WO2005026209A3 - Monoclonal antibodies against hmgb1 - Google Patents
Monoclonal antibodies against hmgb1 Download PDFInfo
- Publication number
- WO2005026209A3 WO2005026209A3 PCT/US2004/029527 US2004029527W WO2005026209A3 WO 2005026209 A3 WO2005026209 A3 WO 2005026209A3 US 2004029527 W US2004029527 W US 2004029527W WO 2005026209 A3 WO2005026209 A3 WO 2005026209A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- monoclonal antibodies
- antibodies against
- hmgb
- polypeptide
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4718—Cytokine-induced proteins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2538763A CA2538763C (en) | 2003-09-11 | 2004-09-10 | Monoclonal antibodies against hmgb1 |
AU2004272607A AU2004272607B2 (en) | 2003-09-11 | 2004-09-10 | Monoclonal antibodies against HMGB1 |
EP04788671A EP1668035A2 (en) | 2003-09-11 | 2004-09-10 | Monoclonal antibodies against hmgb1 |
JP2006526305A JP4792392B2 (en) | 2003-09-11 | 2004-09-10 | Monoclonal antibody against HMGB1 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50256803P | 2003-09-11 | 2003-09-11 | |
US60/502,568 | 2003-09-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005026209A2 WO2005026209A2 (en) | 2005-03-24 |
WO2005026209A3 true WO2005026209A3 (en) | 2005-09-15 |
Family
ID=34312406
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/029527 WO2005026209A2 (en) | 2003-09-11 | 2004-09-10 | Monoclonal antibodies against hmgb1 |
Country Status (7)
Country | Link |
---|---|
US (4) | US7288250B2 (en) |
EP (1) | EP1668035A2 (en) |
JP (2) | JP4792392B2 (en) |
CN (1) | CN1878793A (en) |
AU (1) | AU2004272607B2 (en) |
CA (2) | CA2538763C (en) |
WO (1) | WO2005026209A2 (en) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6303321B1 (en) † | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
US7696169B2 (en) * | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
EP1668035A2 (en) * | 2003-09-11 | 2006-06-14 | Critical Therapeutics, Inc. | Monoclonal antibodies against hmgb1 |
EP1717250A4 (en) * | 2004-02-20 | 2008-10-01 | Immuno Biological Lab Co Ltd | Monoclonal antibody and use thereof |
EP1768698A4 (en) * | 2004-06-17 | 2009-01-28 | Medimmune Inc | Immunogenic compositions comprising hmgb1 polypeptides |
US7470521B2 (en) | 2004-07-20 | 2008-12-30 | Critical Therapeutics, Inc. | RAGE protein derivatives |
US8129130B2 (en) | 2004-10-22 | 2012-03-06 | The Feinstein Institute For Medical Research | High affinity antibodies against HMGB1 and methods of use thereof |
AU2005333602B2 (en) * | 2004-10-22 | 2012-04-12 | Medimmune, Llc | High affinity antibodies against HMGB1 and methods of use thereof |
EP1819731A4 (en) * | 2004-12-08 | 2013-02-13 | Immunomedics Inc | Methods and compositions for immunotherapy and detection of inflammatory and immune-dysregulatory disease, infectious disease, pathologic angiogenesis and cancer |
US20100040607A1 (en) * | 2005-05-13 | 2010-02-18 | Tracey Kevin J | Combination Therapy with Inhibitors of HMGB and Caspase for the Treatment of Inflammatory Diseases |
WO2006138429A2 (en) * | 2005-06-16 | 2006-12-28 | The Feinstein Institute For Medical Research | Antibodies against hmgb1 and fragments thereof |
US20100040608A1 (en) * | 2005-07-18 | 2010-02-18 | Marie Wahren-Herlenius | Use of HMGB1 antagonists for the treatment of inflammatory skin conditions |
ES2543341T3 (en) | 2005-09-13 | 2015-08-18 | National Research Council Of Canada | Methods and compositions to modulate the activity of tumor cells |
WO2007031100A1 (en) * | 2005-09-14 | 2007-03-22 | Ostini, Marco | Active immunotherapy of life-threatening systemic inflammation |
JP3876325B1 (en) * | 2005-10-24 | 2007-01-31 | 国立大学法人 岡山大学 | Cerebral infarction inhibitor |
US20100172909A1 (en) * | 2005-10-24 | 2010-07-08 | Masahiro Nishibori | Cerebral edema suppressant |
CA2631212A1 (en) * | 2005-11-28 | 2007-07-05 | Medimmune, Llc | Antagonists of hmgb1 and/or rage and methods of use thereof |
JP3882090B1 (en) * | 2006-05-19 | 2007-02-14 | 国立大学法人 岡山大学 | Cerebral vasospasm inhibitor |
CN1850863B (en) * | 2006-05-23 | 2012-07-04 | 中国科学院生物物理研究所 | Antibody to self-antigen and/or intergeneric high conservative antigen, and its preparing method |
JP4982739B2 (en) * | 2006-06-01 | 2012-07-25 | 国立大学法人 東京医科歯科大学 | Preventive and therapeutic agent for polyglutamine disease |
EP2105447A4 (en) * | 2006-12-20 | 2010-05-05 | Shino Test Corp | Avian-derived antibody capable of binding specifically to human hmgb1, immunological determination method for human hmgb1, and immunological determination reagent for human hmgb1 |
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CA2538763A1 (en) | 2005-03-24 |
AU2004272607A1 (en) | 2005-03-24 |
JP5513441B2 (en) | 2014-06-04 |
US20090148453A1 (en) | 2009-06-11 |
US20080113385A1 (en) | 2008-05-15 |
US8846047B2 (en) | 2014-09-30 |
WO2005026209A2 (en) | 2005-03-24 |
JP2007527406A (en) | 2007-09-27 |
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