WO2005027895A3 - Thyroid hormone analogs and methods of use in angiogenesis - Google Patents

Thyroid hormone analogs and methods of use in angiogenesis Download PDF

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Publication number
WO2005027895A3
WO2005027895A3 PCT/US2004/030583 US2004030583W WO2005027895A3 WO 2005027895 A3 WO2005027895 A3 WO 2005027895A3 US 2004030583 W US2004030583 W US 2004030583W WO 2005027895 A3 WO2005027895 A3 WO 2005027895A3
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WO
WIPO (PCT)
Prior art keywords
thyroid hormone
angiogenesis
methods
hormone analogs
disclosed
Prior art date
Application number
PCT/US2004/030583
Other languages
French (fr)
Other versions
WO2005027895A2 (en
Inventor
Shaker A Mousa
Faith B Davis
Paul J Davis
Original Assignee
Ordway Res Inst
Shaker A Mousa
Faith B Davis
Paul J Davis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ordway Res Inst, Shaker A Mousa, Faith B Davis, Paul J Davis filed Critical Ordway Res Inst
Priority to EP04784443A priority Critical patent/EP1670449B1/en
Priority to JP2006526439A priority patent/JP2007505837A/en
Priority to AU2004273986A priority patent/AU2004273986B2/en
Priority to CA2539288A priority patent/CA2539288C/en
Publication of WO2005027895A2 publication Critical patent/WO2005027895A2/en
Publication of WO2005027895A3 publication Critical patent/WO2005027895A3/en

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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract

Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of thyroid hormone, or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
PCT/US2004/030583 2003-09-15 2004-09-15 Thyroid hormone analogs and methods of use in angiogenesis WO2005027895A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP04784443A EP1670449B1 (en) 2003-09-15 2004-09-15 Thyroid hormone analogs and methods of use in angiogenesis
JP2006526439A JP2007505837A (en) 2003-09-15 2004-09-15 Thyroid hormone analogs and methods of use in angiogenesis
AU2004273986A AU2004273986B2 (en) 2003-09-15 2004-09-15 Thyroid hormone analogs and methods of use in angiogenesis
CA2539288A CA2539288C (en) 2003-09-15 2004-09-15 Thyroid hormone analogs and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50272103P 2003-09-15 2003-09-15
US60/502,721 2003-09-15

Publications (2)

Publication Number Publication Date
WO2005027895A2 WO2005027895A2 (en) 2005-03-31
WO2005027895A3 true WO2005027895A3 (en) 2005-05-06

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PCT/US2004/030583 WO2005027895A2 (en) 2003-09-15 2004-09-15 Thyroid hormone analogs and methods of use in angiogenesis

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US (3) US7785632B2 (en)
EP (2) EP1670449B1 (en)
JP (2) JP2007505837A (en)
CN (1) CN1878545A (en)
AU (1) AU2004273986B2 (en)
CA (1) CA2539288C (en)
WO (1) WO2005027895A2 (en)

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