WO2003104763A3 - Apparatus and method for relative or quantitative comparison of multiple samples - Google Patents

Apparatus and method for relative or quantitative comparison of multiple samples Download PDF

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Publication number
WO2003104763A3
WO2003104763A3 PCT/US2003/017034 US0317034W WO03104763A3 WO 2003104763 A3 WO2003104763 A3 WO 2003104763A3 US 0317034 W US0317034 W US 0317034W WO 03104763 A3 WO03104763 A3 WO 03104763A3
Authority
WO
WIPO (PCT)
Prior art keywords
relative
multiple samples
samples
quantitative comparison
quantitative
Prior art date
Application number
PCT/US2003/017034
Other languages
French (fr)
Other versions
WO2003104763A2 (en
Inventor
David E Clemmer
Amy E Hilderbrand
Original Assignee
Advanced Res & Tech Inst
David E Clemmer
Amy E Hilderbrand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Res & Tech Inst, David E Clemmer, Amy E Hilderbrand filed Critical Advanced Res & Tech Inst
Priority to AU2003247442A priority Critical patent/AU2003247442A1/en
Publication of WO2003104763A2 publication Critical patent/WO2003104763A2/en
Publication of WO2003104763A3 publication Critical patent/WO2003104763A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/107—Arrangements for using several ion sources
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/623—Ion mobility spectrometry combined with mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions

Abstract

An apparatus (10) and method are provided for conducting comparative, relative or quantitative analysis of multiple samples. The apparatus (10) includes a plurality of ion sources (121, 12N) and a capillary structure (141, 14N, 181, 18N, 20) configured to direct ions to a mass analysis instrument (30). The apparatus and method may include post-ionization, gas-phase combination of one or more of the samples with one or more reagents (161, 16N) for quantitative or relative comparison of one or more of the samples.
PCT/US2003/017034 2002-06-05 2003-05-30 Apparatus and method for relative or quantitative comparison of multiple samples WO2003104763A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003247442A AU2003247442A1 (en) 2002-06-05 2003-05-30 Apparatus and method for relative or quantitative comparison of multiple samples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38662102P 2002-06-05 2002-06-05
US60/386,621 2002-06-05

Publications (2)

Publication Number Publication Date
WO2003104763A2 WO2003104763A2 (en) 2003-12-18
WO2003104763A3 true WO2003104763A3 (en) 2004-03-04

Family

ID=29736187

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/017034 WO2003104763A2 (en) 2002-06-05 2003-05-30 Apparatus and method for relative or quantitative comparison of multiple samples

Country Status (2)

Country Link
AU (1) AU2003247442A1 (en)
WO (1) WO2003104763A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4782796B2 (en) * 2004-11-09 2011-09-28 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー Ion source for mass spectrometer
US7385190B2 (en) * 2005-11-16 2008-06-10 Agilent Technologies, Inc. Reference mass introduction via a capillary
US20080087815A1 (en) * 2006-10-13 2008-04-17 Agilent Technologies, Inc. Time division multiplexing MS with beam converging capillary
GB0704547D0 (en) * 2007-03-09 2007-04-18 Smiths Detection Watford Ltd Ion mobility spectrometers
JP5579706B2 (en) * 2008-05-30 2014-08-27 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド Method and system for providing a regulator to a curtain gas for a differential mobility spectrometer
DE102009037716B4 (en) * 2009-08-17 2013-01-31 Bruker Daltonik Gmbh High-pressure atmospheric pressure ion source for vacuum ion spectrometer
GB201118889D0 (en) 2011-11-02 2011-12-14 Micromass Ltd Multi inlet for solvent assisted inlet ionisation
CN107359104B (en) * 2017-06-14 2018-07-20 中国科学院地质与地球物理研究所 A kind of magnetic substance spectralyzer couples conversion equipment with dual ion sources
EP4080545A1 (en) * 2021-04-20 2022-10-26 Tofwerk AG Method and apparatus for mass analysing a sample

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504326A (en) * 1994-10-24 1996-04-02 Indiana University Foundation Spatial-velocity correlation focusing in time-of-flight mass spectrometry
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
WO1999019899A1 (en) * 1997-10-15 1999-04-22 Analytica Of Branford, Inc. Curved introduction for mass spectrometry
WO2000052735A1 (en) * 1999-03-05 2000-09-08 Bruker Daltronics, Inc. Ionization chamber for atmospheric pressure ionization mass spectrometry
GB2349270A (en) * 1999-04-15 2000-10-25 Hitachi Ltd A mass spectrometer with plural ion sources
US6207954B1 (en) * 1997-09-12 2001-03-27 Analytica Of Branford, Inc. Multiple sample introduction mass spectrometry
US6323482B1 (en) * 1997-06-02 2001-11-27 Advanced Research And Technology Institute, Inc. Ion mobility and mass spectrometer
WO2001095367A2 (en) * 2000-06-05 2001-12-13 Pharmacia & Upjohn Company Multiple source electrospray ionization for mass spectrometry
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US6350617B1 (en) * 1998-03-27 2002-02-26 Ole Hindsgaul Device for delivery of multiple liquid sample streams to a mass spectrometer
GB2367685A (en) * 2000-07-26 2002-04-10 Masslab Ltd Mass spectrometer with multiple ion sources
US20020121598A1 (en) * 2001-03-02 2002-09-05 Park Melvin A. Means and method for multiplexing sprays in an electrospray ionization source
US6501073B1 (en) * 2000-10-04 2002-12-31 Thermo Finnigan Llc Mass spectrometer with a plurality of ionization probes

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504326A (en) * 1994-10-24 1996-04-02 Indiana University Foundation Spatial-velocity correlation focusing in time-of-flight mass spectrometry
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US6323482B1 (en) * 1997-06-02 2001-11-27 Advanced Research And Technology Institute, Inc. Ion mobility and mass spectrometer
US20020014586A1 (en) * 1997-06-02 2002-02-07 Clemmer David E. Instrument for separating ions in time as functions of preselected ion mobility and ion mass
US6207954B1 (en) * 1997-09-12 2001-03-27 Analytica Of Branford, Inc. Multiple sample introduction mass spectrometry
WO1999019899A1 (en) * 1997-10-15 1999-04-22 Analytica Of Branford, Inc. Curved introduction for mass spectrometry
US6350617B1 (en) * 1998-03-27 2002-02-26 Ole Hindsgaul Device for delivery of multiple liquid sample streams to a mass spectrometer
WO2000052735A1 (en) * 1999-03-05 2000-09-08 Bruker Daltronics, Inc. Ionization chamber for atmospheric pressure ionization mass spectrometry
GB2349270A (en) * 1999-04-15 2000-10-25 Hitachi Ltd A mass spectrometer with plural ion sources
WO2001095367A2 (en) * 2000-06-05 2001-12-13 Pharmacia & Upjohn Company Multiple source electrospray ionization for mass spectrometry
GB2367685A (en) * 2000-07-26 2002-04-10 Masslab Ltd Mass spectrometer with multiple ion sources
US6501073B1 (en) * 2000-10-04 2002-12-31 Thermo Finnigan Llc Mass spectrometer with a plurality of ionization probes
US20020121598A1 (en) * 2001-03-02 2002-09-05 Park Melvin A. Means and method for multiplexing sprays in an electrospray ionization source

Non-Patent Citations (9)

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Title
CHUPAKHIN M.S.: "Introduction of gases to be analyzed into the ion source of a mass spectrometer", JOURNAL OF ANALYTICAL CHEMISTRY, vol. 15, no. 2, March 1960 (1960-03-01) - April 1960 (1960-04-01), pages 175 - 178, XP002971688 *
HASKINS N.J.: "Faster compound analysis by mass spectrometry - the ToF revolution", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 25, 2001, pages 767 - 773, XP002971687 *
KOSTIAINEN R. ET AL.: "Effect of multiple sprayers on dynamic range and flow rate liitations in electrospray and ionspray mass spectrometry", RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 8, 1994, pages 549 - 558, XP002929950 *
LEE Y.J. ET AL.: "Development of high-throughput liquid chromatography injected ion mobility", JOURNAL OF CHROMATOGRAPHY B, vol. 782, no. 1-2, 25 December 2002 (2002-12-25), pages 343 - 351, XP004394236 *
NISHI I. ET AL.: "Application of a twin ion source mass spectrometer: simultaneous measurement of respiratory and blood gases", ADVANCES IN MASS SPECTROMETRY, vol. 8B, 1980, pages 1926 - 1933 *
SREBALUS BARNES C.A. ET AL.: "Resolving isomeric peptide mixtures: A combined HPLC/Ion mobility-TOFMS analysis of a 4000-component combinatorial library", ANALYTICAL CHEMISTRY, vol. 74, no. 1, 1 January 2002 (2002-01-01), pages 26 - 36, XP002971689 *
TANG K. ET AL.: "Generation of multiple electrosprays using microfabricated emitter arrays for improved mass spectrometric sensitivity", ANALYTICAL CHEMISTRY, vol. 73, no. 8, 15 April 2001 (2001-04-15), pages 1658 - 1663, XP001030274 *
YANG L. ET AL.: "Evaluation of a four-channel multiplexed electrospray triple quadrupole mass spectrometer for the simultaneous validation of LC/MS/MS methods in four different preclinical matrixes", ANALYTICAL CHEMISTRY, vol. 73, no. 8, 15 April 2001 (2001-04-15), pages 1740 - 1747, XP002971690 *
ZENG L. ET AL.: "Developments of a fully automated parallel HPLC/mass spectrometry system for the analytical characterization and preparative purification of combinatorial libraries", ANALYTICAL CHEMISTRY, vol. 70, no. 20, 15 October 1998 (1998-10-15), pages 4380 - 4388, XP002217928 *

Also Published As

Publication number Publication date
AU2003247442A1 (en) 2003-12-22
WO2003104763A2 (en) 2003-12-18
AU2003247442A8 (en) 2003-12-22

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