WO2004064885A2 - Verfahren und anordnung zur volumenreduktion der lunge - Google Patents
Verfahren und anordnung zur volumenreduktion der lunge Download PDFInfo
- Publication number
- WO2004064885A2 WO2004064885A2 PCT/DE2004/000008 DE2004000008W WO2004064885A2 WO 2004064885 A2 WO2004064885 A2 WO 2004064885A2 DE 2004000008 W DE2004000008 W DE 2004000008W WO 2004064885 A2 WO2004064885 A2 WO 2004064885A2
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- WO
- WIPO (PCT)
- Prior art keywords
- patient
- air
- lungs
- suction
- volume
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0402—Special features for tracheal tubes not otherwise provided for
- A61M16/0404—Special features for tracheal tubes not otherwise provided for with means for selective or partial lung respiration
Definitions
- the invention relates to a method and an arrangement for reducing the volume of the lungs of a patient suffering from emphysema.
- pulmonary emphysema is an overinflation of the lung tissue. It is formed by the fact that the alveoli and the smallest end bronchi burst and perish, so that instead of many small alveoli, there are only a few large blisters, regular sacks. This leads to a reduction in the surface area for gas exchange. As a result, the possibility of oxygen absorption and carbon dioxide emission has decreased. Shortness of breath occurs even with the slightest physical exertion.
- the respiratory organ changes its elasticity and elasticity. However, these are prerequisites for undisturbed breathing.
- the lungs which are greatly stretched when inhaled more deeply, pulls in The elasticity of the muscle pull subsides naturally again. This no longer works in emphysema, at least not enough.
- the lungs remain large and filled with air. Exhalation is banned or even prevented. Most of the breathed air remains in the chest and no fresh air can be inhaled. In extreme cases, the person concerned is in a constant state of inhalation. This can be compensated for in peace. However, shortness of breath and soon a feeling of breathlessness appear, even with small loads, the typical symptoms of a pulmonary emphysema.
- US Pat. No. 6,287,290 B1 counts a method and a device according to the prior art, in which an overblown lung area is reduced in volume via a bronchial catheter by means of a suction device. A plug or stent is then inserted into the feeding segment bronchus.
- the invention is therefore based on the object of improving the method for reducing the volume of the lungs in terms of application technology, a treatment-appropriate suction of an inflated one To enable lung areas and to create an appropriate arrangement for this.
- At the heart of the invention is the consideration of preventing the collapsing of the segment bronchus or lung tissue at the time of the suction or, conversely, of not performing the suction if a collapse occurs.
- a first solution of the procedural part of the task consists in a method according to claim 1.
- a bronchial catheter is inserted into an overblown lung area and from there air is sucked off by means of a suction device.
- the patient's spontaneous breathing is recorded during treatment. This can be done manually, but preferably by means of suitable sensors and measuring devices.
- the air is extracted from the emphysema in synchronism with the patient's inhalation process.
- the invention adopts the property that the lungs are stretched during the inhalation process. The lungs pull the bronchi apart. The phenomenon is called interdependence. In this stretched state, the suction is carried out according to the invention. This can prevent the surrounding airways from collapsing when a negative pressure is applied.
- a second procedural solution is shown in claim 2. Thereafter, the supplying segment bronchus is expanded synchronously with the suction of the air by a pulse of compressed gas.
- the airways adjacent to the distal end of the bronchial catheter are widened by means of a targeted pressure gas shock and are kept open during the suction process.
- a short overpressure pulse is expediently modulated whenever a collapse of the airways is found.
- By applying the compressed gas reverse short pressure peaks occur.
- the bronchus is widened exactly at the time of a collapse. This enables the desired suction to be carried out.
- compressed air, heliox or oxygen can be used as the compressed gas.
- Heliox appears to be particularly suitable, since this gas is low-viscosity and therefore flows very quickly.
- a method is particularly advantageous in which the measures of claims 1 and 2 are combined. Expediently, the patient's spontaneous breathing is sensed and the suction of the air is controlled as a function thereof, as provided for in claim 3.
- the procedure proposed according to the invention suggests a much better suction procedure in the case of emphysema.
- the inflated lung tissue has been emptied and contracted, the corresponding feeding segment bronchus is closed with suitable means.
- suitable means such as stents or stoppers are available for this.
- a first objective solution to the problem on which the invention is based can be seen in an arrangement according to the features of claim 4.
- sensors for detecting the spontaneous breathing of the patient are provided, which are connected to a control unit for activating the suction device.
- the detection of spontaneous breathing can be done in different ways. For example, a sound or flow measurement on the patient's mouth or nose or on the bronchial catheter is conceivable. Chest impedance or chest expansion can also be measured electrically and used as a control signal.
- the state of stretching of the bronchi can be determined by image evaluation of the bronchoscopic image. Suction takes place only when stretched (open).
- this comprises a pressure generator with an associated valve unit.
- the arrangement is timed so that it is synchronized with the extraction of air and / or Ascertaining a pressure drop, the lung or the feeding segment bronchus can be acted upon by a pressure gas pulse.
- a particularly advantageous arrangement further comprises a measuring device for monitoring the extracted air (claim 6).
- the pressure generator can be activated depending on the extracted air flow. This can always take place when no more flow or air flow is registered or the extracted air flow falls below a predefinable limit.
- the supplying segment bronchus is then expanded by the compressed gas pulse, so that the suction process can be carried out.
- one approach of the invention is not to carry out the suction process when the segment bronchus concerned collapses or, in the event of a collapse, the volume is expanded by means of a compressed gas stream.
- an image can also be taken in situ.
- an image recording unit is part of the arrangement, which is linked to a data processing unit for controlling the pressure generator.
- the pictorial scene is expediently recorded continuously.
- the image information is then converted into digital signals and, if necessary after contrast enhancement, used to evaluate the condition in the lung area. In this way, a collapse or an imminent collapse can be determined and a pressure gas surge can be generated in a timely manner.
- Figure 1 schematically shows an arrangement for reducing the volume of the lungs during the treatment of a patient
- Figure 2 technically simplified a first embodiment of an arrangement according to the invention
- Figure 3 is a diagram showing the passage of time
- Figure 4 shows a second embodiment of an inventive
- Figure 5 is a diagram showing the timing of a
- FIG. 1 schematically shows an arrangement according to the invention for reducing the volume of the lungs L of a patient suffering from emphysema during the treatment.
- the area of the lungs affected by emphysema is labeled E.
- the arrangement of the basic structure can be seen in FIG. 2.
- the arrangement comprises a bronchoscope 1 with a bronchial catheter 2, which is connected to a suction device 3.
- the bronchial catheter 2 is inserted into the inflated lung artery.
- the distal end 4 of the bronchial catheter 2 can be sealed off from the surrounding vessel wall by means of suitable blockers (not shown here).
- sensors 5 attached to the patient's chest, the patient's spontaneous breathing is detected by a thoracic impedance measurement.
- the measured values recorded by the sensors 5 are evaluated in a control-controlled unit 6 forming part of the suction device 3 and used to control the suction process (line a).
- the patient's breathing can also be monitored by a sound measurement sensor 7 and / or a sensor 8 on the patient's nose, for example by means of inductance respirometry.
- the sensors 7 and 8 are connected to the control and monitoring unit 6 (lines b and c).
- an image capture unit 9 in the form of a video camera on the bronchoscope 1 can be seen, which is also coupled to the control and monitoring unit 6 (line d). With the image recording Unit 9 can be an optical detection of the current situation of the lung area to be treated.
- the lungs expand when inhaled.
- the segmental bronchus 10 leading to emphysema E is also expanded through the interconnected bronchi.
- This elasticity of the bronchi and the connection to one another is indicated schematically in FIG. 1 by the springs I (interdependence).
- the suction of the air is carried out synchronously with the patient's inhalation process. This means that whenever the patient inhales and as a result the lungs L and the segmental bronchus 10 are expanded, a suction valve 11 (see FIG. 2) of the suction device 3 is opened so that the air is extracted from the emphyseal area in the course of the inhalation rhythm becomes.
- the upper image sequence shows actual images (1-8) of the endoscopically recorded situation in the feeding segment bronchus 10.
- the upper curve K1 represents the breathing process, the curve sections marked EV representing the inhalation process and the curve sections marked AV representing the exhalation process.
- the middle curve K2 represents the activation of the suction valve 11 with the switching states on / off.
- the lower curve K3 shows the pressure curve during the suction.
- the suction valve 11 is open during the inhalation process EV.
- the segmental bronchus 10 is open in this phase (image 1 and 2 of the endoscopy sequence).
- the segmental bronchus 10 collapses. This process begins in Figure 3 of the endoscopy sequence.
- the segmental bronchus 10 is closed. With the onset of collapse it will Suction valve 1 closed. This can be seen in curve K2.
- the suction valve 11 is opened in rhythm with the new inhalation process EV as shown in Figures 5 and 6 of the endoscopy sequence.
- the vacuum U of 5 mbar is then present, as indicated in curve K3, and the suction is carried out.
- the arrangement shown in FIG. 4 also includes a bronchoscope 1 with a bronchial catheter 2 and a suction device 3.
- the suction valve of the suction device 3 is again designated 11.
- a pressure generator 12 with an associated valve unit 13 is integrated in the arrangement. This serves to apply a pressure gas pulse G to the lung L or the segment bronchus 10 (see FIG. 1).
- the pressure gas pulse G is applied in synchronism with the suction of the air.
- the pressure generator 12 is connected via a control valve 14, which links the suction device 3 and the pressure generator 12.
- the supply and discharge lines are generally designated 15 and 16 in FIG.
- curves K4, K5 and K6 show the on / off switching state of control valve 14, valve unit 13 and suction valve 11.
- Lower curve K7 shows the pressure in segmental bronchus 10.
- Part of the arrangement is a measuring device for monitoring the extracted air. If the measuring device does not register any flow or suction flow, the pressure generator 12 is activated and a short burst of compressed gas is introduced into the supplying bronchus 10, so that it is expanded.
- the in-situ situation in the segmental bronchus is visualized by means of the optical image acquisition unit 9 monitored and a picture taken of it.
- a collapse or an impending collapse is recognized and the pressure generator 12 is activated accordingly, so that the collapse can be prevented.
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- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endoscopes (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Surgical Instruments (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04700437A EP1587566A2 (de) | 2003-01-20 | 2004-01-07 | Verfahren und anordnung zur volumenreduktion der lunge |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10302310.0 | 2003-01-20 | ||
DE10302310A DE10302310A1 (de) | 2003-01-20 | 2003-01-20 | Verfahren und Anordnung zur Volumenreduktion der Lunge |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004064885A2 true WO2004064885A2 (de) | 2004-08-05 |
WO2004064885A3 WO2004064885A3 (de) | 2004-10-21 |
Family
ID=32602852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/DE2004/000008 WO2004064885A2 (de) | 2003-01-20 | 2004-01-07 | Verfahren und anordnung zur volumenreduktion der lunge |
Country Status (4)
Country | Link |
---|---|
US (1) | US20050061322A1 (de) |
EP (1) | EP1587566A2 (de) |
DE (1) | DE10302310A1 (de) |
WO (1) | WO2004064885A2 (de) |
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---|---|---|---|---|
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CN104707192A (zh) * | 2015-04-07 | 2015-06-17 | 周韶辉 | 肺大泡反向治疗装置 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7011094B2 (en) * | 2001-03-02 | 2006-03-14 | Emphasys Medical, Inc. | Bronchial flow control devices and methods of use |
US7811274B2 (en) * | 2003-05-07 | 2010-10-12 | Portaero, Inc. | Method for treating chronic obstructive pulmonary disease |
US7426929B2 (en) | 2003-05-20 | 2008-09-23 | Portaero, Inc. | Intra/extra-thoracic collateral ventilation bypass system and method |
US7533667B2 (en) * | 2003-05-29 | 2009-05-19 | Portaero, Inc. | Methods and devices to assist pulmonary decompression |
US7252086B2 (en) * | 2003-06-03 | 2007-08-07 | Cordis Corporation | Lung reduction system |
US7377278B2 (en) | 2003-06-05 | 2008-05-27 | Portaero, Inc. | Intra-thoracic collateral ventilation bypass system and method |
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US7588033B2 (en) | 2003-06-18 | 2009-09-15 | Breathe Technologies, Inc. | Methods, systems and devices for improving ventilation in a lung area |
US7682332B2 (en) * | 2003-07-15 | 2010-03-23 | Portaero, Inc. | Methods to accelerate wound healing in thoracic anastomosis applications |
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US7670282B2 (en) | 2004-06-14 | 2010-03-02 | Pneumrx, Inc. | Lung access device |
WO2006009688A2 (en) * | 2004-06-16 | 2006-01-26 | Pneumrx, Inc. | Intra-bronchial lung volume reduction system |
US7766891B2 (en) * | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Lung device with sealing features |
US7766938B2 (en) * | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Pleural effusion treatment device, method and material |
US7398782B2 (en) * | 2004-11-19 | 2008-07-15 | Portaero, Inc. | Method for pulmonary drug delivery |
US20060118126A1 (en) * | 2004-11-19 | 2006-06-08 | Don Tanaka | Methods and devices for controlling collateral ventilation |
US8220460B2 (en) * | 2004-11-19 | 2012-07-17 | Portaero, Inc. | Evacuation device and method for creating a localized pleurodesis |
US7771472B2 (en) * | 2004-11-19 | 2010-08-10 | Pulmonx Corporation | Bronchial flow control devices and methods of use |
JP4874259B2 (ja) * | 2004-11-23 | 2012-02-15 | ヌームアールエックス・インコーポレーテッド | 標的部位にアクセスするための操縦可能な装置 |
US7824366B2 (en) * | 2004-12-10 | 2010-11-02 | Portaero, Inc. | Collateral ventilation device with chest tube/evacuation features and method |
US8104474B2 (en) * | 2005-08-23 | 2012-01-31 | Portaero, Inc. | Collateral ventilation bypass system with retention features |
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US7406963B2 (en) | 2006-01-17 | 2008-08-05 | Portaero, Inc. | Variable resistance pulmonary ventilation bypass valve and method |
US8888800B2 (en) | 2006-03-13 | 2014-11-18 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US8157837B2 (en) * | 2006-03-13 | 2012-04-17 | Pneumrx, Inc. | Minimally invasive lung volume reduction device and method |
US9402633B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
JP5191005B2 (ja) | 2006-05-18 | 2013-04-24 | ブリーズ テクノロジーズ, インコーポレイテッド | 気管切開の方法およびデバイス |
EP2068992B1 (de) | 2006-08-03 | 2016-10-05 | Breathe Technologies, Inc. | Vorrichtung für minimal invasive atmungsunterstützung |
US8163034B2 (en) * | 2007-05-11 | 2012-04-24 | Portaero, Inc. | Methods and devices to create a chemically and/or mechanically localized pleurodesis |
US7931641B2 (en) | 2007-05-11 | 2011-04-26 | Portaero, Inc. | Visceral pleura ring connector |
US20080281151A1 (en) * | 2007-05-11 | 2008-11-13 | Portaero, Inc. | Pulmonary pleural stabilizer |
US20080283065A1 (en) * | 2007-05-15 | 2008-11-20 | Portaero, Inc. | Methods and devices to maintain patency of a lumen in parenchymal tissue of the lung |
US8062315B2 (en) | 2007-05-17 | 2011-11-22 | Portaero, Inc. | Variable parietal/visceral pleural coupling |
WO2008144589A1 (en) | 2007-05-18 | 2008-11-27 | Breathe Technologies, Inc. | Methods and devices for sensing respiration and providing ventilation therapy |
US20080295829A1 (en) * | 2007-05-30 | 2008-12-04 | Portaero, Inc. | Bridge element for lung implant |
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US8567399B2 (en) | 2007-09-26 | 2013-10-29 | Breathe Technologies, Inc. | Methods and devices for providing inspiratory and expiratory flow relief during ventilation therapy |
WO2009105432A2 (en) * | 2008-02-19 | 2009-08-27 | Portaero, Inc. | Devices and methods for delivery of a therapeutic agent through a pneumostoma |
US8475389B2 (en) * | 2008-02-19 | 2013-07-02 | Portaero, Inc. | Methods and devices for assessment of pneumostoma function |
US8336540B2 (en) * | 2008-02-19 | 2012-12-25 | Portaero, Inc. | Pneumostoma management device and method for treatment of chronic obstructive pulmonary disease |
US8770193B2 (en) | 2008-04-18 | 2014-07-08 | Breathe Technologies, Inc. | Methods and devices for sensing respiration and controlling ventilator functions |
JP5758799B2 (ja) | 2008-04-18 | 2015-08-05 | ブリーズ・テクノロジーズ・インコーポレーテッド | 呼吸作用を感知し、人工呼吸器の機能を制御するための方法およびデバイス |
US11254926B2 (en) | 2008-04-29 | 2022-02-22 | Virginia Tech Intellectual Properties, Inc. | Devices and methods for high frequency electroporation |
US9283051B2 (en) | 2008-04-29 | 2016-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating a treatment volume for administering electrical-energy based therapies |
US10238447B2 (en) | 2008-04-29 | 2019-03-26 | Virginia Tech Intellectual Properties, Inc. | System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress |
US9198733B2 (en) | 2008-04-29 | 2015-12-01 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for electroporation-based therapies |
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US10117707B2 (en) | 2008-04-29 | 2018-11-06 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
WO2009134876A1 (en) | 2008-04-29 | 2009-11-05 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation to create tissue scaffolds |
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US9867652B2 (en) | 2008-04-29 | 2018-01-16 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds |
US10272178B2 (en) | 2008-04-29 | 2019-04-30 | Virginia Tech Intellectual Properties Inc. | Methods for blood-brain barrier disruption using electrical energy |
CA2734296C (en) | 2008-08-22 | 2018-12-18 | Breathe Technologies, Inc. | Methods and devices for providing mechanical ventilation with an open airway interface |
US8632605B2 (en) | 2008-09-12 | 2014-01-21 | Pneumrx, Inc. | Elongated lung volume reduction devices, methods, and systems |
CA2739435A1 (en) | 2008-10-01 | 2010-04-08 | Breathe Technologies, Inc. | Ventilator with biofeedback monitoring and control for improving patient activity and health |
US8347881B2 (en) * | 2009-01-08 | 2013-01-08 | Portaero, Inc. | Pneumostoma management device with integrated patency sensor and method |
US9132250B2 (en) | 2009-09-03 | 2015-09-15 | Breathe Technologies, Inc. | Methods, systems and devices for non-invasive ventilation including a non-sealing ventilation interface with an entrainment port and/or pressure feature |
WO2010115170A2 (en) | 2009-04-02 | 2010-10-07 | Breathe Technologies, Inc. | Methods, systems and devices for non-invasive open ventilation for treating airway obstructions |
US8518053B2 (en) * | 2009-02-11 | 2013-08-27 | Portaero, Inc. | Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease |
US9962512B2 (en) | 2009-04-02 | 2018-05-08 | Breathe Technologies, Inc. | Methods, systems and devices for non-invasive ventilation including a non-sealing ventilation interface with a free space nozzle feature |
US11638603B2 (en) | 2009-04-09 | 2023-05-02 | Virginia Tech Intellectual Properties, Inc. | Selective modulation of intracellular effects of cells using pulsed electric fields |
US11382681B2 (en) | 2009-04-09 | 2022-07-12 | Virginia Tech Intellectual Properties, Inc. | Device and methods for delivery of high frequency electrical pulses for non-thermal ablation |
JP5809621B2 (ja) | 2009-05-18 | 2015-11-11 | ヌームアールエックス・インコーポレーテッド | 患者の肺を治療するインプラント |
US8903488B2 (en) | 2009-05-28 | 2014-12-02 | Angiodynamics, Inc. | System and method for synchronizing energy delivery to the cardiac rhythm |
US9895189B2 (en) | 2009-06-19 | 2018-02-20 | Angiodynamics, Inc. | Methods of sterilization and treating infection using irreversible electroporation |
CA2774902C (en) | 2009-09-03 | 2017-01-03 | Breathe Technologies, Inc. | Methods, systems and devices for non-invasive ventilation including a non-sealing ventilation interface with an entrainment port and/or pressure feature |
US8425455B2 (en) | 2010-03-30 | 2013-04-23 | Angiodynamics, Inc. | Bronchial catheter and method of use |
US9592008B2 (en) | 2010-07-01 | 2017-03-14 | Pulmonx Corporation | Devices and systems for lung treatment |
JP5891226B2 (ja) | 2010-08-16 | 2016-03-22 | ブリーズ・テクノロジーズ・インコーポレーテッド | Loxを使用して換気補助を提供する方法、システム及び装置 |
WO2012045051A1 (en) | 2010-09-30 | 2012-04-05 | Breathe Technologies, Inc. | Methods, systems and devices for humidifying a respiratory tract |
WO2012051433A2 (en) | 2010-10-13 | 2012-04-19 | Angiodynamics, Inc. | System and method for electrically ablating tissue of a patient |
WO2012088149A2 (en) | 2010-12-20 | 2012-06-28 | Virginia Tech Intellectual Properties, Inc. | High-frequency electroporation for cancer therapy |
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US9078665B2 (en) | 2011-09-28 | 2015-07-14 | Angiodynamics, Inc. | Multiple treatment zone ablation probe |
CN112807074A (zh) | 2014-05-12 | 2021-05-18 | 弗吉尼亚暨州立大学知识产权公司 | 电穿孔系统 |
US10390838B1 (en) | 2014-08-20 | 2019-08-27 | Pneumrx, Inc. | Tuned strength chronic obstructive pulmonary disease treatment |
US10694972B2 (en) | 2014-12-15 | 2020-06-30 | Virginia Tech Intellectual Properties, Inc. | Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment |
US10905492B2 (en) | 2016-11-17 | 2021-02-02 | Angiodynamics, Inc. | Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode |
US10792449B2 (en) | 2017-10-03 | 2020-10-06 | Breathe Technologies, Inc. | Patient interface with integrated jet pump |
US11607537B2 (en) | 2017-12-05 | 2023-03-21 | Virginia Tech Intellectual Properties, Inc. | Method for treating neurological disorders, including tumors, with electroporation |
US11925405B2 (en) | 2018-03-13 | 2024-03-12 | Virginia Tech Intellectual Properties, Inc. | Treatment planning system for immunotherapy enhancement via non-thermal ablation |
US11311329B2 (en) | 2018-03-13 | 2022-04-26 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for immunotherapy based treatments using non-thermal ablation techniques |
US11950835B2 (en) | 2019-06-28 | 2024-04-09 | Virginia Tech Intellectual Properties, Inc. | Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6287290B1 (en) | 1999-07-02 | 2001-09-11 | Pulmonx | Methods, systems, and kits for lung volume reduction |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5277177A (en) * | 1984-07-23 | 1994-01-11 | Ballard Medical Products | Single use medical aspirating device and method |
US5562608A (en) * | 1989-08-28 | 1996-10-08 | Biopulmonics, Inc. | Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation |
US6729334B1 (en) * | 1994-06-17 | 2004-05-04 | Trudell Medical Limited | Nebulizing catheter system and methods of use and manufacture |
US6168568B1 (en) * | 1996-10-04 | 2001-01-02 | Karmel Medical Acoustic Technologies Ltd. | Phonopneumograph system |
US5957919A (en) * | 1997-07-02 | 1999-09-28 | Laufer; Michael D. | Bleb reducer |
US6398775B1 (en) * | 1999-10-21 | 2002-06-04 | Pulmonx | Apparatus and method for isolated lung access |
US6527761B1 (en) * | 2000-10-27 | 2003-03-04 | Pulmonx, Inc. | Methods and devices for obstructing and aspirating lung tissue segments |
US6520183B2 (en) * | 2001-06-11 | 2003-02-18 | Memorial Sloan-Kettering Cancer Center | Double endobronchial catheter for one lung isolation anesthesia and surgery |
EP1434615B1 (de) * | 2001-10-11 | 2007-07-11 | Emphasys Medical, Inc. | Bronchiale durchflussvorrichtung |
WO2003041779A1 (en) * | 2001-11-14 | 2003-05-22 | Emphasys Medical, Inc. | Active pump bronchial implant and methods of use thereof |
-
2003
- 2003-01-20 DE DE10302310A patent/DE10302310A1/de not_active Withdrawn
-
2004
- 2004-01-07 WO PCT/DE2004/000008 patent/WO2004064885A2/de active Application Filing
- 2004-01-07 EP EP04700437A patent/EP1587566A2/de not_active Withdrawn
- 2004-11-03 US US10/981,346 patent/US20050061322A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6287290B1 (en) | 1999-07-02 | 2001-09-11 | Pulmonx | Methods, systems, and kits for lung volume reduction |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7670373B1 (en) | 1997-04-30 | 2010-03-02 | Pulmonx Corporation | Occlusion device |
US8136520B2 (en) | 1997-04-30 | 2012-03-20 | Pulmonx Corporation | Occlusion device |
WO2011045735A1 (en) * | 2009-10-16 | 2011-04-21 | Koninklijke Philips Electronics N.V. | System and method for suctioning for secretion removal from the airway of a mechanically ventilated subject |
US10537700B2 (en) | 2009-10-16 | 2020-01-21 | Koninklijke Philips N.V. | System and method for suctioning for secretion removal from the airway of a mechanically ventilated subject |
US11547830B2 (en) | 2009-10-16 | 2023-01-10 | Koninklijke Philips N.V. | System and method for suctioning for secretion removal from the airway of a mechanically ventilated subject |
CN104707192A (zh) * | 2015-04-07 | 2015-06-17 | 周韶辉 | 肺大泡反向治疗装置 |
Also Published As
Publication number | Publication date |
---|---|
DE10302310A1 (de) | 2004-07-29 |
WO2004064885A3 (de) | 2004-10-21 |
US20050061322A1 (en) | 2005-03-24 |
EP1587566A2 (de) | 2005-10-26 |
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