WO2005047512A3 - Plasmid system for multigene expression - Google Patents
Plasmid system for multigene expression Download PDFInfo
- Publication number
- WO2005047512A3 WO2005047512A3 PCT/US2004/037721 US2004037721W WO2005047512A3 WO 2005047512 A3 WO2005047512 A3 WO 2005047512A3 US 2004037721 W US2004037721 W US 2004037721W WO 2005047512 A3 WO2005047512 A3 WO 2005047512A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- plasmid system
- multigene expression
- plasmid
- multigene
- expression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006539876A JP2007510434A (en) | 2003-11-12 | 2004-11-10 | A plasmid system for multigene expression. |
AT04810783T ATE514783T1 (en) | 2003-11-12 | 2004-11-10 | PLASMID SYSTEM FOR EXPRESSING MULTIPLE GENES |
EP04810783A EP1694850B1 (en) | 2003-11-12 | 2004-11-10 | Plasmid system for multigene expression |
CA002545755A CA2545755A1 (en) | 2003-11-12 | 2004-11-10 | Plasmid system for multigene expression |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51923003P | 2003-11-12 | 2003-11-12 | |
US60/519,230 | 2003-11-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005047512A2 WO2005047512A2 (en) | 2005-05-26 |
WO2005047512A3 true WO2005047512A3 (en) | 2005-06-23 |
Family
ID=34590376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/037721 WO2005047512A2 (en) | 2003-11-12 | 2004-11-10 | Plasmid system for multigene expression |
Country Status (8)
Country | Link |
---|---|
US (3) | US7326567B2 (en) |
EP (1) | EP1694850B1 (en) |
JP (2) | JP2007510434A (en) |
CN (1) | CN1938428A (en) |
AT (1) | ATE514783T1 (en) |
CA (1) | CA2545755A1 (en) |
WO (1) | WO2005047512A2 (en) |
ZA (1) | ZA200603731B (en) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003100008A2 (en) | 2002-05-24 | 2003-12-04 | Schering Corporation | Neutralizing human anti-igfr antibody |
US20080050808A1 (en) * | 2002-10-09 | 2008-02-28 | Reed Thomas D | DNA modular cloning vector plasmids and methods for their use |
US7785871B2 (en) * | 2002-10-09 | 2010-08-31 | Intrexon Corporation | DNA cloning vector plasmids and methods for their use |
TW200526684A (en) * | 2003-11-21 | 2005-08-16 | Schering Corp | Anti-IGFR1 antibody therapeutic combinations |
WO2005116231A1 (en) | 2004-05-18 | 2005-12-08 | Intrexon Corporation | Methods for dynamic vector assembly of dna cloning vector plasmids |
CA2587712C (en) * | 2004-11-18 | 2013-02-12 | National University Of Corporation Hiroshima University | Method and kit for expressing protein under regulation of the expression from repeated sequence formed by gene amplification and transformant |
WO2006060419A2 (en) * | 2004-12-03 | 2006-06-08 | Schering Corporation | Biomarkers for pre-selection of patients for anti-igf1r therapy |
CA2604393A1 (en) * | 2005-04-15 | 2006-10-26 | Schering Corporation | Methods and compositions for treating or preventing cancer |
JP2008543283A (en) * | 2005-06-10 | 2008-12-04 | ジェネンテック・インコーポレーテッド | Improving antibody expression using vectors containing insulator elements |
EP2468881A3 (en) | 2005-07-21 | 2012-08-15 | Abbott Laboratories | Multiple gene expression including sorf contructs and methods with polyproteins, pro-proteins, and proteolysis |
US8153598B2 (en) * | 2005-10-19 | 2012-04-10 | Intrexon Corporation | PKD ligands and polynucleotides encoding PKD ligands |
EP2032989B2 (en) * | 2006-06-30 | 2015-10-28 | Merck Sharp & Dohme Corp. | Igfbp2 biomarker |
AU2008233196B2 (en) * | 2007-03-30 | 2011-10-13 | Abbvie Inc. | Recombinant expression vector elements (rEVEs) for enhancing expression of recombinant proteins in host cells |
KR101030978B1 (en) * | 2008-07-10 | 2011-04-28 | (주) 에이프로젠 | Recombinant Expression Vectors for Animal Cells |
AU2009280913A1 (en) * | 2008-08-12 | 2010-02-18 | Avesthagen Limited | An expression vector and a method thereof |
WO2010049777A1 (en) * | 2008-10-28 | 2010-05-06 | Avesthagen Limited | An expression vector and processes thereof |
JP2012508563A (en) * | 2008-11-12 | 2012-04-12 | シェーリング コーポレイション | ΒG1-IGG intron for enhanced anti-IGF1R expression |
US8137933B2 (en) | 2008-11-12 | 2012-03-20 | Schering Corporation | Mammalian expression vector pUHAB |
WO2011015917A2 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | Vectors and compounds for expression of recombinant tnk-tpa (tenecteplase) |
WO2011015916A2 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | Vectors and compounds for expression of recombinant infliximab |
WO2011015918A2 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | Vectors and compounds for expression of recombinant cetuximab |
WO2011015924A2 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | Vectors and compounds for expression of recombinant trastuzumab |
TWI688395B (en) | 2010-03-23 | 2020-03-21 | 英翠克頌公司 | Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof |
EP2694655A4 (en) * | 2011-04-08 | 2015-01-14 | Merck Sharp & Dohme | pAVEC |
MX353958B (en) | 2011-09-22 | 2018-02-07 | Amgen Inc | Cd27l antigen binding proteins. |
WO2013078433A1 (en) | 2011-11-23 | 2013-05-30 | University Of Hawaii | Auto-processing domains for polypeptide expression |
CN102559750B (en) * | 2011-11-25 | 2014-03-12 | 佛山安普泽生物医药有限公司 | Efficient expression vector of antibody and preparation method for efficient expression vector |
JO3623B1 (en) | 2012-05-18 | 2020-08-27 | Amgen Inc | St2 antigen binding proteins |
CN102703498A (en) * | 2012-06-04 | 2012-10-03 | 河北农业大学 | Multi-gene plant expression vector and construction method as well as application thereof |
UY35148A (en) | 2012-11-21 | 2014-05-30 | Amgen Inc | HETERODIMERIC IMMUNOGLOBULINS |
US9580486B2 (en) | 2013-03-14 | 2017-02-28 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
US9708375B2 (en) | 2013-03-15 | 2017-07-18 | Amgen Inc. | Inhibitory polypeptides specific to WNT inhibitors |
EA201592285A1 (en) | 2013-05-30 | 2016-05-31 | Байоджен Ма Инк. | ANTIGENSYCLING PROTEINS TO ONCOSTATIN M RECEPTOR |
EP3712166A1 (en) | 2013-09-05 | 2020-09-23 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
MX2017012966A (en) | 2015-04-10 | 2018-06-06 | Amgen Inc | Interleukin-2 muteins for the expansion of t-regulatory cells. |
CN107787332B (en) | 2015-04-24 | 2022-09-09 | 豪夫迈·罗氏有限公司 | Multispecific antigen binding proteins |
CA2996691A1 (en) | 2015-09-22 | 2017-03-30 | Genentech, Inc. | Expression of fc-containing proteins |
CA3000869A1 (en) | 2015-10-08 | 2017-04-13 | Zymeworks Inc. | Antigen-binding polypeptide constructs comprising kappa and lambda light chains and uses thereof |
SG11201802773RA (en) | 2015-11-02 | 2018-05-30 | Genentech Inc | Methods of making fucosylated and afucosylated forms of a protein |
KR20180133198A (en) | 2016-05-04 | 2018-12-13 | 암젠 인크 | Interleukin-2 mutein for proliferation of T-regulatory cells |
BR112019025105A2 (en) | 2017-06-30 | 2020-10-20 | Zymeworks Inc. | stabilized chimeric fabs |
CA3092069C (en) | 2018-02-27 | 2022-08-30 | Mascull, Roger Thomas | A seating support |
US20220267802A1 (en) * | 2019-07-15 | 2022-08-25 | President And Fellows Of Harvard College | Methods and compositions for gene delivery |
MX2022001866A (en) | 2019-08-13 | 2022-03-11 | Amgen Inc | Interleukin-2 muteins for the expansion of t-regulatory cells. |
CN112941028A (en) * | 2019-12-09 | 2021-06-11 | 上海细胞治疗集团有限公司 | Nano antibody gene modified mesenchymal stem cell and preparation method and application thereof |
JP2023507115A (en) | 2019-12-17 | 2023-02-21 | アムジエン・インコーポレーテツド | Dual interleukin-2/TNF receptor agonist for use in therapy |
CN116284442B (en) * | 2023-02-08 | 2023-10-17 | 中国农业科学院生物技术研究所 | Fusion protein for controlling leaf color and application of fusion protein in research on interaction of plant transcription factors and DNA |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001088121A1 (en) * | 2000-05-19 | 2001-11-22 | Devgen Nv | Vector constructs |
WO2002014525A2 (en) * | 2000-07-29 | 2002-02-21 | Mogam Biotechnology Research Institute | Expression vector using for animal cell |
Family Cites Families (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4543439A (en) | 1982-12-13 | 1985-09-24 | Massachusetts Institute Of Technology | Production and use of monoclonal antibodies to phosphotyrosine-containing proteins |
US5534617A (en) | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
US5977307A (en) | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
CA2025907A1 (en) | 1989-09-21 | 1991-03-22 | Franklin D. Collins | Method of transporting compositions across the blood brain barrier |
AU7444191A (en) | 1990-02-28 | 1991-09-18 | Schering Corporation | Mammalian expression vectors |
CA2078689C (en) | 1990-03-20 | 2003-02-11 | Sherie L. Morrison | Chimeric antibodies with receptor binding ligands in place of their constant region |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
JPH04166089A (en) * | 1990-10-30 | 1992-06-11 | Eiken Chem Co Ltd | Plasmid vector for immunoglobulin gene expression and recombination of v-portion gene using the same |
US5198340A (en) | 1991-01-17 | 1993-03-30 | Genentech, Inc. | Assay for free igf-i, igf-ii, and gh levels in body fluids |
US5262308A (en) | 1992-01-28 | 1993-11-16 | Thomas Jefferson University | Cell lines which constitutively express IGF-1 and IGF-1 R |
AU677216B2 (en) | 1992-07-27 | 1997-04-17 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Targeting of liposomes to the blood-brain barrier |
WO1994023034A2 (en) | 1993-04-06 | 1994-10-13 | Cedars-Sinai Medical Center | Variant insulin-like growth factor i receptor subunits and methods for use thereof |
US20020022023A1 (en) | 1999-01-15 | 2002-02-21 | Axel Ullrich | Treatment of diabetes mellitus and insulin receptor signal transduction |
JP3946256B2 (en) * | 1995-09-11 | 2007-07-18 | 協和醗酵工業株式会社 | Antibody to human interleukin 5 receptor α chain |
US6084085A (en) | 1995-11-14 | 2000-07-04 | Thomas Jefferson University | Inducing resistance to tumor growth with soluble IGF-1 receptor |
US6346390B1 (en) | 1996-03-08 | 2002-02-12 | Receptron, Inc. | Receptor derived peptides involved in modulation of response to ligand binding |
US5958872A (en) | 1996-04-01 | 1999-09-28 | Apoptosis Technology, Inc. | Active survival domains of IGF-IR and methods of use |
AUPN999096A0 (en) | 1996-05-22 | 1996-06-13 | Northstar Biologicals Pty Ltd | Peptides, antibodies, vaccines & uses thereof |
US20020187925A1 (en) | 1996-05-22 | 2002-12-12 | Kingston David J. | Modulating the activity of hormones or their receptors - peptides, antibodies, vaccines and uses thereof |
ZA979295B (en) | 1996-10-18 | 1998-04-20 | Canji Inc | Methods and compositions for delivery and expression of interferon-Ó nucleic acids. |
US20020155095A1 (en) | 1996-10-18 | 2002-10-24 | Tattanahalli L. Nagabhushan | Methods and compositions for delivery and expression of interferon-a nucleic acids |
WO1998022092A1 (en) | 1996-11-22 | 1998-05-28 | The Regents Of The University Of California | Transport of liposomes across the blood-brain barrier |
US6399789B1 (en) * | 1996-12-18 | 2002-06-04 | Kosan Biosciences, Inc. | Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides |
US6294330B1 (en) | 1997-01-31 | 2001-09-25 | Odyssey Pharmaceuticals Inc. | Protein fragment complementation assays for the detection of biological or drug interactions |
TW562807B (en) * | 1997-04-01 | 2003-11-21 | Chugai Pharmaceutical Co Ltd | Novel secretory membrane protein |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
JPH1132779A (en) * | 1997-07-24 | 1999-02-09 | Fujita Gakuen | Gene cloning of protein |
CA2310269A1 (en) | 1997-11-14 | 1999-05-27 | Euro-Celtique, S.A. | Immunoglobulin molecules having a synthetic variable region and modified specificity |
WO1999028347A1 (en) | 1997-11-27 | 1999-06-10 | Commonwealth Scientific And Industrial Research Organisation | Method of designing agonists and antagonists to igf receptor |
WO1999042127A2 (en) | 1998-02-24 | 1999-08-26 | Receptron, Inc. | Receptor derived peptides as modulators of receptor activity |
ZA200007412B (en) | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
MXPA00011248A (en) | 1998-05-15 | 2004-09-06 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
US6875741B2 (en) | 1998-09-02 | 2005-04-05 | Renuka Pillutla | Insulin and IGF-1 receptor agonists and antagonists |
US20030236190A1 (en) | 1998-09-02 | 2003-12-25 | Renuka Pillutla | Isulin and IGF-1 receptor agonists and antagonists |
US7173005B2 (en) | 1998-09-02 | 2007-02-06 | Antyra Inc. | Insulin and IGF-1 receptor agonists and antagonists |
WO2000022130A2 (en) | 1998-10-15 | 2000-04-20 | Chiron Corporation | Metastatic breast and colon cancer regulated genes |
AU3579200A (en) | 1999-02-26 | 2000-09-14 | Saltech I Goteborg Ab | Method and composition for the regulation of hepatic and extrahepatic productionof insulin-like growth factor-1 |
US6316462B1 (en) | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
US6511967B1 (en) * | 1999-04-23 | 2003-01-28 | The General Hospital Corporation | Use of an internalizing transferrin receptor to image transgene expression |
WO2000069454A1 (en) | 1999-05-17 | 2000-11-23 | Board Of Regents, The University Of Texas System | Suppression of endogenous igfbp-2 to inhibit cancer |
AU6607100A (en) | 1999-07-23 | 2001-02-13 | Regents Of The University Of California, The | Anti-growth factor receptor avidin fusion proteins as universal vectors for drugdelivery |
AU1339701A (en) | 1999-10-22 | 2001-05-08 | Lifespan Biosciences, Inc. | Anti-cancer nucleic acid and protein targets |
EP1228237A1 (en) * | 1999-11-01 | 2002-08-07 | Chiron Corporation | Expression vectors, transfection systems, and method of use thereof |
WO2001036632A2 (en) | 1999-11-17 | 2001-05-25 | Compugen Ltd. | Variants of alternative splicing |
WO2001044464A1 (en) | 1999-12-15 | 2001-06-21 | Mcgill University | Targeting of endosomal growth factor processing as anti-cancer therapy |
AU2001245888A1 (en) | 2000-03-21 | 2001-10-03 | University Of South Florida | Growth factor binding molecules |
JP2003527441A (en) | 2000-03-22 | 2003-09-16 | グラクソ グループ リミテッド | Drugs that block cell cycle and drugs that contain antibodies |
TWI310684B (en) | 2000-03-27 | 2009-06-11 | Bristol Myers Squibb Co | Synergistic pharmaceutical kits for treating cancer |
JP2004512010A (en) | 2000-03-29 | 2004-04-22 | ディージーアイ・バイオテクノロジーズ・エル・エル・シー | Insulin and IGF-1 receptor agonists and antagonists |
AU5521401A (en) | 2000-03-31 | 2001-10-15 | Hyseq Inc | Method and materials relating to insulin-like growth factor binding protein-likepolypeptides and polynucleotides |
US6372250B1 (en) | 2000-04-25 | 2002-04-16 | The Regents Of The University Of California | Non-invasive gene targeting to the brain |
US7329745B2 (en) | 2000-06-13 | 2008-02-12 | City Of Hope | Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth |
US20030165502A1 (en) | 2000-06-13 | 2003-09-04 | City Of Hope | Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth |
US20020164333A1 (en) | 2000-07-10 | 2002-11-07 | The Scripps Research Institute | Bifunctional molecules and vectors complexed therewith for targeted gene delivery |
CA2414272A1 (en) | 2000-07-10 | 2002-01-17 | Novartis Ag | Bifunctional molecules and vectors complexed therewith for targeted gene delivery |
WO2002007783A2 (en) | 2000-07-20 | 2002-01-31 | Regents Of The University Of Minnesota | Radiolabeled immunotoxins |
US20030162230A1 (en) | 2000-09-27 | 2003-08-28 | Reagan Kevin J. | Method for quantifying phosphokinase activity on proteins |
US8153121B2 (en) | 2000-10-06 | 2012-04-10 | Los Angeles Biomedical Research Institute at Harbor—UCLA Medical Center | Diagnosis and therapy of antibody-mediated inflammatory autoimmune disorders |
DE10050338A1 (en) | 2000-10-11 | 2002-04-25 | Deutsches Krebsforsch | Diagnosing and staging of cancer, especially of breast, by measuring levels of insulin receptor substrate-1 or insulin-like growth factor-1 receptor beta |
AU2002213196A1 (en) | 2000-10-12 | 2002-04-22 | Icos Corporation | Modulation of ligand binding/enzymatic activity of alpha beta proteins |
WO2002039121A2 (en) | 2000-11-03 | 2002-05-16 | Board Of Regents, The University Of Texas System | Methods for detecting the efficacy of anticancer treatments |
US20020111290A1 (en) | 2000-12-01 | 2002-08-15 | Bernhard Homey | Uses of mammalian genes and related reagents |
ATE444488T1 (en) | 2000-12-14 | 2009-10-15 | Burnham Inst | NON-APOPTOTIC FORMS OF CELL DEATH AND METHOD FOR MODULATION |
AR032028A1 (en) | 2001-01-05 | 2003-10-22 | Pfizer | ANTIBODIES AGAINST THE RECEIVER OF THE SIMILAR TO INSULIN GROWTH FACTOR |
CA2435972C (en) | 2001-01-26 | 2011-09-13 | University Of Lausanne | Matrix attachment regions and methods for use thereof |
JP4117731B2 (en) | 2001-03-14 | 2008-07-16 | ジェネンテック・インコーポレーテッド | IGF antagonist peptide |
US20040116330A1 (en) | 2001-04-27 | 2004-06-17 | Kenichiro Naito | Preventive/therapeutic method for cancer |
FR2824076B1 (en) | 2001-04-27 | 2003-06-13 | Centre Nat Rech Scient | METHOD OF DETECTING ACTIVATORS OR INHIBITORS OF RECEPTORS OF THE INSULIN RECEPTOR FAMILY USING AN ISOLATED CHIMERIC RECEPTOR |
WO2002100326A2 (en) | 2001-05-01 | 2002-12-19 | The General Hospital Corporation | Photoimmunotherapies for cancer using photosensitizer immunoconjugates and combination therapies |
AR035885A1 (en) | 2001-05-14 | 2004-07-21 | Novartis Ag | DERIVATIVES OF 4-AMINO-5-FENIL-7-CYCLLOBUTILPIRROLO (2,3-D) PYRIMIDINE, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION AND THE USE OF SUCH DERIVATIVES FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION |
IL159177A0 (en) | 2001-06-20 | 2004-06-01 | Prochon Biotech Ltd | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
WO2003000928A2 (en) | 2001-06-25 | 2003-01-03 | Buadbo Aps | Methods for identification of cancer cell surface molecules and cancer specific promoters, and therapeutic uses thereof |
IL160091A0 (en) | 2001-08-06 | 2004-06-20 | Stil Biotechnologies Ltd | Methods of identifying functional analogs of peptide regulators of biological pathways |
AUPR870501A0 (en) | 2001-11-07 | 2001-11-29 | Biotech Research Ventures Pte Limited | Composition containing a flavonoid glycone and method for using same as anti-proliferative |
JP4606739B2 (en) | 2002-01-18 | 2011-01-05 | ピエール、ファーブル、メディカマン | Novel anti-IGF-IR antibodies and uses thereof |
US7241444B2 (en) | 2002-01-18 | 2007-07-10 | Pierre Fabre Medicament | Anti-IGF-IR antibodies and uses thereof |
FR2834900B1 (en) | 2002-01-18 | 2005-07-01 | Pf Medicament | NOVEL COMPOSITIONS WITH ANTI-IGF-IR AND ANTI-EGFR ACTIVITY AND THEIR APPLICATIONS |
US7553485B2 (en) | 2002-01-18 | 2009-06-30 | Pierre Fabre Medicament | Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof |
FR2834991B1 (en) | 2002-01-18 | 2004-12-31 | Pf Medicament | NEW ANTI-IGF-IR ANTIBODIES AND THEIR APPLICATIONS |
FR2834990A1 (en) | 2002-01-18 | 2003-07-25 | Pf Medicament | New antibodies that bind to human insulin-like growth factor receptor, useful for treatment, prevention and diagnosis of cancers |
WO2003088910A2 (en) | 2002-04-15 | 2003-10-30 | Rigel Pharmaceuticals, Inc. | Methods of assaying for cell cycle modulators |
US7655397B2 (en) | 2002-04-25 | 2010-02-02 | The United States Of America As Represented By The Department Of Health And Human Services | Selections of genes and methods of using the same for diagnosis and for targeting the therapy of select cancers |
US7485314B2 (en) | 2002-05-06 | 2009-02-03 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Induction of antigen specific immunologic tolerance |
WO2003100008A2 (en) | 2002-05-24 | 2003-12-04 | Schering Corporation | Neutralizing human anti-igfr antibody |
GB0212303D0 (en) | 2002-05-28 | 2002-07-10 | Isis Innovation | Molecular targetting of IGF-1 receptor |
US8034904B2 (en) | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
US7538195B2 (en) | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
US20040086511A1 (en) | 2002-07-12 | 2004-05-06 | The Johns Hopkins University | Neuronal gene expression patterns |
US20040142381A1 (en) | 2002-07-31 | 2004-07-22 | Hubbard Stevan R. | Methods for designing IGF1 receptor modulators for therapeutics |
US20040047835A1 (en) | 2002-09-06 | 2004-03-11 | Cell Therapeutics, Inc. | Combinatorial drug therapy using polymer drug conjugates |
US20030138430A1 (en) | 2002-09-20 | 2003-07-24 | Stimmel Julie Beth | Pharmaceutical comprising an agent that blocks the cell cycle and an antibody |
TW200501960A (en) | 2002-10-02 | 2005-01-16 | Bristol Myers Squibb Co | Synergistic kits and compositions for treating cancer |
US20040102360A1 (en) | 2002-10-30 | 2004-05-27 | Barnett Stanley F. | Combination therapy |
US20060281130A1 (en) | 2002-12-20 | 2006-12-14 | Elisabeth Bock | Metod of modulation of interaction between receptor and ligand |
NZ540971A (en) | 2003-02-13 | 2008-04-30 | Pfizer Prod Inc | Uses of anti-insulin-like growth factor I receptor antibodies |
EP1603948A1 (en) | 2003-03-14 | 2005-12-14 | Pharmacia Corporation | Antibodies to igf-i receptor for the treatment of cancers |
JP4473257B2 (en) | 2003-04-02 | 2010-06-02 | エフ.ホフマン−ラ ロシュ アーゲー | Antibodies against insulin-like growth factor I receptor and uses thereof |
US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
WO2005016970A2 (en) | 2003-05-01 | 2005-02-24 | Imclone Systems Incorporated | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
AR046071A1 (en) | 2003-07-10 | 2005-11-23 | Hoffmann La Roche | ANTIBODIES AGAINST RECEIVER I OF THE INSULINAL TYPE GROWTH FACTOR AND THE USES OF THE SAME |
KR100825156B1 (en) | 2003-08-13 | 2008-04-24 | 화이자 프로덕츠 인코포레이티드 | - modified human igf-ir antibodies |
DE10348391B3 (en) | 2003-10-17 | 2004-12-23 | Beru Ag | Glow method for diesel engine glow plug, uses mathematical model for optimized heating of glow plug to its operating temperature |
TW200526684A (en) | 2003-11-21 | 2005-08-16 | Schering Corp | Anti-IGFR1 antibody therapeutic combinations |
CA2564538A1 (en) | 2004-04-22 | 2005-12-01 | Oregon Health And Science University | Compositions and methods for modulating signaling mediated by igf-1 receptor and erbb receptors |
CA2569277A1 (en) | 2004-06-04 | 2005-12-15 | Pfizer Products Inc. | Method for treating abnormal cell growth |
CA2573821A1 (en) | 2004-07-16 | 2006-01-26 | Pfizer Products Inc. | Combination treatment for non-hematologic malignancies using an anti-igf-1r antibody |
JP2008512352A (en) | 2004-07-17 | 2008-04-24 | イムクローン システムズ インコーポレイティド | Novel tetravalent bispecific antibody |
FR2873699B1 (en) | 2004-07-29 | 2009-08-21 | Pierre Fabre Medicament Sa | NOVEL ANTI-IGF ANTIBODIES IR RT USES THEREOF |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
WO2007093008A1 (en) | 2006-02-17 | 2007-08-23 | Adelaide Research & Innovation Pty Ltd | Antibodies to insulin-like growth factor i receptor |
-
2004
- 2004-11-10 EP EP04810783A patent/EP1694850B1/en active Active
- 2004-11-10 WO PCT/US2004/037721 patent/WO2005047512A2/en active Application Filing
- 2004-11-10 JP JP2006539876A patent/JP2007510434A/en active Pending
- 2004-11-10 CN CNA2004800401656A patent/CN1938428A/en active Pending
- 2004-11-10 CA CA002545755A patent/CA2545755A1/en not_active Abandoned
- 2004-11-10 US US10/986,498 patent/US7326567B2/en not_active Expired - Fee Related
- 2004-11-10 AT AT04810783T patent/ATE514783T1/en not_active IP Right Cessation
-
2006
- 2006-05-10 ZA ZA200603731A patent/ZA200603731B/en unknown
-
2007
- 2007-11-05 JP JP2007287936A patent/JP2008061650A/en active Pending
- 2007-11-19 US US11/986,041 patent/US8062886B2/en not_active Expired - Fee Related
-
2011
- 2011-10-18 US US13/275,746 patent/US8470593B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001088121A1 (en) * | 2000-05-19 | 2001-11-22 | Devgen Nv | Vector constructs |
WO2002014525A2 (en) * | 2000-07-29 | 2002-02-21 | Mogam Biotechnology Research Institute | Expression vector using for animal cell |
Non-Patent Citations (5)
Title |
---|
BEBBINGTON C R: "EXPRESSION OF ANTIBODY GENES IN NONLYMPHOID MAMMALIAN CELLS", METHODS : A COMPANION TO METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC., NEW YORK, NY, US, vol. 2, no. 2, April 1991 (1991-04-01), pages 136 - 145, XP000826961, ISSN: 1046-2023 * |
FLAMEZ D ET AL: "Production in Escherichia coli of a functional murine and murine::human chimeric F(ab')2 fragment and mature antibody directed against human placental alkaline phosphatase.", JOURNAL OF BIOTECHNOLOGY. 29 SEP 1995, vol. 42, no. 2, 29 September 1995 (1995-09-29), pages 133 - 143, XP002325015, ISSN: 0168-1656 * |
NORDERHAUG L ET AL: "Versatile vectors for transient and stable expression of recombinant antibody molecules in mammalian cells", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 204, no. 1, 12 May 1997 (1997-05-12), pages 77 - 87, XP004107719, ISSN: 0022-1759 * |
PAGE M J ET AL: "HIGH LEVEL EXPRESSION OF THE HUMANIZED MONOCLONAL ANTIBODY CAMPATH-1H IN CHINESE HAMSTER OVARY CELLS", BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 9, no. 1, January 1991 (1991-01-01), pages 64 - 68, XP001204851, ISSN: 0733-222X * |
ZHANG R ET AL: "An adenoviral vector expressing functional heterogeneous proteins herpes simplex viral thymidine kinase and human interleukin-2 has enhanced in vivo antitumor activity against medullary thyroid carcinoma.", ENDOCRINE-RELATED CANCER. DEC 2001, vol. 8, no. 4, December 2001 (2001-12-01), pages 315 - 325, XP002325014, ISSN: 1351-0088 * |
Also Published As
Publication number | Publication date |
---|---|
CN1938428A (en) | 2007-03-28 |
US8470593B2 (en) | 2013-06-25 |
US8062886B2 (en) | 2011-11-22 |
ATE514783T1 (en) | 2011-07-15 |
ZA200603731B (en) | 2010-10-27 |
US20080311623A1 (en) | 2008-12-18 |
CA2545755A1 (en) | 2005-05-26 |
JP2007510434A (en) | 2007-04-26 |
EP1694850B1 (en) | 2011-06-29 |
EP1694850A2 (en) | 2006-08-30 |
WO2005047512A2 (en) | 2005-05-26 |
US7326567B2 (en) | 2008-02-05 |
US20050176099A1 (en) | 2005-08-11 |
JP2008061650A (en) | 2008-03-21 |
US20120040402A1 (en) | 2012-02-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2005047512A3 (en) | Plasmid system for multigene expression | |
NO20014534D0 (en) | Method of separating proteins | |
WO2003029262A3 (en) | The human mob-5 (il-24) receptors and uses thereof | |
DK1255826T3 (en) | Automation of protein design for protein libraries | |
WO2002072605A3 (en) | Expression technology for proteins containing a hybrid isotype antibody moiety | |
WO2003062375A3 (en) | Stabilizing polypeptides which have been exposed to urea | |
WO2004099231A3 (en) | Glycopegylation methods and proteins/peptides produced by the methods | |
WO2007133290A8 (en) | Anti-ox40l antibodies and methods using same | |
WO2003011115A3 (en) | Peptide-based multimeric targeted contrast agents | |
WO2008060705A3 (en) | Anti-dll4 antibodies and methods using same | |
WO2002024909A3 (en) | Receptor nucleic acids and polypeptides | |
WO2005056759A3 (en) | Methods of generating variant proteins with increased host string content and compositions thereof | |
PT1257648E (en) | Antagonistic selective binding agents of osteoprotegerin binding protein | |
WO2001047959A3 (en) | Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof | |
WO2004007664A3 (en) | Nucleic acid vectors | |
WO2007016715A3 (en) | Immune response inducing preparations | |
WO2002068453A3 (en) | Methods and compositions for the construction and use of fusion libraries using computational protein design methods | |
EA200600116A1 (en) | OIL SUSPENSION CONCENTRATE CONTAINING DIFLUFENICAN | |
AU2002365269A1 (en) | Mut-il-18 or mut-il-18r proteins, antibodies, compositions, methods and uses | |
WO2004026892A3 (en) | Fragmentation of dna | |
WO2005065711A3 (en) | Mammalian receptor proteins; related reagents and methods | |
NO20024779L (en) | G protein-coupled receptor | |
WO2005052168A3 (en) | System for the inducible expression of recombinant proteins in cyanobacteria | |
WO2003004678A3 (en) | Novel receptors | |
WO2006055680A3 (en) | Method for determining three-dimensional protein structure from primary protein sequence |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
DPEN | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2006539876 Country of ref document: JP Ref document number: 200603731 Country of ref document: ZA Ref document number: 2545755 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2006/005307 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004810783 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 200480040165.6 Country of ref document: CN |
|
WWP | Wipo information: published in national office |
Ref document number: 2004810783 Country of ref document: EP |