WO2004044174A3 - Topoisomerase-targeting agents - Google Patents
Topoisomerase-targeting agents Download PDFInfo
- Publication number
- WO2004044174A3 WO2004044174A3 PCT/US2003/036226 US0336226W WO2004044174A3 WO 2004044174 A3 WO2004044174 A3 WO 2004044174A3 US 0336226 W US0336226 W US 0336226W WO 2004044174 A3 WO2004044174 A3 WO 2004044174A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- topoisomerase
- compounds
- targeting agents
- bond
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03783402.5A EP1562593B1 (en) | 2002-11-12 | 2003-11-12 | Topoisomerase-targeting agents |
CA2510337A CA2510337C (en) | 2002-11-12 | 2003-11-12 | Topoisomerase-targeting agents |
JP2004552172A JP4774212B2 (en) | 2002-11-12 | 2003-11-12 | Topoisomerase-targeting agent |
AU2003290818A AU2003290818A1 (en) | 2002-11-12 | 2003-11-12 | Topoisomerase-targeting agents |
US11/121,292 US7208492B2 (en) | 2002-11-12 | 2005-05-03 | Topoisomerase-targeting agents |
US11/714,680 US7517867B2 (en) | 2002-11-12 | 2007-03-06 | Topoisomerase-targeting agents |
US12/422,394 US7858627B2 (en) | 2002-11-12 | 2009-04-13 | Topoisomerase-targeting agents |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42550302P | 2002-11-12 | 2002-11-12 | |
US42553502P | 2002-11-12 | 2002-11-12 | |
US60/425,535 | 2002-11-12 | ||
US60/425,503 | 2002-11-12 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/121,292 Continuation US7208492B2 (en) | 2002-11-12 | 2005-05-03 | Topoisomerase-targeting agents |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004044174A2 WO2004044174A2 (en) | 2004-05-27 |
WO2004044174A3 true WO2004044174A3 (en) | 2004-08-12 |
Family
ID=32314592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/036226 WO2004044174A2 (en) | 2002-11-12 | 2003-11-12 | Topoisomerase-targeting agents |
Country Status (6)
Country | Link |
---|---|
US (3) | US7208492B2 (en) |
EP (1) | EP1562593B1 (en) |
JP (1) | JP4774212B2 (en) |
AU (1) | AU2003290818A1 (en) |
CA (1) | CA2510337C (en) |
WO (1) | WO2004044174A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1465625T1 (en) * | 2001-11-14 | 2010-06-30 | Univ Rutgers | Solubilized topoisomerase poisons |
JP4774212B2 (en) * | 2002-11-12 | 2011-09-14 | ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー | Topoisomerase-targeting agent |
JP5773888B2 (en) * | 2009-03-06 | 2015-09-02 | ラットガーズ,ザ・ステート・ユニバーシティ・オブ・ニュージャージー | Methylenedioxybenzo [I] phenanthridine derivatives used for cancer treatment |
WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
US8258149B2 (en) * | 2009-05-08 | 2012-09-04 | Hoffmann-La Roche Inc. | Isoquinoline derivatives |
US9073920B2 (en) | 2010-08-17 | 2015-07-07 | Purdue Research Foundation | Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor |
KR101909680B1 (en) * | 2015-04-10 | 2018-10-18 | 삼성에스디아이 주식회사 | Compound, organic optoelectric device and display device |
CA3019945A1 (en) | 2016-04-04 | 2017-10-12 | Rutgers, The State University Of New Jersey | Topoisomerase poisons |
CN108690034A (en) * | 2018-01-12 | 2018-10-23 | 兰州大学 | A kind of fluorination benzo naphthyridones derivative, Preparation method and use |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6140328A (en) * | 1997-12-12 | 2000-10-31 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2981731A (en) | 1961-04-25 | Acridine derivatives | ||
US2985661A (en) * | 1956-02-06 | 1961-05-23 | American Cyanamid Co | Preparation of 2(omicron-aminophenyl)-benzimidazole |
US2915523A (en) * | 1956-12-03 | 1959-12-01 | Parke Davis & Co | Benzacridine compounds |
US3272707A (en) | 1964-07-17 | 1966-09-13 | Smith Kline French Lab | Pharmaceutical compositions and methods for their use |
CH420045A (en) * | 1964-09-01 | 1967-03-15 | Ciba Geigy | Use of new polyazoles as optical brightening agents for textile organic materials |
US3267107A (en) * | 1964-09-17 | 1966-08-16 | American Home Prod | 3-(4'-5'-methylenedioxy-phenyl)-7, 8-dimethoxy-1, 2, 3, 4,-tetrahydroisoquinolines |
US3849561A (en) * | 1964-10-20 | 1974-11-19 | S Naruto | Anti-peptic ulcer substance from corydalis tubers |
DE1670684A1 (en) * | 1966-04-01 | 1970-12-03 | Hoechst Ag | Process for the preparation of basic substituted bis-benzimidazole derivatives |
US3542782A (en) * | 1967-03-15 | 1970-11-24 | Sandoz Ag | 5,6-dihydro-8h-isoquino(1,2-b)quinazolines |
JPS4942700A (en) * | 1972-08-25 | 1974-04-22 | ||
US3912740A (en) * | 1974-02-28 | 1975-10-14 | Us Health | Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds |
PT73763B (en) | 1981-10-01 | 1983-10-26 | Quatrum Empresa Nacional De Qu | PROCESS FOR THE PREPARATION OF NOVEL EPOXIDES OF BENZOFENANTRIDINE ALKALOIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US4749708A (en) * | 1982-05-14 | 1988-06-07 | Maroko Peter R | Composition for improving circulatory performance |
US4980344A (en) * | 1982-05-14 | 1990-12-25 | Maroko Peter R | Compositions for improving circulatory performance |
US4761417A (en) * | 1982-05-14 | 1988-08-02 | Maroko Peter R | Compounds, compositions and method of treatments for improving circulatory performance |
IE55519B1 (en) | 1982-05-14 | 1990-10-10 | Maroko Peter R | Use of a protoberberine alkaloid and composition containing same |
US5153178A (en) * | 1982-05-14 | 1992-10-06 | Maroko Peter R | Compositions and method of treatment for improving circulatory performance |
JPS61130289A (en) * | 1984-11-29 | 1986-06-18 | Ss Pharmaceut Co Ltd | Salt of 13-propylberberine |
FR2595356B1 (en) * | 1986-03-05 | 1991-05-24 | Pasteur Strasbourg Universite | DERIVATIVES OF NITRO OR AMINOBENZYLTETRAHYDROISOQUINOLEINS, PROCESSES FOR OBTAINING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, PHARMACOLOGICAL PROPERTIES AND APPLICATIONS |
US5244903A (en) * | 1987-03-31 | 1993-09-14 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
SU1530628A1 (en) | 1987-11-20 | 1989-12-23 | Ленинградский Технологический Институт Им.Ленсовета | Thrihydrochloride of 2-/2-phenyl-5(6)-benzimidazolyl/-n-(3-dimethyl-aminopropyl)-5(6)-benzimidazolcarboxamide as fluorescent dye for investigating dna |
US5106863A (en) * | 1990-03-26 | 1992-04-21 | Ortho Pharmaceutical Corporation | Substituted imidazole and pyridine derivatives |
US5135934A (en) * | 1990-07-06 | 1992-08-04 | Du Pont Merck Pharmaceutical Company | 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents |
US5126351A (en) * | 1991-01-24 | 1992-06-30 | Glaxo Inc. | Antitumor compounds |
US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
US5428040A (en) * | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
US5646283A (en) * | 1993-09-28 | 1997-07-08 | Kyowa Hakko Kogyo Co., Ltd. | Tetracyclic compound |
US5981731A (en) * | 1994-05-31 | 1999-11-09 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of B-raf gene expression |
US5767142A (en) * | 1996-03-20 | 1998-06-16 | Rutgers, The State University Of New Jersey | Trisbenzimidazoles useful as topoisomerase I inhibitors |
US5807874A (en) * | 1995-05-17 | 1998-09-15 | Rutgers, The State University Of New Jersey | Trisbenzimidazoles useful as topoisomerase I inhibitors |
BR9608476A (en) | 1995-05-17 | 1999-08-17 | Univ Rutgers | Compound process to inhibit the growth of a mammalian tumor cell and therapeutic composition |
AU710070C (en) | 1996-02-12 | 2001-08-30 | Rutgers, The State University Of New Jersey | Coralyne analogs as topoisomerase inhibitors |
US5770617A (en) | 1996-03-20 | 1998-06-23 | Rutgers, The State University Of New Jersey | Terbenzimidazoles useful as antifungal agents |
EP0950054A1 (en) | 1996-09-23 | 1999-10-20 | Rutgers, The State University Of New Jersey | Substituted heterocycles as anti-tumor agents |
EP1123099B1 (en) | 1998-10-14 | 2009-03-04 | Purdue Research Foundation | Novel indenoisoquinolines as antineoplastic agents |
US6272707B1 (en) * | 1998-11-12 | 2001-08-14 | Colbond Inc. | Support pad |
US6740650B2 (en) * | 1999-10-29 | 2004-05-25 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
EP1228045A2 (en) | 1999-10-29 | 2002-08-07 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
RU2203702C1 (en) * | 2001-10-29 | 2003-05-10 | Ширяев Вячеслав Михайлович | Method and device for applying physiotherapeutic treatment |
SI1465625T1 (en) | 2001-11-14 | 2010-06-30 | Univ Rutgers | Solubilized topoisomerase poisons |
CA2467279A1 (en) | 2001-11-14 | 2003-06-26 | Edmond J. Lavoie | Solubilized topoisomerase poison agents |
ATE405568T1 (en) * | 2001-11-14 | 2008-09-15 | Univ Rutgers | CYTOTOXIC AGENTS |
ATE390923T1 (en) * | 2001-11-14 | 2008-04-15 | Univ Rutgers | TOPOISOMERASE TOXICANTS |
US6989387B2 (en) | 2002-08-09 | 2006-01-24 | Rutgers, The State University Of New Jersey | Nitro and amino substituted topoisomerase agents |
JP4774212B2 (en) * | 2002-11-12 | 2011-09-14 | ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー | Topoisomerase-targeting agent |
-
2003
- 2003-11-12 JP JP2004552172A patent/JP4774212B2/en not_active Expired - Fee Related
- 2003-11-12 WO PCT/US2003/036226 patent/WO2004044174A2/en active Application Filing
- 2003-11-12 AU AU2003290818A patent/AU2003290818A1/en not_active Abandoned
- 2003-11-12 EP EP03783402.5A patent/EP1562593B1/en not_active Expired - Lifetime
- 2003-11-12 CA CA2510337A patent/CA2510337C/en not_active Expired - Fee Related
-
2005
- 2005-05-03 US US11/121,292 patent/US7208492B2/en not_active Expired - Fee Related
-
2007
- 2007-03-06 US US11/714,680 patent/US7517867B2/en not_active Expired - Fee Related
-
2009
- 2009-04-13 US US12/422,394 patent/US7858627B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6140328A (en) * | 1997-12-12 | 2000-10-31 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
Also Published As
Publication number | Publication date |
---|---|
US20070225289A1 (en) | 2007-09-27 |
CA2510337C (en) | 2013-01-08 |
EP1562593A2 (en) | 2005-08-17 |
US20060004008A1 (en) | 2006-01-05 |
AU2003290818A1 (en) | 2004-06-03 |
US7517867B2 (en) | 2009-04-14 |
US7858627B2 (en) | 2010-12-28 |
US20090258890A1 (en) | 2009-10-15 |
AU2003290818A8 (en) | 2004-06-03 |
JP4774212B2 (en) | 2011-09-14 |
CA2510337A1 (en) | 2004-05-27 |
JP2006512319A (en) | 2006-04-13 |
EP1562593A4 (en) | 2008-09-24 |
WO2004044174A2 (en) | 2004-05-27 |
EP1562593B1 (en) | 2014-07-16 |
US7208492B2 (en) | 2007-04-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2005080352A3 (en) | Quinazoline derivatives and therapeutic use thereof | |
IL185611A0 (en) | Novel imidazo[1,5-a]pyridine derivatives, method for preparing same and pharmaceutical compositions containing same | |
WO2002057261A3 (en) | Diaminothiazoles and their use as inhibitors of cyclin-dependent kinase | |
WO2006011050A3 (en) | Pyridine derivatives | |
WO2005046603A3 (en) | Pyridine compounds | |
WO2005021544A3 (en) | N3-substituted imidazopyridine-derivatives as c-kit inhibitors | |
WO2003041660A3 (en) | Solubilized topoisomerase poisons | |
UA84712C2 (en) | N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors | |
WO2006016067A3 (en) | Pyrido-pyrido pyrimidine derivatives, preparation thereof, therapeutic use thereof for treating cancer | |
WO2007063391A3 (en) | Spirocyclic quinazoline derivatives as pde7 inhibitors | |
WO2003018553A8 (en) | Oral antidiabetic agents | |
AU2003250471A1 (en) | Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors | |
WO2003041653A3 (en) | Cytotoxic agents | |
WO2001032631A3 (en) | Heterocyclic cytotoxic agents | |
WO2003047505A3 (en) | Topoisomerase poison agents | |
WO2003051289A3 (en) | Solubilized topoisomerase poison agents | |
SG145570A1 (en) | 4-æ7-halo-2-quino(xa-)linyloxy!phenoxy-propionic acid derivatives as antineoplastic agents | |
WO2004014906A3 (en) | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents | |
WO2004044174A3 (en) | Topoisomerase-targeting agents | |
WO2003054001A3 (en) | Method for preparing echinocandin derivatives and their compositions | |
TW200635592A (en) | Pyridyl-substituted spiro-hydantoin compounds and use thereof | |
WO2003051838A3 (en) | Protein kinase inhibitors | |
MY139228A (en) | Imidazolinylmethyl aralkylsulfonamides | |
WO2003080617A8 (en) | Pyrazolopyrimidine derivatives | |
TW200510370A (en) | Urea derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 11121292 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2510337 Country of ref document: CA Ref document number: 2004552172 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003783402 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2003783402 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 11121292 Country of ref document: US |