WO2004082523A2 - Mitral valve repair system - Google Patents
Mitral valve repair system Download PDFInfo
- Publication number
- WO2004082523A2 WO2004082523A2 PCT/US2004/007383 US2004007383W WO2004082523A2 WO 2004082523 A2 WO2004082523 A2 WO 2004082523A2 US 2004007383 W US2004007383 W US 2004007383W WO 2004082523 A2 WO2004082523 A2 WO 2004082523A2
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- WIPO (PCT)
- Prior art keywords
- needle
- catheter
- lumen
- fastener
- suture
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0467—Instruments for cutting sutures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0482—Needle or suture guides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0487—Suture clamps, clips or locks, e.g. for replacing suture knots; Instruments for applying or removing suture clamps, clips or locks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00367—Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like
- A61B2017/00371—Multiple actuation, e.g. pushing of two buttons, or two working tips becoming operational
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00778—Operations on blood vessels
- A61B2017/00783—Valvuloplasty
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0445—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors cannulated, e.g. with a longitudinal through-hole for passage of an instrument
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0446—Means for attaching and blocking the suture in the suture anchor
- A61B2017/0448—Additional elements on or within the anchor
- A61B2017/0451—Cams or wedges holding the suture by friction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0464—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors for soft tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
- A61B2017/0472—Multiple-needled, e.g. double-needled, instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0487—Suture clamps, clips or locks, e.g. for replacing suture knots; Instruments for applying or removing suture clamps, clips or locks
- A61B2017/0488—Instruments for applying suture clamps, clips or locks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22052—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation eccentric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22065—Functions of balloons
- A61B2017/22069—Immobilising; Stabilising
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/30—Surgical pincettes without pivotal connections
- A61B2017/306—Surgical pincettes without pivotal connections holding by means of suction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
Definitions
- the heart is a hollow muscular organ having four pumping chambers: the left atrium, the left ventricle, the right atrium and the right ventricle.
- the atria are isolated from their respective ventricles by one-way valves located at the respective atrial-ventricular junctions. These valves are identified as the mitral (or bicuspid) valve on the left side of the heart, and tricuspid valve on the right side of the heart.
- the exit valves from the left and right ventricles are identified as the aortic and pulmonary valves, respectively.
- the valves of the heart are positioned in valvular annuluses that comprise dense fibrous rings attached either directly or indirectly to the atrial and ventricular muscle fibers.
- Valve leaflets comprising flexible collagenous structures are attached to, and extend inwardly from, the annuluses to meet at coapting edges.
- the aortic, tricuspid and pulmonary valves each have three leaflets, while the mitral valve only has two.
- the leaflets of the mitral valve open as left ventricle dilates thereby permitting blood to flow from the left atrium into the left ventricle.
- the leaflets then coapt (i.e. close) during the contraction cycle of the left ventricle, thereby preventing the blood from returning to the left atrium and forcing the blood to exit the left ventricle through the aortic valve.
- Heart valve stenosis is a condition in which the valve does not open properly.
- Insufficiency is a condition in which the valve does not close properly.
- MR mitral valve regurgitation
- a number of surgical techniques have been developed to repair degraded or otherwise incompetent heart valves.
- a common procedure involves replacement of a native aortic or mitral valve with a prosthetic heart valve. These procedures require the surgeon to gain access to the heart through the patient's chest (or possibly percutaneously), surgically remove the incompetent native heart valve and associated tissue, remodel the surrounding valve annulus, and secure a replacement valve in the remodeled annulus.
- Valvular remodeling can be accomplished by implanting a prosthetic ring (a.k.a. "annuloplasty ring") into the valve annulus to reduce and/or stabilize the structure of the annulus in order to correct valvular insufficiency.
- Annuloplasty rings are typically constructed of a resilient core covered with a fabric sewing material. Annuloplasty procedures can be performed alone, or they can be performed in conjunction with other procedures such as leaflet repair. Although such annuloplasty procedures have become popular and well accepted, reshaping the surrounding annulus and traditional leaflet repairs do not always lead to optimum leaflet coaptation. As a result, some patients may still experience residual mitral valve regurgitation following such annuloplasty procedures.
- a recently developed technique known as a "bow-tie” repair has also been advocated for repairing insufficient heart valves, in particular the mitral valve.
- the mitral valve bow-tie technique involves suturing the anterior and posterior leaflets together near the middle of their coapting edges, thereby causing blood to flow through two newly formed openings. While this does reduce the volume of blood that can flow from the atrium to the ventricle, this loss is compensated by improved leaflet coaptation which reduces mitral regurgitation.
- This process as originally developed by Dr. Ottavio Alfieri involved arresting the heart and placing the patient on extracorporeal bypass and required invasive surgery to access and suture the leaflets together. More recently, however, some have advocated a "beating heart” procedure in which the heart is accessed remotely and remains active throughout the bow-tie procedure.
- the associated device consists of a forceps-like grasper used to grasp and hold the mitral valve leaflets in a coapted position prior to the connecting step. Since the mitral valve leaflets curve toward and slightly into the left ventricular cavity at their mating edges, the grasper device is passed through a sealed aperture in the apex of the left ventricle.
- the edges of the mating mitral valve leaflets are then grasped and held together, and subsequently a fastening device such as a clip or suture is utilized to fasten them.
- a fastening device such as a clip or suture is utilized to fasten them.
- the Mehmet Oz disclosure also discloses teeth on the grasper device that are linearly slidable with respect to one another so as to permit alignment of the mitral valve leaflets prior to fastening. Since the procedure is done on a beating heart, it will be readily understood that the pressures and motions within the left ventricle and mitral valve leaflets are severe and render Dr. Oz's procedure very skill- intensive.
- the present invention solves the problem of effectively stabilizing at least one tissue portion in vivo. Additionally, the present invention provides a device capable of delivering a fastener to the stabilized tissue portion through a catheter from a remote insertion location.
- the present invention is directed to a system for repairing tissue within the heart of a patient and includes a guide catheter having a proximal end, a distal end, and at least one internal lumen formed therein, a therapy catheter capable of applying at least one suture to the tissue, and a fastener catheter capable of attaching at least one fastener to the suture.
- the therapy catheter and the fastener catheter are capable of traversing the internal lumen of the guide catheter.
- the present invention discloses a system for repairing tissue within the heart of a patient and includes a guide wire capable of being inserted into the patient and advanced through a circulatory pathway, a therapy catheter attachable to the guide wire and capable of applying at least one suture to the tissue, and a fastener catheter attachable to the guide wire and capable of attaching at least one fastener to the suture.
- the present invention pertains to a guide catheter for delivering a tissue repair device to tissue located within the heart of a patient and comprises an outer wall defining an outer wall lumen, a directing lumen capable of receiving a steering device therein and a flexible support device positioned within the outer wall lumen.
- the present invention discloses a catheter for delivering a suture to tissue within the heart of a patient and includes an elongated body having a distal end, at least one suction recess formed on the distal end, at least one needle port located proximate to the suction recess, at least one needle lumen having at least one needle positioned therein in communication with the needle port, at least one needle receiving port having at least one needle catch located therein positioned proximate to the suction recess, and at least one actuator member in communication with the needle.
- the present invention is directed to a catheter for delivering a suture to tissue within the heart of a patient and comprises an elongated body having a distal end with at least one suction recess formed thereon, at least one needle port located proximate to the suction recess, at least one needle lumen having at least one detachable needle attached to suture material positioned therein and in communication with the needle port, at least one needle receiving port located proximate to the suction recess, at least one needle trap capable of receiving the detachable needle positioned within the needle receiving port, and at least one actuator member in communication with the needle.
- the present invention pertains to a device for applying a fastener to suture material attached to tissue within the body of a patient and includes a catheter body having a proximal end and a distal end, an inner body defining a suture recess and an actuation recess, and a movable sleeve defining a deployment lumen.
- the suture recess on the inner body is in communication with a fastener lumen capable of receiving a fastener therein.
- the actuation recess is in communication with an actuation lumen formed in the inner body.
- the deployment lumen formed in the movable sleeve is sized to receive the inner body therein and includes a cutting recess having a cutting member located proximate thereto.
- the present invention is directed to a fastener attachable to suture material and comprises a fastener body having at least one attachment lumen formed therein and at least one engagement member attached to the fastener body wherein the engagement member is capable of engaging and retaining the suture material.
- the engagement member defines an engagement aperture which is in communication with the attachment lumen.
- the attachment lumen is capable of receiving at least one suture therein.
- the present invention also discloses various methods of repairing heart valve tissue within the body of a patient.
- a method of repairing tissue within the heart of a patient which includes advancing a guide catheter through a circulatory pathway to a location in the heart proximate to a heart valve, advancing a therapy catheter through the guide catheter to the heart valve, stabilizing a first leaflet with the therapy catheter, deploying a first suture into the stabilized first leaflet, disengaging the first leaflet from the therapy catheter while leaving the first suture attached thereto, stabilizing a second leaflet with the therapy catheter, deploying a second suture into the second leaflet, disengaging the second leaflet from the therapy catheter while leaving the second suture attached thereto, and joining the first and second leaflets by reducing the distance between the first and second sutures.
- An alternate method of repairing tissue within the heart of a patient comprises advancing a guide catheter through a circulatory pathway to a location in the heart proximate to a heart valve, advancing a therapy catheter through the guide catheter to the heart valve, stabilizing a first leaflet with the therapy catheter, deploying a first suture into the stabilized first leaflet, disengaging the first leaflet from the therapy catheter while leaving the first suture attached thereto, stabilizing a second leaflet with said therapy catheter, deploying a second suture into the second leaflet, disengaging the second leaflet from the therapy catheter while leaving the second suture attached thereto, and removing the therapy catheter from the guide catheter.
- a fastener catheter is positioned over the first and second suture and advanced through the guide catheter to the heart valve. Once positioned, the first and second leaflets are joined by reducing the distance between the first and second sutures and a fastener is deployed from the fastener catheter.
- Fig.1 shows a perspective view of an embodiment of the guide catheter of the present invention
- FIG. 2 shows a cross-sectional view of an embodiment of the guide catheter of the present invention
- FIG. 3 shows a cross-sectional view of an alternate embodiment of the guide catheter of the present invention
- FIG. 4 shows a cross-sectional view of the embodiment of the guide catheter shown in Fig. 3;
- FIG. 5 shows a perspective view of an embodiment of the therapy catheter of the present invention
- Fig. 6 shows an embodiment of the therapy device handle of the present invention
- Fig. 7 shows an perspective view of an embodiment of the elongated body of the present invention having a suture attachment tip attached thereto;
- FIG. 8A shows a cross-sectional view of an embodiment of the elongated body of the present invention
- Fig. 8B shows a cross sectional view of an alternate embodiment of the elongated body of the present invention.
- Fig 8C shows a side cross-sectional view of the embodiment of the elongated body shown in Fig. 8B;
- FIG. 9 shows a top cross-sectional view of an embodiment of the elongated body of the present invention.
- Fig. 10 shows a side cross-sectional view of the embodiment of the elongated body shown in Fig. 9 prior to actuation;
- Fig. 11 shows a side cross-sectional view of an embodiment of the elongated body shown in Fig. 10 during actuation;
- Fig. 12 shows a side cross-sectional view of an embodiment of the elongated body shown in Fig. 10 following actuation;
- Fig. 13 shows another side cross-sectional view of an embodiment of the elongated body shown in Fig. 10 during actuation;
- Fig. 14 shows another side cross-sectional view of an embodiment of the elongated body shown in Fig. 10 following actuation;
- Fig. 15 shows a top cross-sectional view of an alternate embodiment of the elongated body of the present invention
- Fig. 16 shows a side cross-sectional view of the embodiment of the elongated body shown in Fig. 15 prior to actuation
- Fig. 17 shows a side cross-sectional view of an embodiment of the elongated body shown in Fig. 15 during actuation;
- Fig. 18 shows a side cross-sectional view of an embodiment of the elongated body shown in Fig. 15 following actuation;
- Fig. 19 shows a perspective view of an embodiment of the fastener catheter of the present invention
- Fig. 20 shows an embodiment of the fastener catheter handle of the present invention
- FIGs. 21 a and 21 b show a perspective view of the components of the fastener tip of the present invention
- Fig. 22 shows a perspective view of the fastener tip of the present invention having a fastener attached thereto;
- Fig. 23 shows a side view of an embodiment of the fastener of the present invention.
- Fig. 24 shows a side view of the fastener of the present invention attached to suture material
- Fig. 25 shows a perspective view of a guidewire traversing the mitral valve within a heart
- Fig. 26 shows a perspective view of a guide catheter positioned proximate to the mitral valve within a heart
- Fig. 27 shows a perspective view of a therapy catheter advancing through a guide catheter to a position proximate to the mitral valve of a heart
- Fig. 28 shows a perspective view of a therapy catheter stabilizing a first leaflet of the mitral valve of a heart
- Fig. 29 shows a perspective view of the first leaflet of the mitral valve having a suture applied thereto;
- Fig. 35 shows a perspective view of another embodiment of the present invention wherein a dilator is used to introduce the guide catheter onto the left atrium;
- Fig. 39 shows a perspective view of the embodiment of the therapy catheter shown in Fig. 38 having an inflatable positioning balloon positioned thereon inflated;
- Fig. 41 shows a perspective view of the first leaflet of the mitral valve having 3 suture attached thereto;
- Fig. 42 shows a perspective view of the embodiment of the therapy catheter shown in Fig. 38 engaging the second leaflet of the mitral valve;
- Fig. 43 shows a perspective view of the first and second leaflets of the mitral valve having sutures attached thereto;
- Fig. 44 shows another perspective view of the first and second leaflets of the mitral valve having sutures attached thereto.
- the mitral valve repair system of the present invention is designed for use in a surgical treatment of bodily tissue.
- the exemplary mitral valve repair system disclosed herein is designed to minimize trauma to the patient before, during, and subsequent to a minimally invasive surgical procedure while providing improved tissue stabilization and enhanced placement of a fastening device thereon.
- the mitral valve repair system of the present invention includes a guide catheter capable of being introduced into body of a patient and advanced to an area of interest, a therapy catheter capable of traversing or otherwise engaging the guide catheter and applying a suture to a repair site, and a fastener catheter capable of applying a fastening device to the attached suture. While the guide catheter, therapy catheter, and fastener catheter cooperatively enable a surgeon to deliver a suture to a repair site in vivo, the various components of the present invention may be used individually. For example, the therapy catheter, the fastener catheter, or both may be coupled to a guidewire and advanced to a repair site in vivo without the use of the guide catheter.
- the mitral valve repair system of the present invention is useful in repairing dysfunctional mitral valve tissue by stabilizing discreet valvular tissue pieces and deploying a fastening device therethrough.
- the mitral valve repair system may be used to repair tissue throughout a patient's body as desired.
- the present invention may also be used to repair arterial septal defects (ASD), ventricular septal defects (VSD), and defects associated with patent foramen ovale (PFO).
- ASD arterial septal defects
- VSD ventricular septal defects
- PFO patent foramen ovale
- Figures 1-4 show various illustrations of the guide catheter of the present invention.
- the guide catheter 10 comprises a guide body 12 having a proximal end 14 and a distal end 16.
- the guide catheter 10 of the present invention may be manufactured from a variety of materials, including, without limitation, various plastics, thermoplastics, silicones, elastomers, ceramics, composite materials, or various combinations of the aforementioned materials.
- the guide catheter 10 may be manufactured in various lengths and widths as desired by the user.
- Figures 2-4 show various embodiments of the guide catheter 10.
- the guide catheter 10 includes an outer wall 18 defining at least one internal lumen 20.
- Figures 3-4 illustrate alternate embodiments wherein the outer wall 18 defines an internal lumen 20 and includes at least one directing lumen 22 formed therein.
- the directing lumen 22 is sized to receive a guidewire (not shown) or steering device (not shown) therein.
- at least one flexible support structure such as a coiled wire support (not shown) may be embedded within the outer wall 18 of the guide catheter 10.
- FIG. 5 shows a perspective view of an embodiment of the therapy catheter 30 of the present invention.
- the therapy catheter 30 includes an elongated body 32 having a therapy device handle 34 located at the proximal end and a suture attachment tip 36 located at the distal end.
- the elongated body 32 may be manufactured in a variety of shape, sizes, lengths, widths, and biologically-compatible materials as desired.
- FIG. 6 shows a more detailed illustration of the therapy device handle 34 of the present invention.
- the therapy device handle 34 comprises a handle body 38 having at least a suction connector 40 and a elongated body receiver 42 attached thereto.
- the suction connector 40 is capable of coupling to a vacuum source (not shown).
- the elongated body receiver 42 is capable of receiving the elongated body 32 (Fig. 5) thereon.
- a first actuator 44 is located within a first actuator recess 46 formed on the handle body 38.
- a second actuator 48 is positioned within a second actuator recess 50 formed in the handle body 38.
- a suction actuator 52 configured to open or close the fluid path between suction connector 40 and elongated body receiver 42, may be located within a suction actuator recess 54 proximal to the first and second actuators 44, 48.
- a first needle lumen 68 having a first needle 70 located therein may be formed in or otherwise positioned proximate to the outer wall 64 of the elongated body 32.
- a second needle lumen 72 having a second needle 74 located therein may be formed in or otherwise positioned proximate to the outer wall 64 of the elongated body 32.
- the first and second needles 70, 74 are coupled to or otherwise in communication with the first and second actuators 44, 48 located on the therapy device handle 34 (Fig. 6).
- first and second actuators 44, 48 results in the longitudinal movement of the first and second needles 70, 74 thereby permitting the first and second needles, 70, 74 to extend from and retract into the first and second needle lumens 68, 72.
- first and second needles 70, 74 may be capable of individual or simultaneous movement.
- a first suture lumen 76 having a first suture 78 located therein and a second suture lumen 80 having a second suture 82 located therein may be formed within or located proximate to the outer wall 64 of the elongated body 32.
- a guidewire lumen 84 sized to receive guidewire 62 therein may be positioned within or proximate to the outer wall 64 of the elongated body 32 and may be in communication with the guidewire port 60 formed on the suture attachment tip 36.
- Figures 8B-8C show various illustrations of an alternate embodiment of the present invention, wherein an inflatable positioning balloon 252 is positioned on the outer wall 64 of the elongated body 32. As shown, the inflatable positioning balloon 252 is in fluid communication with an inflation lumen 84' positioned within the elongated body 32.
- the inflation lumen 84' may be in fluid communication with an inflation source in ways known to those skilled in the art and may be attached to or otherwise in communication with the therapy device handle 34 (Fig. 5), thereby permitting the position of the therapy catheter 30 to be manipulated without using a guidewire. Moreover, the positioning balloon 252 can be used to hold the therapy device steady once in position.
- Figures 9-10 show various illustrations of the present invention prior to use. As shown, a first needle receiving port 86A may be positioned within or proximate to the suction lumen 56 co-aligned with and opposing the first needle port 58A.
- a second needle receiving port 86B may be positioned within or proximate to the suction lumen 56 co-aligned with and opposing the second needle port 58B.
- the first needle receiving port 86A is in communication with the first suture lumen 76 and contains at least a first needle catch 88A attached to the first suture 78 therein.
- the second needle receiving port 86B is positioned proximate to the suction recess 56 opposing the second needle port 58B.
- the second needle receiving port 86B is in communication with the second suture lumen 80 and contains a second needle catch 88B attached to the second suture 82 therein.
- Figures 11-12 show an embodiment of the therapy catheter of the present invention during various stages of use.
- the first needle 70 having the first needle catch 88A attached thereto is retracted through the first needle receiving port 86A, traverses the suction recess 56, and enters the first needle lumen 68 through the first needle port 58A.
- Figure 12 shows the first suture 78 traversing the suction recess 56.
- the second needle 74 having the second needle catch 88B attached thereto is retracted through the second needle receiving port 86B, traverses the suction recess 56, and enters the second needle lumen 72 through the second needle port 58B.
- the second suture 82 which is attached to the second needle catch 88B, thus traverses the suction recess 56.
- Figure 15 illustrates an alternate embodiment of the present invention.
- the elongated body 32 includes a suction recess 90 formed thereon which is in fluid communication with a suction lumen 92 formed therein which in turn is in communication with a vacuum source (not shown) attached to the suction connector 40 (Fig. 6).
- First and second needle ports 94A, 94B, respectively, are positioned within or proximate to the suction recess 90.
- first and second needle receiving ports 96A, 96B respectively, are positioned within or proximate to the suction recess 90 and are co-aligned with and opposed to the first and second needle ports 94A, 94B.
- the first needle port 94A communicates with a first needle lumen 98.
- a first deployment rod 100 having a first detachable needle 102 attached thereto is located within the first needle lumen 98.
- the first detachable needle 102 is coupled to a first suture 104 located within the first needle lumen 98.
- the second needle port 94B communicates with a second needle lumen 106.
- a second deployment rod 108 having a second detachable needle 110 attached thereto is located within the second needle lumen 106.
- the second detachable needle 110 is coupled to a second suture 112 located within the second needle lumen 106.
- Figures 16-18 show the embodiment of Figure 15 during use. Forward movement of the first actuator 44 results in first needle rod 100 extending from first needle lumen 98.
- Figure 17 shows the first needle rod 100 with a first detachable needle 102 attached thereto extended through the first needle port 94A traversing the suction recess 90, and entering into the first needle trap lumen 114A through the first needle receiving port 96A. The first detachable needle then engages the first needle trap 116A. Thereafter, the first needle rod 100 is retracted into the first needle lumen 98, thereby leaving first detachable needle 102 in first needle trap 116A.
- Figure 18 shows the first needle rod 100 retracted into the first needle lumen 98.
- the first suture 104 which is attached to the first detachable needle 102 traverses the suction recess 90.
- a second needle (not shown) may be deployed in a similar manner.
- Figures 19-21 show various illustrations of the fastener catheter of the present invention.
- the fastener catheter 130 comprises a fastener catheter body 132 having a fastener catheter handle 134 attached at the proximal end and a fastening tip 136 at the distal end.
- the fastener catheter 130 may be manufactured in a variety of shapes, sizes, lengths, widths, and biologically-compatible materials as desired.
- FIG 20 shows a more detailed illustration of a preferred fastener catheter handle 134 of the present invention.
- the fastener catheter handle 134 comprises a fastener handle body 138 having an auxiliary connector 140 and a fastener body receiver 142 attached thereto.
- the auxiliary connector 140 may be capable of coupling to a variety of devices including, for example, a vacuum source or a visualization device.
- the fastener body connector 142 is capable of receiving and coupling to the fastener catheter body 132 (Fig. 19).
- a fastener actuator 144 may be positioned within a fastener actuator recess 146 formed on the fastener handle body 138.
- the fastener actuator 144 positioned within the fastener actuator recess 146 may be capable of being positioned in three distinct locations. For example, in a non-actuated condition, the fastener actuator 144 may be located in a first position 148. Thereafter, the user may partially actuate the fastener catheter 130 by positioning the fastener actuator 144 in a second position 150, thereby deploying a fastening device (not shown) from the fastener catheter 130 (Fig. 19).
- the user may then fully actuate the fastener catheter 130 by moving the fastener actuator 144 to a third position 152 within the fastener actuator recess 146, thereby actuating a cutting member (discussed below) located on or proximate to the fastening tip 136.
- FIGS 21a and 21b illustrate, in exploded fashion, pieces of fastening tip 136.
- An inner body 154 includes a suture recess 160 formed in the side thereof, which in turn is in communication with an internal fastener lumen 158.
- Inner body 154 also includes a pin 162 extending radially outward therefrom.
- Sleeve 156 comprises an axial deployment lumen 166 of sufficient diameter to receive inner body 154 therein.
- Sleeve 156 also comprises a cutting recess 168 formed in an axial side thereof and a cutting member 170 on a proximal edge of cutting recess 168.
- Slot 172 extends parallel to the axis of the deployment lumen 166 and may extend radially through to fastener lumen.
- Fastener 180 may be manufactured from a variety of materials including, for example, Nickel-Titanium alloys, shape-memory alloys, stainless steel, titanium, various plastics, and other biologically- compatible materials.
- Fastener 180 has an internal lumen 188 extending axially therethrough and one or more engagement member(s) 184 formed on an end thereof. Between the engagement members is defined engagement aperture 186 which is in communication with attachment lumen 188. Attachment lumen 188 and engagement aperture 186 are sized to receive a first suture lead 176A and a second suture lead 176B therein.
- engagement member(s) 184 Prior to deployment, engagement member(s) 184 are deflected radially away from the axis of the fastener 180 such that engagement aperture 186 has a relative large first diameter sufficient to permit suture leads 176A and 176B to slide therethrough.
- engagement members 184 Upon deployment, i.e. after the suture leads 176A and 176B have been retracted, engagement members 184 are deflected or permitted to spring back toward the axis of the device such that the engagement aperture 186 assumes a second smaller diameter compressing and securing suture leads 176A and 176B in place.
- the engagement member(s) 184 tend to spring toward a natural position at the axis of fastener 180.
- FIG 24 shows the fastener 180 in the deployed configuration in which a suture loop 178 has passed through two discreet tissue portions 200A, 200B and suture leads 176A, 176B are secured in fastener 180.
- Each engagement member(s) 184 may further include a pointed tip 190 which, when the engagement member(s) are in the deployed position, engages and further restricts movement of the suture leads 176A, 176B.
- FIG. 22 An operational fastening tip 136 with fastener 180 attached thereto and ready for deployment can be seen in Figure 22.
- Inner body 154 has been placed inside sleeve 156 such that suture recess 160 is in alignment with cutting recess 168.
- Pin 172 is in slidable communication with slot 162 thereby permitting relative linear motion, but preventing relative rotational motion, between inner body 154 and sleeve 156.
- Fastener 180 has been placed on the end of the fastening tip 136 by deflecting the engagement members 184 radially outward until they can be placed around the outer circumference of the inner body 154.
- the fastener is secured to the end of inner body 154 by means of the frictional engagement between the engagement members 184 and the outer surface of inner body 154.
- Suture loop 178 extends from the fastener 180.
- Suture leads 176A and 176B extend through the lumen 188, through engagement aperture 186, exit the side of inner body 154 through suture recess 160, and exit the side of sleeve 156 through cutting recess 168.
- the fastener tip 136 is coaxed toward the tissue and the suture leads 176A and 176B are pulled away from the tissue until the suture loop is sufficiently cinched around the target tissue.
- Sleeve 156 is then held in place adjacent the tissue while the inner body 154 is pulled axially away. This causes sleeve 156 to push (i.e. slide) fastener 180 off the outer surface of the inner body 154.
- axial movement of the fastener actuator 144 relative to the handle 134 causes similar relative movement between inner body 154 and sleeve 156.
- the distal end of inner body 154 will extend from sleeve 156 a sufficient distance to hold fastener 180 thereon.
- the inner body 154 In the second position 150 the inner body 154 will have been withdrawn into sleeve 156 a sufficient distance to deploy the fastener 180, and in the third position 152 the inner body 154 will have been withdrawn a sufficient distance to cut the suture leads 176A and 176B.
- the present invention also discloses various methods of using the disclose mitral valve repair system to repair discreet tissue portions in vivo.
- the following paragraphs describe methods of repairing a dysfunctional mitral valve, though those skilled in the art will appreciate that the present invention and procedure may be adapted for use on other valves or in other procedures requiring the attachment of two or more pieces of tissue.
- a guidewire capable of traversing the circulatory system and entering the heart of the patient is introduced into the patient through an endoluminal entry point.
- the endoluminal entry point may be formed in a femoral vein or right jugular vein. Thereafter, the guidewire is advanced through the circulatory system, eventually arriving at the heart.
- the guidewire is directed into the right atrium, traverses the right atrium and is made to puncture with the aid of a tran-septai needle or pre-existing hole, the atrial septum, thereby entering the left atrium.
- the guidewire 220 may then be advanced through the mitral valve 222 and into the left ventricle 226.
- the guidewire 220 traverses the aortic valve 228 into the aorta 230 and is made to emerge at the left femoral artery through an endoluminal exit point.
- the endoluminal entry or exit port is dilated to permit entry of a catheter therethrough.
- a protective sheath may be advanced in the venous area to protect the vascular structure.
- the guide catheter 10 of the present invention may be attached to the guidewire 220 and advanced through the dilated guidewire entry port to a point proximate to the mitral valve 222.
- the mitral valve repair system of the present invention may approach the mitral valve from an antegrade position or from a retrograde position as desired by the user.
- the therapy catheter 30 may be advanced through the guide catheter 10 to a position proximate to the mitral valve 222.
- Figure 27 shows the therapy catheter 30 emerging from the guide catheter 10 proximate to the mitral valve 222.
- a suction force is applied from the suction recess 56 formed on the suture attachment tip 36 of the therapy catheter 30 (Fig. 7) to the tissue located proximate thereto.
- a first valve leaflet 240A is engaged and retained by the suction force applied through the suction recess 56. With the first valve leaflet 240A stabilized, the user may apply a suture 242A thereto as described above.
- the user actuates the first actuator 44 located on the therapy device handle 34, which results in the first needle 70 advancing through the first valve leaflet 240A and engaging and retaining the first needle catch 88A, thereby applying a first suture 242A to the tissue (Figs. 6-7). Thereafter, the user may terminate application of suction force to the first valve leaflet 240A thereby releasing the sutured tissue.
- Figure 29 shows the first valve leaflet 240A having a first suture 242A applied thereto.
- the therapy catheter 30 may then be rotated and positioned to engage a second valve leaflet 240B.
- first and second sutures 242A and 242B are actually portions of the same suture such that when the therapy catheter is removed there is a single suture loop through the valve leaflets 240A and 240B.
- the fastener catheter 130 may be attached to the guidewire 220 and will be attached to first and second sutures 242A, 242B. Thereafter, the fastener catheter 130 may be inserted into the guide catheter 10 and advanced to a position proximate to the mitral valve 222. The user then draws the first and second sutures 242A, 242B taut while advancing the fastener catheter 130 to the mitral valve 22, thereby decreasing the distance between the first and second valve leaflets 240A, 240B. The user then actuates the fastener actuator 144 which causes the sleeve 156 to engage and apply the fastener 180 to the first and second sutures 242A, 242B adjacent the leaflets, as described above.
- Figures 35-44 describe an alternate method of repairing tissue, specifically valve leaflets in this embodiment, in vivo.
- a guide catheter 10 is advanced through the circulatory system to the right atrium of the heart.
- a dilator 250 is advanced through the guide catheter 10 and is made to puncture the atrial septum, thereby entering the left atrium.
- the guide catheter 10 is advanced into the left atrium through the punctured atrial septum and positioned proximate to the mitral valve 222.
- the therapy catheter 30 may be inserted into the guide catheter 10 and advanced to a position proximate to the mitral valve 222.
- an inflatable positioning balloon 252 located on the therapy catheter 30 is inflated to orient and steady the catheter.
- the suction actuator 52 on the therapy device handle 34 is then actuated to apply a suction force to the suction recess 56 (see. Fig. 6).
- the inflated balloon 252 engages the second valve leaflet 240B which forces the suction recess 56 towards the first valve leaflet 240A, thereby resulting in the stabilization of the first valve leaflet 240A as shown in Figure 40.
- the user may then apply the first suture 242A to the first valve leaflet 240A as described above. Once the suture is applied, the user may deflate the inflatable positioning balloon 252 and rotates the therapy catheter 30 approximately 180°.
- FIG. 42 the inflatable positioning balloon 252 is again inflated and made to engage the first valve leaflet 240 thereby forcing the suction recess 56 to engage the second valve leaflet 240B and permitting the stabilization of the second valve leaflet 240B as shown in Figure 42.
- the user applies the second suture 242B to the second valve leaflet 240B as described above.
- Figures 43-44 show the first and second valve leaflets 240A, 240B having a first and second suture 242A, 242B applied thereto.
- the therapy catheter 30 is removed from the patient's body and the fastener catheter 130 is used to apply a fastener to the first and second sutures 242A, 242B as described above.
- the embodiments of the invention disclosed herein are illustrative of the principals of the invention. Other modifications may be employed which remain within the scope of the present invention. Accordingly, the present invention is not limited to the embodiments shown and described in this disclosure.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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AU2004222384A AU2004222384A1 (en) | 2003-03-14 | 2004-03-11 | Mitral valve repair system |
EP04719723A EP1605833A2 (en) | 2003-03-14 | 2004-03-11 | Mitral valve repair system |
CA2518962A CA2518962C (en) | 2003-03-14 | 2004-03-11 | Mitral valve repair system and method for use |
JP2006507062A JP4558718B2 (en) | 2003-03-14 | 2004-03-11 | Mitral valve repair system and method for use |
Applications Claiming Priority (2)
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US10/389,721 | 2003-03-14 | ||
US10/389,721 US7381210B2 (en) | 2003-03-14 | 2003-03-14 | Mitral valve repair system and method for use |
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WO2004082523A2 true WO2004082523A2 (en) | 2004-09-30 |
WO2004082523A3 WO2004082523A3 (en) | 2005-03-31 |
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US (4) | US7381210B2 (en) |
EP (2) | EP2401970B1 (en) |
JP (1) | JP4558718B2 (en) |
AU (1) | AU2004222384A1 (en) |
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WO (1) | WO2004082523A2 (en) |
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Also Published As
Publication number | Publication date |
---|---|
US20120289977A1 (en) | 2012-11-15 |
AU2004222384A1 (en) | 2004-09-30 |
US20040181238A1 (en) | 2004-09-16 |
CA2518962A1 (en) | 2004-09-30 |
US8777991B2 (en) | 2014-07-15 |
WO2004082523A3 (en) | 2005-03-31 |
US7381210B2 (en) | 2008-06-03 |
CA2754649C (en) | 2015-04-28 |
EP2401970B1 (en) | 2013-05-08 |
US8226666B2 (en) | 2012-07-24 |
EP1605833A2 (en) | 2005-12-21 |
CA2754649A1 (en) | 2004-09-30 |
WO2004082523A8 (en) | 2005-07-21 |
CA2518962C (en) | 2012-01-03 |
JP4558718B2 (en) | 2010-10-06 |
US20080228201A1 (en) | 2008-09-18 |
JP2006520240A (en) | 2006-09-07 |
US20090318871A1 (en) | 2009-12-24 |
EP2401970A1 (en) | 2012-01-04 |
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