WO2004002986A3 - Novel benzimidazole derivatives - Google Patents

Novel benzimidazole derivatives Download PDF

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Publication number
WO2004002986A3
WO2004002986A3 PCT/JP2003/008161 JP0308161W WO2004002986A3 WO 2004002986 A3 WO2004002986 A3 WO 2004002986A3 JP 0308161 W JP0308161 W JP 0308161W WO 2004002986 A3 WO2004002986 A3 WO 2004002986A3
Authority
WO
WIPO (PCT)
Prior art keywords
nitrogen
benzimidazole derivatives
novel benzimidazole
methine
compound
Prior art date
Application number
PCT/JP2003/008161
Other languages
French (fr)
Other versions
WO2004002986A2 (en
Inventor
Norikazu Otake
Minoru Moriya
Yoshio Ogino
Kenji Matsuda
Yoshikazu Nagae
Akio Kanatani
Takehiro Fukami
Original Assignee
Banyu Pharma Co Ltd
Norikazu Otake
Minoru Moriya
Yoshio Ogino
Kenji Matsuda
Yoshikazu Nagae
Akio Kanatani
Takehiro Fukami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE60336811T priority Critical patent/DE60336811D1/en
Priority to EA200500103A priority patent/EA200500103A1/en
Priority to MXPA04012731A priority patent/MXPA04012731A/en
Priority to EP03761822A priority patent/EP1517908B1/en
Application filed by Banyu Pharma Co Ltd, Norikazu Otake, Minoru Moriya, Yoshio Ogino, Kenji Matsuda, Yoshikazu Nagae, Akio Kanatani, Takehiro Fukami filed Critical Banyu Pharma Co Ltd
Priority to CA2490722A priority patent/CA2490722C/en
Priority to BR0312066-0A priority patent/BR0312066A/en
Priority to AU2003248248A priority patent/AU2003248248B2/en
Priority to YUP-1137/04A priority patent/RS113704A/en
Priority to AT03761822T priority patent/ATE506360T1/en
Publication of WO2004002986A2 publication Critical patent/WO2004002986A2/en
Publication of WO2004002986A3 publication Critical patent/WO2004002986A3/en
Priority to IL16581004A priority patent/IL165810A0/en
Priority to HR20041218A priority patent/HRP20041218A2/en
Priority to NO20050184A priority patent/NO20050184L/en
Priority to IS7667A priority patent/IS7667A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A compound of the formula (I): (wherein A, B, C and D are independently nitrogen or optionally! I substituted methine; E is nitrogen, methine or hydroxyl, substituted methine; n is 0 or 1; T, U, V and W are independently!, nitrogen or optionally substituted methine; X is -N(SOZR4)-, N (COR5) - or -CO- ; Y is -C (R6) (R7) - , -O- or -N (RS) - provided that the compound (I) when E is nitrogen, n is 0, X is -CO-, and Y is -0 is excluded). is useful as an agent for the treatment of various diseases related to NPY neuropeptide Y.
PCT/JP2003/008161 2002-06-28 2003-06-26 Novel benzimidazole derivatives WO2004002986A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
BR0312066-0A BR0312066A (en) 2002-06-28 2003-06-26 New Benzimidazole Derivatives
MXPA04012731A MXPA04012731A (en) 2002-06-28 2003-06-26 Novel benzimidazole derivatives.
EP03761822A EP1517908B1 (en) 2002-06-28 2003-06-26 Novel benzimidazole derivatives
YUP-1137/04A RS113704A (en) 2002-06-28 2003-06-26 Novel benzimidazole derivatives
CA2490722A CA2490722C (en) 2002-06-28 2003-06-26 Novel benzimidazole derivatives
EA200500103A EA200500103A1 (en) 2002-06-28 2003-06-26 NEW BENZIMIDAZOL DERIVATIVES
AU2003248248A AU2003248248B2 (en) 2002-06-28 2003-06-26 Novel benzimidazole derivatives
DE60336811T DE60336811D1 (en) 2002-06-28 2003-06-26 NEW BENZIMIDAZOLE DERIVATIVES
AT03761822T ATE506360T1 (en) 2002-06-28 2003-06-26 NEW BENZIMIDAZOLE DERIVATIVES
IL16581004A IL165810A0 (en) 2002-06-28 2004-12-16 Novel benzimidazole derivatives
HR20041218A HRP20041218A2 (en) 2002-06-28 2004-12-28 Novel benzimidazole derivatives
NO20050184A NO20050184L (en) 2002-06-28 2005-01-12 New benzimidazole derivatives
IS7667A IS7667A (en) 2002-06-28 2005-01-27 New benzimidazole derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002-190978 2002-06-28
JP2002190978 2002-06-28

Publications (2)

Publication Number Publication Date
WO2004002986A2 WO2004002986A2 (en) 2004-01-08
WO2004002986A3 true WO2004002986A3 (en) 2004-04-22

Family

ID=29996905

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/008161 WO2004002986A2 (en) 2002-06-28 2003-06-26 Novel benzimidazole derivatives

Country Status (23)

Country Link
US (3) US7105526B2 (en)
EP (1) EP1517908B1 (en)
CN (2) CN100560585C (en)
AR (1) AR040271A1 (en)
AT (1) ATE506360T1 (en)
AU (1) AU2003248248B2 (en)
BR (1) BR0312066A (en)
CA (1) CA2490722C (en)
DE (1) DE60336811D1 (en)
DO (1) DOP2003000662A (en)
EA (1) EA200500103A1 (en)
EC (1) ECSP045505A (en)
HR (1) HRP20041218A2 (en)
IL (1) IL165810A0 (en)
IS (1) IS7667A (en)
MX (1) MXPA04012731A (en)
NO (1) NO20050184L (en)
PE (1) PE20040583A1 (en)
PL (1) PL374693A1 (en)
RS (1) RS113704A (en)
TW (1) TW200406411A (en)
WO (1) WO2004002986A2 (en)
ZA (1) ZA200409339B (en)

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US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
US8906901B2 (en) 2005-09-14 2014-12-09 Takeda Pharmaceutical Company Limited Administration of dipeptidyl peptidase inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9533984B2 (en) 2013-04-19 2017-01-03 Incyte Holdings Corporation Bicyclic heterocycles as FGFR inhibitors
US9533954B2 (en) 2010-12-22 2017-01-03 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors

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