WO2004004644A3 - Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms - Google Patents

Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms Download PDF

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Publication number
WO2004004644A3
WO2004004644A3 PCT/US2003/020972 US0320972W WO2004004644A3 WO 2004004644 A3 WO2004004644 A3 WO 2004004644A3 US 0320972 W US0320972 W US 0320972W WO 2004004644 A3 WO2004004644 A3 WO 2004004644A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitor
tyrosine kinase
combination
neoplasms
treatment
Prior art date
Application number
PCT/US2003/020972
Other languages
French (fr)
Other versions
WO2004004644A2 (en
Inventor
Benjamin G Neel
Golam Mohi
Original Assignee
Beth Israel Hospital
Benjamin G Neel
Golam Mohi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Hospital, Benjamin G Neel, Golam Mohi filed Critical Beth Israel Hospital
Priority to AU2003248813A priority Critical patent/AU2003248813A1/en
Priority to US10/520,225 priority patent/US20060094674A1/en
Publication of WO2004004644A2 publication Critical patent/WO2004004644A2/en
Publication of WO2004004644A3 publication Critical patent/WO2004004644A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention features methods and compositions including an mTOR inhibitor and a tyrosine kinase inhibitor for reducing the proliferation of and enhancing the apoptosis of neoplastic cells. The addition of an MEK inhibitor to this combination further enhances the effectiveness of this therapeutic method.
PCT/US2003/020972 2002-07-05 2003-07-03 Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms WO2004004644A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003248813A AU2003248813A1 (en) 2002-07-05 2003-07-03 Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms
US10/520,225 US20060094674A1 (en) 2002-07-05 2003-07-03 Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39402902P 2002-07-05 2002-07-05
US60/394,029 2002-07-05
US41240202P 2002-09-20 2002-09-20
US60/412,402 2002-09-20

Publications (2)

Publication Number Publication Date
WO2004004644A2 WO2004004644A2 (en) 2004-01-15
WO2004004644A3 true WO2004004644A3 (en) 2004-05-06

Family

ID=30118396

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/020972 WO2004004644A2 (en) 2002-07-05 2003-07-03 Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms

Country Status (3)

Country Link
US (1) US20060094674A1 (en)
AU (1) AU2003248813A1 (en)
WO (1) WO2004004644A2 (en)

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* Cited by examiner, † Cited by third party
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US20020051730A1 (en) * 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9295673B2 (en) 2011-02-23 2016-03-29 Intellikine Llc Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof

Also Published As

Publication number Publication date
AU2003248813A1 (en) 2004-01-23
WO2004004644A2 (en) 2004-01-15
US20060094674A1 (en) 2006-05-04
AU2003248813A8 (en) 2004-01-23

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