WO2005016258A3 - Treatment of age-related macular degeneration - Google Patents

Treatment of age-related macular degeneration Download PDF

Info

Publication number
WO2005016258A3
WO2005016258A3 PCT/US2004/024005 US2004024005W WO2005016258A3 WO 2005016258 A3 WO2005016258 A3 WO 2005016258A3 US 2004024005 W US2004024005 W US 2004024005W WO 2005016258 A3 WO2005016258 A3 WO 2005016258A3
Authority
WO
WIPO (PCT)
Prior art keywords
catheter
eye
ray tube
age
macular degeneration
Prior art date
Application number
PCT/US2004/024005
Other languages
French (fr)
Other versions
WO2005016258A2 (en
Inventor
Michael Forman
Paul A Lovoi
Peter C Smith
Original Assignee
Xoft Microtube Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xoft Microtube Inc filed Critical Xoft Microtube Inc
Priority to DE602004021943T priority Critical patent/DE602004021943D1/en
Priority to EP04779182A priority patent/EP1660181B1/en
Priority to JP2006522595A priority patent/JP2007501057A/en
Priority to AT04779182T priority patent/ATE435683T1/en
Publication of WO2005016258A2 publication Critical patent/WO2005016258A2/en
Publication of WO2005016258A3 publication Critical patent/WO2005016258A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1014Intracavitary radiation therapy
    • A61N5/1017Treatment of the eye, e.g. for "macular degeneration"
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/30Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
    • A61B2090/306Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure using optical fibres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/0079Methods or devices for eye surgery using non-laser electromagnetic radiation, e.g. non-coherent light or microwaves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/065Light sources therefor
    • A61N2005/0651Diodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0658Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659Radiation therapy using light characterised by the wavelength of light used infrared
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019Sources therefor
    • A61N2005/1022Generators, e.g. X-ray tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092Details
    • A61N2005/1098Enhancing the effect of the particle by an injected agent or implanted device
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0601Apparatus for use inside the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/062Photodynamic therapy, i.e. excitation of an agent

Abstract

Age-related macular degeneration is treated by radiation delivered from a miniature x-ray tube (20) inserted via a catheter(12) around the globe of the eye, to a position behind the macula (16). Methods are described for properly locating the catheter (12) and x-ray tube (20), using illumination on the catheter (12) and viewing through the front of the eye, or sensors on the catheter and a scanned beam shone from the front of the eye. Fluorescent excited by x-rays can also be used. Also described are methods and devices for immobilizing the probe once properly located in the eye, for standoff of the x-ray tube (12) from the target tissue, and for achieving prescription radiation dose in the choroid (22) while eliminating dose to adjacent tissues. The x-ray treatment can be enhanced using a radiosensitizing drug, and can be combined with PDT.
PCT/US2004/024005 2003-08-06 2004-07-26 Treatment of age-related macular degeneration WO2005016258A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE602004021943T DE602004021943D1 (en) 2003-08-06 2004-07-26 TREATMENT OF AGE-RELATED MACULAR AGENCY
EP04779182A EP1660181B1 (en) 2003-08-06 2004-07-26 Treatment of age-related macular degeneration
JP2006522595A JP2007501057A (en) 2003-08-06 2004-07-26 Treatment of age-related macular degeneration
AT04779182T ATE435683T1 (en) 2003-08-06 2004-07-26 TREATMENT OF AGE-RELATED MACULAR DEGENERATION

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/635,421 US20050049508A1 (en) 2003-08-06 2003-08-06 Treatment of age-related macular degeneration
US10/635,421 2003-08-06

Publications (2)

Publication Number Publication Date
WO2005016258A2 WO2005016258A2 (en) 2005-02-24
WO2005016258A3 true WO2005016258A3 (en) 2005-06-23

Family

ID=34193545

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/024005 WO2005016258A2 (en) 2003-08-06 2004-07-26 Treatment of age-related macular degeneration

Country Status (7)

Country Link
US (4) US20050049508A1 (en)
EP (1) EP1660181B1 (en)
JP (1) JP2007501057A (en)
AT (1) ATE435683T1 (en)
DE (1) DE602004021943D1 (en)
ES (1) ES2329580T3 (en)
WO (1) WO2005016258A2 (en)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7273445B2 (en) * 2003-04-30 2007-09-25 Board Of Trustees Of The University Of Illinois Intraocular brachytherapy device and method
ATE488269T1 (en) * 2004-02-12 2010-12-15 Neovista Inc DEVICE FOR INTRAOCULAR BRACHYTHERAPY
US7563222B2 (en) * 2004-02-12 2009-07-21 Neovista, Inc. Methods and apparatus for intraocular brachytherapy
WO2005115543A1 (en) * 2004-05-20 2005-12-08 Wisconsin Alumni Research Foundation Directionally emitting radioactive sources for brachytherapy
US7382857B2 (en) * 2004-12-10 2008-06-03 Carl Zeiss Ag X-ray catheter assembly
BRPI0618677A2 (en) * 2005-11-15 2011-09-06 Neovista Inc methods and apparatus for intraocular brachytherapy
US7620147B2 (en) 2006-12-13 2009-11-17 Oraya Therapeutics, Inc. Orthovoltage radiotherapy
US7535991B2 (en) * 2006-10-16 2009-05-19 Oraya Therapeutics, Inc. Portable orthovoltage radiotherapy
US9232959B2 (en) 2007-01-02 2016-01-12 Aquabeam, Llc Multi fluid tissue resection methods and devices
WO2008098300A1 (en) * 2007-02-14 2008-08-21 Opto Global Holdings Pty Ltd Method and system for control of therapeutic procedure
KR100939458B1 (en) * 2007-05-28 2010-02-05 서울대학교병원 Ophthalmic applicator for pterygium treatment using 32? and/or 103?? radioisotope
US8363783B2 (en) 2007-06-04 2013-01-29 Oraya Therapeutics, Inc. Method and device for ocular alignment and coupling of ocular structures
US8920406B2 (en) 2008-01-11 2014-12-30 Oraya Therapeutics, Inc. Device and assembly for positioning and stabilizing an eye
US7792249B2 (en) * 2007-12-23 2010-09-07 Oraya Therapeutics, Inc. Methods and devices for detecting, controlling, and predicting radiation delivery
US7801271B2 (en) * 2007-12-23 2010-09-21 Oraya Therapeutics, Inc. Methods and devices for orthovoltage ocular radiotherapy and treatment planning
US8602959B1 (en) 2010-05-21 2013-12-10 Robert Park Methods and devices for delivery of radiation to the posterior portion of the eye
US10022558B1 (en) 2008-01-07 2018-07-17 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
US9873001B2 (en) 2008-01-07 2018-01-23 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
US8608632B1 (en) 2009-07-03 2013-12-17 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye
PL2227257T3 (en) * 2008-01-07 2013-12-31 Salutaris Medical Devices Inc Devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye
US9056201B1 (en) 2008-01-07 2015-06-16 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
AU2015204094B2 (en) * 2008-01-07 2017-02-23 Salutaris Medical Devices, Inc Methods and devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye
ES2769535T3 (en) 2008-03-06 2020-06-26 Aquabeam Llc Tissue ablation and cauterization with optical energy carried in a fluid stream
JP2011522603A (en) 2008-06-04 2011-08-04 ネオビスタ、インコーポレイテッド Handheld radiation delivery system for advancing a radiation source wire
USD691268S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to eye
USD691270S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to an eye
USD691269S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to an eye
USD691267S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to eye
US8663210B2 (en) * 2009-05-13 2014-03-04 Novian Health, Inc. Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy
WO2011053908A1 (en) * 2009-11-02 2011-05-05 Salutaris Medical Devices, Inc. Methods and devices for delivering appropriate minimally-invasive extraocular radiation
US8878464B2 (en) 2010-10-01 2014-11-04 Varian Medical Systems Inc. Laser accelerator driven particle brachytherapy devices, systems, and methods
WO2012112543A2 (en) * 2011-02-15 2012-08-23 Seros Medical, Llc Method and apparatus for the delivery of photo-chemical (cross-linking) treatment to scleral tissue
US9504604B2 (en) * 2011-12-16 2016-11-29 Auris Surgical Robotics, Inc. Lithotripsy eye treatment
EP3351196A1 (en) 2012-02-29 2018-07-25 Procept Biorobotics Corporation Automated image-guided tissue resection and treatment
US10383765B2 (en) 2012-04-24 2019-08-20 Auris Health, Inc. Apparatus and method for a global coordinate system for use in robotic surgery
EP2891171A4 (en) * 2012-08-29 2016-04-27 Source Production & Equipment Co Inc Radiation therapy of protruding and/or conformable organs
AU2013341157B2 (en) * 2012-11-07 2017-08-31 Ip Liberty Vision Corporation Light-guided ophthalmic radiation device
US10231867B2 (en) 2013-01-18 2019-03-19 Auris Health, Inc. Method, apparatus and system for a water jet
US9867635B2 (en) 2013-03-08 2018-01-16 Auris Surgical Robotics, Inc. Method, apparatus and system for a water jet
US10149720B2 (en) 2013-03-08 2018-12-11 Auris Health, Inc. Method, apparatus, and a system for facilitating bending of an instrument in a surgical or medical robotic environment
US10080576B2 (en) 2013-03-08 2018-09-25 Auris Health, Inc. Method, apparatus, and a system for facilitating bending of an instrument in a surgical or medical robotic environment
WO2014201165A1 (en) 2013-06-11 2014-12-18 Auris Surgical Robotics, Inc. System for robotic assisted cataract surgery
US10426661B2 (en) 2013-08-13 2019-10-01 Auris Health, Inc. Method and apparatus for laser assisted cataract surgery
US9737373B2 (en) 2013-10-24 2017-08-22 Auris Surgical Robotics, Inc. Instrument device manipulator and surgical drape
EP3689284A1 (en) 2013-10-24 2020-08-05 Auris Health, Inc. System for robotic-assisted endolumenal surgery and related methods
US10166143B2 (en) 2013-12-31 2019-01-01 Ip Liberty Vision Corporation Versatile light-guided ophthalmic treatment system
US10117578B2 (en) 2013-12-31 2018-11-06 Ip Liberty Vision Corporation Luminescent ophthalmic device
US10792464B2 (en) 2014-07-01 2020-10-06 Auris Health, Inc. Tool and method for using surgical endoscope with spiral lumens
US9788910B2 (en) 2014-07-01 2017-10-17 Auris Surgical Robotics, Inc. Instrument-mounted tension sensing mechanism for robotically-driven medical instruments
US11045665B2 (en) 2015-05-06 2021-06-29 Ip Liberty Vision Corporation Light-guided ophthalmic radiation device
CN108348133B (en) 2015-09-09 2020-11-13 奥瑞斯健康公司 Instrument device manipulator for surgical robotic system
USD814637S1 (en) 2016-05-11 2018-04-03 Salutaris Medical Devices, Inc. Brachytherapy device
USD815285S1 (en) 2016-05-11 2018-04-10 Salutaris Medical Devices, Inc. Brachytherapy device
USD814638S1 (en) 2016-05-11 2018-04-03 Salutaris Medical Devices, Inc. Brachytherapy device
USD808528S1 (en) 2016-08-31 2018-01-23 Salutaris Medical Devices, Inc. Holder for a brachytherapy device
USD808529S1 (en) 2016-08-31 2018-01-23 Salutaris Medical Devices, Inc. Holder for a brachytherapy device
WO2018109733A2 (en) * 2016-12-15 2018-06-21 Luseed Vascular Ltd. Methods and devices for treating vascular related disorders
WO2023077074A1 (en) * 2021-10-29 2023-05-04 Salutaris Medical Devices, Inc. Radionuclide brachytherapy source systems for ocular radiotherapy of chronic serous chorioretinopathy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637073A (en) * 1995-08-28 1997-06-10 Freire; Jorge E. Radiation therapy for treating macular degeneration and applicator
US6443881B1 (en) * 2000-06-06 2002-09-03 Paul T. Finger Ophthalmic brachytherapy device
US6554757B1 (en) * 2000-11-10 2003-04-29 Scimed Life Systems, Inc. Multi-source x-ray catheter
US20030179854A1 (en) * 2002-03-20 2003-09-25 Ali Jaafar X-ray apparatus with field emission current stabilization and method of providing x-ray radiation therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649151A (en) * 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
US6799075B1 (en) * 1995-08-24 2004-09-28 Medtronic Ave, Inc. X-ray catheter
US6587618B2 (en) * 2001-03-16 2003-07-01 Corning Incorporated Collimator array and method and system for aligning optical fibers to a lens array
US7273445B2 (en) * 2003-04-30 2007-09-25 Board Of Trustees Of The University Of Illinois Intraocular brachytherapy device and method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637073A (en) * 1995-08-28 1997-06-10 Freire; Jorge E. Radiation therapy for treating macular degeneration and applicator
US6443881B1 (en) * 2000-06-06 2002-09-03 Paul T. Finger Ophthalmic brachytherapy device
US6554757B1 (en) * 2000-11-10 2003-04-29 Scimed Life Systems, Inc. Multi-source x-ray catheter
US20030179854A1 (en) * 2002-03-20 2003-09-25 Ali Jaafar X-ray apparatus with field emission current stabilization and method of providing x-ray radiation therapy

Also Published As

Publication number Publication date
WO2005016258A2 (en) 2005-02-24
EP1660181A4 (en) 2007-05-02
ES2329580T3 (en) 2009-11-27
DE602004021943D1 (en) 2009-08-20
US7351193B2 (en) 2008-04-01
EP1660181A2 (en) 2006-05-31
US20070016126A1 (en) 2007-01-18
JP2007501057A (en) 2007-01-25
ATE435683T1 (en) 2009-07-15
US20050049508A1 (en) 2005-03-03
EP1660181B1 (en) 2009-07-08
US20070010746A1 (en) 2007-01-11
US20060078087A1 (en) 2006-04-13

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