WO2004050022A3 - Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes - Google Patents

Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes Download PDF

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Publication number
WO2004050022A3
WO2004050022A3 PCT/US2003/037825 US0337825W WO2004050022A3 WO 2004050022 A3 WO2004050022 A3 WO 2004050022A3 US 0337825 W US0337825 W US 0337825W WO 2004050022 A3 WO2004050022 A3 WO 2004050022A3
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WIPO (PCT)
Prior art keywords
diabetes
dipeptidyl peptidase
prevention
treatment
phenylalanine derivatives
Prior art date
Application number
PCT/US2003/037825
Other languages
French (fr)
Other versions
WO2004050022B1 (en
WO2004050022A8 (en
WO2004050022A2 (en
Inventor
Joseph L Duffy
Robert J Mathvink
Ann E Weber
Jinyou Xu
Original Assignee
Merck & Co Inc
Joseph L Duffy
Robert J Mathvink
Ann E Weber
Jinyou Xu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Joseph L Duffy, Robert J Mathvink, Ann E Weber, Jinyou Xu filed Critical Merck & Co Inc
Priority to US10/537,476 priority Critical patent/US7309714B2/en
Priority to JP2004557341A priority patent/JP2006510630A/en
Priority to EP03812453A priority patent/EP1578414A4/en
Priority to AU2003297564A priority patent/AU2003297564A1/en
Priority to CA002508487A priority patent/CA2508487A1/en
Publication of WO2004050022A2 publication Critical patent/WO2004050022A2/en
Publication of WO2004050022A3 publication Critical patent/WO2004050022A3/en
Publication of WO2004050022B1 publication Critical patent/WO2004050022B1/en
Publication of WO2004050022A8 publication Critical patent/WO2004050022A8/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Abstract

The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
PCT/US2003/037825 2002-12-04 2003-11-26 Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes WO2004050022A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/537,476 US7309714B2 (en) 2002-12-04 2003-11-26 Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
JP2004557341A JP2006510630A (en) 2002-12-04 2003-11-26 Phenylalanine derivatives as dipeptidyl peptidase inhibitors for treating or preventing diabetes
EP03812453A EP1578414A4 (en) 2002-12-04 2003-11-26 Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
AU2003297564A AU2003297564A1 (en) 2002-12-04 2003-11-26 Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
CA002508487A CA2508487A1 (en) 2002-12-04 2003-11-26 Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43083602P 2002-12-04 2002-12-04
US60/430,836 2002-12-04

Publications (4)

Publication Number Publication Date
WO2004050022A2 WO2004050022A2 (en) 2004-06-17
WO2004050022A3 true WO2004050022A3 (en) 2004-08-05
WO2004050022B1 WO2004050022B1 (en) 2004-09-30
WO2004050022A8 WO2004050022A8 (en) 2004-12-16

Family

ID=32469540

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Application Number Title Priority Date Filing Date
PCT/US2003/037825 WO2004050022A2 (en) 2002-12-04 2003-11-26 Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Country Status (6)

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US (1) US7309714B2 (en)
EP (1) EP1578414A4 (en)
JP (1) JP2006510630A (en)
AU (1) AU2003297564A1 (en)
CA (1) CA2508487A1 (en)
WO (1) WO2004050022A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
US8906901B2 (en) 2005-09-14 2014-12-09 Takeda Pharmaceutical Company Limited Administration of dipeptidyl peptidase inhibitors

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