WO2005019804A3 - Microfluidic chip with enhanced tip for stable electrospray ionization - Google Patents
Microfluidic chip with enhanced tip for stable electrospray ionization Download PDFInfo
- Publication number
- WO2005019804A3 WO2005019804A3 PCT/US2004/027774 US2004027774W WO2005019804A3 WO 2005019804 A3 WO2005019804 A3 WO 2005019804A3 US 2004027774 W US2004027774 W US 2004027774W WO 2005019804 A3 WO2005019804 A3 WO 2005019804A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tip
- fluid channels
- microfluidic chip
- electrospray
- open
- Prior art date
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
- H01J49/167—Capillaries and nozzles specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
- B81B1/006—Microdevices formed as a single homogeneous piece, i.e. wherein the mechanical function is obtained by the use of the device, e.g. cutters
- B81B1/008—Microtips
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0013—Miniaturised spectrometers, e.g. having smaller than usual scale, integrated conventional components
- H01J49/0018—Microminiaturised spectrometers, e.g. chip-integrated devices, MicroElectro-Mechanical Systems [MEMS]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
- B01L2400/027—Drop detachment mechanisms of single droplets from nozzles or pins electrostatic forces between substrate and tip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B2201/00—Specific applications of microelectromechanical systems
- B81B2201/05—Microfluidics
- B81B2201/058—Microfluidics not provided for in B81B2201/051 - B81B2201/054
Abstract
A microfluidic chip (10) formed with multiple fluid channels (12) terminating at a tapered electrospray ionization tip (14) for mass spectrometric analysis. The fluid channels (12) may be formed onto a channel plate that are in fluid communication with corresponding reservoirs. The electrospray tip (15) can be formed along a defined distal portion of the channel plate that can include a single or multiple tapered surfaces. The fluid channels (12) may terminate at an open-tip region (18) of the electrospray tip (15). A covering plate (5) may substantially enclose most portions of the fluid channels (12) formed on the channel plate except for the open-tip region (18). Another aspect of the invention provides methods for conducting mass spectrometric analysis of multiple samples flowing through individual fluid channels (12) in a single microfluidic chip (10) that is formed with a tapered electrospray tip (14) having an open-tip region (18).
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/649,350 | 2003-08-26 | ||
US10/649,350 US6803568B2 (en) | 2001-09-19 | 2003-08-26 | Multi-channel microfluidic chip for electrospray ionization |
US10/871,498 US7105812B2 (en) | 2003-08-26 | 2004-06-18 | Microfluidic chip with enhanced tip for stable electrospray ionization |
US10/871,498 | 2004-06-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005019804A2 WO2005019804A2 (en) | 2005-03-03 |
WO2005019804A3 true WO2005019804A3 (en) | 2006-01-26 |
Family
ID=34216926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/027774 WO2005019804A2 (en) | 2003-08-26 | 2004-08-25 | Microfluidic chip with enhanced tip for stable electrospray ionization |
Country Status (2)
Country | Link |
---|---|
US (2) | US6803568B2 (en) |
WO (1) | WO2005019804A2 (en) |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1166340A4 (en) * | 1998-11-19 | 2009-04-22 | California Inst Of Techn | Polymer-based electrospray nozzle for mass spectrometry |
US6967324B2 (en) * | 2000-02-17 | 2005-11-22 | Agilent Technologies, Inc. | Micro matrix ion generator for analyzers |
US6803568B2 (en) * | 2001-09-19 | 2004-10-12 | Predicant Biosciences, Inc. | Multi-channel microfluidic chip for electrospray ionization |
US20030148539A1 (en) * | 2001-11-05 | 2003-08-07 | California Institute Of Technology | Micro fabricated fountain pen apparatus and method for ultra high density biological arrays |
US7105810B2 (en) * | 2001-12-21 | 2006-09-12 | Cornell Research Foundation, Inc. | Electrospray emitter for microfluidic channel |
US7303727B1 (en) * | 2002-03-06 | 2007-12-04 | Caliper Life Sciences, Inc | Microfluidic sample delivery devices, systems, and methods |
GB0226160D0 (en) * | 2002-11-08 | 2002-12-18 | Diagnoswiss Sa | Apparatus for dispensing a sample in electrospray mass spectrometers |
US20030166263A1 (en) * | 2002-12-30 | 2003-09-04 | Haushalter Robert C. | Microfabricated spotting apparatus for producing low cost microarrays |
SE0300454D0 (en) * | 2003-02-19 | 2003-02-19 | Aamic Ab | Nozzles for electrospray ionization and methods of fabricating them |
US7007710B2 (en) * | 2003-04-21 | 2006-03-07 | Predicant Biosciences, Inc. | Microfluidic devices and methods |
US7425700B2 (en) * | 2003-05-22 | 2008-09-16 | Stults John T | Systems and methods for discovery and analysis of markers |
JP4174599B2 (en) * | 2003-07-08 | 2008-11-05 | 株式会社島津製作所 | High-performance liquid chromatograph fractionator |
US7537807B2 (en) | 2003-09-26 | 2009-05-26 | Cornell University | Scanned source oriented nanofiber formation |
US20050072915A1 (en) * | 2003-10-07 | 2005-04-07 | Biospect Inc. | Methods and apparatus for self-optimization of electrospray ionization devices |
US20050101025A1 (en) * | 2003-11-12 | 2005-05-12 | Ho Winston Z. | Apparatus for proteins and nucleic acids analysis |
US20070178014A1 (en) * | 2003-12-12 | 2007-08-02 | Parallel Synthesis Technologies, Inc. | Device and method for microcontact printing |
US20050133712A1 (en) * | 2003-12-18 | 2005-06-23 | Predicant Biosciences, Inc. | Scan pipelining for sensitivity improvement of orthogonal time-of-flight mass spectrometers |
US7282705B2 (en) * | 2003-12-19 | 2007-10-16 | Agilent Technologies, Inc. | Microdevice having an annular lining for producing an electrospray emitter |
JP4207782B2 (en) * | 2004-01-06 | 2009-01-14 | 株式会社島津製作所 | Liquid chromatograph fractionator |
JP4148143B2 (en) * | 2004-01-19 | 2008-09-10 | 株式会社島津製作所 | Fractionation device such as liquid chromatograph |
FR2865806B1 (en) * | 2004-01-30 | 2007-02-02 | Commissariat Energie Atomique | ON-CHIP LABORATORY COMPRISING A MICRO-FLUIDIC NETWORK AND A COPLANAR ELECTRONEBULATING NOSE |
TW200600777A (en) * | 2004-02-23 | 2006-01-01 | Metara Inc | Multiple electrospray probe interface for mass spectrometry |
US8394341B2 (en) * | 2004-03-08 | 2013-03-12 | Agilent Technologies, Inc. | Microfluidic chip frame |
US6958473B2 (en) * | 2004-03-25 | 2005-10-25 | Predicant Biosciences, Inc. | A-priori biomarker knowledge based mass filtering for enhanced biomarker detection |
US20060022130A1 (en) * | 2004-07-29 | 2006-02-02 | Predicant Biosciences, Inc., A Delaware Corporation | Microfluidic devices and methods with integrated electrical contact |
US20060057209A1 (en) * | 2004-09-16 | 2006-03-16 | Predicant Biosciences, Inc. | Methods, compositions and devices, including microfluidic devices, comprising coated hydrophobic surfaces |
US20060060769A1 (en) * | 2004-09-21 | 2006-03-23 | Predicant Biosciences, Inc. | Electrospray apparatus with an integrated electrode |
US8496818B2 (en) * | 2004-10-07 | 2013-07-30 | Waters Technologies Corporation | HPLC capillary column device |
US20080279727A1 (en) * | 2005-03-01 | 2008-11-13 | Haushalter Robert C | Polymeric Fluid Transfer and Printing Devices |
US20070017812A1 (en) * | 2005-03-30 | 2007-01-25 | Luc Bousse | Optimized Sample Injection Structures in Microfluidic Separations |
CN101176001A (en) * | 2005-05-19 | 2008-05-07 | 柯尼卡美能达医疗印刷器材株式会社 | Testing chip and micro integrated analysis system |
EP1746631B1 (en) | 2005-07-20 | 2013-06-19 | Microsaic Systems PLC | Microengineered nanospray electrode system |
WO2007016432A2 (en) * | 2005-07-29 | 2007-02-08 | West Virginia University Research Corporation | Apparatus and method for coupling microfluidic systems with a mass spectrometer utilizing rapid voltage switching |
EP1922364A4 (en) | 2005-08-09 | 2010-04-21 | Univ North Carolina | Methods and materials for fabricating microfluidic devices |
US20070140918A1 (en) * | 2005-12-19 | 2007-06-21 | Hongfeng Yin | Fluidic separation devices and methods with reduced sample broadening |
US8282873B2 (en) * | 2006-01-03 | 2012-10-09 | Victor Barinov | Controlled electrospinning of fibers |
JP5077227B2 (en) * | 2006-03-29 | 2012-11-21 | コニカミノルタエムジー株式会社 | Reaction method and analysis device in flow path of microchip |
WO2008020326A2 (en) * | 2006-04-07 | 2008-02-21 | Victor Barinov | Controlled electrospinning of fibers |
US7495210B2 (en) * | 2006-05-04 | 2009-02-24 | Agilent Technologies, Inc. | Micro fluidic gas assisted ionization device and method |
US7880140B2 (en) * | 2007-05-02 | 2011-02-01 | Dh Technologies Development Pte. Ltd | Multipole mass filter having improved mass resolution |
JP5494480B2 (en) | 2007-06-11 | 2014-05-14 | 和光純薬工業株式会社 | Microchip large capacity PCR using integrated real-time CE detection |
WO2009111431A2 (en) * | 2008-03-04 | 2009-09-11 | Waters Technologies Corporation | Interfacing with a digital microfluidic device |
WO2009114951A1 (en) * | 2008-03-21 | 2009-09-24 | Queen's University At Kingston | Multi-channel electrospray emitter |
FR2934179B1 (en) * | 2008-07-24 | 2010-09-17 | Commissariat Energie Atomique | LABORATORY ON CHIP COMPRISING A MICRO-FLUIDIC NETWORK AND A COPLANAR ELECTRONEBULATING NOSE. |
US8709356B2 (en) * | 2009-04-10 | 2014-04-29 | Canon U.S. Life Sciences, Inc. | Systems and methods for minimization or elimination of diffusion effects in a microfluidic system |
CN102421517B (en) * | 2009-05-07 | 2015-04-22 | 国际商业机器公司 | Multilayer microfluidic probe head and method of fabrication thereof |
WO2010141131A1 (en) | 2009-06-04 | 2010-12-09 | Lockheed Martin Corporation | Multiple-sample microfluidic chip for dna analysis |
CA2715365C (en) * | 2009-09-21 | 2019-04-23 | Queen's University At Kingston | Multi-channel electrospray emitter |
US8207496B2 (en) | 2010-02-05 | 2012-06-26 | Thermo Finnigan Llc | Multi-needle multi-parallel nanospray ionization source for mass spectrometry |
GB201011019D0 (en) | 2010-07-01 | 2010-08-18 | Weston Richard | Ionisation mass spectrometry |
AU2011315951B2 (en) | 2010-10-15 | 2015-03-19 | Lockheed Martin Corporation | Micro fluidic optic design |
TWI532530B (en) * | 2010-10-29 | 2016-05-11 | 萬國商業機器公司 | Multilayer microfluidic probe head with immersion channels and fabrication thereof |
US9006648B2 (en) * | 2011-03-11 | 2015-04-14 | The University Of North Carolina At Chapel Hill | Microchips with integrated multiple electrospray ionization emitters and related methods, systems and devices |
WO2012125381A1 (en) * | 2011-03-11 | 2012-09-20 | Waters Technologies Corporation | Electrokinetically controlled calibrant delivery |
US9234880B2 (en) * | 2011-06-03 | 2016-01-12 | University Of Washington Through Its Center For Commercialization | Sheath-flow electrospray interface |
WO2013003795A1 (en) * | 2011-06-29 | 2013-01-03 | The Regents Of The University Of California | Multinozzle emitter arrays for ultrahigh-throughput nanoelectrospray mass spectrometry |
EP2739341B1 (en) | 2011-08-01 | 2021-02-17 | Alcyone Lifesciences, Inc. | Microfluidic drug delivery devices |
US11053535B2 (en) | 2011-09-12 | 2021-07-06 | The University Of North Carolina At Chapel Hill | Devices with a fluid transport nanochannel intersected by a fluid sensing nanochannel and related methods |
EP3591408A1 (en) | 2012-02-10 | 2020-01-08 | The University of North Carolina at Chapel Hill | Devices with fluidic nanofunnels, associated methods, fabrication and analysis systems |
EP2815420B1 (en) * | 2012-02-13 | 2022-12-21 | Waters Technologies Corporation | Ionization of analyte molecules comprised in a flow of gas |
US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
WO2013191908A1 (en) | 2012-06-20 | 2013-12-27 | The University Of North Carolina At Chapel Hill | Integrated sample processing for electrospray ionization devices |
CN102764676B (en) * | 2012-07-23 | 2014-08-06 | 西安交通大学 | Microfluidic chip with non-contact light drive-bipolar electrode (BPE) |
CN102886280B (en) * | 2012-08-28 | 2014-06-11 | 博奥生物有限公司 | Microfluidic chip and application thereof |
US8992458B2 (en) | 2012-12-18 | 2015-03-31 | Alcyone Lifesciences, Inc. | Systems and methods for reducing or preventing backflow in a delivery system |
EP2962117B1 (en) | 2013-02-28 | 2019-10-09 | The University of North Carolina At Chapel Hill | Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis |
NZ711033A (en) | 2013-03-13 | 2020-03-27 | Univ North Carolina Chapel Hill | Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis |
US9064680B2 (en) * | 2013-05-01 | 2015-06-23 | Ut-Battelle, Llc | AFM fluid delivery/liquid extraction surface sampling/electrostatic spray cantilever probe |
JP2016522069A (en) | 2013-06-17 | 2016-07-28 | アルキオーネ・ライフサイエンシズ・インコーポレイテッドAlcyone Lifesciences, Inc. | Method and apparatus for protecting catheter tip and stereotaxic fixture for microcatheter |
JP6498670B2 (en) | 2013-07-31 | 2019-04-10 | アルキオーネ・ライフサイエンシズ・インコーポレイテッドAlcyone Lifesciences, Inc. | Systems and methods for drug delivery, therapy, and monitoring |
EP3089811B1 (en) * | 2013-12-30 | 2019-11-06 | Purdue Research Foundation | Mass spectrometry probes and systems for ionizing a sample |
WO2015112429A1 (en) * | 2014-01-23 | 2015-07-30 | Newomics Inc | Methods and systems for diagnosing diseases |
KR101562865B1 (en) * | 2014-01-24 | 2015-10-26 | 한국과학기술연구원 | Micro sensing system for detecting Neurotrophic Factors |
US10000789B2 (en) | 2014-06-17 | 2018-06-19 | The Board Of Regents Of The University Of Oklahoma | Cellular probe device, system and analysis method |
US9595428B2 (en) | 2014-06-17 | 2017-03-14 | The Board Of Regents Of The University Oklahoma | Cellular probe device, system and analysis method |
US10806396B2 (en) | 2015-01-26 | 2020-10-20 | Alcyone Lifesciences, Inc. | Drug delivery methods with tracer |
US10297435B2 (en) | 2015-01-27 | 2019-05-21 | Queen's University At Kingston | Micro-nozzle array |
US10471428B2 (en) | 2015-05-11 | 2019-11-12 | The University Of North Carolina At Chapel Hill | Fluidic devices with nanoscale manifolds for molecular transport, related systems and methods of analysis |
WO2016183521A1 (en) | 2015-05-13 | 2016-11-17 | Newomics Inc. | Methods and systems for biomonitoring |
KR101691508B1 (en) * | 2015-09-03 | 2016-12-30 | 한국과학기술연구원 | Neural probe structure comprising cover element where fluid delivery channel is formed |
US10329079B2 (en) * | 2015-10-06 | 2019-06-25 | Hamilton Sundstrand Corporation | Aerosol/solvent delivery nozzles |
WO2017062609A1 (en) * | 2015-10-06 | 2017-04-13 | University Of Miami | Multiwell culture devices with perfusion and oxygen control |
AU2016365121B2 (en) * | 2015-11-30 | 2022-03-03 | Intabio, Inc. | Devices and methods for sample characterization |
CN108472019A (en) | 2016-01-04 | 2018-08-31 | 亚克安娜生命科学有限公司 | Method and apparatus for treating apoplexy |
AU2017213725B2 (en) | 2016-02-01 | 2021-12-23 | Li-Cor, Inc. | Capillary electrophoresis inkjet dispensing |
US10672601B2 (en) * | 2016-06-07 | 2020-06-02 | The Regents Of The University Of California | Detecting compounds in microfluidic droplets using mass spectrometry |
AU2017311105A1 (en) * | 2016-08-08 | 2019-02-21 | Li-Cor, Inc. | Multi-sheath flow and on-chip terminating electrode for microfluidic direct-blotting |
CA3031212A1 (en) | 2016-08-08 | 2018-02-15 | Li-Cor, Inc. | Microchip electrophoresis inkjet dispensing |
CN106881160A (en) * | 2017-05-03 | 2017-06-23 | 山东大学 | A kind of candida albicans bacterium micro-fluidic chip |
CN108666201A (en) * | 2017-12-31 | 2018-10-16 | 宁波华仪宁创智能科技有限公司 | Incude Nanoliter electrospray ion source and its working method |
EP3746211A4 (en) * | 2018-01-29 | 2021-10-27 | Intabio, Inc. | Devices, methods and kits for sample characterization |
SG11202011729UA (en) | 2018-05-31 | 2020-12-30 | Intabio Inc | Software for microfluidic systems interfacing with mass spectrometry |
WO2021026172A1 (en) | 2019-08-05 | 2021-02-11 | Seer, Inc. | Systems and methods for sample preparation, data generation, and protein corona analysis |
US11285484B2 (en) | 2019-08-12 | 2022-03-29 | Intabio, Llc | Multichannel isoelectric focusing devices and high voltage power supplies |
US11635353B2 (en) * | 2020-06-17 | 2023-04-25 | The United States Of America, As Represented By The Secretary Of The Navy | Sample collection device |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6465776B1 (en) * | 2000-06-02 | 2002-10-15 | Board Of Regents, The University Of Texas System | Mass spectrometer apparatus for analyzing multiple fluid samples concurrently |
US20030089605A1 (en) * | 2001-10-19 | 2003-05-15 | West Virginia University Research Corporation | Microfluidic system for proteome analysis |
US6803568B2 (en) * | 2001-09-19 | 2004-10-12 | Predicant Biosciences, Inc. | Multi-channel microfluidic chip for electrospray ionization |
Family Cites Families (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4443319A (en) * | 1982-09-30 | 1984-04-17 | E. I. Du Pont De Nemours And Company | Device for electrophoresis |
US4483885A (en) | 1982-09-30 | 1984-11-20 | E. I. Du Pont De Nemours & Company | Method and device for electrophoresis |
USRE34757E (en) * | 1988-04-05 | 1994-10-18 | Battelle Memorial Institute | Combined electrophoresis-electrospray interface and method |
US4908112A (en) | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
CA1307859C (en) | 1988-12-12 | 1992-09-22 | Donald James Douglas | Mass spectrometer and method with improved ion transmission |
US5228989A (en) | 1989-07-06 | 1993-07-20 | Perseptive Biosystems, Inc. | Perfusive chromatography |
US6176962B1 (en) * | 1990-02-28 | 2001-01-23 | Aclara Biosciences, Inc. | Methods for fabricating enclosed microchannel structures |
US6054034A (en) * | 1990-02-28 | 2000-04-25 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
US5858188A (en) * | 1990-02-28 | 1999-01-12 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
US5935401A (en) * | 1996-09-18 | 1999-08-10 | Aclara Biosciences | Surface modified electrophoretic chambers |
US5170053A (en) * | 1990-08-30 | 1992-12-08 | Finnigan Corporation | Electrospray ion source and interface apparatus and method |
US5115131A (en) | 1991-05-15 | 1992-05-19 | The University Of North Carolina At Chapel Hill | Microelectrospray method and apparatus |
US6462337B1 (en) | 2000-04-20 | 2002-10-08 | Agilent Technologies, Inc. | Mass spectrometer electrospray ionization |
DE59108591D1 (en) * | 1991-12-06 | 1997-04-10 | Ciba Geigy Ag | Electrophoretic separation device and electrophoretic separation process |
US5306910A (en) | 1992-04-10 | 1994-04-26 | Millipore Corporation | Time modulated electrified spray apparatus and process |
US5223226A (en) | 1992-04-14 | 1993-06-29 | Millipore Corporation | Insulated needle for forming an electrospray |
US5637469A (en) | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
US5958202A (en) * | 1992-09-14 | 1999-09-28 | Perseptive Biosystems, Inc. | Capillary electrophoresis enzyme immunoassay |
US5358618A (en) * | 1993-01-22 | 1994-10-25 | The Penn State Research Foundation | Capillary electrophoresis apparatus with improved electroosmotic flow control |
EP0620432B1 (en) * | 1993-04-15 | 2004-08-25 | Zeptosens AG | Method for controlling sample introduction in microcolumn separation techniques and sampling device |
US5423964A (en) * | 1993-08-02 | 1995-06-13 | Battelle Memorial Institute | Combined electrophoresis-electrospray interface and method |
DE59410283D1 (en) * | 1993-11-11 | 2003-06-18 | Aclara Biosciences Inc | Device and method for the electrophoretic separation of fluid substance mixtures |
US6001229A (en) * | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
US5658413A (en) | 1994-10-19 | 1997-08-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
US5587582A (en) * | 1995-05-19 | 1996-12-24 | Cornell Research Foundation, Inc. | Self-aligning liquid junction |
US5624539A (en) * | 1995-06-19 | 1997-04-29 | The Penn State Research Foundation | Real time monitoring of electroosmotic flow in capillary electrophoresis |
US5872010A (en) * | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
US5705813A (en) | 1995-11-01 | 1998-01-06 | Hewlett-Packard Company | Integrated planar liquid handling system for maldi-TOF MS |
US5716825A (en) | 1995-11-01 | 1998-02-10 | Hewlett Packard Company | Integrated nucleic acid analysis system for MALDI-TOF MS |
EP0888169A4 (en) * | 1996-01-19 | 2006-06-14 | Univ Northeastern | Subatmospheric, variable pressure sample delivery chamber for electrospray ionization/mass spectrometry and other applications |
US5868322A (en) | 1996-01-31 | 1999-02-09 | Hewlett-Packard Company | Apparatus for forming liquid droplets having a mechanically fixed inner microtube |
US5917184A (en) * | 1996-02-08 | 1999-06-29 | Perseptive Biosystems | Interface between liquid flow and mass spectrometer |
US5885470A (en) * | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
US5945678A (en) | 1996-05-21 | 1999-08-31 | Hamamatsu Photonics K.K. | Ionizing analysis apparatus |
US5800690A (en) | 1996-07-03 | 1998-09-01 | Caliper Technologies Corporation | Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces |
SE9602638D0 (en) | 1996-07-03 | 1996-07-03 | Pharmacia Biotech Ab | An improved method for the capillary electrophoresis of nucleic acids, proteins and low molecular charged compounds |
US5699157A (en) * | 1996-07-16 | 1997-12-16 | Caliper Technologies Corp. | Fourier detection of species migrating in a microchannel |
US6136212A (en) | 1996-08-12 | 2000-10-24 | The Regents Of The University Of Michigan | Polymer-based micromachining for microfluidic devices |
US5788166A (en) | 1996-08-27 | 1998-08-04 | Cornell Research Foundation, Inc. | Electrospray ionization source and method of using the same |
US6110343A (en) * | 1996-10-04 | 2000-08-29 | Lockheed Martin Energy Research Corporation | Material transport method and apparatus |
US5914184A (en) | 1996-12-30 | 1999-06-22 | Kimberly-Clark Worldwide, Inc. | Breathable laminate including filled film and continuous film |
WO1998035376A1 (en) | 1997-01-27 | 1998-08-13 | California Institute Of Technology | Mems electrospray nozzle for mass spectroscopy |
US6159739A (en) | 1997-03-26 | 2000-12-12 | University Of Washington | Device and method for 3-dimensional alignment of particles in microfabricated flow channels |
US6391622B1 (en) * | 1997-04-04 | 2002-05-21 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
US6187190B1 (en) * | 1997-05-09 | 2001-02-13 | Battelle Memorial Institute | Apparatus for molecular weight separation |
US6090251A (en) * | 1997-06-06 | 2000-07-18 | Caliper Technologies, Inc. | Microfabricated structures for facilitating fluid introduction into microfluidic devices |
US5869004A (en) | 1997-06-09 | 1999-02-09 | Caliper Technologies Corp. | Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems |
US5993633A (en) | 1997-07-31 | 1999-11-30 | Battelle Memorial Institute | Capillary electrophoresis electrospray ionization mass spectrometry interface |
DE69829398T2 (en) * | 1997-09-12 | 2006-04-13 | Analytica of Branford, Inc., Branford | MORE SAMPLE LAUNCH MASS |
CA2301557A1 (en) * | 1997-09-19 | 1999-04-01 | Aclara Biosciences, Inc. | Apparatus and method for transferring liquids |
US6012902A (en) * | 1997-09-25 | 2000-01-11 | Caliper Technologies Corp. | Micropump |
US6007775A (en) * | 1997-09-26 | 1999-12-28 | University Of Washington | Multiple analyte diffusion based chemical sensor |
US5842787A (en) * | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
US6139734A (en) | 1997-10-20 | 2000-10-31 | University Of Virginia Patent Foundation | Apparatus for structural characterization of biological moieties through HPLC separation |
US6576896B2 (en) * | 1997-12-12 | 2003-06-10 | University Of Washington | Electroosmotic fluidic device and related methods |
US5969353A (en) * | 1998-01-22 | 1999-10-19 | Millennium Pharmaceuticals, Inc. | Microfluid chip mass spectrometer interface |
US6318970B1 (en) | 1998-03-12 | 2001-11-20 | Micralyne Inc. | Fluidic devices |
US6123798A (en) * | 1998-05-06 | 2000-09-26 | Caliper Technologies Corp. | Methods of fabricating polymeric structures incorporating microscale fluidic elements |
US6459080B1 (en) * | 1998-06-12 | 2002-10-01 | Agilent Technologies, Inc. | Miniaturized device for separating the constituents of a sample and delivering the constituents of the separated sample to a mass spectrometer |
US6245227B1 (en) | 1998-09-17 | 2001-06-12 | Kionix, Inc. | Integrated monolithic microfabricated electrospray and liquid chromatography system and method |
CN1312473C (en) * | 1998-09-17 | 2007-04-25 | 阿德文生物科学公司 | Liquid phase chromatographic system, chemical separating device and mass spectrometer and method |
US6625208B2 (en) * | 1998-09-25 | 2003-09-23 | Intel Corporation | Modem using batch processing of signal samples |
US6086243A (en) * | 1998-10-01 | 2000-07-11 | Sandia Corporation | Electrokinetic micro-fluid mixer |
US6605472B1 (en) * | 1998-10-09 | 2003-08-12 | The Governors Of The University Of Alberta | Microfluidic devices connected to glass capillaries with minimal dead volume |
US6240790B1 (en) * | 1998-11-09 | 2001-06-05 | Agilent Technologies, Inc. | Device for high throughout sample processing, analysis and collection, and methods of use thereof |
US6450189B1 (en) | 1998-11-13 | 2002-09-17 | Universidad De Sevilla | Method and device for production of components for microfabrication |
US6416642B1 (en) * | 1999-01-21 | 2002-07-09 | Caliper Technologies Corp. | Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection |
ATE469699T1 (en) * | 1999-02-23 | 2010-06-15 | Caliper Life Sciences Inc | MANIPULATION OF MICROPARTICLES IN MICROFLUID SYSTEMS |
US6500323B1 (en) | 1999-03-26 | 2002-12-31 | Caliper Technologies Corp. | Methods and software for designing microfluidic devices |
US6368562B1 (en) * | 1999-04-16 | 2002-04-09 | Orchid Biosciences, Inc. | Liquid transportation system for microfluidic device |
US6375817B1 (en) * | 1999-04-16 | 2002-04-23 | Perseptive Biosystems, Inc. | Apparatus and methods for sample analysis |
US6524456B1 (en) * | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes |
US6284115B1 (en) * | 1999-09-21 | 2001-09-04 | Agilent Technologies, Inc. | In-line flow through micro-dialysis apparatus and method for high performance liquid phase separations |
DE19947496C2 (en) * | 1999-10-01 | 2003-05-22 | Agilent Technologies Inc | Microfluidic microchip |
DE19964337B4 (en) * | 1999-10-01 | 2004-09-16 | Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto | Microfluidic microchip with bendable suction tube |
DE19949551C2 (en) | 1999-10-14 | 2001-12-13 | Agilent Technologies Inc | Microfluidic microchip, energy supply device and method for operating a microfluidic microchip |
WO2001050499A1 (en) * | 1999-12-30 | 2001-07-12 | Advion Biosciences, Inc. | Multiple electrospray device, systems and methods |
US6596988B2 (en) * | 2000-01-18 | 2003-07-22 | Advion Biosciences, Inc. | Separation media, multiple electrospray nozzle system and method |
SE0000300D0 (en) * | 2000-01-30 | 2000-01-30 | Amersham Pharm Biotech Ab | Microfluidic assembly, covering method for the manufacture of the assembly and the use of the assembly |
WO2001062887A1 (en) * | 2000-02-23 | 2001-08-30 | Zyomyx, Inc. | Chips having elevated sample surfaces |
US6733645B1 (en) * | 2000-04-18 | 2004-05-11 | Caliper Technologies Corp. | Total analyte quantitation |
SE0004233D0 (en) * | 2000-06-08 | 2000-11-17 | Jonas Bergquist Jonas | Electrospray emitter |
US6939451B2 (en) * | 2000-09-19 | 2005-09-06 | Aclara Biosciences, Inc. | Microfluidic chip having integrated electrodes |
AU2001296551A1 (en) * | 2000-10-05 | 2002-04-15 | E.I. Du Pont De Nemours And Company | Polymeric microfabricated fluidic device suitable for ultraviolet detection |
ATE432466T1 (en) * | 2000-10-31 | 2009-06-15 | Caliper Life Sciences Inc | MICROFLUIDIC PROCESS FOR IN-SITU MATERIAL CONCENTRATION |
US6607644B1 (en) * | 2000-10-31 | 2003-08-19 | Agilent Technolgoies, Inc. | Microanalytical device containing a membrane for molecular identification |
US6879162B2 (en) * | 2000-11-07 | 2005-04-12 | Sri International | System and method of micro-fluidic handling and dispensing using micro-nozzle structures |
AU2002248149A1 (en) * | 2000-11-16 | 2002-08-12 | Fluidigm Corporation | Microfluidic devices for introducing and dispensing fluids from microfluidic systems |
US6783992B2 (en) * | 2001-01-03 | 2004-08-31 | Agilent Technologies, Inc. | Methods and using chemico-mechanical microvalve devices for the selective separation of components from multi-component fluid samples |
CN1253238C (en) * | 2001-01-26 | 2006-04-26 | 阿德维昂生物科学公司 | Robotic autosampler for automated electrospray from microfluidic chip |
WO2002060754A1 (en) * | 2001-01-29 | 2002-08-08 | Caliper Technologies Corp. | Non-mechanical valves for fluidic systems |
US20020100714A1 (en) * | 2001-01-31 | 2002-08-01 | Sau Lan Tang Staats | Microfluidic devices |
GB0103516D0 (en) * | 2001-02-13 | 2001-03-28 | Cole Polytechnique Federale De | Apparatus for dispensing a sample |
SE0100952D0 (en) * | 2001-03-19 | 2001-03-19 | Gyros Ab | A microfluidic system (MS) |
CA2448387C (en) * | 2001-05-24 | 2008-02-05 | New Objective, Inc. | Method and apparatus for feedback controlled electrospray |
EP1270073B1 (en) * | 2001-06-28 | 2005-02-16 | Agilent Technologies, Inc. (a Delaware corporation) | Microfluidic system with controller |
US7128876B2 (en) * | 2001-07-17 | 2006-10-31 | Agilent Technologies, Inc. | Microdevice and method for component separation in a fluid |
US7060227B2 (en) * | 2001-08-06 | 2006-06-13 | Sau Lan Tang Staats | Microfluidic devices with raised walls |
WO2003025991A1 (en) * | 2001-09-17 | 2003-03-27 | Advion Biosciences, Inc. | Fabrication of a microchip-based electrospray device |
US6627076B2 (en) * | 2001-10-19 | 2003-09-30 | Sandia National Laboratories | Compact microchannel system |
AU2002351291A1 (en) * | 2001-12-06 | 2003-06-23 | Nanostream, Inc. | Adhesiveless microfluidic device fabrication |
US6800849B2 (en) * | 2001-12-19 | 2004-10-05 | Sau Lan Tang Staats | Microfluidic array devices and methods of manufacture and uses thereof |
US20030153007A1 (en) * | 2001-12-28 | 2003-08-14 | Jian Chen | Automated systems and methods for analysis of protein post-translational modification |
US20030180965A1 (en) * | 2002-03-25 | 2003-09-25 | Levent Yobas | Micro-fluidic device and method of manufacturing and using the same |
US6621076B1 (en) * | 2002-04-30 | 2003-09-16 | Agilent Technologies, Inc. | Flexible assembly for transporting sample fluids into a mass spectrometer |
US6909981B2 (en) * | 2003-01-27 | 2005-06-21 | Ciphergen Biosystems, Inc. | Data management system and method for processing signals from sample spots |
-
2003
- 2003-08-26 US US10/649,350 patent/US6803568B2/en not_active Expired - Fee Related
-
2004
- 2004-06-18 US US10/871,498 patent/US7105812B2/en not_active Expired - Fee Related
- 2004-08-25 WO PCT/US2004/027774 patent/WO2005019804A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6465776B1 (en) * | 2000-06-02 | 2002-10-15 | Board Of Regents, The University Of Texas System | Mass spectrometer apparatus for analyzing multiple fluid samples concurrently |
US6803568B2 (en) * | 2001-09-19 | 2004-10-12 | Predicant Biosciences, Inc. | Multi-channel microfluidic chip for electrospray ionization |
US20030089605A1 (en) * | 2001-10-19 | 2003-05-15 | West Virginia University Research Corporation | Microfluidic system for proteome analysis |
Also Published As
Publication number | Publication date |
---|---|
US20040113068A1 (en) | 2004-06-17 |
US20050047969A1 (en) | 2005-03-03 |
US6803568B2 (en) | 2004-10-12 |
US7105812B2 (en) | 2006-09-12 |
WO2005019804A2 (en) | 2005-03-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2005019804A3 (en) | Microfluidic chip with enhanced tip for stable electrospray ionization | |
WO2004094994A3 (en) | Microfluidic devices and methods | |
CA2375092A1 (en) | Disposable sensor and method of making | |
GB2356285B (en) | Parallel fluid electrospray mass spectrometer | |
WO2000022409A3 (en) | Microfluidic devices connected to capillaries with minimal dead volume | |
WO2005033663A3 (en) | Methods of making substrates for mass spectrometry analysis and related devices | |
WO2002064253A3 (en) | Method and apparatus for sample injection in microfabricated devices | |
WO2002030486A3 (en) | Microfluidic device based sample injection system for analytical devices | |
WO2006034432A3 (en) | Electrospray apparatus with an integrated electrode | |
WO2004051697A3 (en) | Apparatus for dispensing a sample in electrospray mass spectrometers | |
AU2003254093A1 (en) | Methods for mass spectrometry analysis utilizing an integrated microfluidics sample platform | |
WO2004099029A3 (en) | Sprayer actuator, sprayer, and method of making the same | |
WO2007136386A3 (en) | Droplet-based on-chip sample preparation for mass spectrometry | |
WO2004100208A3 (en) | Sample plate for matrix-assisted laser desorption and ionization mass spectrometry | |
WO2003102537A3 (en) | A high speed combination multi-mode ionization source for mass spectrometers | |
EP1632983A3 (en) | Capillaries for mass spectrometry | |
WO2006133171A3 (en) | Biosensor strips and methods of preparing same | |
WO2007148285A3 (en) | Capillary flow control in a flow channel | |
ATE447237T1 (en) | MICROFLUIDIC DEVICE HAVING AN ELECTROSPRAY NOSE | |
CA2493875A1 (en) | Sampling device for liquid samples | |
AU2003237282A1 (en) | Automated protein analysis system comprising capillary electrophoresis-tandem mass spectrometry | |
WO2003066821A3 (en) | Molecules interacting with casl (mical) polynucleotides, polypeptides, and methods of using the same | |
WO2003000392A3 (en) | Method and apparatus for controlling fluid flow rate in a microfluidic circuit | |
GB9900969D0 (en) | Multiple flow sampling using an autotraversing sample probe | |
AU4429401A (en) | Improved device for sample analysis by multiple capillary electrophoresis with solid/solid thermal control |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
122 | Ep: pct application non-entry in european phase |