WO2005026701A3 - Method and device for measuring multiple physiological properties of cells - Google Patents

Method and device for measuring multiple physiological properties of cells Download PDF

Info

Publication number
WO2005026701A3
WO2005026701A3 PCT/US2004/029163 US2004029163W WO2005026701A3 WO 2005026701 A3 WO2005026701 A3 WO 2005026701A3 US 2004029163 W US2004029163 W US 2004029163W WO 2005026701 A3 WO2005026701 A3 WO 2005026701A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
media
vessel
volume
reduced volume
Prior art date
Application number
PCT/US2004/029163
Other languages
French (fr)
Other versions
WO2005026701B1 (en
WO2005026701A2 (en
Inventor
Jay S Teich
Andy C Neilson
Michael R Sweeney
Geoff Uhl
Original Assignee
Thermogenic Imaging
Jay S Teich
Andy C Neilson
Michael R Sweeney
Geoff Uhl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermogenic Imaging, Jay S Teich, Andy C Neilson, Michael R Sweeney, Geoff Uhl filed Critical Thermogenic Imaging
Priority to JP2006526241A priority Critical patent/JP2007505316A/en
Priority to EP04788615.5A priority patent/EP1664740B1/en
Publication of WO2005026701A2 publication Critical patent/WO2005026701A2/en
Publication of WO2005026701A3 publication Critical patent/WO2005026701A3/en
Publication of WO2005026701B1 publication Critical patent/WO2005026701B1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/22—Transparent or translucent parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials

Abstract

A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.
PCT/US2004/029163 2003-09-10 2004-09-08 Method and device for measuring multiple physiological properties of cells WO2005026701A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2006526241A JP2007505316A (en) 2003-09-10 2004-09-08 Method and apparatus for measuring a plurality of physiological properties of a cell
EP04788615.5A EP1664740B1 (en) 2003-09-10 2004-09-08 Method and device for measuring multiple physiological properties of cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50241703P 2003-09-10 2003-09-10
US60/502,417 2003-09-10
US10/688,791 2003-10-17
US10/688,791 US7276351B2 (en) 2003-09-10 2003-10-17 Method and device for measuring multiple physiological properties of cells

Publications (3)

Publication Number Publication Date
WO2005026701A2 WO2005026701A2 (en) 2005-03-24
WO2005026701A3 true WO2005026701A3 (en) 2005-05-12
WO2005026701B1 WO2005026701B1 (en) 2005-06-16

Family

ID=34228905

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/029163 WO2005026701A2 (en) 2003-09-10 2004-09-08 Method and device for measuring multiple physiological properties of cells

Country Status (4)

Country Link
US (6) US7276351B2 (en)
EP (2) EP2322913B1 (en)
JP (1) JP2007505316A (en)
WO (1) WO2005026701A2 (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040107986A1 (en) * 2002-12-06 2004-06-10 Neilson Andy C. High throughput microcalorimeter systems and methods
US7276351B2 (en) 2003-09-10 2007-10-02 Seahorse Bioscience Method and device for measuring multiple physiological properties of cells
US20070087401A1 (en) * 2003-10-17 2007-04-19 Andy Neilson Analysis of metabolic activity in cells using extracellular flux rate measurements
US8658349B2 (en) 2006-07-13 2014-02-25 Seahorse Bioscience Cell analysis apparatus and method
JP2007522801A (en) * 2004-01-07 2007-08-16 リーブテック，インコーポレイテッド Mixing bag with integral sparger and sensor receptacle
SE531493C2 (en) * 2006-10-31 2009-04-28 Knut Johansen Sensor
WO2009009124A1 (en) * 2007-07-12 2009-01-15 Smiths Detection Inc. Fiber optic detection system
US8202702B2 (en) * 2008-10-14 2012-06-19 Seahorse Bioscience Method and device for measuring extracellular acidification and oxygen consumption rate with higher precision
WO2011102804A1 (en) * 2010-02-22 2011-08-25 Agency For Science, Technology And Research An electro-fluidic interface to a multi-well plate
JP2013540986A (en) * 2010-07-12 2013-11-07 ナノスポツト・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング Microstructured measuring chip for optical measurement of properties of artificial membranes or biological membranes and method for its manufacture
WO2012054321A2 (en) 2010-10-19 2012-04-26 University Of Miami Assays, methods and kits for predicting renal disease and personalized treatment strategies
WO2012065122A2 (en) * 2010-11-12 2012-05-18 Abbott Laboratories High throughput, optical method and system for determining the effect of a test substance on living cells
MX2020000205A (en) 2012-04-13 2022-06-06 L&F Res Llc Method of using cyclodextrin.
CN104704362B (en) 2012-10-09 2018-08-28 宝洁公司 The method of benefit active and the composition comprising it are assessed in identification
WO2014059009A1 (en) 2012-10-09 2014-04-17 The Procter & Gamble Company Method of identifying synergistic cosmetic combinations
US9494577B2 (en) 2012-11-13 2016-11-15 Seahorse Biosciences Apparatus and methods for three-dimensional tissue measurements based on controlled media flow
WO2014134090A1 (en) * 2013-02-27 2014-09-04 Corning Incorporated Ultrasonic apparatus and method for cell release
ES2705702T3 (en) * 2013-03-13 2019-03-26 Us Gov Sec Navy Nanoplasmonic imaging technique for spatio-temporal mapping of single-cell secretions in real time
SG11201510526VA (en) * 2013-06-24 2016-01-28 Wolf Wilson Mfg Corp Closed system device and methods for gas permeable cell culture process
WO2015157345A2 (en) 2014-04-07 2015-10-15 Wake Forest University Health Sciences Bioenergetic profiling of circulating blood cells and systems, devices, and methods relating thereto
USD732186S1 (en) 2014-06-02 2015-06-16 Seahorse Bioscience Cartridge
EP3148700B1 (en) 2014-06-02 2020-03-18 Agilent Technologies, Inc. Single column microplate system and carrier for analysis of biological samples
AU2015302025B2 (en) 2014-08-11 2021-08-19 The Regents Of The University Of California Continuous analyte sensor
WO2016112315A2 (en) 2015-01-09 2016-07-14 President And Fellows Of Harvard College Nanowire arrays for neurotechnology and other applications
CN107430055B (en) 2015-03-27 2020-10-30 安捷伦科技有限公司 Methods and systems for determining integrated metabolic baseline and potential of living cells
US10761028B2 (en) * 2015-06-19 2020-09-01 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Determining extracellular analyte concentration with nanoplasmonic sensors
CN107735684A (en) 2015-06-26 2018-02-23 柯尼卡美能达美国研究所有限公司 Quick and high sensitive Bacteria Detection
US9952122B2 (en) * 2015-08-03 2018-04-24 Palo Alto Research Center Incorporated Polysensing bioelectronic test plate
EP3349900A4 (en) 2015-09-18 2019-03-13 Arizona Board of Regents on behalf of Arizona State University Layered structure for improved sealing of microwell arrays
US20190086391A1 (en) 2016-03-08 2019-03-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Method and system for continuous biosensing
US10883978B2 (en) * 2017-01-31 2021-01-05 Agilent Technologies, Inc. Method and device for calibration of biological flux
US11639925B2 (en) * 2017-04-06 2023-05-02 Agilent Technologies, Inc. Method and apparatus for measuring physiological properties of biological samples
US11768196B2 (en) 2017-07-07 2023-09-26 President And Fellows Of Harvard College Current-based stimulators for electrogenic cells and related methods
WO2019169295A1 (en) * 2018-03-02 2019-09-06 Ecolab Usa Inc. Ultralow range fluorometer calibration
WO2020041765A1 (en) * 2018-08-24 2020-02-27 Polybiomics, Inc. Integrated platforms for precise poly-sensing and imaging
JP2020048435A (en) * 2018-09-25 2020-04-02 国立大学法人 熊本大学 Real-time measuring tray of floating cells, measuring apparatus, and measuring method using the tray
SG11202106255SA (en) 2018-12-21 2021-07-29 Ecolab Usa Inc Quick tracer injection for monitoring osmosis membrane integrity
GB201903813D0 (en) 2019-03-20 2019-05-01 Cn Bio Innovations Ltd Dual circulation microphysiological system
EP4168172A1 (en) 2020-06-17 2023-04-26 President and Fellows of Harvard College Systems and methods for patterning and spatial electrochemical mapping of cells
CA3187265A1 (en) 2020-06-17 2021-12-23 President And Fellows Of Harvard College Apparatuses for cell mapping via impedance measurements and methods to operate the same
EP4166643A1 (en) * 2020-11-06 2023-04-19 PHC Holdings Corporation Sensor unit and cell culture analysis device having same
EP4308906A1 (en) 2021-03-14 2024-01-24 Agilent Technologies, Inc. System and method for analyzing biological material
US20230128888A1 (en) 2021-10-12 2023-04-27 Agilent Technologies, Inc. Methods and systems for determining metabolic poise and capacity of living cells
WO2023081354A1 (en) 2021-11-05 2023-05-11 Agilent Technologies, Inc. Apparatus and methods for generating and analyzing three-dimensional cellular materials
WO2023086372A1 (en) 2021-11-09 2023-05-19 Agilent Technologies, Inc. Wellplate apparatus and method for filling same
US20230256435A1 (en) 2022-02-03 2023-08-17 Agilent Technologies, Inc. Apparatuses and methods for analyzing live cells
WO2023196547A1 (en) 2022-04-08 2023-10-12 Agilent Technologies, Inc. Microtiter plate lid and magnetic adapter

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065357A (en) * 1974-01-21 1977-12-27 General Electric Company Detection of catalase-containing bacteria
US4599315A (en) * 1983-09-13 1986-07-08 University Of California Regents Microdroplet test apparatus
DE4016617A1 (en) * 1990-05-23 1991-11-28 Rainer Dylla Holder plate e.g. for blood samples - used with structured second plate to form gaps of variable vol. allowing use of small samples
US5250419A (en) * 1988-12-16 1993-10-05 L'oreal Method for the direct measurement of at least one chemical parameter of skin using a biosensor
DE4405375A1 (en) * 1994-02-19 1995-08-24 Fritz Nerbe Nachfolger Juergen Microtiter plate
WO1998015645A1 (en) * 1996-10-08 1998-04-16 Photonics Biosystems Microbiological assessment method and device utilizing oxygen gradient sensing
FR2792333A1 (en) * 1999-04-14 2000-10-20 Labonord DEVICE FOR DEPOSITING CELLS ON AN ANALYSIS PLATE
WO2002002736A1 (en) * 2000-06-30 2002-01-10 Precision System Science Co.,Ltd. Reaction vessel, reaction device and temperature control method for reaction liquid
WO2003004596A1 (en) * 2001-07-06 2003-01-16 Precision System Science Co., Ltd. Reaction container and reaction device
WO2003059518A1 (en) * 2002-01-17 2003-07-24 Univ College Cork Nat Univ Ie An assay device and method for chemical or biological screening

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US438632A (en) * 1890-10-21 Telephone
US438633A (en) * 1890-10-21 Machine for grinding wood to pulp
US438631A (en) * 1890-10-21 Island
FR2296476A1 (en) 1975-01-06 1976-07-30 Cardus Francis ELECTRICAL APPLIANCE FOR THE APPLICATION OF A MAINTENANCE OR TREATMENT PRODUCT
DE2711432A1 (en) 1977-03-16 1978-09-21 Bosch Gmbh Robert IGNITION SYSTEM, IN PARTICULAR FOR COMBUSTION MACHINERY
US4256832A (en) 1978-12-12 1981-03-17 Bioresearch Inc. Carcinogen and mutagen screening method and apparatus
US4405375A (en) 1980-05-21 1983-09-20 The B. F. Goodrich Company Niyuminouzbituminous emulsion roof resaturant
US4461328A (en) 1982-06-04 1984-07-24 Drummond Scientific Company Pipette device
US4498510A (en) 1982-08-20 1985-02-12 Minshew Jr Edward C Device for drawing, holding and dispensing liquid
US4593728A (en) * 1982-11-20 1986-06-10 Whitehead Thomas P Dispensing device and recording apparatus
DE3321285C2 (en) 1983-06-13 1985-06-20 Anton 8240 Berchtesgaden Stigler Method for producing a profile from dry powder material and device for this
US4711851A (en) * 1984-05-21 1987-12-08 State University Of New York Test apparatus for determining a metabolic characteristic of microorganisms
US5001048A (en) 1987-06-05 1991-03-19 Aurthur D. Little, Inc. Electrical biosensor containing a biological receptor immobilized and stabilized in a protein film
US5286364A (en) 1987-06-08 1994-02-15 Rutgers University Surface-modified electochemical biosensor
JPH0292270A (en) 1988-09-30 1990-04-03 Terumo Corp Device for cell culture
DE68922390T2 (en) * 1988-10-21 1995-10-05 Molecular Devices Corp METHOD AND APPARATUS FOR MEASURING THE EFFECTS OF CELL EFFECTIVE AGENTS ON LIVING CELLS.
US5278048A (en) * 1988-10-21 1994-01-11 Molecular Devices Corporation Methods for detecting the effect of cell affecting agents on living cells
US5200051A (en) 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5491097A (en) 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
US5156810A (en) 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
WO1994003583A1 (en) * 1992-07-29 1994-02-17 Oncotherapeutics An improved system for electronically monitoring and recording cell cultures
US5104804A (en) * 1990-06-04 1992-04-14 Molecular Devices Corporation Cell assay device used in a microphysiometer
KR930002824B1 (en) 1990-08-21 1993-04-10 손병기 Biosensor using ion sensitive field effect transistor
US5120421A (en) 1990-08-31 1992-06-09 The United States Of America As Represented By The United States Department Of Energy Electrochemical sensor/detector system and method
AU647609B2 (en) * 1991-04-18 1994-03-24 Becton Dickinson & Company Microbial monitoring device
US6395506B1 (en) * 1991-04-18 2002-05-28 Becton, Dickinson And Company Device for monitoring cells
US5264103A (en) 1991-10-18 1993-11-23 Matsushita Electric Industrial Co., Ltd. Biosensor and a method for measuring a concentration of a substrate in a sample
AU2907092A (en) 1991-10-21 1993-05-21 James W. Holm-Kennedy Method and device for biochemical sensing
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5370842A (en) 1991-11-29 1994-12-06 Canon Kabushiki Kaisha Sample measuring device and sample measuring system
DE4217868C2 (en) 1992-05-29 1995-01-26 Univ Schiller Jena Temperable multicuvette
US5345213A (en) 1992-10-26 1994-09-06 The United States Of America, As Represented By The Secretary Of Commerce Temperature-controlled, micromachined arrays for chemical sensor fabrication and operation
US5459300A (en) * 1993-03-03 1995-10-17 Kasman; David H. Microplate heater for providing uniform heating regardless of the geometry of the microplates
US6258325B1 (en) * 1993-04-19 2001-07-10 Ashok Ramesh Sanadi Method and apparatus for preventing cross-contamination of multi-well test plates
US5512492A (en) 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
DE4318519C2 (en) 1993-06-03 1996-11-28 Fraunhofer Ges Forschung Electrochemical sensor
US5766875A (en) * 1993-07-30 1998-06-16 Molecular Devices Corporation Metabolic monitoring of cells in a microplate reader
US5468605A (en) * 1993-10-15 1995-11-21 Molecular Devices Corp. Transverse flow plungers for microphysiometers
US5515864A (en) * 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
US6080574A (en) * 1994-05-10 2000-06-27 Becton, Dickinson And Company Composite optical blood culture sensor
US5792426A (en) * 1994-10-11 1998-08-11 Schweizerische Eidgenossenschaft Vertreten Durch Das Ac-Laboratorium Spiez Der Gruppe Rustung Multi-well titerplate for instrumental analysis
US6030917A (en) * 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
EP0722136A2 (en) 1995-01-12 1996-07-17 Joachim Schulz Thermostatised shaker
DE19512117A1 (en) 1995-04-04 1996-10-10 Itt Ind Gmbh Deutsche Measuring device
US20020168679A1 (en) 1998-06-11 2002-11-14 Gregory J. Naus Staining agents and protocols for characterizing malignant cells in culture
US20040023375A1 (en) 2002-07-30 2004-02-05 Precision Therapeutics, Inc. Method for preparing cell cultures from biological specimens for chemotherapeutic and other assays
US5728541A (en) 1996-07-12 1998-03-17 Precision Therapeutics, Inc. Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays
US6416967B2 (en) 1996-07-12 2002-07-09 Precision Therapeutics, Inc. Method of using multicellular particulates to analyze malignant or hyperproliferative tissue
US20040072722A1 (en) 2002-10-10 2004-04-15 Kornblith Paul L. Methods for assessing efficacy of chemotherapeutic agents
US5795426A (en) * 1996-08-05 1998-08-18 Boeing North American, Inc. Method and apparatus for effecting continuous multi-directional laminating
DE69735411T2 (en) * 1996-10-09 2006-09-07 Symyx Technologies, Inc., Santa Clara INFRARED SPECTROSCOPY AND LIBRARY IMAGING
DE19646505A1 (en) * 1996-11-12 1998-05-14 Itt Ind Gmbh Deutsche Device for carrying out tests on cell samples and the like
US6083761A (en) 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
US5774214A (en) * 1996-12-12 1998-06-30 Photometrics, Ltd. Multi-mode imaging apparatus for radiation-emitting or absorbing samples
US5830138A (en) * 1996-12-16 1998-11-03 Trustees Of The University Of Pennsylvania Intravascular catheter probe for clinical oxygen, pH and CO2 measurement
US6146967A (en) 1997-08-20 2000-11-14 Micron Technology, Inc. Selective deposition of amorphous silicon film seeded in a chlorine gas and a hydride gas ambient when forming a stacked capacitor with HSG
US6486947B2 (en) * 1998-07-22 2002-11-26 Ljl Biosystems, Inc. Devices and methods for sample analysis
EP0921391A1 (en) * 1997-12-05 1999-06-09 Interuniversitair Micro-Elektronica Centrum Vzw A device and a method thermal sensing
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
US6881584B1 (en) * 1998-05-15 2005-04-19 Smithkline Beecham Corporation Infrared thermography
JP3586194B2 (en) 1998-05-15 2004-11-10 グラクソ グループ リミテッド Infrared thermography
US5998517A (en) * 1998-06-05 1999-12-07 Becton, Dickinson And Company Composition for the detection of microorganisms in a sample
US6306658B1 (en) * 1998-08-13 2001-10-23 Symyx Technologies Parallel reactor with internal sensing
US6485692B1 (en) 1998-12-04 2002-11-26 Symyx Technologies, Inc. Continuous feed parallel reactor
JP2002532717A (en) 1998-12-11 2002-10-02 サイミックス テクノロジーズ、インク Sensor array based system and method for rapid material characterization
DE19903506C2 (en) * 1999-01-29 2002-04-04 Inst Chemo Biosensorik Method, vessel and device for monitoring the metabolic activity of cell cultures in liquid media
US6078698A (en) * 1999-09-20 2000-06-20 Flir Systems, Inc. System for reading data glyphs
DE19920811B4 (en) 1999-05-06 2004-08-19 Micronas Gmbh Device for carrying out tests on cell cultures
US7795012B2 (en) * 1999-05-06 2010-09-14 Micronas Gmbh Device for performing analysis on cell cultures
US6395555B1 (en) * 1999-10-14 2002-05-28 David F. Wilson Method and apparatus for determining the effect of a drug on cells
USD438631S1 (en) 1999-12-21 2001-03-06 Compucyte Corporation Reagent treatment cartridge
USD438632S1 (en) 1999-12-21 2001-03-06 Compucyte Corporation Multi-well reagent cartridge for treating a sample
USD438633S1 (en) 1999-12-21 2001-03-06 Compucyte Corporation Reagent cartridge for treating a sample
US7485454B1 (en) * 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
AUPQ653000A0 (en) 2000-03-28 2000-04-20 Cook Incorporated Perfusion incubator
US6880158B1 (en) 2000-04-10 2005-04-12 International Business Machines Corporation Network processor services architecture that is platform and operating system independent
WO2001080997A1 (en) * 2000-04-19 2001-11-01 Corning Incorporated Multi-well plate and method of manufacture
WO2001085901A2 (en) 2000-05-08 2001-11-15 Interuniversitair Micro-Elektronica Centrum Microphysiometer
AU2001268077A1 (en) 2000-06-22 2002-01-02 Atto Instruments, Llc. High efficiency cell analysis system and high throughput drug screening system
AU7166201A (en) * 2000-06-28 2002-01-08 Illumina Inc Composite arrays utilizing microspheres with a hybridization chamber
AU2001244834A1 (en) 2000-07-22 2002-02-05 Inbionet Corporation Novel strain for decomposing tmah, and method of wastewater treatment using the same
GB0019176D0 (en) 2000-08-05 2000-09-27 Cambridge Material Science Lim Monitoring thermal events
AU2001282908A1 (en) * 2000-08-14 2002-02-25 University Of Maryland Biotechnology Institute Bioreactor and bioprocessing technique
US6653124B1 (en) * 2000-11-10 2003-11-25 Cytoplex Biosciences Inc. Array-based microenvironment for cell culturing, cell monitoring and drug-target validation
US6821787B2 (en) * 2000-11-17 2004-11-23 Thermogenic Imaging, Inc. Apparatus and methods for infrared calorimetric measurements
US20040110301A1 (en) * 2000-11-17 2004-06-10 Neilson Andy C Apparatus and methods for measuring reaction byproducts
US20020132360A1 (en) * 2000-11-17 2002-09-19 Flir Systems Boston, Inc. Apparatus and methods for infrared calorimetric measurements
US20020098592A1 (en) * 2000-11-17 2002-07-25 Flir Systems Boston, Inc. Apparatus and methods for infrared calorimetric measurements
WO2002072423A1 (en) 2001-03-09 2002-09-19 Biomicro Systems, Inc. Microplate lid
JP2004527247A (en) 2001-04-10 2004-09-09 バイオプロセッサーズ コーポレイション Microfermentor devices and cell-based screening methods
US7118909B2 (en) 2001-05-30 2006-10-10 Gevaert Matthew R Apparatus and method for biomaterial assay
DE10136005C1 (en) 2001-06-06 2002-11-28 Infineon Technologies Ag Semiconductor temperature sensor using spreading-resistance principle, has 2 relatively spaced electrodes provided at surface of semiconductor layer
WO2002099386A2 (en) 2001-06-07 2002-12-12 Proligo Llc Microcalorimetric detection of analytes and binding events
US6794191B2 (en) 2001-06-25 2004-09-21 Photonic Systems Process for forming polymer structures containing an oxygen sensor
US6766817B2 (en) 2001-07-25 2004-07-27 Tubarc Technologies, Llc Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
JP2005528582A (en) * 2001-09-07 2005-09-22 コーニング インコーポレイテッド Array based on a microcolumn platform for high-throughput analysis
US20040086888A1 (en) 2001-10-18 2004-05-06 Kornblith Paul L Method for tandem genomic/proteomic analysis of proliferating cells
US20040009583A1 (en) * 2002-02-05 2004-01-15 Genome Therapeutics Corporation Seal for microtiter plate and methods of use thereof
EP1499705A2 (en) * 2002-05-01 2005-01-26 Massachusetts Institute of Technology Microfermentors for rapid screening and analysis of biochemical processes
US20040107986A1 (en) * 2002-12-06 2004-06-10 Neilson Andy C. High throughput microcalorimeter systems and methods
WO2004065618A2 (en) * 2003-01-16 2004-08-05 Thermogenic Imaging Methods and devices for monitoring cellular metabolism in microfluidic cell-retaining chambers
FI115060B (en) 2003-04-22 2005-02-28 Chip Man Technologies Oy Analysis and breeding equipment
DE10329983A1 (en) 2003-06-27 2005-03-31 Siemens Ag Micro-reactor module allows multiple different reactions to be performed simultaneously and to be serviced by a standard automatic micro-titer head, is formed of a multiple recessed base plate which is sealed by a releasable cover plate
US7276351B2 (en) 2003-09-10 2007-10-02 Seahorse Bioscience Method and device for measuring multiple physiological properties of cells
DE10346451B4 (en) * 2003-10-03 2007-08-02 Bionas Gmbh Method for monitoring changes and conditions in reaction chambers
US8658349B2 (en) 2006-07-13 2014-02-25 Seahorse Bioscience Cell analysis apparatus and method
US20070087401A1 (en) 2003-10-17 2007-04-19 Andy Neilson Analysis of metabolic activity in cells using extracellular flux rate measurements
BRPI0619944B8 (en) 2005-12-14 2018-03-20 Basf Catalysts Llc method for preparing a metal-promoted zeolite catalyst, zeolite catalyst, and method for reducing nox in an exhaust gas or combustible gas stream
US8202702B2 (en) 2008-10-14 2012-06-19 Seahorse Bioscience Method and device for measuring extracellular acidification and oxygen consumption rate with higher precision

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065357A (en) * 1974-01-21 1977-12-27 General Electric Company Detection of catalase-containing bacteria
US4599315A (en) * 1983-09-13 1986-07-08 University Of California Regents Microdroplet test apparatus
US5250419A (en) * 1988-12-16 1993-10-05 L'oreal Method for the direct measurement of at least one chemical parameter of skin using a biosensor
DE4016617A1 (en) * 1990-05-23 1991-11-28 Rainer Dylla Holder plate e.g. for blood samples - used with structured second plate to form gaps of variable vol. allowing use of small samples
DE4405375A1 (en) * 1994-02-19 1995-08-24 Fritz Nerbe Nachfolger Juergen Microtiter plate
WO1998015645A1 (en) * 1996-10-08 1998-04-16 Photonics Biosystems Microbiological assessment method and device utilizing oxygen gradient sensing
FR2792333A1 (en) * 1999-04-14 2000-10-20 Labonord DEVICE FOR DEPOSITING CELLS ON AN ANALYSIS PLATE
WO2002002736A1 (en) * 2000-06-30 2002-01-10 Precision System Science Co.,Ltd. Reaction vessel, reaction device and temperature control method for reaction liquid
WO2003004596A1 (en) * 2001-07-06 2003-01-16 Precision System Science Co., Ltd. Reaction container and reaction device
WO2003059518A1 (en) * 2002-01-17 2003-07-24 Univ College Cork Nat Univ Ie An assay device and method for chemical or biological screening

Also Published As

Publication number Publication date
US8697431B2 (en) 2014-04-15
WO2005026701B1 (en) 2005-06-16
US7638321B2 (en) 2009-12-29
US20160096173A1 (en) 2016-04-07
US7851201B2 (en) 2010-12-14
US20050054028A1 (en) 2005-03-10
EP1664740B1 (en) 2019-04-17
US9170253B2 (en) 2015-10-27
US20070238165A1 (en) 2007-10-11
EP2322913B1 (en) 2018-04-18
US7276351B2 (en) 2007-10-02
US20100105578A1 (en) 2010-04-29
US20100227385A1 (en) 2010-09-09
EP1664740A2 (en) 2006-06-07
JP2007505316A (en) 2007-03-08
EP2322913A3 (en) 2012-10-03
EP2322913A2 (en) 2011-05-18
US20140248650A1 (en) 2014-09-04
WO2005026701A2 (en) 2005-03-24

Similar Documents

Publication Publication Date Title
WO2005026701A3 (en) Method and device for measuring multiple physiological properties of cells
WO2006091426A3 (en) Methods and apparatus for extracting and analyzing a bodily fluid
AU2002304121A1 (en) Biosensor apparatus and method with sample type and volume detection
EP1633235A4 (en) Method and apparatus for body fluid sampling and analyte sensing
WO2007003344A3 (en) Device for quantitative analysis of a metabolite profile
WO2005016125A3 (en) Method and apparatus for body fluid sampling with integrated analyte detecting member
NO20042295L (en) Device, system and method for extracting body fluid and monitoring an analyte therein
HK1162898A1 (en) Method of inputting data into an analyte testing device
AU2003296946A1 (en) A biological sample storage device and method for biological sample contamination testing
WO2006049969A3 (en) Simultaneous detection of vitamins d2 and d3 using lc-ms/ms
WO2007106232A3 (en) Volume measurement using gas laws
WO2006054296A3 (en) Methods of detecting prostate cancer
EP1784637A4 (en) Method and device for extracting an analyte
AU2003297205A1 (en) Method and apparatus for measuring analytes
AU2003229893A1 (en) Method of detecting an analyte in a fluid
EP1657627A3 (en) Method and apparatus for navigating a menu in a display unit of an electronic device
EP1819283A4 (en) System and method for analyte sampling and analysis with hydrogel
WO2006052765A3 (en) Cycle and load measurement device
AU2001262709A1 (en) Method for measuring fluorescence, apparatus for measuring fluorescence and apparatus for evaluating sample using it
WO2007006661A3 (en) System and method for characterizing a chemical sample
WO2004113834A3 (en) Method of determining a dimension of a sample of a construction material and associated appartus
EP1720998A4 (en) Method and apparatus for measuring changes in cell volume
GB2492022A (en) Fluid sampling and analysis downhole using microconduit system
EP1678501A4 (en) Device, system and method of detecting targets in a fluid sample
AU2003246669A1 (en) Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200480029825.0

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BW BY BZ CA CH CN CO CR CU CZ DK DM DZ EC EE EG ES FI GB GD GE GM HR HU ID IL IN IS JP KE KG KP KZ LC LK LR LS LT LU LV MA MD MK MN MW MX MZ NA NI NO NZ PG PH PL PT RO RU SC SD SE SG SK SY TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SZ TZ UG ZM ZW AM AZ BY KG MD RU TJ TM AT BE BG CH CY DE DK EE ES FI FR GB GR HU IE IT MC NL PL PT RO SE SI SK TR BF CF CG CI CM GA GN GQ GW ML MR SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
B Later publication of amended claims

Effective date: 20050429

WWE Wipo information: entry into national phase

Ref document number: 1170/DELNP/2006

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2004788615

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2006526241

Country of ref document: JP

DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
WWP Wipo information: published in national office

Ref document number: 2004788615

Country of ref document: EP