WO2005040742A3 - A method and device for detecting a small number of molecules using surface-enhanced coherent anti-stokes raman spectroscopy - Google Patents

A method and device for detecting a small number of molecules using surface-enhanced coherent anti-stokes raman spectroscopy Download PDF

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Publication number
WO2005040742A3
WO2005040742A3 PCT/US2004/033054 US2004033054W WO2005040742A3 WO 2005040742 A3 WO2005040742 A3 WO 2005040742A3 US 2004033054 W US2004033054 W US 2004033054W WO 2005040742 A3 WO2005040742 A3 WO 2005040742A3
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WO
WIPO (PCT)
Prior art keywords
raman spectroscopy
coherent anti
stokes raman
small number
detecting
Prior art date
Application number
PCT/US2004/033054
Other languages
French (fr)
Other versions
WO2005040742A2 (en
Inventor
Tae-Woong Koo
Mineo Yamakawa
Christopher Gerth
Original Assignee
Intel Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intel Corp filed Critical Intel Corp
Priority to EP04794416A priority Critical patent/EP1766346A2/en
Publication of WO2005040742A2 publication Critical patent/WO2005040742A2/en
Publication of WO2005040742A3 publication Critical patent/WO2005040742A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/656—Raman microprobe

Abstract

The device and method disclosed herein concern detecting, identifying, and or quantifying analytes, such as nucleic acids, with high resolution and fast response times using surface enhanced coherent anti-Stokes Raman spectroscopy. In certain embodiments of the invention, a small number molecular sample of the analyte 210 such as a nucleotide, passes through a microfluidic channel, microchannel, or nanochannel 185 and sample cell 175 that contains Raman-active surfaces, and is detected by surface enhanced, coherent anti-Stokes Raman spectroscopy (SECARS). Other embodiments of the invention concern an apparatus for analyte detection.
PCT/US2004/033054 2003-10-17 2004-10-06 A method and device for detecting a small number of molecules using surface-enhanced coherent anti-stokes raman spectroscopy WO2005040742A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04794416A EP1766346A2 (en) 2003-10-17 2004-10-06 A method and device for detecting a small number of molecules using surface-enhanced coherent anti-stokes raman spectroscopy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/688,680 2003-10-17
US10/688,680 US20050084980A1 (en) 2003-10-17 2003-10-17 Method and device for detecting a small number of molecules using surface-enhanced coherant anti-stokes raman spectroscopy

Publications (2)

Publication Number Publication Date
WO2005040742A2 WO2005040742A2 (en) 2005-05-06
WO2005040742A3 true WO2005040742A3 (en) 2007-04-26

Family

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PCT/US2004/033054 WO2005040742A2 (en) 2003-10-17 2004-10-06 A method and device for detecting a small number of molecules using surface-enhanced coherent anti-stokes raman spectroscopy

Country Status (5)

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US (2) US20050084980A1 (en)
EP (1) EP1766346A2 (en)
CN (1) CN1954199A (en)
TW (1) TWI304129B (en)
WO (1) WO2005040742A2 (en)

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Publication number Publication date
TWI304129B (en) 2008-12-11
CN1954199A (en) 2007-04-25
US20050084980A1 (en) 2005-04-21
WO2005040742A2 (en) 2005-05-06
US20050110990A1 (en) 2005-05-26
TW200525136A (en) 2005-08-01
EP1766346A2 (en) 2007-03-28

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