WO2003092621A3 - Composition and method for dermatological treatment - Google Patents

Composition and method for dermatological treatment Download PDF

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Publication number
WO2003092621A3
WO2003092621A3 PCT/US2003/013830 US0313830W WO03092621A3 WO 2003092621 A3 WO2003092621 A3 WO 2003092621A3 US 0313830 W US0313830 W US 0313830W WO 03092621 A3 WO03092621 A3 WO 03092621A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
retinoid
dermatological treatment
antibiotic
formulation
Prior art date
Application number
PCT/US2003/013830
Other languages
French (fr)
Other versions
WO2003092621A2 (en
Inventor
Pravin M Patel
Original Assignee
Ferndale Lab Inc
Pravin M Patel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferndale Lab Inc, Pravin M Patel filed Critical Ferndale Lab Inc
Priority to AU2003232044A priority Critical patent/AU2003232044A1/en
Publication of WO2003092621A2 publication Critical patent/WO2003092621A2/en
Publication of WO2003092621A3 publication Critical patent/WO2003092621A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Abstract

A topical composition for the treatment of acne and other dermatological conditions comprises a liposonal formulation of a retinoid and an antibiotic in which the retinoid is disposed in the lipid phase of the formulation, and the antibiotic is disposed in the aqueous phase. Lincosamides, such as clindamycin, are one group of antibiotics which may be used in the composition. Tretinoin is one preferred retinoid. Also disclosed are methods for making the compositions and methods for using the composition.
PCT/US2003/013830 2002-04-30 2003-04-30 Composition and method for dermatological treatment WO2003092621A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003232044A AU2003232044A1 (en) 2002-04-30 2003-04-30 Composition and method for dermatological treatment

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37700202P 2002-04-30 2002-04-30
US60/377,002 2002-04-30
US10/425,359 US20030215493A1 (en) 2002-04-30 2003-04-29 Composition and method for dermatological treatment
US10/425,359 2003-04-29

Publications (2)

Publication Number Publication Date
WO2003092621A2 WO2003092621A2 (en) 2003-11-13
WO2003092621A3 true WO2003092621A3 (en) 2004-07-29

Family

ID=29406778

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/013830 WO2003092621A2 (en) 2002-04-30 2003-04-30 Composition and method for dermatological treatment

Country Status (3)

Country Link
US (2) US20030215493A1 (en)
AU (1) AU2003232044A1 (en)
WO (1) WO2003092621A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060189552A1 (en) * 2000-12-12 2006-08-24 Mohan Vishnupad Dispenser for dispensing three or more actives
US7060732B2 (en) * 2000-12-12 2006-06-13 Imaginative Research Associates, Inc. Antibiotic/benzoyl peroxide dispenser
US20060014834A1 (en) * 2004-05-11 2006-01-19 Mohan Vishnupad Retinoid solutions and formulations made therefrom
US7662855B2 (en) * 2004-05-11 2010-02-16 Imaginative Research Associates, Inc. Retinoid solutions and formulations made therefrom
KR20070091613A (en) * 2004-11-08 2007-09-11 그렌마크 파머수티칼스 엘티디. Topical pharmaceutical compositions containing an antiacne compound and antibiotic compound
JP2008519764A (en) * 2004-11-09 2008-06-12 イマジナティブ リサーチ アソシエィツ インコーポレーテッド Retinoid solutions and formulations made from them
US20060222712A1 (en) * 2005-02-17 2006-10-05 Connetics Corporation Acne gel
AR054805A1 (en) * 2005-06-29 2007-07-18 Stiefel Laboratories TOPICAL COMPOSITIONS FOR SKIN TREATMENT
GB2431380A (en) * 2005-10-18 2007-04-25 Ultra Electronics Ltd A buoy having fixed hydrodynamic surfaces
US9107844B2 (en) * 2006-02-03 2015-08-18 Stiefel Laboratories Inc. Topical skin treating compositions
CA2645073A1 (en) * 2006-03-08 2007-09-13 Nuviance, Inc. Transdermal drug delivery compositions and topical compositions for application on the skin
PL2206494T3 (en) 2006-03-31 2016-06-30 Stiefel Res Australia Pty Ltd Foamable suspension gel
EP1967180A1 (en) * 2007-03-06 2008-09-10 Almirall Hermal GmbH Topical composition comprising a retinoid receptor agonist
US20080287373A1 (en) * 2007-05-17 2008-11-20 Popp Karl F Topical skin treating kits
WO2010090654A1 (en) * 2009-02-05 2010-08-12 Tdt, Ltd. Methods of reducing the proliferation and viability of microbial agents
CN101912363A (en) * 2010-07-29 2010-12-15 蔡海德 Dissolving ultrafiltration-spray drying-molecule dispersion coating-hydration palletizing-freeze drying method for preparing liposome combination medicine
CN103275143B (en) * 2013-06-05 2016-06-08 天津大学 The new crystal �� of Clindamycin Phosphate and preparation method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034228A (en) * 1985-12-11 1991-07-23 Moet-Hennessy Recherche Pharmaceutical composition, in particular dermatological or cosmetic, comprising hydrous lipidic lamellar phases or liposomes containing a retinoid or a structural analogue thereof such as a carotenoid
US5409917A (en) * 1991-03-05 1995-04-25 Marvin S. Towsend Topical treatment of acne with cephalosporins

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3969516A (en) * 1974-12-19 1976-07-13 Nelson Research & Development Company Composition and method for treatment of acne
US4336200A (en) * 1980-01-31 1982-06-22 The Upjohn Company 17α-Acyloxy-5β-corticoids
US4761288A (en) * 1984-09-24 1988-08-02 Mezei Associates Limited Multiphase liposomal drug delivery system
IL90069A (en) * 1988-04-26 1994-04-12 Us Health 13-cis- retinoic acid for use in the preparation of a medicament for treating conglobate and nodulocystic acne
SK279919B6 (en) * 1993-07-01 1999-05-07 Yamanouchi Europe B.V. Pharmaceutical and cosmetic agent for topical skin application
FR2714602B1 (en) * 1993-12-30 1996-02-09 Oreal Anti-acne composition for the simultaneous treatment of the superficial and deep layers of the skin, its use.
FR2716110B1 (en) * 1994-02-16 1996-04-05 Roussel Uclaf Cosmetic or pharmaceutical compositions comprising liposomes.
ES2208946T3 (en) * 1996-08-23 2004-06-16 Sequus Pharmaceuticals, Inc. LIPOSOMES CONTAINING A CISPLATIN COMPOUND.
US5962517A (en) * 1997-01-31 1999-10-05 Murad; Howard Pharmaceutical compositions and methods for treating acne

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034228A (en) * 1985-12-11 1991-07-23 Moet-Hennessy Recherche Pharmaceutical composition, in particular dermatological or cosmetic, comprising hydrous lipidic lamellar phases or liposomes containing a retinoid or a structural analogue thereof such as a carotenoid
US5409917A (en) * 1991-03-05 1995-04-25 Marvin S. Towsend Topical treatment of acne with cephalosporins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZOUBOULIS C.: "A multicentre, single-blind, randomized comparison of a fixed clindamycin phosphate/tretinoin gel formulation (Velac) applied once daily and a clindamycin lotion formulatio (Dalacin T) applied twice daily in the topical treatment of acne vulgaris", BRITISH J. OF DERMATOLOGY, vol. 143, 2000, pages 498 - 505, XP002977035 *

Also Published As

Publication number Publication date
AU2003232044A1 (en) 2003-11-17
WO2003092621A2 (en) 2003-11-13
US20030215493A1 (en) 2003-11-20
US20090148511A1 (en) 2009-06-11
AU2003232044A8 (en) 2003-11-17

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