WO2003095617A3 - A method and apparatus for providing signal analysis of a bionems resonator or transducer - Google Patents

A method and apparatus for providing signal analysis of a bionems resonator or transducer Download PDF

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Publication number
WO2003095617A3
WO2003095617A3 PCT/US2003/014286 US0314286W WO03095617A3 WO 2003095617 A3 WO2003095617 A3 WO 2003095617A3 US 0314286 W US0314286 W US 0314286W WO 03095617 A3 WO03095617 A3 WO 03095617A3
Authority
WO
WIPO (PCT)
Prior art keywords
signal
transducer
receptor
free ligand
bionems
Prior art date
Application number
PCT/US2003/014286
Other languages
French (fr)
Other versions
WO2003095617A2 (en
Inventor
Michael L Roukes
Scott E Fraser
Jerry E Solomon
Original Assignee
California Inst Of Techn
Michael L Roukes
Scott E Fraser
Jerry E Solomon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn, Michael L Roukes, Scott E Fraser, Jerry E Solomon filed Critical California Inst Of Techn
Priority to US10/502,466 priority Critical patent/US7330795B2/en
Priority to AU2003249610A priority patent/AU2003249610A1/en
Publication of WO2003095617A2 publication Critical patent/WO2003095617A2/en
Priority to US10/826,007 priority patent/US7302856B2/en
Publication of WO2003095617A3 publication Critical patent/WO2003095617A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Abstract

An outputs signal, v(t), is generated from a bioNEMs transducer and mixed with a reference signal and then filtered to generate a correlator output, r(t). The correlator output is detected to generate a signal u(t) and then determined whether the signal u(t) satisfies a predetermined threshold. If qualified, it is then decided whether the signal u(t) represents a predetermined type of interaction between a free ligand in a fluid in which the NEMS device is immersed and a receptor attached to the transducer. The threshold is the Neyman-Pearson criterion based on a predetermined probability of false detection, Pfa. The interaction may be binding of a free ligand to the receptor or releasing a bound ligand from the receptor by competitive binding with the free ligand. The step of detecting comprises detecting the envelope of the signal, r(t).
PCT/US2003/014286 2002-05-07 2003-05-07 A method and apparatus for providing signal analysis of a bionems resonator or transducer WO2003095617A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/502,466 US7330795B2 (en) 2002-05-07 2003-05-07 Method and apparatus for providing signal analysis of a BioNEMS resonator or transducer
AU2003249610A AU2003249610A1 (en) 2002-05-07 2003-05-07 A method and apparatus for providing signal analysis of a bionems resonator or transducer
US10/826,007 US7302856B2 (en) 2003-05-07 2004-04-16 Strain sensors based on nanowire piezoresistor wires and arrays

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US37950702P 2002-05-07 2002-05-07
US37955502P 2002-05-07 2002-05-07
US37971202P 2002-05-07 2002-05-07
US37961802P 2002-05-07 2002-05-07
US60/379,555 2002-05-07
US60/379,712 2002-05-07
US60/379,507 2002-05-07
US60/379,618 2002-05-07

Related Child Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2003/014284 Continuation-In-Part WO2003095616A2 (en) 2000-08-09 2003-05-07 Dynamics bionems sensors and arrays of bionems sensor immersed in fluids
US10/826,007 Continuation-In-Part US7302856B2 (en) 2003-05-07 2004-04-16 Strain sensors based on nanowire piezoresistor wires and arrays

Publications (2)

Publication Number Publication Date
WO2003095617A2 WO2003095617A2 (en) 2003-11-20
WO2003095617A3 true WO2003095617A3 (en) 2004-04-29

Family

ID=29424757

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/014286 WO2003095617A2 (en) 2002-05-07 2003-05-07 A method and apparatus for providing signal analysis of a bionems resonator or transducer

Country Status (3)

Country Link
US (1) US7330795B2 (en)
AU (1) AU2003249610A1 (en)
WO (1) WO2003095617A2 (en)

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US7375321B2 (en) * 2000-08-09 2008-05-20 California Institute Of Technology Dynamics bionems sensors and arrays of bionems sensor immersed in fluids
US7302856B2 (en) 2003-05-07 2007-12-04 California Institute Of Technology Strain sensors based on nanowire piezoresistor wires and arrays
US7434476B2 (en) 2003-05-07 2008-10-14 Califronia Institute Of Technology Metallic thin film piezoresistive transduction in micromechanical and nanomechanical devices and its application in self-sensing SPM probes
US7552645B2 (en) 2003-05-07 2009-06-30 California Institute Of Technology Detection of resonator motion using piezoresistive signal downmixing
US6763705B1 (en) * 2003-06-16 2004-07-20 Ut-Battelle, Llc High throughput microcantilever detector
WO2006073426A2 (en) 2004-04-20 2006-07-13 California Institute Of Technology Microscale calorimeters
WO2005117554A2 (en) 2004-06-01 2005-12-15 California Institute Of Technology Microfabricated neural probes and methods of making same
US20060058027A1 (en) * 2004-09-14 2006-03-16 Motorola, Inc. Method and apparatus for carrier frequency estimation and correction for GPS
WO2007016113A2 (en) 2005-07-27 2007-02-08 Wisconsin Alumni Research Foundation Nanoelectromechanical and microelectromechanical sensors and analyzers
US7884324B2 (en) 2007-06-03 2011-02-08 Wisconsin Alumni Research Foundation Nanopillar arrays for electron emission
EP2053400A1 (en) * 2007-10-22 2009-04-29 Consejo Superior De Investigaciones Cientificas Method and system for detection of a selected type of molecules in a sample
KR20090090929A (en) * 2008-02-22 2009-08-26 삼성전자주식회사 Multi-port correlator and receiver using thereof
US9442021B2 (en) * 2008-08-05 2016-09-13 California Institute Of Technology Uncooled IR detector arrays based on nanoelectromechanical systems
US8347729B2 (en) * 2009-11-12 2013-01-08 International Business Machines Corporation Piezoresistive strain sensor based nanowire mechanical oscillator
US9605307B2 (en) 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
DE102011053684B4 (en) 2010-09-17 2019-03-28 Wisconsin Alumni Research Foundation Method for carrying out jet impact activated dissociation in the already existing ion injection path of a mass spectrometer
US8587539B2 (en) * 2011-01-21 2013-11-19 Blackberry Limited Multi-bend display activation adaptation
US9581563B2 (en) 2011-01-24 2017-02-28 Genia Technologies, Inc. System for communicating information from an array of sensors
US8507845B2 (en) 2011-06-02 2013-08-13 Wisconsin Alumni Research Foundation Membrane detector for time-of-flight mass spectrometry
EP2754176A4 (en) 2011-09-08 2015-04-15 Univ California Sensor for law force-noise detection in liquids
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
US9347815B2 (en) 2012-05-09 2016-05-24 California Institute Of Technology Single-protein nanomechanical mass spectrometry in real time
WO2014130095A2 (en) 2013-02-22 2014-08-28 California Institute Of Technology Shape analysis and mass spectrometry of individual molecules by nanomechanical systems
US9551697B2 (en) 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
EP3248210A1 (en) 2015-01-23 2017-11-29 California Institute of Technology Integrated hybrid nems mass spectrometry
US11289319B2 (en) 2019-08-06 2022-03-29 Thermo Fisher Scientific (Bremen) Gmbh System to analyze particles, and particularly the mass of particles

Citations (5)

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US4847193A (en) * 1987-06-18 1989-07-11 Gene-Trak Systems Signal amplification in an assay employing a piezoelectric oscillator
US6118124A (en) * 1996-01-18 2000-09-12 Lockheed Martin Energy Research Corporation Electromagnetic and nuclear radiation detector using micromechanical sensors
US20030033876A1 (en) * 2001-05-04 2003-02-20 Roukes Michael L. Apparatus and method for ultrasensitive nanoelectromechanical mass detection
US20030043925A1 (en) * 2001-05-29 2003-03-06 Tioga Technologies, Ltd. Method and system for detecting, timing, and correcting impulse noise
US20030137216A1 (en) * 2000-04-20 2003-07-24 Tamayo De Miguel Javier Resonant probe driving arrangement and a scanning probe microscope including such an arrangement

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US4695817A (en) * 1985-06-26 1987-09-22 Kulite Semiconductor Products, Inc. Environmentally protected pressure transducers employing two electrically interconnected transducer arrays
JPH0529879A (en) * 1991-07-22 1993-02-05 Toshiba Corp Afc circuit in radio communication equipment
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847193A (en) * 1987-06-18 1989-07-11 Gene-Trak Systems Signal amplification in an assay employing a piezoelectric oscillator
US6118124A (en) * 1996-01-18 2000-09-12 Lockheed Martin Energy Research Corporation Electromagnetic and nuclear radiation detector using micromechanical sensors
US20030137216A1 (en) * 2000-04-20 2003-07-24 Tamayo De Miguel Javier Resonant probe driving arrangement and a scanning probe microscope including such an arrangement
US20030033876A1 (en) * 2001-05-04 2003-02-20 Roukes Michael L. Apparatus and method for ultrasensitive nanoelectromechanical mass detection
US20030043925A1 (en) * 2001-05-29 2003-03-06 Tioga Technologies, Ltd. Method and system for detecting, timing, and correcting impulse noise

Also Published As

Publication number Publication date
AU2003249610A8 (en) 2003-11-11
WO2003095617A2 (en) 2003-11-20
US7330795B2 (en) 2008-02-12
US20060155478A1 (en) 2006-07-13
AU2003249610A1 (en) 2003-11-11

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