WO2004083427A3 - Ligational encoding of small molecules - Google Patents
Ligational encoding of small molecules Download PDFInfo
- Publication number
- WO2004083427A3 WO2004083427A3 PCT/DK2004/000195 DK2004000195W WO2004083427A3 WO 2004083427 A3 WO2004083427 A3 WO 2004083427A3 DK 2004000195 W DK2004000195 W DK 2004000195W WO 2004083427 A3 WO2004083427 A3 WO 2004083427A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chemical entities
- template
- encoded molecule
- codon
- identifier polynucleotide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04722237A EP1608748B1 (en) | 2003-03-20 | 2004-03-22 | Ligational encoding of small molecules |
DK04722237T DK1608748T3 (en) | 2003-03-20 | 2004-03-22 | Ligation coding of small molecules |
US10/549,619 US7915201B2 (en) | 2003-03-20 | 2004-03-22 | Ligational encoding of small molecules |
DE602004019764T DE602004019764D1 (en) | 2003-03-20 | 2004-03-22 | LIGATION-RELATED CODING OF SMALL MOLECULES |
PCT/DK2005/000199 WO2005090566A2 (en) | 2004-03-22 | 2005-03-22 | Ligational encoding using building block oligonucleotides |
EP05715120A EP1730277B1 (en) | 2004-03-22 | 2005-03-22 | Ligational encoding using building block oligonucleotides |
US10/593,868 US7704925B2 (en) | 2004-03-22 | 2005-03-22 | Ligational encoding using building block oligonucleotides |
AT05715120T ATE447020T1 (en) | 2004-03-22 | 2005-03-22 | LIGATION CODING USING OLIGONUCLEOTIDE BUILDING BLOCKS |
DK05715120.1T DK1730277T3 (en) | 2004-03-22 | 2005-03-22 | Coding by ligation using building block oligonucleotides |
DE602005017370T DE602005017370D1 (en) | 2004-03-22 | 2005-03-22 | LIGATION CODING USING OLIGONUCLEOTIDE COMPONENTS |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45585803P | 2003-03-20 | 2003-03-20 | |
DKPA200300430 | 2003-03-20 | ||
DKPA200300430 | 2003-03-20 | ||
US60/455,858 | 2003-03-20 |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/549,619 Continuation-In-Part US7915201B2 (en) | 2003-03-20 | 2004-03-22 | Ligational encoding of small molecules |
PCT/DK2004/000195 Continuation-In-Part WO2004083427A2 (en) | 2003-03-20 | 2004-03-22 | Ligational encoding of small molecules |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/549,619 A-371-Of-International US7915201B2 (en) | 2003-03-20 | 2004-03-22 | Ligational encoding of small molecules |
PCT/DK2004/000195 Continuation-In-Part WO2004083427A2 (en) | 2003-03-20 | 2004-03-22 | Ligational encoding of small molecules |
US10/593,868 Continuation-In-Part US7704925B2 (en) | 2004-03-22 | 2005-03-22 | Ligational encoding using building block oligonucleotides |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004083427A2 WO2004083427A2 (en) | 2004-09-30 |
WO2004083427A3 true WO2004083427A3 (en) | 2005-02-17 |
Family
ID=33031172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK2004/000195 WO2004083427A2 (en) | 2003-03-20 | 2004-03-22 | Ligational encoding of small molecules |
Country Status (6)
Country | Link |
---|---|
US (1) | US7915201B2 (en) |
EP (2) | EP1608748B1 (en) |
AT (1) | ATE424455T1 (en) |
DE (1) | DE602004019764D1 (en) |
DK (2) | DK1608748T3 (en) |
WO (1) | WO2004083427A2 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8206901B2 (en) | 2002-10-30 | 2012-06-26 | Nuevolution A/S | Method for the synthesis of a bifunctional complex |
RU2459869C2 (en) * | 2005-06-09 | 2012-08-27 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Compound containing coding oligonucleotide, production method thereof, library of compounds, production method thereof, method of identifying compound bound with biological target (versions) |
US8808984B2 (en) | 2002-03-15 | 2014-08-19 | Neuvolution A/S | Method for synthesising templated molecules |
US8932992B2 (en) | 2001-06-20 | 2015-01-13 | Nuevolution A/S | Templated molecules and methods for using such molecules |
US9096951B2 (en) | 2003-02-21 | 2015-08-04 | Nuevolution A/S | Method for producing second-generation library |
US9121110B2 (en) | 2002-12-19 | 2015-09-01 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
US9574189B2 (en) | 2005-12-01 | 2017-02-21 | Nuevolution A/S | Enzymatic encoding methods for efficient synthesis of large libraries |
JP7010875B2 (en) | 2009-02-13 | 2022-01-26 | エックス-ケム インコーポレイテッド | How to make and screen a DNA coding library |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10730906B2 (en) | 2002-08-01 | 2020-08-04 | Nuevolutions A/S | Multi-step synthesis of templated molecules |
JP4657919B2 (en) * | 2002-08-19 | 2011-03-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Evolving new molecular functions |
AU2003266932B2 (en) * | 2002-09-27 | 2009-04-09 | Mpm-Holding Aps | Spatially encoded polymer matrix |
DE602004019764D1 (en) | 2003-03-20 | 2009-04-16 | Nuevolution As | LIGATION-RELATED CODING OF SMALL MOLECULES |
US8017323B2 (en) * | 2003-03-26 | 2011-09-13 | President And Fellows Of Harvard College | Free reactant use in nucleic acid-templated synthesis |
WO2005026387A1 (en) | 2003-09-18 | 2005-03-24 | Nuevolution A/S | A method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
US7972994B2 (en) | 2003-12-17 | 2011-07-05 | Glaxosmithkline Llc | Methods for synthesis of encoded libraries |
NZ547723A (en) | 2003-12-17 | 2009-09-25 | Praecis Pharm Inc | Methods for synthesis of encoded libraries |
US20090239211A1 (en) * | 2004-02-17 | 2009-09-24 | Nuevolution A/S | Method For Enrichment Involving Elimination By Mismatch Hybridisation |
EP1730277B1 (en) * | 2004-03-22 | 2009-10-28 | Nuevolution A/S | Ligational encoding using building block oligonucleotides |
DE602005012319D1 (en) | 2004-11-22 | 2009-02-26 | Peter Birk Rasmussen | MATRESSED SPLIT AND MIX SYNTHESIS OF LIBRARY LIBRARIES |
US7883848B2 (en) * | 2005-07-08 | 2011-02-08 | Olink Ab | Regulation analysis by cis reactivity, RACR |
EP1940755A2 (en) * | 2005-10-28 | 2008-07-09 | Praecis Pharmaceuticals Inc. | Methods for identifying compounds of interest using encoded libraries |
US7727745B2 (en) | 2006-08-14 | 2010-06-01 | Bio-Id Diagnostic Inc. | Synthesis of single-stranded DNA |
WO2009077173A2 (en) * | 2007-12-19 | 2009-06-25 | Philochem Ag | Dna-encoded chemical libraries |
WO2009097673A1 (en) * | 2008-02-07 | 2009-08-13 | Bio-Id Diagnostic Inc. | Synthesis of single-stranded dna |
US11225655B2 (en) | 2010-04-16 | 2022-01-18 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
EP2405000A1 (en) * | 2010-07-06 | 2012-01-11 | Alacris Theranostics GmbH | Synthesis of chemical libraries |
WO2013036810A1 (en) | 2011-09-07 | 2013-03-14 | X-Chem, Inc. | Methods for tagging dna-encoded libraries |
IL236633B (en) | 2012-07-13 | 2022-07-01 | X Chem Inc | Dna-encoded libraries comprising a complex having a cross-linking oligonucleotide linkage |
US9765375B2 (en) | 2013-06-28 | 2017-09-19 | General Electric Company | Methods for developing binding-elements and uses thereof |
GB201322692D0 (en) | 2013-12-20 | 2014-02-05 | Philochem Ag | Production of encoded chemical libraries |
GB201603789D0 (en) * | 2016-03-04 | 2016-04-20 | Apta Biosciences Ltd | Oligonucleotides and methods for preparing |
JP7283727B2 (en) | 2016-06-16 | 2023-05-30 | ヘイスタック サイエンシィズ コーポレーション | Oligonucleotides Directed and Recorded for Combinatorial Synthesis of Code Probe Molecules |
US11795580B2 (en) | 2017-05-02 | 2023-10-24 | Haystack Sciences Corporation | Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same |
CN107802276B (en) * | 2017-09-01 | 2020-11-27 | 深圳市菲森科技有限公司 | Tracing drawing device and method for skull image |
EP4041310A1 (en) | 2019-10-10 | 2022-08-17 | 1859, Inc. | Methods and systems for microfluidic screening |
WO2021104514A1 (en) * | 2019-11-29 | 2021-06-03 | Bgi Shenzhen Co., Ltd. | Enzymatic synthesis of oligonucleotides |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995004160A1 (en) * | 1993-07-30 | 1995-02-09 | Isis Innovation Limited | Tag reagent and assay method |
DE19646372C1 (en) * | 1995-11-11 | 1997-06-19 | Evotec Biosystems Gmbh | Conjugates of polypeptide and encoding nucleic acid |
WO2000023458A1 (en) * | 1998-10-19 | 2000-04-27 | The Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library chemistry |
WO2002074929A2 (en) * | 2001-03-19 | 2002-09-26 | President And Fellows Of Harvard College | Evolving new molecular function |
WO2002103008A2 (en) * | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Templated molecules and methods for using such molecules |
WO2004013070A2 (en) * | 2002-08-01 | 2004-02-12 | Nuevolution A/S | Multi-step synthesis of templated molecules |
WO2004016767A2 (en) * | 2002-08-19 | 2004-02-26 | The President And Fellows Of Harvard College | Evolving new molecular function |
Family Cites Families (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4822731A (en) * | 1986-01-09 | 1989-04-18 | Cetus Corporation | Process for labeling single-stranded nucleic acids and hybridizaiton probes |
US5449602A (en) | 1988-01-13 | 1995-09-12 | Amoco Corporation | Template-directed photoligation |
WO1990005785A1 (en) | 1988-11-18 | 1990-05-31 | The Regents Of The University Of California | Method for site-specifically incorporating unnatural amino acids into proteins |
ES2118066T3 (en) | 1989-10-05 | 1998-09-16 | Optein Inc | SYNTHESIS AND ISOLATION, EXEMPTED FROM CELLS, FROM NEW GENES AND POLYPEPTIDES. |
US5723289A (en) | 1990-06-11 | 1998-03-03 | Nexstar Pharmaceuticals, Inc. | Parallel selex |
AU2313392A (en) | 1991-08-01 | 1993-03-02 | University Research Corporation | Systematic polypeptide evolution by reverse translation |
US5639603A (en) * | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
AU669489B2 (en) | 1991-09-18 | 1996-06-13 | Affymax Technologies N.V. | Method of synthesizing diverse collections of oligomers |
US5573905A (en) * | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
DE69433010T2 (en) * | 1993-04-12 | 2004-06-09 | Northwestern University, Evanston | METHOD FOR PRESENTING OLIGONUCLEOTIDES |
US5681943A (en) * | 1993-04-12 | 1997-10-28 | Northwestern University | Method for covalently linking adjacent oligonucleotides |
US5840485A (en) * | 1993-05-27 | 1998-11-24 | Selectide Corporation | Topologically segregated, encoded solid phase libraries |
US5473060A (en) * | 1993-07-02 | 1995-12-05 | Lynx Therapeutics, Inc. | Oligonucleotide clamps having diagnostic applications |
US5571903A (en) * | 1993-07-09 | 1996-11-05 | Lynx Therapeutics, Inc. | Auto-ligating oligonucleotide compounds |
US5503805A (en) * | 1993-11-02 | 1996-04-02 | Affymax Technologies N.V. | Apparatus and method for parallel coupling reactions |
CN1134156A (en) | 1993-11-02 | 1996-10-23 | 阿菲马克斯技术公司 | Synthesizing and screening molecular diversity |
US6165778A (en) * | 1993-11-02 | 2000-12-26 | Affymax Technologies N.V. | Reaction vessel agitation apparatus |
US5605793A (en) * | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
AU689924B2 (en) | 1994-06-23 | 1998-04-09 | Affymax Technologies N.V. | Photolabile compounds and methods for their use |
US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
US5843650A (en) * | 1995-05-01 | 1998-12-01 | Segev; David | Nucleic acid detection and amplification by chemical linkage of oligonucleotides |
US5830658A (en) * | 1995-05-31 | 1998-11-03 | Lynx Therapeutics, Inc. | Convergent synthesis of branched and multiply connected macromolecular structures |
US5780613A (en) * | 1995-08-01 | 1998-07-14 | Northwestern University | Covalent lock for self-assembled oligonucleotide constructs |
WO1998031700A1 (en) * | 1997-01-21 | 1998-07-23 | The General Hospital Corporation | Selection of proteins using rna-protein fusions |
US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
EP0985032B2 (en) * | 1997-05-28 | 2009-06-03 | Discerna Limited | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
US6969584B2 (en) | 1997-06-12 | 2005-11-29 | Rigel Pharmaceuticals, Inc. | Combinatorial enzymatic complexes |
US20030004122A1 (en) * | 1997-11-05 | 2003-01-02 | Leonid Beigelman | Nucleotide triphosphates and their incorporation into oligonucleotides |
EP1068356B8 (en) | 1998-04-03 | 2007-01-03 | Adnexus Therapeutics, Inc. | Addressable protein arrays |
EP1073730A1 (en) * | 1998-04-17 | 2001-02-07 | Whitehead For Biomedical Research | Use of a ribozyme to join nucleic acids and peptides |
WO2000021909A2 (en) | 1998-10-09 | 2000-04-20 | Pharmacopeia, Inc. | Selecting codes to be used for encoding combinatorial libraries |
WO2000032823A1 (en) | 1998-12-02 | 2000-06-08 | Phylos, Inc. | Dna-protein fusions and uses thereof |
EP1208219A1 (en) | 1999-04-08 | 2002-05-29 | Pavel Sergeev | Synthesis of biologically active compounds in cells |
CA2376623C (en) | 1999-06-25 | 2011-04-19 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
ES2383332T3 (en) * | 1999-07-27 | 2012-06-20 | Bristol-Myers Squibb Company | Peptide Acceptor Ligation Procedure |
DE60002821T2 (en) * | 1999-08-27 | 2004-05-06 | Japan Science And Technology Corp., Kawaguchi | REVERSIBLE PHOTOCOUPLING NUCLEIC ACID AND PHOSPHORAMIDITE |
WO2002102820A1 (en) | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Nucleoside derivatives for library preparation |
AU2003218629A1 (en) | 2002-03-15 | 2003-09-29 | Nuevolution A/S | A building block forming a c-c or a c-hetero atom bond uponreaction |
EP1487848A2 (en) | 2002-03-15 | 2004-12-22 | Nuevolution A/S | A building block forming a c=c double bond upon reaction |
AU2003214033A1 (en) | 2002-03-15 | 2003-09-29 | Nuevolution A/S | A building block capable of transferring a functional entity |
AU2003253069A1 (en) | 2002-03-15 | 2003-09-29 | Nuevolution A/S | A building block forming a c-c bond upon reaction |
US7413854B2 (en) | 2002-03-15 | 2008-08-19 | Nuevolution A/S | Method for synthesising templated molecules |
AU2003226008A1 (en) | 2002-03-22 | 2003-10-13 | Emory University | Template-driven processes for synthesizing polymers and components related to such processes |
EP1520040A2 (en) | 2002-06-20 | 2005-04-06 | Nuevolution A/S | Microarrays displaying encoded molecules |
EP1527173A1 (en) | 2002-07-23 | 2005-05-04 | Nuevolution A/S | Gene shuffing by template switching |
EP1539953A2 (en) | 2002-09-12 | 2005-06-15 | Nuevolution A/S | Proximity-aided synthesis of templated molecules |
EP3299463B1 (en) | 2002-10-30 | 2020-10-21 | Nuevolution A/S | Enzymatic encoding |
WO2004056994A2 (en) | 2002-12-19 | 2004-07-08 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
WO2004074429A2 (en) | 2003-02-21 | 2004-09-02 | Nuevolution A/S | Method for producing second-generation library |
EP1597394A2 (en) | 2003-02-21 | 2005-11-23 | Nuevolution A/S | A method for obtaining structural information about an encoded molecule |
DE602004019764D1 (en) | 2003-03-20 | 2009-04-16 | Nuevolution As | LIGATION-RELATED CODING OF SMALL MOLECULES |
WO2004099441A2 (en) | 2003-05-09 | 2004-11-18 | Hyscite Discovery As | Selection and evolution of chemical libraries |
WO2004110964A2 (en) | 2003-06-16 | 2004-12-23 | Nuevolution A/S | Encoded molecules by translation (emt) |
WO2005003778A2 (en) | 2003-07-02 | 2005-01-13 | Nuevolution A/S | A method for identifying a synthetic molecule having affinity towards a target |
EP1533385A1 (en) | 2003-09-05 | 2005-05-25 | Nuevolution A/S | Templated compounds for generation of encoded molecules and directional methods using such compounds |
WO2005026387A1 (en) | 2003-09-18 | 2005-03-24 | Nuevolution A/S | A method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
DK1809743T3 (en) | 2004-11-08 | 2009-05-04 | Vipergen Aps | Structural nucleic acid-controlled chemical synthesis |
DE602005012319D1 (en) | 2004-11-22 | 2009-02-26 | Peter Birk Rasmussen | MATRESSED SPLIT AND MIX SYNTHESIS OF LIBRARY LIBRARIES |
-
2004
- 2004-03-22 DE DE602004019764T patent/DE602004019764D1/en not_active Expired - Lifetime
- 2004-03-22 US US10/549,619 patent/US7915201B2/en active Active
- 2004-03-22 AT AT04722237T patent/ATE424455T1/en not_active IP Right Cessation
- 2004-03-22 DK DK04722237T patent/DK1608748T3/en active
- 2004-03-22 WO PCT/DK2004/000195 patent/WO2004083427A2/en active Application Filing
- 2004-03-22 EP EP04722237A patent/EP1608748B1/en not_active Expired - Lifetime
- 2004-03-22 EP EP09154197.9A patent/EP2236606B1/en not_active Expired - Lifetime
- 2004-03-22 DK DK09154197.9T patent/DK2236606T3/en active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995004160A1 (en) * | 1993-07-30 | 1995-02-09 | Isis Innovation Limited | Tag reagent and assay method |
DE19646372C1 (en) * | 1995-11-11 | 1997-06-19 | Evotec Biosystems Gmbh | Conjugates of polypeptide and encoding nucleic acid |
WO2000023458A1 (en) * | 1998-10-19 | 2000-04-27 | The Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library chemistry |
WO2002074929A2 (en) * | 2001-03-19 | 2002-09-26 | President And Fellows Of Harvard College | Evolving new molecular function |
WO2002103008A2 (en) * | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Templated molecules and methods for using such molecules |
WO2004013070A2 (en) * | 2002-08-01 | 2004-02-12 | Nuevolution A/S | Multi-step synthesis of templated molecules |
WO2004016767A2 (en) * | 2002-08-19 | 2004-02-26 | The President And Fellows Of Harvard College | Evolving new molecular function |
Non-Patent Citations (2)
Title |
---|
VISSCHER J ET AL: "TEMPLATE-DIRECTED SYNTHESIS OF ACYCLIC OLIGONUCLEOTIDE ANALOGUES", JOURNAL OF MOLECULAR EVOLUTION, SPRINGER VERLAG, NEW YORK, NY, US, vol. 28, no. 1/2, 1988, pages 3 - 6, XP000857353, ISSN: 0022-2844 * |
WALDER J A ET AL: "COMPLEMENTARY CARRIER PEPTIDE SYNTHESIS: GENERAL STRATEGY AND IMPLICATIONS FOR PREBIOTIC ORIGIN OF PEPTIDE SYNTHESIS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 76, no. 1, January 1979 (1979-01-01), pages 51 - 55, XP000857351, ISSN: 0027-8424 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8932992B2 (en) | 2001-06-20 | 2015-01-13 | Nuevolution A/S | Templated molecules and methods for using such molecules |
US8808984B2 (en) | 2002-03-15 | 2014-08-19 | Neuvolution A/S | Method for synthesising templated molecules |
US8206901B2 (en) | 2002-10-30 | 2012-06-26 | Nuevolution A/S | Method for the synthesis of a bifunctional complex |
US8722583B2 (en) | 2002-10-30 | 2014-05-13 | Nuevolution A/S | Method for selecting a chemical entity from a tagged library |
US9109248B2 (en) | 2002-10-30 | 2015-08-18 | Nuevolution A/S | Method for the synthesis of a bifunctional complex |
US9284600B2 (en) | 2002-10-30 | 2016-03-15 | Neuvolution A/S | Method for the synthesis of a bifunctional complex |
US9121110B2 (en) | 2002-12-19 | 2015-09-01 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
US9096951B2 (en) | 2003-02-21 | 2015-08-04 | Nuevolution A/S | Method for producing second-generation library |
RU2459869C2 (en) * | 2005-06-09 | 2012-08-27 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Compound containing coding oligonucleotide, production method thereof, library of compounds, production method thereof, method of identifying compound bound with biological target (versions) |
US9574189B2 (en) | 2005-12-01 | 2017-02-21 | Nuevolution A/S | Enzymatic encoding methods for efficient synthesis of large libraries |
JP7010875B2 (en) | 2009-02-13 | 2022-01-26 | エックス-ケム インコーポレイテッド | How to make and screen a DNA coding library |
Also Published As
Publication number | Publication date |
---|---|
EP2236606B1 (en) | 2013-11-06 |
US20060246450A1 (en) | 2006-11-02 |
ATE424455T1 (en) | 2009-03-15 |
WO2004083427A2 (en) | 2004-09-30 |
EP1608748B1 (en) | 2009-03-04 |
US7915201B2 (en) | 2011-03-29 |
EP2236606A2 (en) | 2010-10-06 |
EP1608748A2 (en) | 2005-12-28 |
EP2236606A3 (en) | 2010-10-20 |
DK1608748T3 (en) | 2009-06-29 |
DE602004019764D1 (en) | 2009-04-16 |
DK2236606T3 (en) | 2014-02-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2004083427A3 (en) | Ligational encoding of small molecules | |
WO2005090566A3 (en) | Ligational encoding using building block oligonucleotides | |
WO2005051970A3 (en) | Highly parallel dna synthesiser based on matrices | |
WO2004074429A3 (en) | Method for producing second-generation library | |
AU2003291962A1 (en) | Polypeptides having cellobiohydrolase ii activity and polynucleotides encoding same | |
WO2004074501A3 (en) | A method for obtaining structural information about an encoded molecule | |
DK1828381T3 (en) | Template-directed split-and-mix synthesis of small molecule libraries | |
EP2295544A3 (en) | Polypeptides having cellobiohydrolase I activity and polynucleotides encoding same | |
IL161769A0 (en) | Anbtimicrobial polypeptides from pseudoplectania nigrella | |
EP1225234A3 (en) | Synthesis of nucleic acid | |
DK0876509T3 (en) | Methods for generating polynucleotides with desired properties by repeated selection and recombination | |
AU2496900A (en) | Enhanced sequencing by hybridization using pools of probes | |
EP2290073A3 (en) | Methods and compositions involving microRNA | |
WO2003072753A3 (en) | Multimeric binding complexes | |
EP4249602A3 (en) | Method of preparing libraries of template polynucleotides | |
WO2002095014A3 (en) | Polypeptides having cellobiase activity and polynucleotides encoding same | |
WO2004024929A3 (en) | Proximity-aided synthesis of templated molecules | |
IL206072A (en) | Method for generating and screening an antibody library | |
GB2421950B (en) | Method of mutagenesis | |
JP2004533259A5 (en) | ||
WO2006105339A3 (en) | Gene synthesis using pooled dna | |
DE50209497D1 (en) | METHOD FOR THE PRODUCTION OF MAGNESIUM DIBORIDE AND MAGNESIUM DIBORIDE FORM BODIES OF MAGNESIUM HYDRIDE AND ELEMENTARY BORON BY PULSE PLASMA SYNTHESIS | |
WO2004013282A3 (en) | Bis (amino acid) molecular scaffolds | |
WO2005025737A3 (en) | Molecule arrays and method for producing the same | |
WO2004085651A3 (en) | Pantolactone hydrolase |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2004722237 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2004722237 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006246450 Country of ref document: US Ref document number: 10549619 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 10549619 Country of ref document: US |