WO2004097370A3 - Systems and methods for monitoring chemical and biolgical activities using differential measurements - Google Patents

Systems and methods for monitoring chemical and biolgical activities using differential measurements Download PDF

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Publication number
WO2004097370A3
WO2004097370A3 PCT/US2004/012614 US2004012614W WO2004097370A3 WO 2004097370 A3 WO2004097370 A3 WO 2004097370A3 US 2004012614 W US2004012614 W US 2004012614W WO 2004097370 A3 WO2004097370 A3 WO 2004097370A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
measurement
biolgical
activities
systems
Prior art date
Application number
PCT/US2004/012614
Other languages
French (fr)
Other versions
WO2004097370A2 (en
Inventor
John J Hefti
Dean M Drako
Original Assignee
Prometheus Biosciences Inc
John J Hefti
Dean M Drako
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2003/013181 external-priority patent/WO2003091732A2/en
Application filed by Prometheus Biosciences Inc, John J Hefti, Dean M Drako filed Critical Prometheus Biosciences Inc
Priority to EP04750558A priority Critical patent/EP1623211A4/en
Publication of WO2004097370A2 publication Critical patent/WO2004097370A2/en
Publication of WO2004097370A3 publication Critical patent/WO2004097370A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
    • G01D1/00—Measuring arrangements giving results other than momentary value of variable, of general application
    • G01D1/16—Measuring arrangements giving results other than momentary value of variable, of general application giving a value which is a function of two or more values, e.g. product or ratio
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B23/00—Testing or monitoring of control systems or parts thereof
    • G05B23/02—Electric testing or monitoring
    • G05B23/0205—Electric testing or monitoring by means of a monitoring system capable of detecting and responding to faults
    • G05B23/0218—Electric testing or monitoring by means of a monitoring system capable of detecting and responding to faults characterised by the fault detection method dealing with either existing or incipient faults
    • G05B23/0224—Process history based detection method, e.g. whereby history implies the availability of large amounts of data
    • G05B23/0227—Qualitative history assessment, whereby the type of data acted upon, e.g. waveforms, images or patterns, is not relevant, e.g. rule based assessment; if-then decisions
    • G05B23/0237—Qualitative history assessment, whereby the type of data acted upon, e.g. waveforms, images or patterns, is not relevant, e.g. rule based assessment; if-then decisions based on parallel systems, e.g. comparing signals produced at the same time by same type systems and detect faulty ones by noticing differences among their responses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00191—Control algorithm
    • B01J2219/00193—Sensing a parameter
    • B01J2219/00195—Sensing a parameter of the reaction system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00191—Control algorithm
    • B01J2219/00211—Control algorithm comparing a sensed parameter with a pre-set value
    • B01J2219/0022—Control algorithm comparing a sensed parameter with a pre-set value calculating difference
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00191—Control algorithm
    • B01J2219/00222—Control algorithm taking actions
    • B01J2219/00227—Control algorithm taking actions modifying the operating conditions
    • B01J2219/00229—Control algorithm taking actions modifying the operating conditions of the reaction system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

Abstract

A system operable to monitoring bio/chemical activities includes a first measurement probe, a second measurement probe and a comparator. The first measurement probe is operable to interrogate one or more physical properties of a sample at a first location of the sample, and to output, in response, a first measurement signal. The second measurement probe is operable to interrogate one or more physical properties of the sample at a second location of the sample, and to output, in response, a second measurement signal. The comparator is coupled to receive the first and second measurement signals, the comparator configured to output a difference signal comprising the difference between the first and second measurement signals, the difference signal corresponding to the difference in one or more bio/chemical activities occurring at the first location of the sample relative to the second location of the sample.
PCT/US2004/012614 2003-04-25 2004-04-23 Systems and methods for monitoring chemical and biolgical activities using differential measurements WO2004097370A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04750558A EP1623211A4 (en) 2003-04-25 2004-04-23 Systems and methods for monitoring chemical and biolgical activities using differential measurements

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/US2003/013181 WO2003091732A2 (en) 2002-04-26 2003-04-25 Diffusion-based method and system for detecting and monitoring activity of biologic and chemical species
USPCT/US03/13181 2003-04-25
US10/799,000 US7713477B2 (en) 2002-04-26 2004-03-11 Systems and methods for monitoring chemical and biological activities using differential measurements
US10/799,000 2004-03-11

Publications (2)

Publication Number Publication Date
WO2004097370A2 WO2004097370A2 (en) 2004-11-11
WO2004097370A3 true WO2004097370A3 (en) 2005-03-24

Family

ID=33422364

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/012614 WO2004097370A2 (en) 2003-04-25 2004-04-23 Systems and methods for monitoring chemical and biolgical activities using differential measurements

Country Status (2)

Country Link
EP (1) EP1623211A4 (en)
WO (1) WO2004097370A2 (en)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941563A (en) * 1974-04-23 1976-03-02 E. I. Du Pont De Nemours & Company Method and apparatus for detecting hexavalent chromium
US3999047A (en) * 1972-09-05 1976-12-21 Green James E Method and apparatus utilizing color algebra for analyzing scene regions
US5192507A (en) * 1987-06-05 1993-03-09 Arthur D. Little, Inc. Receptor-based biosensors
US5554339A (en) * 1988-11-14 1996-09-10 I-Stat Corporation Process for the manufacture of wholly microfabricated biosensors
US5910286A (en) * 1995-02-21 1999-06-08 Thomson-Csf Highly selective chemical sensor
US6241950B1 (en) * 1998-02-13 2001-06-05 Airxpert Systems, Inc. Fluid sampling system
US6455000B1 (en) * 1999-07-12 2002-09-24 Fantom Technologies Inc. Method and apparatus for measuring the concentration of a gas
US6534012B1 (en) * 2000-08-02 2003-03-18 Sensys Medical, Inc. Apparatus and method for reproducibly modifying localized absorption and scattering coefficients at a tissue measurement site during optical sampling
US6825655B2 (en) * 2001-08-31 2004-11-30 Imego Ab Method and arrangement for detecting changes of a magnetic response in magnetic particles

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3592043A (en) * 1969-01-27 1971-07-13 Varian Associates Micro-adsorption detector and method of using same
JPS5646450A (en) * 1979-09-21 1981-04-27 Terumo Corp Detector for hematic emulsion in blood specimen
US4690152A (en) * 1985-10-23 1987-09-01 American Mediscan, Inc. Apparatus for epithelial tissue impedance measurements
US5004583A (en) * 1987-01-29 1991-04-02 Medtest Systems, Inc. Universal sensor cartridge for use with a universal analyzer for sensing components in a multicomponent fluid
US5212988A (en) * 1988-02-29 1993-05-25 The Reagents Of The University Of California Plate-mode ultrasonic structure including a gel
US5427663A (en) * 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
DE19520298A1 (en) * 1995-06-02 1996-12-05 Bayer Ag Sorting device for biological cells or viruses
EP1211507A3 (en) * 2000-09-29 2003-09-24 Kabushiki Kaisha Toshiba Nucleic acid detection sensor

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3999047A (en) * 1972-09-05 1976-12-21 Green James E Method and apparatus utilizing color algebra for analyzing scene regions
US3941563A (en) * 1974-04-23 1976-03-02 E. I. Du Pont De Nemours & Company Method and apparatus for detecting hexavalent chromium
US5192507A (en) * 1987-06-05 1993-03-09 Arthur D. Little, Inc. Receptor-based biosensors
US5554339A (en) * 1988-11-14 1996-09-10 I-Stat Corporation Process for the manufacture of wholly microfabricated biosensors
US5910286A (en) * 1995-02-21 1999-06-08 Thomson-Csf Highly selective chemical sensor
US6241950B1 (en) * 1998-02-13 2001-06-05 Airxpert Systems, Inc. Fluid sampling system
US6455000B1 (en) * 1999-07-12 2002-09-24 Fantom Technologies Inc. Method and apparatus for measuring the concentration of a gas
US6534012B1 (en) * 2000-08-02 2003-03-18 Sensys Medical, Inc. Apparatus and method for reproducibly modifying localized absorption and scattering coefficients at a tissue measurement site during optical sampling
US6825655B2 (en) * 2001-08-31 2004-11-30 Imego Ab Method and arrangement for detecting changes of a magnetic response in magnetic particles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1623211A4 *

Also Published As

Publication number Publication date
EP1623211A2 (en) 2006-02-08
WO2004097370A2 (en) 2004-11-11
EP1623211A4 (en) 2006-10-25

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