WO2004039434B1 - Method and apparatus for sequential delivery of multiple injectable substances stored in a prefilled syringe - Google Patents

Method and apparatus for sequential delivery of multiple injectable substances stored in a prefilled syringe

Info

Publication number
WO2004039434B1
WO2004039434B1 PCT/US2003/034842 US0334842W WO2004039434B1 WO 2004039434 B1 WO2004039434 B1 WO 2004039434B1 US 0334842 W US0334842 W US 0334842W WO 2004039434 B1 WO2004039434 B1 WO 2004039434B1
Authority
WO
WIPO (PCT)
Prior art keywords
syringe
new
fluid
disc
plunger
Prior art date
Application number
PCT/US2003/034842
Other languages
French (fr)
Other versions
WO2004039434A3 (en
WO2004039434A2 (en
Inventor
Kyongtae T Bae
Original Assignee
Kyongtae T Bae
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyongtae T Bae filed Critical Kyongtae T Bae
Priority to AU2003290566A priority Critical patent/AU2003290566A1/en
Publication of WO2004039434A2 publication Critical patent/WO2004039434A2/en
Publication of WO2004039434A3 publication Critical patent/WO2004039434A3/en
Publication of WO2004039434B1 publication Critical patent/WO2004039434B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14546—Front-loading type injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M2005/1787—Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M2005/3132—Syringe barrels having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16827—Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase

Abstract

A syringe (12) capable of injecting two substances (142, 152) sequentially is provided. The syringe (120) has first (140) and second (150) chambers capable of separately storing a contents of the syringe (120) before and during injection. The syringe (120) has an outlet (122) through which the contents stored in the first (140) and second chamber (150) flow during injection. After completing injection of the contents stored in the first chamber (140), the second chamber (150) is aligned with the outlet (122) to allow injection of the contents stored in the second chamber (150).

Claims

AMENDED CLAIMS
[received by the International Bureau on 12 July 2004 (12.07.04); original claim 1 replaced by new claim 1; remaining claims unchanged (1 page)]
The claims of the application are amended as follows: Claims 1- 21 (canceled)
22. (new) A pre-filled, sequential injection syringe comprising a generally cylindrical barrel portion, a plunger and an intermediate disc being disposed in a spaced apart relationship within said barrel portion, each of said plunger and disc being sized to be in sealing engagement with said barrel portion, an outlet portion disposed generally at a distal end of said syringe, said outlet portion having an outlet opening through which fluids contained within said syringe are expelled, a first fluid contained within said syringe and between the outlet portion and the disc, and a second fluid contained within said syringe and between the disc and the plunger, said outlet portion having a discontinuity so that as said intermediate disc is advanced thereinto it loses sealing engagement with said syringe to thereby allow the second fluid to flow through the outlet opening after the first fluid has been substantially expelled therethrough.
23. (new) The pre-filled, sequential injection syringe of claim 22 further comprising at least one baffle located within said outlet portion, said at least one baffle separating the disc from the opening so that as said disc loses sealing engagement with the syringe it does not block the outlet opening.
24. (new) The pre-filled, sequential injection syringe of claim 23 wherein said discontinuity comprises a generally cylindrical portion having a larger diameter than said barrel portion.
25. (new) The pre-filled, sequential injection syringe of claim 24 wherein said discontinuity has a central axis offset from a central axis of said barrel portion.
26. (new) The pre-filled, sequential injection syringe of claim 24 wherein said discontinuity has a central axis generally co-axial with a central axis of said barrel portion.
27. (new) The pre-filled, sequential injection syringe of claim 23 wherein said at least one baffle is formed at a bottom of the syringe.
28. (new) The pre-filled, sequential injection syringe of claim 23 wherein said at least one baffle is formed in a sidewall of said outlet portion.
29. (new) The pre-filled, sequential injection syringe of claim 23 further comprising at least one channel formed between the at least one baffle and the syringe through which the second fluid flows to reach the outlet opening.
30. (new) The pre-filled, sequential injection syringe of claim 29 wherein said at least one baffle further comprise a seat for receiving the disc as it is advanced into the outlet portion.
31. (new) The pre-filled, sequential injection syringe of claim 22 wherein said discontinuity comprises a generally cylindrical portion having a larger diameter than said barrel portion.
32. (new) A sequential injection syringe comprising a generally cylindrical barrel portion, a plunger and an intermediate disc being disposed in a spaced apart relationship within said barrel portion, each of said plunger and disc being sized to be in sealing engagement with said barrel portion, an outlet portion disposed generally at a distal end of said syringe, said outlet portion having an outlet opening through which fluids contained within said syringe are expelled, a first chamber for containing a first fluid within said syringe formed between the outlet portion and the disc, and a second chamber for containing a second fluid within said syringe formed between the disc and the plunger, said outlet portion having a discontinuity so that as said intermediate disc is advanced thereinto it loses sealing engagement with said syringe to thereby allow the second fluid to flow through the outlet opening after the first fluid has been substantially expelled therethrough.
33. (new) The sequential injection syringe of claim 32 further comprising at least one baffle located within said outlet portion, said at least one baffle separating the disc from the opening so that as said disc loses sealing engagement with the syringe it does not block the outlet opening.
34. (new) The sequential injection syringe of claim 33 wherein said discontinuity comprises a generally cylindrical portion having a larger diameter than said barrel portion.
35. (new) The sequential injection syringe of claim 34 wherein said discontinuity has a central axis offset from a central axis of said barrel portion.
36. (new) The sequential injection syringe of claim 34 wherein said discontinuity has a central axis generally co-axial with a central axis of said barrel portion.
37. (new) The sequential injection syringe of claim 33 wherein said at least one baffle is formed at a bottom of the syringe.
38. (new) The sequential injection syringe of claim 33 wherein said at least one baffle is formed in a sidewall of said outlet portion.
39. (new) The sequential injection syringe of claim 33 further comprising at least one channel formed between the at least one baffle and the syringe through which the second fluid flows to reach the outlet opening.
40. (new) The sequential injection syringe of claim 39 wherein said at least one baffle further comprise a seat for receiving the disc as it is advanced into the outlet portion.
41. (new) The sequential injection syringe of claim 40 wherein said discontinuity comprises a generally cylindrical portion having a larger diameter than said barrel portion.
42. (new) A pre-filled, sequential injection syringe comprising a generally cylindrical barrel portion for containing a first fluid, a plunger, a bag for containing a second fluid, said bag being positioned adjacent the plunger, the barrel portion having an outlet opening, and at least one barb located near the outlet opening so that as the plunger advances the bag to substantially expel the first fluid the at least one barb breaches the bag and the second fluid is then expelled out the opening.
43. (new) The pre-filled sequential injection syringe of claim 42 wherein the bag has substantially the same diameter as the barrel to thereby fill its cross-section as the plunger is advanced.
44. (new) A method for sequentially expelling at least two fluids from a single syringe without mixing of the fluids comprising the steps of: providing the syringe with a first fluid between a syringe opening and an intermediate disc and a second fluid between the intermediate disc and a plunger, each of the disc and plunger being in sealing engagement with the syringe, advancing the plunger and disc within the syringe to expel the first fluid, dis-engaging the disc from its sealing engagement with the syringe to thereby put the second fluid in communication with the syringe opening, and continuing to advance the plunger to thereby expel the second fluid from the syringe.
45. (new) A method for sequentially expelling at least two fluids from a single syringe without mixing of the fluids comprising the steps of:
21 providing the syringe with a first fluid between a syringe opening and a bag and a second fluid within the bag, the bag being adjacent a plunger advancing the plunger within the syringe to expel the first fluid through the syringe opening, continuing to advance the plunger to bring the bag into contact with at least one barb to thereby breach the bag and thereby put the second fluid in communication with the syringe opening, and continuing to advance the plunger to thereby expel the second fluid from the syringe.
46. (new) A syringe comprising a barrel and an outlet portion, with a plunger and an intermediate disc being disposed for sealing engagement within the barrel, said outlet portion having means to disrupt the sealing engagement of the disc as the disc is advanced into the outlet portion.
22
PCT/US2003/034842 2002-10-31 2003-10-30 Method and apparatus for sequential delivery of multiple injectable substances stored in a prefilled syringe WO2004039434A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003290566A AU2003290566A1 (en) 2002-10-31 2003-10-30 Method and apparatus for sequential delivery of multiple injectable substances stored in a prefilled syringe

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/285,001 2002-10-31
US10/285,001 US6866653B2 (en) 2002-10-31 2002-10-31 Method and apparatus for sequential delivery of multiple injectable substances stored in a prefilled syringe

Publications (3)

Publication Number Publication Date
WO2004039434A2 WO2004039434A2 (en) 2004-05-13
WO2004039434A3 WO2004039434A3 (en) 2004-09-23
WO2004039434B1 true WO2004039434B1 (en) 2004-11-11

Family

ID=32228811

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/034842 WO2004039434A2 (en) 2002-10-31 2003-10-30 Method and apparatus for sequential delivery of multiple injectable substances stored in a prefilled syringe

Country Status (3)

Country Link
US (1) US6866653B2 (en)
AU (1) AU2003290566A1 (en)
WO (1) WO2004039434A2 (en)

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Also Published As

Publication number Publication date
AU2003290566A8 (en) 2004-05-25
WO2004039434A3 (en) 2004-09-23
AU2003290566A1 (en) 2004-05-25
WO2004039434A2 (en) 2004-05-13
US6866653B2 (en) 2005-03-15
US20040097875A1 (en) 2004-05-20

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