WO2004047004A3 - Measurement of mitotic activity - Google Patents

Measurement of mitotic activity Download PDF

Info

Publication number
WO2004047004A3
WO2004047004A3 PCT/GB2003/004916 GB0304916W WO2004047004A3 WO 2004047004 A3 WO2004047004 A3 WO 2004047004A3 GB 0304916 W GB0304916 W GB 0304916W WO 2004047004 A3 WO2004047004 A3 WO 2004047004A3
Authority
WO
WIPO (PCT)
Prior art keywords
mitotic
grown
pixels
profile
image
Prior art date
Application number
PCT/GB2003/004916
Other languages
French (fr)
Other versions
WO2004047004A2 (en
Inventor
Christelle Marie Guittet
Paul Gerard Ducksbury
Maria Petrou
Anastasios Kesidis
Roberto Cipolla
Margaret Jai Varga
Original Assignee
Qinetiq Ltd
Christelle Marie Guittet
Paul Gerard Ducksbury
Maria Petrou
Anastasios Kesidis
Roberto Cipolla
Margaret Jai Varga
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qinetiq Ltd, Christelle Marie Guittet, Paul Gerard Ducksbury, Maria Petrou, Anastasios Kesidis, Roberto Cipolla, Margaret Jai Varga filed Critical Qinetiq Ltd
Priority to AU2003302054A priority Critical patent/AU2003302054A1/en
Priority to EP03811421A priority patent/EP1579375B1/en
Priority to US10/535,140 priority patent/US7577280B2/en
Priority to JP2004552855A priority patent/JP4174050B2/en
Priority to DE60310267T priority patent/DE60310267T2/en
Publication of WO2004047004A2 publication Critical patent/WO2004047004A2/en
Publication of WO2004047004A3 publication Critical patent/WO2004047004A3/en

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G01N15/1433—
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

Abstract

A method of measurement of mitotic activity from histopathological specimen images initially identifies image pixels with luminances corresponding to mitotic figures and selects from them a reference pixel to provide a reference colour. Pixels similar to the reference colour are located; image regions are grown on located pixels by adding pixels satisfying thresholds of differences to background and image region luminances. Grown regions are thresholded in area, compactness, width/height ratio, luminance ratio to background and difference between areas grown with perturbed thresholds. Grown regions are counted as indicating mitotic figures by thresholding region number, area and luminance. An alternative method of measuring mitotic activity measures a profile of an image region and counts the image region as corresponding to a mitotic figure if its profile is above a threshold at an intensity associated with mitotic figures. A mitotic figure is also indicated if the profile does not meet the previous criterion but has three other values satisfying respective threshold criteria.
PCT/GB2003/004916 2002-11-18 2003-11-13 Measurement of mitotic activity WO2004047004A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2003302054A AU2003302054A1 (en) 2002-11-18 2003-11-13 Measurement of mitotic activity
EP03811421A EP1579375B1 (en) 2002-11-18 2003-11-13 Measurement of mitotic activity
US10/535,140 US7577280B2 (en) 2002-11-18 2003-11-13 Measurement of mitotic activity
JP2004552855A JP4174050B2 (en) 2002-11-18 2003-11-13 Measurement of mitotic activity
DE60310267T DE60310267T2 (en) 2002-11-18 2003-11-13 MEASUREMENT OF MITOSE ACTIVITY

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0226787.0 2002-11-18
GBGB0226787.0A GB0226787D0 (en) 2002-11-18 2002-11-18 Measurement of mitotic activity

Publications (2)

Publication Number Publication Date
WO2004047004A2 WO2004047004A2 (en) 2004-06-03
WO2004047004A3 true WO2004047004A3 (en) 2005-08-11

Family

ID=9947976

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/004916 WO2004047004A2 (en) 2002-11-18 2003-11-13 Measurement of mitotic activity

Country Status (8)

Country Link
US (1) US7577280B2 (en)
EP (2) EP1579375B1 (en)
JP (2) JP4174050B2 (en)
AT (2) ATE347718T1 (en)
AU (1) AU2003302054A1 (en)
DE (2) DE60310267T2 (en)
GB (1) GB0226787D0 (en)
WO (1) WO2004047004A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7333656B2 (en) * 2003-11-26 2008-02-19 Matsushita Electric Industrial Co., Ltd. Image processing method and image processing apparatus
US7689038B2 (en) * 2005-01-10 2010-03-30 Cytyc Corporation Method for improved image segmentation
US7536064B2 (en) * 2005-05-31 2009-05-19 Microsoft Corporation Image comparison by metric embeddings
GB2430026A (en) 2005-09-09 2007-03-14 Qinetiq Ltd Automated selection of image regions
JP4921858B2 (en) * 2006-06-07 2012-04-25 オリンパス株式会社 Image processing apparatus and image processing program
TWI314424B (en) * 2006-06-23 2009-09-01 Marketech Int Corp System and method for image signal contrast adjustment and overflow compensation
JP4944641B2 (en) * 2007-03-05 2012-06-06 学校法人順天堂 Automatic detection of positive cells in stained tissue specimens
US8379961B2 (en) * 2008-07-03 2013-02-19 Nec Laboratories America, Inc. Mitotic figure detector and counter system and method for detecting and counting mitotic figures
US11226347B2 (en) 2008-10-07 2022-01-18 Biotrack Holding B.V. Method for simultaneously and automatically analyzing microorganisms in a sample using filter cytometry
JP5535727B2 (en) * 2010-04-01 2014-07-02 ソニー株式会社 Image processing apparatus, image processing method, and program
CN101866484B (en) * 2010-06-08 2012-07-04 华中科技大学 Method for computing significance degree of pixels in image
WO2012049845A1 (en) * 2010-10-12 2012-04-19 パナソニック株式会社 Color signal processing device
US8351676B2 (en) * 2010-10-12 2013-01-08 Sony Corporation Digital image analysis using multi-step analysis
JP5670695B2 (en) * 2010-10-18 2015-02-18 ソニー株式会社 Information processing apparatus and method, and program
WO2012063107A1 (en) * 2010-11-08 2012-05-18 Manipal Institute Of Technology Automated tuberculosis screening
KR20120102447A (en) * 2011-03-08 2012-09-18 삼성전자주식회사 Method and apparatus for diagnostic
US10186236B2 (en) * 2013-05-23 2019-01-22 Intel Corporation Universal codec
US9495753B2 (en) * 2013-05-30 2016-11-15 Canon Kabushiki Kaisha Spectral image data processing apparatus and two-dimensional spectral apparatus
MA41117A (en) 2014-12-05 2017-10-10 Myfiziq Ltd IMAGING OF A BODY
DE102016105102A1 (en) * 2016-03-18 2017-09-21 Leibniz-Institut für Photonische Technologien e. V. Method for examining distributed objects
US10152630B2 (en) * 2016-08-09 2018-12-11 Qualcomm Incorporated Methods and systems of performing blob filtering in video analytics
JP7181886B2 (en) * 2017-03-14 2022-12-01 サンシャイン・レイク・ファーマ・カンパニー・リミテッド A dual targeting fusion protein comprising the Fc portion of an immunoglobulin
US20240019416A1 (en) 2020-11-10 2024-01-18 Perkinelmer Japan G.K. Method of classifying sample of material

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5526258A (en) * 1990-10-10 1996-06-11 Cell Analysis System, Inc. Method and apparatus for automated analysis of biological specimens

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101522A (en) 1992-04-08 1997-09-30 Combact Imaging Systems Ltd Detection of microorganisms in a sample and determination of the sensitivity of microorganisms to antibiotics
JPH0993445A (en) * 1995-09-20 1997-04-04 Fuji Xerox Co Ltd Image processor
US6215892B1 (en) * 1995-11-30 2001-04-10 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
AU2993599A (en) * 1998-03-09 1999-09-27 Regents Of The University Of California, The Regulation of the cell cycle by sterols
US6876760B1 (en) * 2000-12-04 2005-04-05 Cytokinetics, Inc. Classifying cells based on information contained in cell images
AU5874000A (en) * 1999-07-29 2001-02-19 Wistar Institute Of Anatomy And Biology, The Compositions and methods to enhance sensitivity of cancer cells to mitotic stress
KR20020079742A (en) * 1999-11-24 2002-10-19 컨퍼마, 인코포레이티드 Convolution filtering of similarity data for visual display of enhanced image
JP3393106B2 (en) * 2000-03-01 2003-04-07 株式会社テプコシステムズ Thick line extraction method
US7016787B2 (en) * 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5526258A (en) * 1990-10-10 1996-06-11 Cell Analysis System, Inc. Method and apparatus for automated analysis of biological specimens

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MADACHY R J ET AL: "Image analysis for automatic classification of MITOTIC cervical cells", IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY, 10TH ANNUAL INT. CONFERENCE, 4 November 1988 (1988-11-04), pages 372 - 374, XP010074652 *
SUNDBLAD LARS-GORAN ET AL: "The use of image analysis and automation for measuring mitotic index in apical conifer mersitems", JOURNAL OF EXPERIMENTAL BOTANY, OXFORD UNIVERSITY PRESS, GB, vol. 49, no. 327, October 1998 (1998-10-01), pages 1749 - 1756, XP002233559, ISSN: 0022-0957 *

Also Published As

Publication number Publication date
DE60329792D1 (en) 2009-12-03
JP2008077677A (en) 2008-04-03
EP1760634A3 (en) 2007-08-01
ATE347718T1 (en) 2006-12-15
US20060098858A1 (en) 2006-05-11
JP4174050B2 (en) 2008-10-29
US7577280B2 (en) 2009-08-18
ATE446557T1 (en) 2009-11-15
JP2006506635A (en) 2006-02-23
EP1579375B1 (en) 2006-12-06
EP1760634A2 (en) 2007-03-07
GB0226787D0 (en) 2002-12-24
WO2004047004A2 (en) 2004-06-03
DE60310267T2 (en) 2007-06-14
EP1579375A2 (en) 2005-09-28
EP1760634B1 (en) 2009-10-21
DE60310267D1 (en) 2007-01-18
AU2003302054A1 (en) 2004-06-15
JP4864857B2 (en) 2012-02-01

Similar Documents

Publication Publication Date Title
WO2004047004A3 (en) Measurement of mitotic activity
CN102231264B (en) Dynamic contrast enhancement device and method
US8724897B2 (en) Picture quality controlling device, picture quality controlling method, and picture quality controlling program
CN102957934B (en) Display processing method, device and display device
US20110090369A1 (en) Image processing device, storage medium, and image processing method
EP1359543A3 (en) Method for detecting subject matter regions in images
CN101620679B (en) Method for eliminating red eye in image
CN110956925A (en) Display device, electronic equipment and method for aging compensation of display panel
CN1941923B (en) Automatic white balance method for color digital image
WO2004017052A3 (en) Histological assessment
TW200642486A (en) Noise reduction method
US10417976B2 (en) Pixel rendering method and pixel rendering device
US11030971B2 (en) Display device and image processing method for color correction based on image type
CN107301384A (en) A kind of driver takes phone behavioral value method and system
CN102088539B (en) Method and system for evaluating pre-shot picture quality
DE102010040191A1 (en) Apparatus and method for image processing
CN103848329B (en) The monitor unit of passenger conveying appliance traffic areas
CN103500457B (en) A kind of method of video image color cast detection
CN100363942C (en) Binary method and system for image
US9219896B1 (en) Method of color processing using a color and white filter array
CN101150731B (en) Color filtering array for digital imaging and its imaging method
CN112740667A (en) Display compensation method, device and terminal
CN101739678B (en) Method for detecting shadow of object
CN106157301A (en) A kind of threshold value for Image Edge-Detection is from determining method and device
ATE309672T1 (en) IMAGE PROCESSING METHOD OF RASTER IMAGES

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2055/DELNP/2005

Country of ref document: IN

ENP Entry into the national phase

Ref document number: 2006098858

Country of ref document: US

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2004552855

Country of ref document: JP

Ref document number: 10535140

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2003811421

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003811421

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 10535140

Country of ref document: US

WWG Wipo information: grant in national office

Ref document number: 2003811421

Country of ref document: EP