WO2003103768A1 - Device for treating tumor and fat using microwave - Google Patents

Device for treating tumor and fat using microwave Download PDF

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Publication number
WO2003103768A1
WO2003103768A1 PCT/KR2002/001378 KR0201378W WO03103768A1 WO 2003103768 A1 WO2003103768 A1 WO 2003103768A1 KR 0201378 W KR0201378 W KR 0201378W WO 03103768 A1 WO03103768 A1 WO 03103768A1
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WO
WIPO (PCT)
Prior art keywords
output
signal
tumor
amplifier
electrode
Prior art date
Application number
PCT/KR2002/001378
Other languages
French (fr)
Inventor
Seung-Kee Mo
Nam-Tae Kim
Original Assignee
Seung-Kee Mo
Nam-Tae Kim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seung-Kee Mo, Nam-Tae Kim filed Critical Seung-Kee Mo
Priority to AU2002328566A priority Critical patent/AU2002328566A1/en
Publication of WO2003103768A1 publication Critical patent/WO2003103768A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60Q—ARRANGEMENT OF SIGNALLING OR LIGHTING DEVICES, THE MOUNTING OR SUPPORTING THEREOF OR CIRCUITS THEREFOR, FOR VEHICLES IN GENERAL
    • B60Q1/00—Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor
    • B60Q1/26—Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to indicate the vehicle, or parts thereof, or to give signals, to other traffic
    • B60Q1/2696—Mounting of devices using LEDs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60Q—ARRANGEMENT OF SIGNALLING OR LIGHTING DEVICES, THE MOUNTING OR SUPPORTING THEREOF OR CIRCUITS THEREFOR, FOR VEHICLES IN GENERAL
    • B60Q1/00—Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor
    • B60Q1/26—Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to indicate the vehicle, or parts thereof, or to give signals, to other traffic
    • B60Q1/2661—Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to indicate the vehicle, or parts thereof, or to give signals, to other traffic mounted on parts having other functions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60Q—ARRANGEMENT OF SIGNALLING OR LIGHTING DEVICES, THE MOUNTING OR SUPPORTING THEREOF OR CIRCUITS THEREFOR, FOR VEHICLES IN GENERAL
    • B60Q1/00—Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor
    • B60Q1/26—Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to indicate the vehicle, or parts thereof, or to give signals, to other traffic
    • B60Q1/28—Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to indicate the vehicle, or parts thereof, or to give signals, to other traffic for indicating front of vehicle

Definitions

  • the present invention relates to an apparatus for treating tumor and obesity, and
  • RF radiofrequency
  • the present invention is proposed to overcome the aforementioned problems
  • An object of the present invention is to
  • Another object of the present invention is to provide an apparatus for
  • Still another object of the present invention is to provide an apparatus for
  • a RF output device for generating a high frequency
  • RF signal to induce the thermal motion of tumor or fat cells
  • the RF transmission cable for radiating a high frequency RF signal generated from the
  • RF transmission cable to internal tumor or fat cells, wherein said RF output device may
  • bio information decision unit to determine a state of tumor or fat cells by
  • the RF output device may further comprise a RF output unit for amplifying and
  • control unit for determining a size of the RF signal by extracting a portion of the RF
  • interface unit for receiving information such as size, frequency, output time, mode of
  • the RF output unit may comprise a signal producer for generating a RF signal
  • a drive amplifier for amplifying the output
  • control unit an output amplifier for amplifying the signal generated from the output
  • controller according to characteristic information of tumor and fat cellsto be removed
  • a coupler/detector for extracting a portion of the signal generated from the output
  • the RF output control unit may comprise an amplifier for amplifying the output
  • control signal producer for providing a control signal to control output of the RF output unit according to the signal generated from the output comparator.
  • the drive amplifier and the output amplifier may comprise at least one of an
  • the output controller may comprise a PIN diode whose intrinsic resistance
  • the output comparator may comprise a logarithmic amplifier for transforming
  • the comparator may compare a size of and an amount of output by mapping
  • the comparator may comprise a first comparator for comparing the first
  • the control signal producer may comprise a voltage/current transformer for
  • the bio information decision unit may comprise an impedance measurement
  • a blood flow measurement unit for measuring blood
  • the RF electrode may comprise a handle and an infiltrative electrode for
  • the infiltrative electrode may comprise an internal conductor, an external
  • the RF electrode may be a RF pad radiating the RF signal to the internal body
  • the RF pad may comprise a ground conductor for blocking the radiation of the
  • the apparatus according to the present invention may further an
  • ultrasonic sensor for providing route information for the infiltrative electrode to
  • Fig la is a schematic view of the apparatus for treating tumor and obesity using
  • Fig lb is a schematic view of the apparatus for treatmg tumor and obesity
  • Fig lc is a schematic view of the apparatus for treating tumor and obesity using
  • Id is a view showing an example that the infiltrative electrode according to other preferred embodiment of the present invention infiltrates tumor.
  • Fig 2 is a view showing the external configuration of the RF output device
  • Fig 3 is a block diagram showing an internal component of the RF output
  • Fig 4 is a block diagram showing a detailed component of the RF output unit
  • Fig 5 is a block diagram showing a detailed component of the RF output control
  • Fig 6a is a view showing a component of the comparator according to the
  • Fig 6b is a view showing a component of the comparator according to another
  • Fig 7a is a block diagram showing a component of the bio information process
  • Fig 7b is a view showing an example for determining a bio information by
  • Fig 8a is a view showing a longitudinal cross-section of the RF electrode
  • Fig 8b is a view showing a transverse cross-section of the RF electrode according to the preferred embodiment of the present invention.
  • Fig 9 is a view showing the radiation pattern of the RF signal when using the
  • Fig 10a is a view showing a longitudinal cross-section of a internal structure of
  • Fig 10b and 10c are a view showing a transverse cross-section of a internal
  • Fig 11 is a Figure showing the radiation pattern at the RF pad according to the
  • the apparatus for treating tumor and obesity using a high frequency according to
  • Fig la is a schematic view of the apparatus for treating tumor and obesity using
  • Fig la represents a structure of the apparatus for eliminating
  • a RF output device 100
  • a RF transmission cable 102
  • a RF electrode 1066
  • the RF output device (100) may generate a high frequency RF signal
  • the RF output device should amplify the
  • the RF output device (100) not only generates the RF signal but also controls
  • the RF output device (100) has a user interface for inputting a variety
  • the RF output device (100) may provide the means for measuring bio
  • the RF output device can determine
  • the RF transmission cable (102) may provide the RF signal generated from the RF output device to the RF electrode.
  • the RF transmission cable (102) can be a general
  • the RF electrode (106) freely by using a handle (104), it is preferable to use a flexible RF electrode (106) freely by using a handle (104), it is preferable to use a flexible RF electrode (106) freely by using a handle (104), it is preferable to use a flexible RF electrode (106) freely by using a handle (104), it is preferable to use a flexible RF electrode (106) freely by using a handle (104), it is preferable to use a flexible
  • a characteristic impedance of the RF transmission cable is 50 ohm and it
  • the RF transmission cable (102) is connected to the RF output device (100)
  • a connector which can be SMA(Sub-Miniature A) in general.
  • the infiltrative electrode (108) infiltrates to the internal body and provides a
  • the end of the infiltrative electrode (108) is sharply made and the interior of the
  • the radiated signal infiltrates into the tumor and radiates a high frequency RF signal.
  • the RF high frequency signal radiated to the tumor may induce a thermal
  • intensity of radiation are determined according to a power and a frequency of the high
  • the RF signal When the RF signal transmits to the internal body, it may induce
  • the tumor is necrotized.
  • the conventional method is to necrotize tumor by transmitting heat.
  • the present invention is to transmit the radiation energy of high frequency
  • infiltrative electrode (108) depend on the type and size of tumor. They are manipulated
  • a length and size of the infiltrative electrode may be modified
  • the infiltrative electrode may be also used by a means for measuring
  • Fig lb is a schematic view of an apparatus for treatmg tumor and obesity
  • the apparatus for treating tumor and obesity as shown in Fig 2b further has an
  • the ultrasonic sensor (112) can be equipped to the
  • the ultrasonic sensor (112) can be equipped to a
  • the ultrasonic sensor (112) provides an ultrasonic signal
  • the ultrasonic sensor can control a resolution up to
  • the focus of the infiltrative electrode can be localized to the tumor
  • the infiltrative electrode is preferably surface-treated in
  • the infiltrative electrode is preferably surface-treated with Teflon.
  • Fig Id is an example that the infiltrative electrode infiltrates a tumor. As shown
  • the infiltrative electrode (107) can induce a route of inserting to tumor by
  • Fig lb describes an example of receiving image information about tumor using
  • Fig lc is a schematic view of the apparatus for treating tumor and obesity
  • Fig la and lb show a structure of an apparatus for eliminating tumor by
  • Fig lc shows a structure of an
  • apparatus for eliminating body fat in a comparatively large area by radiating RF signal from an external body.
  • Another embodiment of the present invention may include the RF output device (100),
  • Fig lc shows the apparatus where the RF electrode (106) is replaced with RF
  • the RF output device (100) and the RF transmission cable (102) operate very
  • the RF pad (114) is located on the surface of the fat abdomen or thigh and
  • the RF pad (114) may include the antenna
  • the frequency RF signal radiated from the antenna may infiltrate to the internal body.
  • the high frequency RF signal radiated from the RF pad (114) may induce the
  • thermal motion of fat molecules and the thermal motion may melt fat molecules.
  • the RF pad (114) is made to have flexibility for wrapping an
  • FIG. 1 shows the exterior structure of the RF output device according to the
  • preferred embodiment of the present invention may include a state display (200), a
  • the state display (200) functions as displaying state
  • the state display (200) indicates state
  • the present invention is not limited
  • LCD may fall within the scope of the present invention.
  • the output power control dial (202) is to control the size of the RF signal
  • Fig 2 shows a structure of controlling the output
  • the output power is determined by
  • the output frequency control dial (204) is to control a frequency of the RF signal generated from the RF output device.
  • the dial is controlled in considering that
  • the output frequency depends on the thickness of tumor or fat cells to be controlled.
  • the timer (206) is a device for controlling the output time of the RF signal
  • RF signal is controlled according to the characteristics of tumor and fat cells.
  • time of the RF signal predetermined by the timer (206) is time-divisioned by the
  • the start switch (208) is a switch for directing the output of the RF signal.
  • the RF signal cannot transmit to the infiltrative electrode or the RF pad.
  • the power switch (210) is a switch for directing turning on the RF output
  • the power switch If the power switch is turned on, a user can control a frequency, a power, time of
  • the output display instrument (212) displays information about the size of the
  • the output display instrument (212) can be used as an analogue type such as a
  • the mode setting dial (214) is a dial for selecting whether the output display
  • instrument (212) displays information of frequency or information of the size of the RF
  • the RF output device can operate as an output mode for providing the RF
  • the change of the mode is executed through the mode setting dial.
  • the input terminal (216) is a terminal associated with the RF transmission cable
  • the infiltrative electrode of the RF electrode (106) provides information about
  • the output terminal (218) is a terminal associated with RF transmission cable
  • the high frequency RF signal for eliminating tumor or fat cells is provided to the RF
  • Fig 3 is a block diagram describing the internal component of the RF output device according to the preferred embodiment of the present invention.
  • the RF output device As shown in Fig 3, the RF output device according to the preferred embodiment
  • a RF output unit (300)
  • a RF output control unit (300)
  • the RF output unit (300) in Fig 3 generates a high frequency RF signal to
  • the RF output unit (300) amplifies a weak signal of a high
  • Tumor has a
  • output unit (300) includes a multi-stage amplifier for generating a variety of intensities
  • the RF output control unit (302) controls an intensity of the RF signal
  • the RF output control unit (302) is to extract a portion of signals
  • the user interface unit (306) receives information about an intensity, a
  • the control unit (304) controls overall operations of the RF output device in
  • the bio information decision unit (308) receives bio information measured by
  • the infiltrative electrode determines characteristic information about tumor or body
  • characteristic information As described above, characteristic information
  • the bio information decision unit (308) can be used to determine whether or not to
  • Fig 4 is a block drawing showing a detailed structure of the RF output unit
  • the RF output unit As shown in Fig 4, the RF output unit according to the preferred embodiment of
  • the present invention may include a signal producer (400), a first isolator (402), an input
  • the signal producer (400) operates as the output source
  • a RF element such as an amplifier is coupled or a portion of the transmitted RF signals is reflected when a medium is changed.
  • the first isolator (402) is to match
  • RF signal generated from the signal producer (400) can pass the input switch (404)
  • the input switch (404) blocks the RF signal generated from the signal producer
  • the input switch can be a generally used mechanical coaxial switch or
  • a switch to electrically block the RF signal.
  • the input switch (404) is driven to bock output of the RF signal.
  • the second isolator (406) matches impedance between the input switch (404)
  • the drive amplifier (408) amplifies a level of the RF signal generated from the
  • the drive amplifier can be a component such as
  • the driven amplifier has an advantage of being controlled according
  • amplifier functions as amplifying the real generated RF signal. Likewise, the
  • amplification using the drive amplifier (408) at a front end of the output amplifier (416) can ensure a linearity of control in offset state to facilitate controlling of output level.
  • the amplification rate of the drive amplifier can be modified by varying value of
  • component such as impedance, capacity or inductor.
  • the third isolator (410) matches impedance between the drive amplifier (408)
  • the output controller (412) controls an intensity of signal generated form the
  • the output controller (412) is coupled with the RF output controller
  • RF output control unit (302) is to extract a portion of output signals at the RF output
  • control level of the RF signal wherein a control signal for controlling the output level is
  • controller is to control level of the output signal using PIN diode attenuator.
  • PIN diode PIN diode
  • resistance varies according to an amount of a control current flow to change the
  • the fourth isolator (414) functions as matching impedance between the ouput
  • the output amplifier (416) functions as amplifying a signal generated form the
  • output controller (412) It can be used as an individual type of MESFET, MOSFET, and
  • the output amplifier is preferably constituted
  • the output amplifier needs the matching circuit of input and output to
  • a matching point is
  • amplification can be executed as a predetermined amplifying rate.
  • matching circuit is preferably used than a single reactance matching circuit.
  • the coupler/detector (420) is to extract a portion of signals generated from an
  • the coupler extracts a portion of signals generated form the output amplifier
  • 50% of the output signal can be extracted by the
  • the coupler is
  • the available coupler for super high frequency can
  • the detector transforms a signal extracted from the coupler into a direct current
  • the detector includes
  • a diode and a capacitor to transform the RF signal, an alternating current signal to a
  • the diode transforms the alternating current signal which
  • the capacitor transforms a signal of sine wave type to a direct signal of flat form.
  • the diode uses short
  • the detector is preferably designed in considering of a characteristic
  • the sixth isolator (422) functions as matching impedance between the
  • the output switch (424) blocks a signal generated from the
  • the seventh isolator (426) matches impedance between the output switch (424)
  • the output terminal (428) is a terminal that the RF transmission cable (102) is
  • the output terminal (428) is transmitted to the infiltrative electrode (108) through the RF
  • transmission cable (102) to eventually propagate to tumor or fat cell.
  • Fig 5 shows a block drawing of a detailed structure of the RF output control
  • the RF output control unit As shown in Fig. 5, the RF output control unit according to the preferred
  • differential amplifier 500
  • logarithmic amplifier 506
  • linear amplifier 508
  • comparator (510) a reference voltage producer (512) and the inverse amplifier (514),
  • the differential amplifier (500) amplifies the signal detected from a
  • the differential amplifier having high input impedance
  • the video amplifier for broadband can be used as a
  • a high input impedance buffer can be equipped at a front terminal
  • the output comparator (502) receives a signal generated from the differential
  • the output comparator includes a logarithmic amplifier
  • the level of the output signal generated from the RF output unit varies with
  • the RF output control unit (302) should
  • invention may transform a signal generated from the coupler/detector (420) to a log
  • the linear amplifier (508) transforms a log scale signal transformed at logarithmic amplifier (506) to a linear scale signal and amplifies it. Since the
  • logarithmic amplifier (506) transforms a signal generated from the coupler/detector
  • the present invention transforms a output signal
  • the reference voltage producer (512) generates the first reference voltage for a
  • a reference voltage According to another embodiment of the present invention, a reference voltage
  • producer can provide the first reference voltage for the maximum power and the second
  • the comparator (508) functions for comparing the first reference voltage for a
  • Fig. 6a shows a structure of a comparator according to one embodiment
  • the comparator (602) consisting an OP amp, an instantaneous voltage signal of a linear
  • integrator (600) are switched by two switches (604, 606) and they are input to the
  • the reference voltage producer (512) switches the first reference voltage
  • the second reference voltage inputs it to the reference input component of the
  • the comparator can be a transistor consisting of an
  • Fig 6b shows a structure of the comparator according to another embodiment of
  • Fig 6a shows a structure that an OP amp and a reference voltage producer compare an instantaneous voltage with an integrating voltage by switching
  • Fig 6b shows a structure that an OP amp and a reference voltage producer compare an instantaneous voltage with an integrating voltage by switching
  • the first comparator (608) is input to the first comparator (608) consisting of the OP amp.
  • comparator (608) compares the output signal of the linear amplifier (508) with the
  • the second comparator (612) generates the output signal when the integration
  • the output voltage of the second reference producer is set for determination by mapping
  • the comparator (510) generates the output
  • the inverse amplifier (514) reconstructs the log scale signal transformed by the
  • logarithmic amplifier (506) into an original signal.
  • the inverse amplifier (514) are components for easy control, and thus they need not be
  • the control signal producer (506) functions as transforming the output voltage
  • a size of the RF signal generated from the RF output unit is
  • the output controller (412) controls a size of the RF signal.
  • output controller (412) is embodied to a PIN diode and the PIN diode controls a size of
  • the RF output control unit as shown in Fig 5 controls RF output by feedback a
  • the RF output can be controlled. Also, this modification of
  • Fig 7a is a block diagram showing a structure of the bio information process
  • the bio information process unit includes a impedance measurement unit (700), a
  • the impedance measurement unit (700) functions as measuring impedance of
  • the impedance can be measured by determining a
  • the blood flow measurement unit (702) functions as measuring a blood flow of
  • the blood flow can be determined by measuring a charge
  • the blood flow measurement unit (702) can measure a blood
  • the characteristic information decision unit (704) can determine a state of
  • the characteristic information decision unit (704) provides information
  • the bio information decision unit as shown in Fig 7a describes a method for a
  • diagnosis parameter can be used by one skilled in the art.
  • the bio information decision unit determines a bio information through a blood flow and an impedance. However, it is apparent to one
  • Fig 7b is a Figure showing an example for determining a bio information by
  • a diameter of the electrode is smaller than that of
  • test current is applied to the infiltrative electrode (710). At this time, if
  • Fig 8a is a figure showing a longitudinal cross-sectional view of the RF
  • Fig 8b is a
  • the RF electrode according to one preferred
  • embodiment of the present invention can include a internal conductor (800), an external
  • external conductor (804) functions as a ground and the RF signal does not propagate
  • Fig 9 is a pattern of the RF signal when the infiltrative electrode is used
  • the external conductor (804) does not extend at the end of
  • the RF signal can radiate outward through the end which the
  • external conductor (804) does not extend, namely, a slot of part of coupling the internal
  • the RF signal having a power and frequency to induce thermal motion
  • Fig 10a is a longitudinal cross-sectional view of a internal structure of the RF
  • the RF pad may include an external dielectric (1000), a ground conductor (1002), and an internal conductor (1004).
  • the internal conductor (1004) may include a plurality of
  • the respective antenna electrode (1006) operates as
  • Fig 10b shows a configuration that a general dipole antenna electrode is
  • antenna electrode can be equipped.
  • Fig 10c is a transverse cross-sectional view showing an internal structure of the
  • the RF signal can radiate to a human body in a high density of power.
  • Fig 11 is a Figure showing the radiation pattern at the RF pad according to the
  • a ground conductor (1100) is positioned to an exterior of
  • the RF signal cannot be radiated to an outside of the ground conductor but
  • an antenna electrode (1102) is a type of
  • the RF signal radiates circularly in center of the respective antenna electrode.
  • the RF pad is generally used in eliminating body fat. The RF signal radiated
  • the apparatus for treating tumor and obesity according to the present invention

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

The present invention relates to an apparatus for treating tumor and obesity using a high frequency, comprising: a RIF output device for generating a high frequency RIF signal to induce a thermal motion of tumor or fat cell; a RIF transmission cable which is associated with the RIF output device for transmitting the high frequency RIF signal generated from the RIF output device; and a RIF electrode which is associated with the RIF transmission cable for radiating the high frequency RIF signal generated from the RIF transmission cable to internal tumor or fat cell, wherein said RIF output device includes a bio information decision unit for applying a test current and a test voltage to internal tumor or fat cell to determine a state of tumor of fat cell. The present invention can eliminate tumor or fat cell simply and safely without surgical operation.

Description

DEVICE FOR TREATING TUMOR AND FAT USING MICROWAVE
FIELD OF THE INVENTION
The present invention relates to an apparatus for treating tumor and obesity, and
more particularly, an apparatus for treating tumor and obesity by radiating a high
frequency RF (radiofrequency) signal to tumor and fat cells and inducing the thermal
motion of molecules thereof by the radiated RF signal.
BACKGROUND OF THE INVENTION
According to the conventional technology, it is general to exclude tumor
through surgical operation or burn tumor by applying heat for treatment of tumor. Since
the conventional method in the treatment of tumor by heating directly should keep
cooling an electrode conducting heat, a diameter of an electrode becomes larger. Further,
if a cooling system is in trouble, an electrode may be broken down. Thus, this method
cannot be practical for use.
Also, in the treatment of obesity, it is generally used to take diet food or
eliminate fat deposits using a medical device such as liposuction device. The
conventional liposuction is a complicate operation requiring multi steps including
incising in the skin of abdomen or femur , separating and puncturing the fat cells,and
suctioning them out throung the cannula or tube by employing a vacuum pump.. DETAILED DESCRIPTION OF THE PRESENT INVENTION
The present invention is proposed to overcome the aforementioned problems
associated with the conventional technologies. An object of the present invention is to
provide an apparatus for treatmg tumor and obesity using a high frequency to eliminate
tumor and fat cells without any surgical operation.
Also, another object of the present invention is to provide an apparatus for
treating tumor and obesity by inducing the thermal motion of molecules of tumor or fat
cells using a high frequency RF signal.
Also, still another object of the present invention is to provide an apparatus for
eliminating tumor and fat cells without any harm to a human body.
To achieve the aforementioned objects, according to a preferred embodiment
of the present invention, there is provided an apparatus for treating tumor and obesity
using a high frequency, comprising: a RF output device for generating a high frequency
RF signal to induce the thermal motion of tumor or fat cells; a RF transmission cable
which is associated with the RF output device for transmitting the high frequency RF
signal generated from the RF output device; and a RF electrode which is associated with
the RF transmission cable for radiating a high frequency RF signal generated from the
RF transmission cable to internal tumor or fat cells, wherein said RF output device may
include a bio information decision unit to determine a state of tumor or fat cells by
applying test currents or test voltages. The RF output device may further comprise a RF output unit for amplifying and
generating a RF signal to induce the thermal motion of tumor and fat cells; a RF output
control unit for determining a size of the RF signal by extracting a portion of the RF
signal generated from the RF output unit, and controlling a size of the RF signal; a user
interface unit for receiving information such as size, frequency, output time, mode of
RF signal from a user.
The RF output unit may comprise a signal producer for generating a RF signal
corresponding to a predetermined frequency; a drive amplifier for amplifying the output
signal at the signal producer; an output controller for controlling the signal generated
from the drive amplifier according to the control signal generated from the RF output
control unit; an output amplifier for amplifying the signal generated from the output
controller according to characteristic information of tumor and fat cellsto be removed;
a coupler/detector for extracting a portion of the signal generated from the output
amplifier, transforming it to the voltage and providing it to the RF output control unit;
and an output terminal which is associated with the RF transmission cable for
transmitting the signal generated from the output amplifier to the RF transmission cable.
The RF output control unit may comprise an amplifier for amplifying the output
signal at the coupler/detector; an output comparator for detecting whether the RF signal
exceeds a predetermined voltage by the signal generated from the differential amplifier;
and a control signal producer for providing a control signal to control output of the RF output unit according to the signal generated from the output comparator.
The drive amplifier and the output amplifier may comprise at least one of an
individual type of MESFET, MOSFET, and GaAsFET transistor and an integrated type
of power OP amp.
The output controller may comprise a PIN diode whose intrinsic resistance
changes with current.
The output comparator may comprise a logarithmic amplifier for transforming
the output signal at the differential amplifier to a log scale signal; a linear amplifier for
amplifying the output signal at the logarithmic amplifier; a reference voltage producer
for generating the first reference voltage to detect an instantaneous maximum voltage of
the RF signal generated from the RF output unit, and the second reference voltage to
compare a integrating voltage of the RF signal generated from the RF output unit; a
comparator for comparing the output signal at the linear amplifier with the first
reference voltage, and comparing the second reference voltage with the value acquired
by integrating the output signal at the linear amplifier; and an inverse amplifier for
reconstructing the log scale signal transformed by the logarithmic amplifier into an
original signal.
The comparator may compare a size of and an amount of output by mapping
values acquired by integrating the first reference voltage and the output signal at the
linear amplifier, and the second reference voltage and the output signal at the linear amplifier at perdetermined time intervals according to the switch operation.
The comparator may comprise a first comparator for comparing the first
reference voltage with the output signal at the linear amplifier; and a second comparator
for comparing the second reference voltage with value acquired by integrating the
output signal at the linear amplifier.
The control signal producer may comprise a voltage/current transformer for
transforming the output voltage at the inverse amplifier to a current signal.
The bio information decision unit may comprise an impedance measurement
unit for measuring an impedance of tumor or fat cells to be removed using a response to
the test voltage or the test current; a blood flow measurement unit for measuring blood
flow of tumor or fat cell to be removed using a response to the test voltage or the test
current; and a characteristic information decision unit for determining the characteristic
information of tumor or fat cells to be removed by matching the output information of
the impedance measurement unit and the blood flow measurement unit with a
predetermined mapping table.
The RF electrode may comprise a handle and an infiltrative electrode for
radiating the RF signal to tumor or fat cells to be removed by infiltrating body.
The infiltrative electrode may comprise an internal conductor, an external
conductor, an internal dielectric equipped between the internal conductor and the
external conductor, and an external dielectric surrounding the outside of the external conductor.
The RF electrode may be a RF pad radiating the RF signal to the internal body
with an adhesion to the exterior of a body.
The RF pad may comprise a ground conductor for blocking the radiation of the
RF signal to the other directions excepting for a body; a reference conductor; and an
internal conductor comprising a plurality of an antenna electrode radiating the RF signal
to the internal body which is electrically associated with the reference conductor.
Also, the apparatus according to the present invention may further an
ultrasonic sensor for providing route information for the infiltrative electrode to
infiltrate a tumor.
BRIEF DESCRIPTION OF THE DRAWINGS
Fig la is a schematic view of the apparatus for treating tumor and obesity using
a high frequency according to the preferred embodiment of the present invention.
Fig lb is a schematic view of the apparatus for treatmg tumor and obesity
using a high frequency according to another preferred embodiment of the present
invention.
Fig lc is a schematic view of the apparatus for treating tumor and obesity using
a high frequency according to other preferred embodiment of the present invention.Fig
Id is a view showing an example that the infiltrative electrode according to other preferred embodiment of the present invention infiltrates tumor.
Fig 2 is a view showing the external configuration of the RF output device
according to the preferred embodiment of the present invention.
Fig 3 is a block diagram showing an internal component of the RF output
device according to the preferred embodiment of the present invention.
Fig 4 is a block diagram showing a detailed component of the RF output unit
according to the preferred embodiment of the present invention.
Fig 5 is a block diagram showing a detailed component of the RF output control
unit according to the preferred embodiment of the present invention.
Fig 6a is a view showing a component of the comparator according to the
preferred embodiment of the present invention.
Fig 6b is a view showing a component of the comparator according to another
embodiment of the present invention.
Fig 7a is a block diagram showing a component of the bio information process
unit according to the preferred embodiment of the present invention.
Fig 7b is a view showing an example for determining a bio information by
applying a test voltage or a test current by an infiltrative electrode.
Fig 8a is a view showing a longitudinal cross-section of the RF electrode
according to the preferred embodiment of the present invention.
Fig 8b is a view showing a transverse cross-section of the RF electrode according to the preferred embodiment of the present invention.
Fig 9 is a view showing the radiation pattern of the RF signal when using the
infiltrative electrode according to the preferred embodiment of the present invention.
Fig 10a is a view showing a longitudinal cross-section of a internal structure of
the RF pad according to the preferred embodiment of the present invention.
Fig 10b and 10c are a view showing a transverse cross-section of a internal
structure of the RF pad according to the preferred embodiment of the present invention.
Fig 11 is a Figure showing the radiation pattern at the RF pad according to the
preferred embodiment of the present invention.
EMBODIMENTS
The apparatus for treating tumor and obesity using a high frequency according
to the present invention will be described in further detail by way of example with
reference to the accompanying drawings.
Fig la is a schematic view of the apparatus for treating tumor and obesity using
a high frequency according to the preferred embodiment of the present invention.
As shown in Fig la which represents a structure of the apparatus for eliminating
tumor mainly, the apparatus for treating tumor and obesity using a high frequency
according to the preferred embodiment of the present invention may include a RF output device (100), a RF transmission cable (102), and a RF electrode (106)
comprising a handle (104) and an infiltrative electrode (108).
In Fig la, the RF output device (100) may generate a high frequency RF signal
and provide it to the RF transmission cable. The RF output device should amplify the
signal at RF signal output producer because the conventional RF signal output producer
produces very weak signals.
The RF output device (100) not only generates the RF signal but also controls
the power of the RF signal provided to RF transmission cable (102). The RF output
device (100) controls a voltage of the generated RF signal by extracting a portion of the
RF signal generated through a detector and detecting whether a RF signal corresponding
to a total power predetermined by a user is provided.
Also, the RF output device (100) has a user interface for inputting a variety
ofparameter information predetermined by a user for treating tumor or obesity. An
external component of a user interface will be described in further detail with reference
to additional drawings.
The RF output device (100) may provide the means for measuring bio
information for whether tumor or obesity is treated. Since tumor and fat cell
respectively has a specific impedance or blood flow, the RF output device can determine
whether ttumor or obesity is treated by measuring an impedance or a blood flow.
The RF transmission cable (102) may provide the RF signal generated from the RF output device to the RF electrode. The RF transmission cable (102) can be a general
cable functioning as a transmission line, preferably a coaxial cable. Also, since the
apparatus for treating tumor and obesity according to the present invention should move
the RF electrode (106) freely by using a handle (104), it is preferable to use a flexible
coaxial cable. A characteristic impedance of the RF transmission cable is 50 ohm and it
is apparent to one skilled in the art that a cable having other characteristic impedances
such as 75 ohm can be used according to the manufacturing method.
The RF transmission cable (102) is connected to the RF output device (100)
through a connector which can be SMA(Sub-Miniature A) in general.
When a user moves the infiltrative electrode (108), a user can use a handle
(104) to insert the infiltrative electrode into the tumor.
The infiltrative electrode (108) infiltrates to the internal body and provides a
high frequency RF signal transmitted from the RF transmission cable (102) to the tumor.
The end of the infiltrative electrode (108) is sharply made and the interior of the
electrode is made as one-piece or built-up. The edge of the infiltrative electrode (108)
infiltrates into the tumor and radiates a high frequency RF signal. The radiated signal
transmits to the tumor.
The RF high frequency signal radiated to the tumor may induce a thermal
motion in atoms or molecules of the tumor. When a high frequency transmits, because
the internal molecules cannot recognize changes between negative and positive charges of the high frequency signal, the atoms or molecules vibrate. This vibration is
transformed into the heat energy.
When a high frequency RF signal transmits to the internal body, a depth and an
intensity of radiation are determined according to a power and a frequency of the high
frequency RF signal. When the RF signal transmits to the internal body, it may induce
vibrations of the internal ion atoms or molecules, which clashes itself or each other.
This is transformed to the heat energy and is integrated according to the radiation time,
so temperature is increased. Therefore, in controlling a temperature by conditioning
power and frequency of a high frequency RF signal, it results in thermal effect,
dehydration, and destruction which correspond to blood circulation theory, fat
elimination theory, and tumor elimination theory, respectively.
As shown in Fig 12, the possibility of recovery into an equilibrium state in the
internal tissue after the radiation of a high frequency may depend on a critical
temperature( Fig 1 can be referenced). Therefore, if the heat energy is increased higher
than the critical temperature, the tumor is necrotized. On the other hand,if the heat
energy is kept below the critical temperature, the body fat is eliminated due to the
dehydration of the fat cells. The necrotized tumor is naturally absorbed into the internal
body by the biophysical phenomenon. Therefore, it discharges outward from the body
as waste or it remains as a necrotized state in the body. The existence of the necrotized
tumor in the internal body does not harm on the function of the body. Further, the dehydration of the body fat at below the critical point is recovered into the equilibrium
state and only the body fat is removed without any harm.
That is, the conventional method is to necrotize tumor by transmitting heat.
However, the present invention is to transmit the radiation energy of high frequency
signals and induce thermal motions of internal atoms or molecules of an object within
the range of the radiation energy in order to necrotize tumor of the object.
The power and frequency of the high frequency RF signal radiated from the
infiltrative electrode (108) depend on the type and size of tumor. They are manipulated
by a user interface. Also, a length and size of the infiltrative electrode may be modified
depending on the position and size of tumor.
The infiltrative electrode may be also used by a means for measuring
impedances or blood flows of tumors in infiltrating into the internal body.
Fig lb is a schematic view of an apparatus for treatmg tumor and obesity
according to another embodiment of the present invention.
The apparatus for treating tumor and obesity as shown in Fig 2b further has an
ultrasonic sensor (112) in comparison with an apparatus as shown in Fig la.
As shown in Fig lb, the ultrasonic sensor (112) can be equipped to the
infiltrative electrode. Alternatively, the ultrasonic sensor (112) can be equipped to a
position physically isolated from the apparatus. The ultrasonic sensor (112) provides an
image of route to tumor in three-dimension to insert the infiltrative electrode to tumor using a handle by a user. Since the ultrasonic sensor can control a resolution up to
millimeter (mm), the focus of the infiltrative electrode can be localized to the tumor
cells by the ultrasonic sensor. The infiltrative electrode is preferably surface-treated in
order to control a reflection coefficient high or low so that an image can be detected by
employing the ultrasonic sensor. According to the preferable embodiment of the present
invention, the infiltrative electrode is preferably surface-treated with Teflon.
Fig Id is an example that the infiltrative electrode infiltrates a tumor. As shown
in Fig Id, the infiltrative electrode (107) can induce a route of inserting to tumor by
using the ultrasonic sensor (112) and the inserted infiltrative electrode can radiate the
high frequency RF signal to necrotize a tumor. Therefore, the infiltrative electrode
should be made with a detectable material by the ultrasonic sensor as described above.
Fig lb describes an example of receiving image information about tumor using
the ultrasonic sensor. It is apparent to one skilled in the art that localization of tumor or
fat cell through other means for acquiring images such as MRI falls within the present
invention.
Fig lc is a schematic view of the apparatus for treating tumor and obesity
according to another embodiment of the present invention.
Fig la and lb show a structure of an apparatus for eliminating tumor by
infiltrating the infiltrative electrode to internal body, and Fig lc shows a structure of an
apparatus for eliminating body fat in a comparatively large area by radiating RF signal from an external body.
As shown in Fig lc, the apparatus for treating tumor and obesity according to
another embodiment of the present invention may include the RF output device (100),
the RF transmission cable (102), the connector (110) and the RF pad (114).
Fig lc shows the apparatus where the RF electrode (106) is replaced with RF
pad (114) in the apparatus as shown in Fig la.
The RF output device (100) and the RF transmission cable (102) operate very
similarly to Fig la.
The RF pad (114) is located on the surface of the fat abdomen or thigh and
radiates a high frequency RF signal thereto. The RF pad (114) may include the antenna
that can radiate the high frequency signal to the comparatively large area. The high
frequency RF signal radiated from the antenna may infiltrate to the internal body. The
internal component of the RF pad (114) and the pattern of radiation will be described
below with reference to additional drawings.
The high frequency RF signal radiated from the RF pad (114) may induce the
thermal motion of fat molecules and the thermal motion may melt fat molecules. A
frequency and size of the RF signal radiated from RF pad (114) are modified depending
on the thickness of the body fat.
Preferably, the RF pad (114) is made to have flexibility for wrapping an
abdomen or a thigh. Fig 2 shows the exterior structure of the RF output device according to the
preferred embodiment of the present invention.
As shown in Fig 2, the exterior of the RF output device according to the
preferred embodiment of the present invention may include a state display (200), a
output power control dial (202), a output frequency control dial (204), a timer (206), a
starting switch (208), a power switch (210), an output display instrument (212), a mode
setting dial (214), an input terminal (216) and an output terminal (218).
As shown in Fig 2, the state display (200) functions as displaying state
information of the RF output device. Specifically, the state display (200) indicates state
information of power state, operation state, error state, risk, and overoutput. According
to the preferred embodiment of the present invention, use of switching LED can
indicate the state of the RF output device. However, the present invention is not limited
to indicate the state by using LED. Further, other state displays including the use of
LCD may fall within the scope of the present invention.
The output power control dial (202) is to control the size of the RF signal
generated from the RF output device. Fig 2 shows a structure of controlling the output
power through a dial and it is apparent to one skilled in the art to control the output
power by using a button or key pad and so on. The output power is determined by
characteristics of tumor or fat cell to be removed.
The output frequency control dial (204) is to control a frequency of the RF signal generated from the RF output device. The dial is controlled in considering that
the output frequency depends on the thickness of tumor or fat cells to be controlled.
The timer (206) is a device for controlling the output time of the RF signal
generated from the RF output device. Since the power applying to tumor or fat cells is
modified depending on the size and output time of the RF signal, the output time of the
RF signal is controlled according to the characteristics of tumor and fat cells. The output
time of the RF signal predetermined by the timer (206) is time-divisioned by the
integrating value that the generated power is totally added up. The relationship of time
setting by the timer about the integrating value of the power will be described below
with reference to additional drawings.
The start switch (208) is a switch for directing the output of the RF signal.
Although the power source of the RF output device is turned on, unless a start switch is
turned on, the RF signal cannot transmit to the infiltrative electrode or the RF pad.
The power switch (210) is a switch for directing turning on the RF output
device. If the power switch is turned on, a user can control a frequency, a power, time of
output.
The output display instrument (212) displays information about the size of the
RF signal being generated. A user should monitor the size of the generating RF signal
through the output display instrument (212) because it is different from the size of the
predetermined signal due to noise or couplmg coefficient, although the size of the output is determined by the output control dial (202). One skilled in the art can easily
know that the output display instrument (212) can be used as an analogue type such as a
moving iron or a digital type such as LCD.
The mode setting dial (214) is a dial for selecting whether the output display
instrument (212) displays information of frequency or information of the size of the RF
signal if RF output device is in an output mode after selecting whether the RF output
device is in an input mode or an output mode
The RF output device can operate as an output mode for providing the RF
signal to the internal body, or as in input mode for measuring bio information of the
internal body. The change of the mode is executed through the mode setting dial.
The input terminal (216) is a terminal associated with the RF transmission cable
(102) and the RF electrode (216) when the RF output device operates as an input mode.
The infiltrative electrode of the RF electrode (106) provides information about
impedance or blood flow of a portion inserted to the internal body to the RF output
device through the input terminal (216).
The output terminal (218) is a terminal associated with RF transmission cable
(102) and the RF electrode (106) when the RF output device operates in an output mode.
The high frequency RF signal for eliminating tumor or fat cells is provided to the RF
transmission cable (102) through the output terminal.
Fig 3 is a block diagram describing the internal component of the RF output device according to the preferred embodiment of the present invention.
As shown in Fig 3, the RF output device according to the preferred embodiment
of the present invention may include a RF output unit (300), a RF output control unit
(302), a control unit (304), a user interface unit (306) and a bio information decision
unit (308).
The RF output unit (300) in Fig 3 generates a high frequency RF signal to
eliminate tumor or fat cells. The RF output unit (300) amplifies a weak signal of a high
frequency output source to provide it to the RF transmission cable (102). Tumor has a
variety of characteristics and sizes, and therefore a different intensity of signals need to
be generated according to its characteristic and size. Thus, it is preferable that the RF
output unit (300) includes a multi-stage amplifier for generating a variety of intensities
of signals in the linear step.
The RF output control unit (302) controls an intensity of the RF signal
generated from the RF output unit (300). According to the preferred embodiment of the
present invention, the RF output control unit (302) is to extract a portion of signals
generated from the RF output unit, determine a intensity of signal, and control power in
order to keep a output signal generated from RF output unit (300) uniformly in case of
reaching a predetermined power.
The user interface unit (306) receives information about an intensity, a
frequency, an output time and a mode of the RF signal and provides it to the control unit (304). The control unit (304) controls overall operations of the RF output device in
accordance with a user setting information provided by the user interface unit (306).
The bio information decision unit (308) receives bio information measured by
the infiltrative electrode, and determines characteristic information about tumor or body
fat using the received bio information. As described above, characteristic information
can be determined by measuring impedance and blood flow of tumor or body fat. Also,
the bio information decision unit (308) can be used to determine whether or not to
eliminate tumors by measuring impedance of tumor.
Fig 4 is a block drawing showing a detailed structure of the RF output unit
according to the preferred embodiment of the present invention.
As shown in Fig 4, the RF output unit according to the preferred embodiment of
the present invention may include a signal producer (400), a first isolator (402), an input
switch (404), a second isolator (406), a drive amplifier (408), a third isolator (410), a
output controller (412), a fourth isolator (414), a power amplifier (416), a fifth isolator
(418), a coupler/detector (420), a sixth isolator (422), an output switch (424), a seventh
isolator (426) and an output terminal (428).
As shown in Fig 4, the signal producer (400) operates as the output source
generating a high frequency RF signal which is 1 mW ~ 10 mW and comparatively
weak.
In transmitting the RF signal, a RF element such as an amplifier is coupled or a portion of the transmitted RF signals is reflected when a medium is changed. To prevent
this reflection phenomenon, impedance need to be matched and an isolator functions as
matching impedances coupled at both terminals. The first isolator (402) is to match
impedance between the signal producer (400) and the input switch (404), and thus the
RF signal generated from the signal producer (400) can pass the input switch (404)
without any reflection.
The input switch (404) blocks the RF signal generated from the signal producer
in a certain case. The input switch can be a generally used mechanical coaxial switch or
a switch to electrically block the RF signal. When the RF output device operates in an
input mode, the input switch (404) is driven to bock output of the RF signal.
The second isolator (406) matches impedance between the input switch (404)
and the drive amplifier (408).
The drive amplifier (408) amplifies a level of the RF signal generated from the
signal producer (400) to a certain level. The drive amplifier can be a component such as
an individual type of MESFET, MOSFET, and GaAsFET transister or an integrated type
of power OP amp. The driven amplifier has an advantage of being controlled according
to offset power so that the output amplifier at the back end can be controlled in a range
of input and output. The output amplifier (416) located at the back end of the drive
amplifier functions as amplifying the real generated RF signal. Likewise, the
amplification using the drive amplifier (408) at a front end of the output amplifier (416) can ensure a linearity of control in offset state to facilitate controlling of output level.
The amplification rate of the drive amplifier can be modified by varying value of
component such as impedance, capacity or inductor.
The third isolator (410) matches impedance between the drive amplifier (408)
and the output controller (412).
The output controller (412) controls an intensity of signal generated form the
drive amplifier. The output controller (412) is coupled with the RF output controller
(302) and can control the output signal level of the drive amplifier according to the
control signal provided by the RF output control unit (302).
As above described, according to one embodiment of the present invention, the
RF output control unit (302) is to extract a portion of output signals at the RF output
unit (300), determine a power of the RF signal transmitted to tumor or body fat, and
control level of the RF signal, wherein a control signal for controlling the output level is
input into the output controller (412).
According to the preferred embodiment of the present invention, the output
controller is to control level of the output signal using PIN diode attenuator. PIN diode
has substantially pure intrinsic resistance component in band of super high frequency
that varies depending on an electric current. Thus, when PIN diode attenuator
constitutes the output controller (412), the control signal is input as a type of electric
current and an intrinsic resistance component varies according to current flow to control an intensity of the RF signal. But, in this case, because a component of the intrinsic
resistance varies according to an amount of a control current flow to change the
impedance at input and output terminal, a degree of reflection at input or output
terminal is not consistent. Such a problem can be solved by way of matching by the
third isolator (410).
The fourth isolator (414) functions as matching impedance between the ouput
controller (412) and the output amplifier (416).
The output amplifier (416) functions as amplifying a signal generated form the
output controller (412). It can be used as an individual type of MESFET, MOSFET, and
GaAsFET transister or an integrated type of power OP amp like the drive amplifier
(408).
To expand a linear range of power, the output amplifier is preferably constituted
with two-stage. The output amplifier needs the matching circuit of input and output to
amplify the RF signal as a predetermined amplifying rate. A matching point is
determined by using Smith chart. In case of impedance within a matching point,
amplification can be executed as a predetermined amplifying rate. A double reactance
matching circuit is preferably used than a single reactance matching circuit.
The coupler/detector (420) is to extract a portion of signals generated from an
output amplifier, transform it to a direct current voltage signal and provide it to the RF
output controller. The coupler extracts a portion of signals generated form the output amplifier
and the ratio of the extracted signal is determined by the coupling coefficient. For
example, when 3dB coupler is used, 50% of the output signal can be extracted by the
coupler. According to the preferred embodiment of the present invention, the coupler is
embodied to a microstrip parallel coupling line. Alternatively, according to the preferred
embodiment of the present invention, the available coupler for super high frequency can
be used additionally.
The detector transforms a signal extracted from the coupler into a direct current
voltage signal and provides it to the RF output control unit (302). The detector includes
a diode and a capacitor to transform the RF signal, an alternating current signal to a
direct current voltage signal. The diode transforms the alternating current signal which
positive value and negative value are intersected, to a signal that has only positive value.
The capacitor transforms a signal of sine wave type to a direct signal of flat form.
According to the preferred embodiment of the present invention, the diode uses short
key diode. The detector is preferably designed in considering of a characteristic
modification depending on temperature.
The sixth isolator (422) functions as matching impedance between the
coupler/detector (42) and the output switch (424).
In a certain case, the output switch (424) blocks a signal generated from the
output amplifier (416). In dangerous situation due to the misoperation of a manufacturer, it drives the output switch (424) and blocks the output power. The output switch (424)
can be a generally used as a mechanical coaxial switch like the input switch, and an
electrically RF signal blocking switch.
The seventh isolator (426) matches impedance between the output switch (424)
and the output terminal (428).
The output terminal (428) is a terminal that the RF transmission cable (102) is
coupled with. SMA(Sub-Miniature A) connector which the input loss and standing
wave ratio is small can be used for the output terminal (428). The signal generated from
the output terminal (428) is transmitted to the infiltrative electrode (108) through the RF
transmission cable (102) to eventually propagate to tumor or fat cell.
Fig 5 shows a block drawing of a detailed structure of the RF output control
unit according to the preferred embodiment of the present invention.
As shown in Fig. 5, the RF output control unit according to the preferred
embodiment of the present invention includes a output comparator comprising a
differential amplifier (500), a logarithmic amplifier (506), a linear amplifier (508), a
comparator (510), a reference voltage producer (512) and the inverse amplifier (514),
and a control signal producer (504).
The differential amplifier (500) amplifies the signal detected from a
coupler/detector because an intensity of the signal is comparatively weak since a signal
generated from the coupler/detector is to detect a portion of the output signal. It is preferable to use the differential amplifier having high input impedance
because high input impedance is need to transform the detected RF signal. It is apparent
to one skilled in the art that the video amplifier for broadband can be used as a
differential amplifier. A high input impedance buffer can be equipped at a front terminal
of the differential amplifier when a differential amplifier having high input impedance is
unavailable.
The output comparator (502) receives a signal generated from the differential
amplifier (500), compares the RF signal generated from the RF output unit each other
and determines whether it reach a level or amount of power predetermined by a user.
Therefore, it functions as correcting of error or controlling of output.
As shown in Fig 5, the output comparator includes a logarithmic amplifier
(506), a linear amplifier (508), a comparator (510), a reference voltage producer (512),
and a reverse amplifier (514).
The level of the output signal generated from the RF output unit varies with
characteristics and sizes of tumor or body fat. The RF output control unit (302) should
process different levels of the output signals, but an element that can process an output
signal having large deviation is rare. Therefore, the preferred embodiment of the present
invention may transform a signal generated from the coupler/detector (420) to a log
scale signal by using the logarithmic amplifier (506).
The linear amplifier (508) transforms a log scale signal transformed at logarithmic amplifier (506) to a linear scale signal and amplifies it. Since the
logarithmic amplifier (506) transforms a signal generated from the coupler/detector
(420) to a log scale signal, a signal generated from the logarithmic amplifier (506) is not
in linear scale but small. Thus, the present invention transforms a output signal
generated from the logarithmic amplifier (506) to a linear scale signal and amplifies it
by using the linear amplifier (508) for easy control.
The reference voltage producer (512) generates the first reference voltage for a
maximum RF power generated from the RF output unit, and the second reference
voltage for comparing an integrating RF power.
According to the preferred embodiment of the present invention, two reference
voltage producers are equipped, where the first reference voltage producer generates the
first reference voltage for the maximum power and the second reference voltage
producer generates the second reference voltage for comparing the integrating power.
According to another embodiment of the present invention, a reference voltage
producer can provide the first reference voltage for the maximum power and the second
reference voltage for comparing the integrating power according to a determined time
interval in an alternative way through a switch or in a respective way.
The comparator (508) functions for comparing the first reference voltage for a
maximum power generated from the reference voltage producer (512) with a voltage
signal generated from the linear amplifier (508), and for comparing the second reference voltage for an added power generated from the reference voltage producer (512) with a
value acquired by integrating a signal generated from the linear amplifier (508).
Fig. 6a shows a structure of a comparator according to one embodiment
according to the present invention.
As shown in Fig. 6a, according to one embodiment of the present invention, in
the comparator (602) consisting an OP amp, an instantaneous voltage signal of a linear
amplifier (508) depending on the RF output power, and a voltage integrated through a
integrator (600) are switched by two switches (604, 606) and they are input to the
comparator input component.
The reference voltage producer (512) switches the first reference voltage and
the second reference voltage, and inputs it to the reference input component of the
comparator (602). When the first reference voltage is input, the switch (604) is shut off
and the instantaneous voltage of the linear amplifier (508) is input to the comparator
(602). When the second reference voltage is input, the second switch (606) is shut ott
and a output signal of the integrator (600) is input to the comparator (602). It is apparent
to one skilled in the art that the comparator can be a transistor consisting of an
individual component or an integrated OP amp.
Fig 6b shows a structure of the comparator according to another embodiment of
the present invention.
Fig 6a shows a structure that an OP amp and a reference voltage producer compare an instantaneous voltage with an integrating voltage by switching, and Fig 6b
shows a structure that two OP amps and two reference voltage producers are used
simultaneously.
As shown in Fig 6b, an instantaneous voltage generated from the linear
amplifier (608) is input to the first comparator (608) consisting of the OP amp. The first
comparator (608) compares the output signal of the linear amplifier (508) with the
reference voltage generated from the first reference voltage producer (610).
The integrating voltage generated by the integrator (600) and the output voltage
generated by the second reference voltage producer are input to the second comparator
(612). The second comparator (612) generates the output signal when the integration
voltage of the integrator is larger than that of the second reference voltage producer. The
integration voltage of the integrator generating to the second comparator refers to the
total integrating power of a power generated through the output terminal (428). Thus,
the output voltage of the second reference producer is set for determination by mapping
with a time set through a timer by a user.
That is, when a power over the maximum power and/or the integrating power
predetermined by a user according to a size and a characteristic of tumor and fat cell is
generated from the RF output unit. Alternatively, when the generating RF signal is
excessively large due to mechanical disorder, the comparator (510) generates the output
signal. The inverse amplifier (514) reconstructs the log scale signal transformed by the
logarithmic amplifier (506) into an original signal. The logarithmic amplifier (506) and
the inverse amplifier (514) are components for easy control, and thus they need not be
equipped when the deviation of RF output signal is not large.
The control signal producer (506) functions as transforming the output voltage
of the inverse amplifier (514) to an electric current and providing a control signal to the
output controller (412). A size of the RF signal generated from the RF output unit is
controlled according to the output signal of the output comparator (502). As above
described, in this case the output controller (412) controls a size of the RF signal. The
output controller (412) is embodied to a PIN diode and the PIN diode controls a size of
the RF signal when an intrinsic impedance changes by current amount. Thus, the control
signal producer (504) transforms a voltage signal of the inverse amplifier (514) to
current.
The RF output control unit as shown in Fig 5 controls RF output by feedback a
signal generated from the RF output unit. This is only one preferred embodiment and
according to other methods the RF output can be controlled. Also, this modification of
output control method falls within the scope of the present invention.
Fig 7a is a block diagram showing a structure of the bio information process
unit according to the preferred embodiment of the present invention.
As shown in Fig 7b, the bio information process unit according to the preferred embodiment of the present invention includes a impedance measurement unit (700), a
blood flow measurement unit (702), and a characteristic information decision unit (704).
The impedance measurement unit (700) functions as measuring impedance of
tumor or body fat to be removed. The impedance can be measured by determining a
voltage of tumor or fat cell when applying test current to tumor or fat to be removed.
The blood flow measurement unit (702) functions as measuring a blood flow of
tumor or fat to be removed. The blood flow can be determined by measuring a charge
amount and a phase. Thus, the blood flow measurement unit (702) can measure a blood
flow by integrating a current signal at tumor or fat through test current or voltage or by
phase control loop.
The characteristic information decision unit (704) can determine a state of
tumor or fat by receiving information provided from the impedance measurement unit
(700) or the blood flow measurement unit (702) and using the previously stored
mapping table. The characteristic information decision unit (704) provides information
whether mmor or fat is removed according to the results of measuring impedance or
blood flow as well as characteristic information of tumor or fat.
The bio information decision unit as shown in Fig 7a describes a method for a
diagnosis of a bio information through blood flow and impedance and other electric
diagnosis parameter can be used by one skilled in the art.
As shown in Fig 7a, the bio information decision unit determines a bio information through a blood flow and an impedance. However, it is apparent to one
skilled in the art that other electric diagnostic parameter can be used.
Fig 7b is a Figure showing an example for determining a bio information by
applying a test voltage or a test current to an infiltrative electrode.
As shown in Fig 7, many electrode (712) for measurement are inserted to the
interior of the infiltrative electrode (710) for measuring a bio information such as a
blood flow and impedance, wherein a diameter of the electrode is smaller than that of
the infiltrative electrode.
When the infiltrative electrode (710) is infiltrated to internal body to locate
internal tumor, test current is applied to the infiltrative electrode (710). At this time, if
voltage between the infiltrative electrode (710) and electrode for a measurement (712)
is measured, information about impedance of tumor can be calculated.
Fig 8a is a figure showing a longitudinal cross-sectional view of the RF
electrode according to the preferred embodiment of the present invention. Fig 8b is a
Figure showing a transverse cross-sectional view of the RF electrode according to the
preferred embodiment of the present invention.
As shown in Fig 8a and Fig 8b, the RF electrode according to one preferred
embodiment of the present invention can include a internal conductor (800), an external
conductor (804) and an external dielectric.
While the RF signal totally reflects between the internal conductor (800) and the external conductor (804), it propagates through the internal conductor (802). The
external conductor (804) functions as a ground and the RF signal does not propagate
outside of the RF transmission cable due to the external conductor (804).
Fig 9 is a pattern of the RF signal when the infiltrative electrode is used
according to the preferred embodiment of the present invention.
As shown in Fig 9, the external conductor (804) does not extend at the end of
the infiltrative electrode. The RF signal can radiate outward through the end which the
external conductor (804) does not extend, namely, a slot of part of coupling the internal
dielectric (802) with the external dielectric (806). The radiation depth of the RF signal
varies depending on a characteristic of tumor or fat and power and frequency of the RF
signal. Thus, once a characteristic information and depth of tumor or fat is determined, a
pertinent frequency and power should be set so that the RF signal can reach the end of
tumor. Thus, the RF signal having a power and frequency to induce thermal motion
should radiate so that an atom or a molecule in tumor or fat cell can thermally move to
according to the RF signal.
Fig 10a is a longitudinal cross-sectional view of a internal structure of the RF
pad according to the preferred embodiment of the present invention and FiglOb is a
transverse cross-sectional view of a internal structure of the RF pad according to the
preferred embodiment of the present invention.
As shown in Fig 10a, the RF pad may include an external dielectric (1000), a ground conductor (1002), and an internal conductor (1004).
As shown in Fig 10b, the internal conductor (1004) may include a plurality of
antenna electrodes (1006) and a reference conductor (1008) electrically coupling the
plurality of antenna electrodes. The respective antenna electrode (1006) operates as
dipole antenna to propagate the RF signal to the body.
Fig 10b shows a configuration that a general dipole antenna electrode is
equipped within the pad. Still, it is apparent to one skilled in the art that other types of
antenna electrode can be equipped.
Fig 10c is a transverse cross-sectional view showing an internal structure of the
RF pad according to another embodiment of the present invention.
As shown in Fig 10c, there are two reference conductors (1010, 1012) that are
positioned to upper and lower and are associated with the antenna electrodes (1014). As
shown in Fig 10c, when the antenna electrodes (1014) are arranged in a high density,
the RF signal can radiate to a human body in a high density of power.
Fig 11 is a Figure showing the radiation pattern at the RF pad according to the
preferred embodiment of the present invention.
As shown in Fig 11, a ground conductor (1100) is positioned to an exterior of
the RF pad. The RF signal cannot be radiated to an outside of the ground conductor but
it can be radiated to internal body. Because an antenna electrode (1102) is a type of
dipole antenna, the RF signal radiates circularly in center of the respective antenna electrode. The RF pad is generally used in eliminating body fat. The RF signal radiated
to body induces a thermal motion of fat cell, which can melt. The melted body fat is
discharged to outside of body.
Although the present invention has been described with the preferred
embodiment, the spirit and the scope of the present invention will be determined only
by the following claims. Also, it will be apparent for those skilled in the art that
modifications or amendments to the aforementioned embodiment within the spirit and
the scope of the present invention are possible without departing from the boundary of
the claimed invention
Industrial applicability
The apparatus for treating tumor and obesity according to the present invention
can simply eliminate tumor or fat cell without surgical operation.
Also, the apparatus for treating tumor and obesity according to the present
invention can eliminate tumor comparatively safely through thermal motion generated
by a high frequency signal instead of the direct transmission of heat or surgical
operation.
In addition, the apparatus for treatmg tumor and obesity according to the
present invention cost low expensive because the apparatus according to the present
invention does not need a cooling water that is required for the conventional apparatus.

Claims

Claims
l.An apparatus for treating tumor and obesity using a high frequency, comprising:
a RF output device for generating a high frequency RF signal to induce a
thermal motion of tumor or fat cells;
a RF transmission cable which is associated with the RF output device for
transmitting the high frequency RF signal generated from the RF output device; and
a RF electrode which is associated with the RF transmission cable for
radiating the high frequency RF signal generated from the RF transmission cable to
internal tumor or fat cell,
wherein said RF output device includes a bio information decision unit for
applying test currents and test voltages to the internal tumor or fat cells to determine a
state of tumor of fat cells.
2. The apparatus as described in the Claim 1, wherein the RF output device further
comprises;
a RF output unit for amplifying and generating a RF signal to induce a
thermal motion of tumor and fat cells;
a RF output control unit for determining a size of the RF signal generated
by extracting a portion of the RF signal generated from the RF output unit, and
controlling a size of the RF signal; and an user interface unit for receiving information such as a size, a frequency,
output time, a mode of the RF signal from a user.
3. The device as described in the Claim 2, wherein the RF output unit comprises;
a signal producer for generating a RF signal corresponding to a predetermined
frequency;
a drive amplifier for amplifying an output signal at the signal producer;
an output controller for controlling a signal generated from the drive amplifier
according to a control signal generated from the RF output control unit;
an output amplifier for amplifying a signal generated from the output
controller according to a characteristic information of tumor and fat cell to be removed;
a coupler/detector for extracting a portion of the signal generated from the
output amplifier, transforming it to voltage and providing it to the RF output control
unit; and
an output terminal which is associated with the RF transmission cable for
transmitting the signal generated from the output amplifier to the RF transmission cable.
4. The apparatus as described in Claim 2, wherein the RF output control unit
comprises;
an amplifier for amplifying an output signal at the coupler/detector; an output comparator for detecting whether the RF signal exceed a
predetermined voltage by a signal generated from the differential amplifier; and
a control signal producer for providing a control signal to control output of the
RF output unit according to the signal generated from the output comparator
5. The apparatus as described in Claim 3, wherein the drive amplifier and the output
amplifier comprises at least one of an individual type of MESFET, MOSFET, and
GaAsFET transister and an integrated type of power OP amp.
6. The apparatus as described in Claim 3, wherein the output controller comprises a
PIN diode which a intrinsic resistance changes according to current.
7. The apparatus as described in Claim 4, wherein the output comparator comprises;
a logarithmic amplifier for transforming the output signal at the differential
amplifier to a log scale signal;
a linear amplifier for amplifying the output signal at the logarithmic
amplifier;
a reference voltage producer for generating the first reference voltage to
detect an instantaneous maximum voltage of the RF signal generated from the RF
output unit, and the second reference voltage to compare a integrating voltage of the RF signal generated from the RF output unit;
a comparator for comparing the output signal at the linear amplifier with
the first reference voltage, and comparing the second reference voltage with value
acquired by integrating the output signal at the linear amplifier; and
an inverse amplifier for reconstructing the log scale signal transformed by
the logarithmic amplifier into an original signal.
8. The apparatus as described in Claim 7, wherein the comparator compares a size
and an amount of output by mapping values acquired by integrating the first reference
voltage and the output signal at the linear amplifier, and the second reference voltage
and the output signal at the linear amplifier in a perdetermined time interval according
to switch operation.
9. The apparatus as described in Claim 7, the comparator comprises;
a first comparator for comparing the first reference voltage with the output
signal at the linear amplifier; and
a second comparator for comparing the second reference voltage with value
acquired by integrating the output signal at the linear amplifier.
10. The apparatus as described in Claim 4 or 7, the control signal producer comprises the voltage/current transformer for transforming the output voltage at the
inverse amplifier to a current signal.
11. The apparatus as described in Claim 1, wherein the bio information decision
unit comprises;
an impedance measurement unit for measuring an impedance of tumor or
fat cell to be removed using a response to the test voltage or the test current;
a blood flow measurement unit for measuring a blood flow of tumor or fat
cell to be removed using a response to the test voltage or the test current; and
a characteristic information decision unit for determining a characteristic
information of tumor or fat cell to be removed by matching the output information of
the impedance measurement unit and the blood flow measurement unit with a
predetermined mapping table.
12. The apparatus as described in Claim 1, wherein the RF electrode comprises a
handle and an infiltrative electrode for radiating the RF signal to tumor or fat cell to be
removed by infiltrating body.
13. The apparatus as described in Claim 12, wherein the infiltrative electrode
comprises an internal conductor, an external conductor, an internal dielectric equipped between the internal conductor and the external conductor, and an external dielectric
surrounding an outside of the external conductor.
14. The apparatus as described in Claim 1, wherein the RF electrode is a RF pad for
radiating the RF signal to an internal body with an adhesion to an exterior of a body.
15. The apparatus as described in Claim 14, wherein the RF pad comprises;
a ground conductor for blocking a radiation of the RF signal to other directions
excepting for a body; a reference conductor and an internal conductor comprising a
plurality of an antenna electrode radiating the RF signal internal to an internal body
which is electrically associated with a reference conductor.
16. The apparatus as described in Claim 13, wherein the infiltrative electrode
further comprises a ultrasonic sensor for providing route information for the infiltrative
electrode to infiltrate a tumor.
17. The apparatus as described in Claim 16, wherein the infiltrative electrode is
surface-treated with a material in order to control a reflection coefficient and to be
detected by a ultrasonic sensor.
18. The apparatus as described in Claim 17, wherein the material for surface-
treating the infiltrative electrode is Teflon.
PCT/KR2002/001378 2002-06-08 2002-07-23 Device for treating tumor and fat using microwave WO2003103768A1 (en)

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Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
KR10-2002-0032207A KR100508112B1 (en) 2002-06-08 2002-06-08 Device for Treating Tumor and Fat Using Microwave
KR2002/32207 2002-06-08

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AU (1) AU2002328566A1 (en)
WO (1) WO2003103768A1 (en)

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