-06-11 | Oregon Health Sciences University | Non-invasive method of determining inflammation of the gastrointestinal tract |
US5558673A (en) | 1994-09-30 | 1996-09-24 | Vidamed, Inc. | Medical probe device and method having a flexible resilient tape stylet |
US5571116A (en) | 1994-10-02 | 1996-11-05 | United States Surgical Corporation | Non-invasive treatment of gastroesophageal reflux disease |
US6142994A (en) | 1994-10-07 | 2000-11-07 | Ep Technologies, Inc. | Surgical method and apparatus for positioning a diagnostic a therapeutic element within the body |
US5514130A (en) * | 1994-10-11 | 1996-05-07 | Dorsal Med International | RF apparatus for controlled depth ablation of soft tissue |
US5840077A (en) | 1994-10-18 | 1998-11-24 | Blairden Precision Instruments, Inc. | Uterine manipulating assembly for laparoscopic hysterectomy |
US5779835A (en) * | 1994-11-21 | 1998-07-14 | Cms Gilbreth Packaging Systems, Inc. | Method and apparatus for applying labels to articles using bottom feed chain conveyor |
US5588960A (en) | 1994-12-01 | 1996-12-31 | Vidamed, Inc. | Transurethral needle delivery device with cystoscope and method for treatment of urinary incontinence |
US5868740A (en) | 1995-03-24 | 1999-02-09 | Board Of Regents-Univ Of Nebraska | Method for volumetric tissue ablation |
CH688174A5 (en) * | 1995-03-28 | 1997-06-13 | Norman Godin | Prosthesis to oppose the gastric reflux into the esophagus. |
US5752522A (en) | 1995-05-04 | 1998-05-19 | Cardiovascular Concepts, Inc. | Lesion diameter measurement catheter and method |
US5651788A (en) | 1995-05-17 | 1997-07-29 | C.R. Bard, Inc. | Mucosectomy process and device |
US5895355A (en) * | 1995-05-23 | 1999-04-20 | Cardima, Inc. | Over-the-wire EP catheter |
US6363937B1 (en) * | 1995-06-07 | 2002-04-02 | Arthrocare Corporation | System and methods for electrosurgical treatment of the digestive system |
US5709224A (en) * | 1995-06-07 | 1998-01-20 | Radiotherapeutics Corporation | Method and device for permanent vessel occlusion |
US5702438A (en) | 1995-06-08 | 1997-12-30 | Avitall; Boaz | Expandable recording and ablation catheter system |
WO1997004702A1 (en) | 1995-07-28 | 1997-02-13 | Ep Technologies, Inc. | Systems and methods for conducting electrophysiological testing using high-voltage energy pulses to stun heart tissue |
US6023638A (en) | 1995-07-28 | 2000-02-08 | Scimed Life Systems, Inc. | System and method for conducting electrophysiological testing using high-voltage energy pulses to stun tissue |
US5624439A (en) * | 1995-08-18 | 1997-04-29 | Somnus Medical Technologies, Inc. | Method and apparatus for treatment of air way obstructions |
JP4020965B2 (en) * | 1995-10-06 | 2007-12-12 | フォトエレクトロン コーポレイション | Device for irradiating the inner surface of a body cavity with X-rays |
US5591195A (en) * | 1995-10-30 | 1997-01-07 | Taheri; Syde | Apparatus and method for engrafting a blood vessel |
US5823955A (en) | 1995-11-20 | 1998-10-20 | Medtronic Cardiorhythm | Atrioventricular valve tissue ablation catheter and method |
NL1001890C2 (en) | 1995-12-13 | 1997-06-17 | Cordis Europ | Catheter with plate-shaped electrode array. |
US5830213A (en) | 1996-04-12 | 1998-11-03 | Ep Technologies, Inc. | Systems for heating and ablating tissue using multifunctional electrode structures |
US5836874A (en) * | 1996-04-08 | 1998-11-17 | Ep Technologies, Inc. | Multi-function electrode structures for electrically analyzing and heating body tissue |
US5871483A (en) * | 1996-01-19 | 1999-02-16 | Ep Technologies, Inc. | Folding electrode structures |
US5925038A (en) * | 1996-01-19 | 1999-07-20 | Ep Technologies, Inc. | Expandable-collapsible electrode structures for capacitive coupling to tissue |
US5904711A (en) | 1996-02-08 | 1999-05-18 | Heartport, Inc. | Expandable thoracoscopic defibrillation catheter system and method |
US6036687A (en) * | 1996-03-05 | 2000-03-14 | Vnus Medical Technologies, Inc. | Method and apparatus for treating venous insufficiency |
US6033397A (en) * | 1996-03-05 | 2000-03-07 | Vnus Medical Technologies, Inc. | Method and apparatus for treating esophageal varices |
JP4060887B2 (en) | 1996-03-05 | 2008-03-12 | ヴィナス メディカル テクノロジーズ インコーポレイテッド | Vascular catheter utilization system for heating tissue |
US6152899A (en) | 1996-03-05 | 2000-11-28 | Vnus Medical Technologies, Inc. | Expandable catheter having improved electrode design, and method for applying energy |
US5863291A (en) * | 1996-04-08 | 1999-01-26 | Cardima, Inc. | Linear ablation assembly |
US5769880A (en) * | 1996-04-12 | 1998-06-23 | Novacept | Moisture transport system for contact electrocoagulation |
US6013053A (en) * | 1996-05-17 | 2000-01-11 | Qlt Photo Therapeutics Inc. | Balloon catheter for photodynamic therapy |
WO1997043971A2 (en) | 1996-05-22 | 1997-11-27 | Somnus Medical Technologies, Inc. | Method and apparatus for ablating turbinates |
DE19626408A1 (en) | 1996-07-01 | 1998-01-08 | Berchtold Gmbh & Co Geb | Trocar for laparoscopic operations |
SE509241C2 (en) | 1996-07-18 | 1998-12-21 | Radinvent Ab | Devices for electrodynamic radiation therapy of tumor diseases |
US5957920A (en) | 1997-08-28 | 1999-09-28 | Isothermix, Inc. | Medical instruments and techniques for treatment of urinary incontinence |
US5820629A (en) * | 1996-08-13 | 1998-10-13 | Medtronic, Inc. | Intimal lining transition device and endarterectomy method |
US6039701A (en) | 1996-09-05 | 2000-03-21 | Ob Inovations, Inc. | Method and apparatus for monitoring cervical diameter |
WO1998010822A1 (en) | 1996-09-16 | 1998-03-19 | Green Philip S | System and method for endosurgery employing conjoint operation of an endoscope and endosurgical instrument |
US5891134A (en) * | 1996-09-24 | 1999-04-06 | Goble; Colin | System and method for applying thermal energy to tissue |
US6464697B1 (en) | 1998-02-19 | 2002-10-15 | Curon Medical, Inc. | Stomach and adjoining tissue regions in the esophagus |
US6016437A (en) * | 1996-10-21 | 2000-01-18 | Irvine Biomedical, Inc. | Catheter probe system with inflatable soft shafts |
US5827268A (en) | 1996-10-30 | 1998-10-27 | Hearten Medical, Inc. | Device for the treatment of patent ductus arteriosus and method of using the device |
US6091995A (en) | 1996-11-08 | 2000-07-18 | Surx, Inc. | Devices, methods, and systems for shrinking tissues |
US6073052A (en) | 1996-11-15 | 2000-06-06 | Zelickson; Brian D. | Device and method for treatment of gastroesophageal reflux disease |
JP2001505100A (en) | 1996-11-21 | 2001-04-17 | ボストン サイエンティフィック コーポレイション | Mucosal detachment using light |
US5910104A (en) * | 1996-12-26 | 1999-06-08 | Cryogen, Inc. | Cryosurgical probe with disposable sheath |
US5916213A (en) | 1997-02-04 | 1999-06-29 | Medtronic, Inc. | Systems and methods for tissue mapping and ablation |
US6338726B1 (en) | 1997-02-06 | 2002-01-15 | Vidacare, Inc. | Treating urinary and other body strictures |
US5882329A (en) | 1997-02-12 | 1999-03-16 | Prolifix Medical, Inc. | Apparatus and method for removing stenotic material from stents |
DE69823406T2 (en) * | 1997-02-21 | 2005-01-13 | Medtronic AVE, Inc., Santa Rosa | X-ray device provided with a strain structure for local irradiation of the interior of a body |
US5833688A (en) | 1997-02-24 | 1998-11-10 | Boston Scientific Corporation | Sensing temperature with plurality of catheter sensors |
US6547787B1 (en) * | 1997-03-13 | 2003-04-15 | Biocardia, Inc. | Drug delivery catheters that attach to tissue and methods for their use |
US7425212B1 (en) | 1998-06-10 | 2008-09-16 | Asthmatx, Inc. | Devices for modification of airways by transfer of energy |
US6634363B1 (en) | 1997-04-07 | 2003-10-21 | Broncus Technologies, Inc. | Methods of treating lungs having reversible obstructive pulmonary disease |
US5876340A (en) * | 1997-04-17 | 1999-03-02 | Irvine Biomedical, Inc. | Ablation apparatus with ultrasonic imaging capabilities |
US6012457A (en) | 1997-07-08 | 2000-01-11 | The Regents Of The University Of California | Device and method for forming a circumferential conduction block in a pulmonary vein |
US6024740A (en) | 1997-07-08 | 2000-02-15 | The Regents Of The University Of California | Circumferential ablation device assembly |
USH2037H1 (en) | 1997-05-14 | 2002-07-02 | David C. Yates | Electrosurgical hemostatic device including an anvil |
US6027499A (en) * | 1997-05-23 | 2000-02-22 | Fiber-Tech Medical, Inc. (Assignee Of Jennifer B. Cartledge) | Method and apparatus for cryogenic spray ablation of gastrointestinal mucosa |
JPH10328203A (en) | 1997-06-05 | 1998-12-15 | Asahi Optical Co Ltd | Cautery for endoscope |
US6514249B1 (en) | 1997-07-08 | 2003-02-04 | Atrionix, Inc. | Positioning system and method for orienting an ablation element within a pulmonary vein ostium |
US5984861A (en) | 1997-09-29 | 1999-11-16 | Boston Scientific Corporation | Endofluorescence imaging module for an endoscope |
US6059719A (en) | 1997-08-06 | 2000-05-09 | Olympus Optical Co., Ltd. | Endoscope system |
AU712738B2 (en) * | 1997-09-24 | 1999-11-18 | Eclipse Surgical Technologies, Inc. | Steerable catheter |
US6468272B1 (en) | 1997-10-10 | 2002-10-22 | Scimed Life Systems, Inc. | Surgical probe for supporting diagnostic and therapeutic elements in contact with tissue in or around body orifices |
US6451581B1 (en) * | 1997-10-28 | 2002-09-17 | E.I. Du Pont De Nemours And Company | Plant branched-chain amino acid biosynthetic enzymes |
US6917834B2 (en) | 1997-12-03 | 2005-07-12 | Boston Scientific Scimed, Inc. | Devices and methods for creating lesions in endocardial and surrounding tissue to isolate focal arrhythmia substrates |
US6440128B1 (en) * | 1998-01-14 | 2002-08-27 | Curon Medical, Inc. | Actively cooled electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions |
WO1999035988A1 (en) | 1998-01-14 | 1999-07-22 | Conway-Stuart Medical, Inc. | Electrosurgical device for sphincter treatment |
JP2002508989A (en) | 1998-01-14 | 2002-03-26 | キューロン メディカル,インコーポレイテッド | Electrosurgical instruments and methods for treating gastroesophageal reflux disease (GERD) |
AU2317899A (en) * | 1998-01-14 | 1999-08-02 | Conway-Stuart Medical, Inc. | Gerd treatment apparatus and method |
US7329254B2 (en) | 1998-02-19 | 2008-02-12 | Curon Medical, Inc. | Systems and methods for treating dysfunctions in the intestines and rectum that adapt to the anatomic form and structure of different individuals |
US6258087B1 (en) * | 1998-02-19 | 2001-07-10 | Curon Medical, Inc. | Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions |
US6273886B1 (en) * | 1998-02-19 | 2001-08-14 | Curon Medical, Inc. | Integrated tissue heating and cooling apparatus |
US6325798B1 (en) | 1998-02-19 | 2001-12-04 | Curon Medical, Inc. | Vacuum-assisted systems and methods for treating sphincters and adjoining tissue regions |
US6790207B2 (en) | 1998-06-04 | 2004-09-14 | Curon Medical, Inc. | Systems and methods for applying a selected treatment agent into contact with tissue to treat disorders of the gastrointestinal tract |
US6402744B2 (en) | 1998-02-19 | 2002-06-11 | Curon Medical, Inc. | Systems and methods for forming composite lesions to treat dysfunction in sphincters and adjoining tissue regions |
US7165551B2 (en) | 1998-02-19 | 2007-01-23 | Curon Medical, Inc. | Apparatus to detect and treat aberrant myoelectric activity |
US6358245B1 (en) | 1998-02-19 | 2002-03-19 | Curon Medical, Inc. | Graphical user interface for association with an electrode structure deployed in contact with a tissue region |
US6355031B1 (en) * | 1998-02-19 | 2002-03-12 | Curon Medical, Inc. | Control systems for multiple electrode arrays to create lesions in tissue regions at or near a sphincter |
US6091993A (en) * | 1998-02-19 | 2000-07-18 | American Medical Systems, Inc. | Methods and apparatus for an electrode balloon |
US6645201B1 (en) | 1998-02-19 | 2003-11-11 | Curon Medical, Inc. | Systems and methods for treating dysfunctions in the intestines and rectum |
US6423058B1 (en) * | 1998-02-19 | 2002-07-23 | Curon Medical, Inc. | Assemblies to visualize and treat sphincters and adjoining tissue regions |
US7468060B2 (en) | 1998-02-19 | 2008-12-23 | Respiratory Diagnostic, Inc. | Systems and methods for treating obesity and other gastrointestinal conditions |
US6860878B2 (en) | 1998-02-24 | 2005-03-01 | Endovia Medical Inc. | Interchangeable instrument |
US6169926B1 (en) | 1998-02-27 | 2001-01-02 | James A. Baker | RF electrode array for low-rate collagen shrinkage in capsular shift procedures and methods of use |
AU754424B2 (en) | 1998-02-27 | 2002-11-14 | Curon Medical, Inc. | Apparatus to electrosurgically treat esophageal sphincters |
US20030135206A1 (en) | 1998-02-27 | 2003-07-17 | Curon Medical, Inc. | Method for treating a sphincter |
US6096054A (en) * | 1998-03-05 | 2000-08-01 | Scimed Life Systems, Inc. | Expandable atherectomy burr and method of ablating an occlusion from a patient's blood vessel |
CA2320109A1 (en) | 1998-03-06 | 1999-09-10 | Curon Medical, Inc. | Apparatus to electrosurgically treat esophageal sphincters |
US5951550A (en) | 1998-03-11 | 1999-09-14 | Utah Medical Products, Inc. | Endocervical conization electrode apparatus |
US20030109837A1 (en) | 1998-03-13 | 2003-06-12 | Mcbride-Sakal Marcia | Brush to clear occluded stents |
US6146149A (en) | 1998-03-30 | 2000-11-14 | Lucent Technologies Inc | Building entrance protector with replaceable fusible link assembly |
US6325800B1 (en) | 1998-04-15 | 2001-12-04 | Boston Scientific Corporation | Electro-cautery catheter |
US6432104B1 (en) * | 1998-04-15 | 2002-08-13 | Scimed Life Systems, Inc. | Electro-cautery catherer |
US20020065542A1 (en) | 1998-04-22 | 2002-05-30 | Ronald G. Lax | Method and apparatus for treating an aneurysm |
WO1999055245A1 (en) | 1998-04-30 | 1999-11-04 | Edwards Stuart D | Electrosurgical sphincter treatment apparatus |
US6740082B2 (en) | 1998-12-29 | 2004-05-25 | John H. Shadduck | Surgical instruments for treating gastro-esophageal reflux |
US6837885B2 (en) | 1998-05-22 | 2005-01-04 | Scimed Life Systems, Inc. | Surgical probe for supporting inflatable therapeutic devices in contact with tissue in or around body orifices and within tumors |
US6802841B2 (en) | 1998-06-04 | 2004-10-12 | Curon Medical, Inc. | Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction |
US5997534A (en) * | 1998-06-08 | 1999-12-07 | Tu; Hosheng | Medical ablation device and methods thereof |
US6322559B1 (en) | 1998-07-06 | 2001-11-27 | Vnus Medical Technologies, Inc. | Electrode catheter having coil structure |
JP3919947B2 (en) | 1998-07-09 | 2007-05-30 | アルフレッサファーマ株式会社 | Microwave surgical electrode device |
US6296639B1 (en) | 1999-02-12 | 2001-10-02 | Novacept | Apparatuses and methods for interstitial tissue removal |
US6112123A (en) * | 1998-07-28 | 2000-08-29 | Endonetics, Inc. | Device and method for ablation of tissue |
US6572639B1 (en) * | 1998-07-31 | 2003-06-03 | Surx, Inc. | Interspersed heating/cooling to shrink tissues for incontinence |
US6156060A (en) | 1998-07-31 | 2000-12-05 | Surx, Inc. | Static devices and methods to shrink tissues for incontinence |
US6183468B1 (en) | 1998-09-10 | 2001-02-06 | Scimed Life Systems, Inc. | Systems and methods for controlling power in an electrosurgical probe |
US6053913A (en) * | 1998-09-10 | 2000-04-25 | Tu; Lily Chen | Rapid exchange stented balloon catheter having ablation capabilities |
US6245065B1 (en) | 1998-09-10 | 2001-06-12 | Scimed Life Systems, Inc. | Systems and methods for controlling power in an electrosurgical probe |
WO2000019926A1 (en) * | 1998-10-05 | 2000-04-13 | Scimed Life Systems, Inc. | Large area thermal ablation |
DE69940706D1 (en) | 1998-10-23 | 2009-05-20 | Covidien Ag | Endoscopic bipolar electrosurgical forceps |
US6123718A (en) * | 1998-11-02 | 2000-09-26 | Polymerex Medical Corp. | Balloon catheter |
US6102908A (en) * | 1999-01-04 | 2000-08-15 | Tu; Lily Chen | Rotatable apparatus having ablation capabilities |
GB2347083B (en) | 1999-02-24 | 2001-06-27 | Samuel George | Surgical biopsy instrument |
US20020058956A1 (en) | 1999-09-17 | 2002-05-16 | John S. Honeycutt | Rotational atherectomy system with side balloon |
US6409723B1 (en) | 1999-04-02 | 2002-06-25 | Stuart D. Edwards | Treating body tissue by applying energy and substances |
US6425877B1 (en) * | 1999-04-02 | 2002-07-30 | Novasys Medical, Inc. | Treatment of tissue in the digestive circulatory respiratory urinary and reproductive systems |
US6149647A (en) | 1999-04-19 | 2000-11-21 | Tu; Lily Chen | Apparatus and methods for tissue treatment |
US6162237A (en) * | 1999-04-19 | 2000-12-19 | Chan; Winston Kam Yew | Temporary intravascular stent for use in retrohepatic IVC or hepatic vein injury |
US6138046A (en) | 1999-04-20 | 2000-10-24 | Miravant Medical Technologies, Inc. | Dosimetry probe |
WO2000066017A1 (en) * | 1999-05-04 | 2000-11-09 | Curon Medical, Inc. | Electrodes for creating lesions in tissue regions at or near a sphincter |
WO2000069376A1 (en) | 1999-05-18 | 2000-11-23 | Silhouette Medical Inc. | Surgical weight control device |
US6237355B1 (en) | 1999-06-25 | 2001-05-29 | Cryogen, Inc. | Precooled cryogenic ablation system |
US7160312B2 (en) | 1999-06-25 | 2007-01-09 | Usgi Medical, Inc. | Implantable artificial partition and methods of use |
US6238392B1 (en) * | 1999-06-29 | 2001-05-29 | Ethicon Endo-Surgery, Inc. | Bipolar electrosurgical instrument including a plurality of balloon electrodes |
US6358197B1 (en) * | 1999-08-13 | 2002-03-19 | Enteric Medical Technologies, Inc. | Apparatus for forming implants in gastrointestinal tract and kit for use therewith |
US6575966B2 (en) | 1999-08-23 | 2003-06-10 | Cryocath Technologies Inc. | Endovascular cryotreatment catheter |
CA2388376A1 (en) | 1999-09-08 | 2001-03-15 | Curon Medical, Inc. | Systems and methods for monitoring and controlling use of medical devices |
CA2384273A1 (en) | 1999-09-08 | 2001-03-15 | Curon Medical, Inc. | Systems and methods for monitoring and controlling use of medical devices |
WO2001017452A1 (en) | 1999-09-08 | 2001-03-15 | Curon Medical, Inc. | System for controlling a family of treatment devices |
WO2001022897A1 (en) | 1999-09-28 | 2001-04-05 | Novasys Medical, Inc. | Treatment of tissue by application of energy and drugs |
US6287304B1 (en) | 1999-10-15 | 2001-09-11 | Neothermia Corporation | Interstitial cauterization of tissue volumes with electrosurgically deployed electrodes |
AU780278B2 (en) | 1999-11-16 | 2005-03-10 | Covidien Lp | System and method of treating abnormal tissue in the human esophagus |
US20060095032A1 (en) | 1999-11-16 | 2006-05-04 | Jerome Jackson | Methods and systems for determining physiologic characteristics for treatment of the esophagus |
US20040215235A1 (en) | 1999-11-16 | 2004-10-28 | Barrx, Inc. | Methods and systems for determining physiologic characteristics for treatment of the esophagus |
US20040215296A1 (en) | 1999-11-16 | 2004-10-28 | Barrx, Inc. | System and method for treating abnormal epithelium in an esophagus |
JP2004512856A (en) | 1999-12-23 | 2004-04-30 | シーラス、コーポレイション | Imaging and therapeutic ultrasound transducers |
US6547776B1 (en) * | 2000-01-03 | 2003-04-15 | Curon Medical, Inc. | Systems and methods for treating tissue in the crura |
US6689131B2 (en) | 2001-03-08 | 2004-02-10 | Tissuelink Medical, Inc. | Electrosurgical device having a tissue reduction sensor |
US6544226B1 (en) * | 2000-03-13 | 2003-04-08 | Curon Medical, Inc. | Operative devices that can be removably fitted on catheter bodies to treat tissue regions in the body |
EP1642544B1 (en) * | 2000-05-03 | 2009-04-08 | C.R.Bard, Inc. | Apparatus for mapping and ablation in electrophysiology procedures |
AU2001263221A1 (en) | 2000-05-16 | 2001-11-26 | Atrionix, Inc. | Deflectable tip catheter with guidewire tracking mechanism |
US6743239B1 (en) | 2000-05-25 | 2004-06-01 | St. Jude Medical, Inc. | Devices with a bendable tip for medical procedures |
JP2001358214A (en) * | 2000-06-15 | 2001-12-26 | Mitsubishi Electric Corp | Semiconductor device and its manufacturing method |
US6454790B1 (en) * | 2000-07-21 | 2002-09-24 | Ceramoptec Industries, Inc. | Treatment for Barrett's syndrome |
US7678106B2 (en) | 2000-08-09 | 2010-03-16 | Halt Medical, Inc. | Gynecological ablation procedure and system |
US6572578B1 (en) * | 2000-08-25 | 2003-06-03 | Patrick A. Blanchard | Fluid-jet catheter and its application to flexible endoscopy |
ATE378014T1 (en) | 2000-11-16 | 2007-11-15 | Barrx Medical Inc | SYSTEM FOR TREATING ABNORMAL TISSUE IN THE HUMAN ESOPHAUS |
US20040087936A1 (en) * | 2000-11-16 | 2004-05-06 | Barrx, Inc. | System and method for treating abnormal tissue in an organ having a layered tissue structure |
US6551315B2 (en) | 2000-12-06 | 2003-04-22 | Syntheon, Llc | Methods and apparatus for the treatment of gastric ulcers |
US20020087151A1 (en) | 2000-12-29 | 2002-07-04 | Afx, Inc. | Tissue ablation apparatus with a sliding ablation instrument and method |
US6415016B1 (en) * | 2001-01-09 | 2002-07-02 | Medtronic Ave, Inc. | Crystal quartz insulating shell for X-ray catheter |
EP1357842B1 (en) | 2001-01-16 | 2010-11-03 | Cytyc Surgical Products | Apparatus and method for treating venous reflux |
US6699243B2 (en) | 2001-09-19 | 2004-03-02 | Curon Medical, Inc. | Devices, systems and methods for treating tissue regions of the body |
US20020177847A1 (en) | 2001-03-30 | 2002-11-28 | Long Gary L. | Endoscopic ablation system with flexible coupling |
US20030181900A1 (en) * | 2002-03-25 | 2003-09-25 | Long Gary L. | Endoscopic ablation system with a plurality of electrodes |
US6918906B2 (en) | 2001-03-30 | 2005-07-19 | Gary L. Long | Endoscopic ablation system with improved electrode geometry |
US7097644B2 (en) | 2001-03-30 | 2006-08-29 | Ethicon Endo-Surgery, Inc. | Medical device with improved wall construction |
US6800083B2 (en) * | 2001-04-09 | 2004-10-05 | Scimed Life Systems, Inc. | Compressible atherectomy burr |
US20020161363A1 (en) | 2001-04-26 | 2002-10-31 | Steven Fodor | Rotational guided electrosurgical electrode loop (GREEL) |
US6558400B2 (en) | 2001-05-30 | 2003-05-06 | Satiety, Inc. | Obesity treatment tools and methods |
US7083629B2 (en) | 2001-05-30 | 2006-08-01 | Satiety, Inc. | Overtube apparatus for insertion into a body |
JP3722729B2 (en) * | 2001-06-04 | 2005-11-30 | オリンパス株式会社 | Endoscope treatment device |
US6572610B2 (en) | 2001-08-21 | 2003-06-03 | Cryogen, Inc. | Cryogenic catheter with deflectable tip |
US6953469B2 (en) * | 2001-08-30 | 2005-10-11 | Ethicon, Inc, | Device and method for treating intraluminal tissue |
US7615049B2 (en) | 2001-09-19 | 2009-11-10 | Mederi Therapeutics, Inc. | Devices, systems and methods for treating tissue regions of the body |
US20060155261A1 (en) | 2001-09-19 | 2006-07-13 | Curon Medical, Inc. | Systems and methods for treating tissue regions of the body |
US6652518B2 (en) | 2001-09-28 | 2003-11-25 | Ethicon, Inc. | Transmural ablation tool and method |
WO2003047448A1 (en) | 2001-11-29 | 2003-06-12 | Medwaves, Inc. | Radio-frequency-based catheter system with improved deflection and steering mechanisms |
US6641581B2 (en) | 2001-12-11 | 2003-11-04 | Mohiuddin M. Muzzammel | Variable angle cervical excision electrode |
ATE423511T1 (en) | 2001-12-27 | 2009-03-15 | Olympus Corp | COVER WITH DEVICES FOR ENDOSCOPIC HARVESTING OF BLOOD VESSELS |
US20030153905A1 (en) | 2002-01-25 | 2003-08-14 | Edwards Stuart Denzil | Selective ablation system |
AU2003208309A1 (en) | 2002-02-22 | 2003-09-09 | Hans Gregersen | Method and apparatus for investigating force-deformation properties in muscles in walls of bodily hollow systems |
US7137981B2 (en) * | 2002-03-25 | 2006-11-21 | Ethicon Endo-Surgery, Inc. | Endoscopic ablation system with a distally mounted image sensor |
US6929642B2 (en) | 2002-06-28 | 2005-08-16 | Ethicon, Inc. | RF device for treating the uterus |
US20040082947A1 (en) | 2002-10-25 | 2004-04-29 | The Regents Of The University Of Michigan | Ablation catheters |
US7083620B2 (en) | 2002-10-30 | 2006-08-01 | Medtronic, Inc. | Electrosurgical hemostat |
US7744583B2 (en) | 2003-02-03 | 2010-06-29 | Boston Scientific Scimed | Systems and methods of de-endothelialization |
US6923808B2 (en) | 2003-02-24 | 2005-08-02 | Boston Scientific Scimed, Inc. | Probes having helical and loop shaped inflatable therapeutic elements |
US7686802B2 (en) * | 2003-03-28 | 2010-03-30 | C.R. Bard, Inc. | Junction of catheter tip and electrode |
US20040215180A1 (en) | 2003-04-25 | 2004-10-28 | Medtronic, Inc. | Ablation of stomach lining to treat obesity |
US7090637B2 (en) | 2003-05-23 | 2006-08-15 | Novare Surgical Systems, Inc. | Articulating mechanism for remote manipulation of a surgical or diagnostic tool |
WO2004105807A2 (en) | 2003-05-27 | 2004-12-09 | Venture Manufacturing, Llc | Balloon centered radially expanding ablation device |
US7160294B2 (en) | 2003-09-02 | 2007-01-09 | Curon Medical, Inc. | Systems and methods for treating hemorrhoids |
US7416549B2 (en) | 2003-10-10 | 2008-08-26 | Boston Scientific Scimed, Inc. | Multi-zone bipolar ablation probe assembly |
US20050090817A1 (en) | 2003-10-22 | 2005-04-28 | Scimed Life Systems, Inc. | Bendable endoscopic bipolar device |
US7252665B2 (en) * | 2003-10-31 | 2007-08-07 | Medtronic, Inc | Ablation of stomach lining to reduce stomach acid secretion |
US7150745B2 (en) | 2004-01-09 | 2006-12-19 | Barrx Medical, Inc. | Devices and methods for treatment of luminal tissue |
US20050288664A1 (en) | 2004-06-21 | 2005-12-29 | Curon Medical, Inc. | Systems and methods for treating tissue regions of the body |
DE602004015470D1 (en) | 2004-11-09 | 2008-09-11 | Radi Medical Systems | Reduction of leakage currents in guidewires |
US20070011814A1 (en) * | 2005-07-14 | 2007-01-18 | Jeremy Rotert | Surgical table attachment |
US7997278B2 (en) | 2005-11-23 | 2011-08-16 | Barrx Medical, Inc. | Precision ablating method |
US7959627B2 (en) | 2005-11-23 | 2011-06-14 | Barrx Medical, Inc. | Precision ablating device |
AU2006318617B2 (en) | 2005-11-23 | 2012-07-05 | Covidien Lp | Precision ablating device |
US8702694B2 (en) | 2005-11-23 | 2014-04-22 | Covidien Lp | Auto-aligning ablating device and method of use |
WO2008061528A1 (en) | 2006-11-22 | 2008-05-29 | Kamran Behzadian | Medical device for substantially uniform ablation of animal or human surface tissue |
US7896840B2 (en) | 2007-04-05 | 2011-03-01 | Boston Scientific Scimed, Inc. | Catheter having internal mechanisms to encourage balloon re-folding |
US8641711B2 (en) | 2007-05-04 | 2014-02-04 | Covidien Lp | Method and apparatus for gastrointestinal tract ablation for treatment of obesity |
US8784338B2 (en) | 2007-06-22 | 2014-07-22 | Covidien Lp | Electrical means to normalize ablational energy transmission to a luminal tissue surface of varying size |
US8251992B2 (en) | 2007-07-06 | 2012-08-28 | Tyco Healthcare Group Lp | Method and apparatus for gastrointestinal tract ablation to achieve loss of persistent and/or recurrent excess body weight following a weight-loss operation |
AU2008275316B2 (en) | 2007-07-06 | 2013-11-14 | Covidien Lp | Ablation in the gastrointestinal tract to achieve hemostasis and eradicate lesions with a propensity for bleeding |
US20090012518A1 (en) | 2007-07-06 | 2009-01-08 | Utley David S | Method and Apparatus for Ablation of Benign, Pre-Cancerous and Early Cancerous Lesions That Originate Within the Epithelium and are Limited to the Mucosal Layer of the Gastrointestinal Tract |
US8273012B2 (en) | 2007-07-30 | 2012-09-25 | Tyco Healthcare Group, Lp | Cleaning device and methods |
US8646460B2 (en) | 2007-07-30 | 2014-02-11 | Covidien Lp | Cleaning device and methods |
US8308763B2 (en) | 2007-10-05 | 2012-11-13 | Coaptus Medical Corporation | Systems and methods for transeptal cardiac procedures, including separable guidewires |
US20090318914A1 (en) | 2008-06-18 | 2009-12-24 | Utley David S | System and method for ablational treatment of uterine cervical neoplasia |
US10278774B2 (en) | 2011-03-18 | 2019-05-07 | Covidien Lp | Selectively expandable operative element support structure and methods of use |
DE102013104948A1 (en) | 2013-05-14 | 2014-11-20 | Acandis Gmbh & Co. Kg | Medical catheter for hypothermic treatment, treatment system with such a catheter and manufacturing method |
JP2016523147A (en) | 2013-06-21 | 2016-08-08 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Renal denervation balloon catheter with a riding-type electrode support |
JP2016524949A (en) | 2013-06-21 | 2016-08-22 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Medical device for renal nerve ablation having a rotatable shaft |
US9763733B2 (en) | 2013-10-25 | 2017-09-19 | Covidien Lp | Unfurling electrode devices with the multiple longitudinal electrode segments |
US9743981B2 (en) | 2013-10-25 | 2017-08-29 | Covidien Lp | Unfurling electrode devices with spring |
-
2004
- 2004-01-09 US US10/754,444 patent/US7150745B2/en active Active
-
2005
- 2005-01-06 WO PCT/US2005/000646 patent/WO2005067668A2/en active Application Filing
-
2006
- 2006-11-07 US US11/557,445 patent/US7344535B2/en not_active Expired - Lifetime
-
2007
- 2007-12-18 US US11/959,310 patent/US8192426B2/en active Active
-
2012
- 2012-05-03 US US13/463,683 patent/US9393069B2/en active Active
-
2016
- 2016-06-20 US US15/186,809 patent/US10278776B2/en active Active
-
2019
- 2019-04-09 US US16/379,517 patent/US10856939B2/en not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5462545A (en) * | 1994-01-31 | 1995-10-31 | New England Medical Center Hospitals, Inc. | Catheter electrodes |
US6006755A (en) * | 1994-06-24 | 1999-12-28 | Edwards; Stuart D. | Method to detect and treat aberrant myoelectric activity |
US6123703A (en) * | 1998-09-19 | 2000-09-26 | Tu; Lily Chen | Ablation catheter and methods for treating tissues |
US6258118B1 (en) * | 1998-11-25 | 2001-07-10 | Israel Aircraft Industries Ltd. | Removable support device |
US6964661B2 (en) * | 2003-04-02 | 2005-11-15 | Boston Scientific Scimed, Inc. | Endovenous ablation mechanism with feedback control |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10856939B2 (en) | 2004-01-09 | 2020-12-08 | Covidien Lp | Devices and methods for treatment of luminal tissue |
US10278776B2 (en) | 2004-01-09 | 2019-05-07 | Covidien Lp | Devices and methods for treatment of luminal tissue |
CN102688092B (en) * | 2007-07-06 | 2015-04-22 | 柯惠有限合伙公司 | Ablation in the gastrointestinal tract to achieve hemostasis and eradicate lesions with a propensity for bleeding |
US9539046B2 (en) | 2010-08-03 | 2017-01-10 | Medtronic Cryocath Lp | Cryogenic medical mapping and treatment device |
WO2012016320A1 (en) * | 2010-08-03 | 2012-02-09 | Medtronic Cryocath Lp | Cryogenic medical mapping and treatment device |
US10285755B2 (en) | 2011-07-29 | 2019-05-14 | Medtronic Ablation Frontiers Llc | Mesh-overlayed ablation and mapping device |
US9387031B2 (en) | 2011-07-29 | 2016-07-12 | Medtronic Ablation Frontiers Llc | Mesh-overlayed ablation and mapping device |
US9113911B2 (en) | 2012-09-06 | 2015-08-25 | Medtronic Ablation Frontiers Llc | Ablation device and method for electroporating tissue cells |
US9345540B2 (en) | 2013-03-15 | 2016-05-24 | Medtronic Ablation Frontiers Llc | Contact specific RF therapy balloon |
JP2015083133A (en) * | 2013-10-25 | 2015-04-30 | コヴィディエン リミテッド パートナーシップ | Unfurling electrode devices with multiple longitudinal electrode segments |
US9743981B2 (en) | 2013-10-25 | 2017-08-29 | Covidien Lp | Unfurling electrode devices with spring |
US9763733B2 (en) | 2013-10-25 | 2017-09-19 | Covidien Lp | Unfurling electrode devices with the multiple longitudinal electrode segments |
US9918789B2 (en) | 2013-10-25 | 2018-03-20 | Covidien Lp | Unfurling electrode devices with the protection element |
US10898263B2 (en) | 2013-10-25 | 2021-01-26 | Covidien Lp | Unfurling electrode devices |
CN104546118A (en) * | 2013-10-25 | 2015-04-29 | 柯惠有限合伙公司 | Unfurling electrode devices with the multiple longitudinal electrode segments |
EP3400895A1 (en) * | 2013-10-25 | 2018-11-14 | Covidien LP | Unfurling electrode devices with the multiple longitudinal electrode segments |
EP2865349A1 (en) * | 2013-10-25 | 2015-04-29 | Covidien LP | Unfurling electrode devices with the multiple longitudinal electrode segments |
JP2019055238A (en) * | 2013-10-25 | 2019-04-11 | コヴィディエン リミテッド パートナーシップ | Unfurling electrode devices with multiple longitudinal electrode segments |
US10631910B2 (en) | 2015-01-14 | 2020-04-28 | Covidien Lp | Arrangement of multi-channel bipolar elecrode zones to minimize leakage and edge effects |
US10368934B2 (en) | 2015-01-14 | 2019-08-06 | Covidien Lp | Arrangement of multi-channel bipolar electrode zones to minimize leakage and edge effects |
US10149716B2 (en) | 2015-02-02 | 2018-12-11 | Covidien Lp | Self-sizing catheter features to prevent over-tightening of the electrode |
WO2017024056A1 (en) * | 2015-08-03 | 2017-02-09 | Boston Scientific Scimed, Inc. | Systems and methods for mapping and ablation in the bladder |
JP2018519934A (en) * | 2015-08-03 | 2018-07-26 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | System and method for intravesical mapping and ablation |
CN107920855A (en) * | 2015-08-03 | 2018-04-17 | 波士顿科学医学有限公司 | For carrying out mapping and the System and method for of ablation in bladder |
US11083516B2 (en) | 2015-08-03 | 2021-08-10 | Boston Scientific Scimed, Inc. | Systems and methods for mapping and ablation in the bladder |
Also Published As
Publication number | Publication date |
---|---|
US10856939B2 (en) | 2020-12-08 |
US20080097427A1 (en) | 2008-04-24 |
US7150745B2 (en) | 2006-12-19 |
US8192426B2 (en) | 2012-06-05 |
US20190231422A1 (en) | 2019-08-01 |
WO2005067668A3 (en) | 2006-04-27 |
US10278776B2 (en) | 2019-05-07 |
US20160354145A1 (en) | 2016-12-08 |
US7344535B2 (en) | 2008-03-18 |
US20120220996A1 (en) | 2012-08-30 |
US20070066973A1 (en) | 2007-03-22 |
US9393069B2 (en) | 2016-07-19 |
US20050171524A1 (en) | 2005-08-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10856939B2 (en) | Devices and methods for treatment of luminal tissue | |
US9597147B2 (en) | Methods and systems for treatment of tissue in a body lumen | |
EP1708636B1 (en) | System for treating abnormal epithelium in an esophagus | |
US9555222B2 (en) | Methods and systems for determining physiologic characteristics for treatment of the esophagus | |
CA2427978C (en) | System and method of treating abnormal tissue in the human esophagus | |
AU2001263143A1 (en) | System and method of treating abnormal tissue in the human esophagus | |
KR20100058465A (en) | Ablation in the gastrointestinal tract to achieve hemostasis and eradicate lesions with a propensity for bleeding | |
JP6647374B2 (en) | Deployable electrode device having a plurality of longitudinal electrode segments | |
AU2013200263B2 (en) | System and method for treating abnormal epithelium in an esophagus |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: DE |
|
32PN | Ep: public notification in the ep bulletin as address of the adressee cannot be established |
Free format text: COMMUNICATION PURSUANT TO RULE 69(1) EPC (FORM 1205A) SENT 15.09.2006. |
|
122 | Ep: pct application non-entry in european phase |