WO2003086419A1 - Antibiotic/benzoyl peroxide dispenser - Google Patents
Antibiotic/benzoyl peroxide dispenser Download PDFInfo
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- WO2003086419A1 WO2003086419A1 PCT/US2003/011363 US0311363W WO03086419A1 WO 2003086419 A1 WO2003086419 A1 WO 2003086419A1 US 0311363 W US0311363 W US 0311363W WO 03086419 A1 WO03086419 A1 WO 03086419A1
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- retinoid
- benzoyl peroxide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/35—Ketones, e.g. benzophenone
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- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
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- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Definitions
- compositions and apparatus for dispensing two distinct substances. More specifically, this disclosure relates to compositions and apparatus which allow long-term storage and subsequent dispensing of two compositions, to wit, a first composition containing a first active ingredient for treating acne and a second composition containing a second active ingredient that is incompatible with the first active ingredient.
- Background of Related Art Acne is a common inflammatory disease of human skin, and concentrates in skin areas where sebaceous glands are largest, most numerous, and most active. In its milder types, it is a more or less superficial disorder which is evidenced by slight, spotty irritations and ordinary skin hygiene is a satisfactory treatment.
- Antibacterial soaps have been used as well as bactericidal agents such as sulfur and resorcinol.
- Other topical compositions have separately contained benzoyl peroxide, hexachlorophene, erythromycin or neomycin sulfate. None of these prior preparations has been completely effective. .
- a mixture on the skin of a peroxide especially benzoyl peroxide and an antibiotic or antibacterial such as clindamycin, neomycin, sodium sulfacetamide, sulfur, tetracycline or erythromycin is particularly beneficial as they can exert a statistically significant synergistic effect.
- Peroxides inhibit the formation of free fatty acids in the skin, primarily through inactivation of extracellular lipase (via oxidation) necessary to cleave triglycerides into free fatty acids and glycerol.
- the antibiotic or antibacterial component reduces the concentration of Corynebacterium acnes (i.e., P. acnes), a normal anaerobic bacteria which is the prime source of the lipase.
- Corynebacterium acnes i.e., P. acnes
- peroxides such as stabilized hydrogen peroxide and peroxides of organic acids, such as a lauroyl peroxide, may be used.
- erythromycin and benzoyl peroxide may be applied to the skin in combination in a preformulated aqueous-alcoholic gel.
- a mixture is first made up and then applied to the skin, it is best that the mixture be made at the time of application or that the mixture be used within twenty- four hours.
- the prompt use of a premix is necessary due to the chemical incompatibility of the two active agents. Because of this, it is advisable that the two agents be put in separate vials, bottles or other containers.
- the Klein et al. patent discloses a kit containing, separately bottled liquid compositions comprising 5% benzoyl
- a dispensing and applicator system intended to overcome these difficulties is disclosed in U.S. Patent No. 5,562,642.
- a dual-pad package is disclosed therein that purportedly can contain, preserve and deliver single unit, doses of two or more chemically- or physically-incompatible active ingredients.
- an antibiotic in combination with a liquid, semi-liquid (cream) or gelled aqueous or non-aqueous vehicle can be absorbed by and retained by the first pad and a second ingredient which is physically- or chemically-incompatible with the antibiotic, such as a peroxide, can be absorbed and retained by the second pad, preferably in combination with the appropriate vehicle.
- a second ingredient which is physically- or chemically-incompatible with the antibiotic such as a peroxide
- a dual dispenser and has two chambers and a pump means for removing first and second compositions from the chambers through one or more outlets.
- the first chamber contains a first composition that includes a first active ingredient that is effective in treating acne; and the second chamber contains a second composition containing a second active ingredient that is incompatible with the first active ingredient.
- both the first and second active ingredients are effective against acne.
- the first active ingredient is an antibiotic and the second active ingredient is benzoyl peroxide.
- the first active ingredient is an antibiotic and the second active ingredient is a retinoid .
- the first active ingredient is benzoyl peroxide and the second active ingredient is a retinoid .
- a dual dispenser contains i) a first composition that is substantially anhydrous and includes a polar solvent, an antibiotic and a thickening agent selected from the group consisting of acrylic acid polymers and polyacrylamides; and i ⁇ ) a second composition containing benzoyl peroxide.
- a dual dispenser contains i) a first composition that is substantially anhydrous and includes a polar solvent, an antibiotic and a thickening agent selected from the group consisting of acrylic acid polymers and polyacrylamides; and ii) a second composition that is substantially anhydrous, and includes a polar solvent, a retinoid, and a thickening agent selected from the group consisting of acrylic acid polymers and polyacrylamides.
- the first and second compositions have viscosities that differ by no greater than 25%.
- FIG. 1 is an schematic view of a container suitable for dispensing the first and second compositions in accordance with this disclosure. Detailed Description of Preferred Embodiments
- the dual dispensers described herein include a first chamber containing a first composition, a second chamber containing a second composition and pump means for simultaneously dispensing the first and second compositions.
- the first and second compositions can be any cream, lotion, gel emulsion or suspension that is of an appropriate consistency to be pumped out of the chambers by pump means.
- the first and second compositions can thus have a viscosity greater than about 1000 centipoise (cps) when measured using a Brookfield viscometer (model LNT) at room temperature using spindle number 3 or 4 at 0.3 to 30 rpm. It should be understood that all viscosities referred to herein are measured in this manner.
- the first and second compositions have a viscosity greater than 5,000 cps.
- the compositions have a viscosity in the range of from about 1000 to about two
- the first and second compositions have a viscosity in the range of about 10,000 cps to about 1,000,000 cps.
- the first and second compositions advantageously have viscosities that
- the first composition contains a first active ingredient effective in treating acne.
- the first composition can be substantially anhydrous or aqueous.
- the first composition should be formulated to provide stability for the first active ingredient. If the first active ingredient is susceptible to deterioration from contact with water, then the first composition should be substantially anhydrous.
- substantially anhydrous it is meant that, other than water of hydration contained in the various components used to formulate the composition, no free water is added to the composition.
- the water content of the composition will be less than 5% by weight.
- the water content of the composition is less than 3% and most preferably less than about 1% by weight of the composition.
- aqueous formulations are acceptable for the first composition, including solutions, suspensions and water-in-oil emulsions.
- One class of active ingredients known to be effective in treating acne is antibiotics.
- the antibiotic is one currently known to be useful in treating acne, such as, for example, erythromycin, tetracyclin, clindamycin, their derivatives or pharmaceutically acceptable salts.
- the antibiotic is present in the first composition in an effective acne-treating amount, preferably an amount from about 0.001 wt. % to about 5 wt. %, more preferably about 0.1 wt. % to about 1.0 wt. %.
- the first composition is substantially anhydrous and contains a polar solvent, a thickening agent and an antibiotic.
- Polar solvents useful in this embodiment of the first composition include polyols.
- a polyol is a compound with at least two hydroxyl groups per molecule, i.e., a compound having multiple hydroxyl groups as part of its molecular structure.
- the useful polyols are polyhydric alcohols.
- Propylene glycol, dipropylene glycol, polyethylene glycol and glycerine are particularly preferred polar solvents for use in the first composition.
- the thickening agent used in this embodiment of the first composition is selected from the group consisting of acrylic acid polymers and polyacrylamides.
- the thickemng agent are used in an amount sufficient to obtain a composition of viscosity in the desired range.
- Useful acrylic acid polymers include copolymers of (meth)acrylic acid and of monomers containing at least one fatty chain; these monomers are chosen from hydrophobic monomers with a fatty chain, amphiphilic monomers containing a hydrophobic part with a fatty chain and a hydrophilic part, or alternatively their mixtures.
- Suitable materials include, for example, copolymers of C ⁇ o- 3 o alkyl acrylates with one or more monomers of acrylic acid, methacrylic acid, or one of their short chain (i.e., C 1 alcohol) esters, wherein the crosslinking agent is an allyl ether of sucrose or pentaerythritol.
- copolymers are commonly referred to as acrylates/C 10-30 alkyl acrylate crosspolymers and are commercially available under the tradename CARBOPOL® from B.F. Goodrich, Cleveland, Ohio U.S.A.
- Other polymers useful in the preparation of the present compositions are polymers of polyacrylic acid crosslinked with from about 0.75% to about 2.0% of polyalkyl sucrose or polyalkyl pentaerythritol often with molecular weights of 4 to 5 million or more that are commercially available, for example, under the trade designation CARBOPOL® 934, 940 and 941 from B.F. Goodrich, Cleveland, Ohio U.S.A.
- Anionic amphiphilic polymers which comprise 95% to 60% by weight of acrylic recurring structural units, 4% to 40% by weight of acrylate recurring structural units and 0.1% to 6% by
- crosslinking monomer or (ii) which comprise 98% to 96% by weight of acrylic recurring structural units, 1% to 4% by weight of acrylate recurring structural units and 0.1%) to 0.6% by weight of crosslinking monomer are also useful as the thickening agent in the present compositions.
- Such polymers include, for example, those hydrophobically-modified cross-linked polymers of acrylic acid having amphipathic properties marketed by B.F. Goodrich under the trademarks CARBOPOL® 1342 and CARBOPOL® 1382. Also useful is ULTREZ® 10 (available from B. F.
- an oil in water emulsion of a modified acrylic copolymer comprising of a major portion of a monoolefinically unsaturated carboxylic acid monomer or its anhydride having a length of from about 3 to 6 carbon atoms and a minor portion of a C 8 - 3 o chain acrylate or methacrylate ester monomer wherein the carboxylic acid or its anhydride is from about 80 to about 99% by weight and the C 8 . 3o chain acrylate or methacrylate ester monomer is from about 1% to about 20% by weight.
- the polymer is described in U.S. Pat. No. 5,004,598, hereby incorporated by reference in its entirety. When used, these acrylic acid polymers are present in the first composition at a level from about 0.05% to about 20%, preferably from about 0.5% to 10% and most preferably from about 1% to about 10%.
- the first composition can alternatively contain polyacrylamide polymers as the thickening agent, especially nonionic polyacrylamide polymers.
- polyacrylamide polymers are branched or unbranched polyacrylamides and substituted polyacrylamides. These polymers are non-ionic polymers which can be formed from a variety of monomers including acrylamide and methacrylamide which are unsubstituted or substituted with one or two alkyl groups (preferably .5). Preferred acrylate
- amides and methacrylate amides in which the amide nitrogen is unsubstituted, or substituted with one or two C 1 - 5 alkyl groups (preferably: methyl, ethyl or propyl), for example, acrylamide, methacrylamide, N-methylacrylamide, N-methylmethacrylamide, N,N-dimethylmethacrylamide, N-isopropylacrylamide, N-isopropylmethacrylamide and N,N-dimethylacrylamide.
- C 1 - 5 alkyl groups preferably: methyl, ethyl or propyl
- acrylamide, methacrylamide, N-methylacrylamide, N-methylmethacrylamide, N,N-dimethylmethacrylamide, N-isopropylacrylamide, N-isopropylmethacrylamide and N,N-dimethylacrylamide These monomers are generally disclosed in U.S. Pat. No. 4,963,348 which is incorporated by reference herein in its entirety.
- non-ionic copolymers may have a molecular weight greater than about 1,000,000 preferably greater than about 1,500,000 and range up to about 30,000,000.
- Most preferred among these polyacrylamide polymers is the nonionic polymer given the CTFA designation polyacrylamide and isoparaffin and laureth-7, available under the tradename SEPIGEL® 305 from Seppic Corporation (Fairfield, N. J.).
- Other polyacrylamide polymers useful herein include ulti -block copolymers of acrylamides and substituted acrylamides with acrylic acids and substituted acrylic acids.
- Commercially available examples of these multi-block copolymers include Hypan SR150H, SS500V, SS500W, SSSA100H, from Lipo Chemicals*, Inc., (Patterson, N.J.).
- these non-ionic polyacrylamides are present in the first composition at a level from about 0.05% to about 20%, preferably from about 0.5% to 10% and most preferably from about 1% to about 10%.
- the thickening agents need not be dispersed in an aqueous medium or neutralized to provide the desired thickening.
- Benzoyl peroxide is another active ingredient known to be an effective anti-acne treatment that can be incorporated into the first composition.
- the first composition can be either substantially anhydrous or may contain water and can be any benzoyl peroxide-containing cream, lotion, gel or suspension.
- benzoyl peroxide compositions that are suitable for use in accordance with this disclosure include, but are not limited to the compositions disclosed in U.S. Patent No. 5,632,996, the disclosure of which is incorporated herein by reference.
- the benzoyl peroxide composition is also substantially anhydrous.
- compositions containing a) a polar solvent, b) a thickening agent selected from the group consisting of acrylic acid polymers, polyacrylamides and combinations thereof (as described above), c) benzoyl peroxide, d) alkyl benzoate and, optionally e) a synthetic cleanser.
- Suitable synthetic cleansers include, but are not limited to sodium cocoyl isethionate, alpha olefin sulfonate sarcosynates and acyl glutamates.
- the amount of benzoyl peroxide in the composition can be from about 0.1 to about 20 percent by weight based on the total weight of the composition, preferably from about 1.0 to about 15 weight percent, most preferably from about 1.5 to about 10 weight percent.
- the benzoyl peroxide-containing composition can have a viscosity greater than about 1000 centipoise (cps) when measured using a Brookfield viscometer (model LVT) at room temperature using spindle number 3 or 4 at 0.3 to 30 rpm.
- the benzoyl peroxide- containing composition has a viscosity greater than 5,000 cps.
- the benzoyl peroxide-containing composition has a viscosity in the range of from
- the benzoyl peroxide-containing composition has a viscosity in the range of about 10,000 cps to about 1,000,000 cps.
- the first composition contains a retinoid.
- Suitable retinoids include, for example, retinol, retinoic acid, retinyl palmitate, retinyl propionate or retinyl acetate as well as synthetic retinoid mimics.
- the retinoid is preferably present in the second composition in an amount from about 0.001 wt. % to about 5 wt. %, more preferably about 0.1 wt. % to about 2.0 wt. %.
- the retinoid-containing compositions are also substantially anhydrous and contains a polar solvent, a thickening agent and a retinoid. Suitable polar solvents and thickening agents for the second composition are the same as described above for the antibiotic and benzoyl peroxide compositions described above.
- the retinoid-containing composition can have a viscosity greater than about 1000 centipoise (cps) when measured using a Brookfield viscometer (model LNT) at room temperature using spindle number 3 or 4 at 0.3 to 30 rpm.
- the retinoid-containing composition has a viscosity greater than 5,000 cps.
- the second, retinoid- containing composition has a viscosity in the range of from about 1000 to about two million centipoise. Most preferably, the second, retinoid-containing composition has a viscosity in the range of about 10,000 cps to about 1,000,000 cps.
- the second composition contains a second active ingredient that is incompatible with the
- the second active ingredient may be effective in treating acne or may
- alpha-hydroxy acids or anti-irritants The second composition can be substantially identical to alpha-hydroxy acids or anti-irritants.
- the second composition can be substantially identical to alpha-hydroxy acids or anti-irritants.
- the second composition can be substantially identical to alpha-hydroxy acids or anti-irritants.
- the second composition is formulated to provide stability for the second
- the second active ingredient is susceptible to deterioration from contact with
- the second composition should be substantially anhydrous.
- aqueous formulations are acceptable for the second composition, including solutions, suspensions and water-in-oil emulsions.
- Combinations of first and second active ingredients for use in the first and second compositions include but are mot limited to: a) anibiotic in the first composition and benzoyl peroxide in the second composition; b) antibiotic in the first composition and a retinoid in the second composition; and c) benzoyl peroxide in the first composition and a retinoid in the second composition.
- the first and second compositions preferably have viscosities that are similar to provide a
- the difference in viscosity between the first and second compositions is no more than about 25%.
- compositions may also contain a variety of non-essential ingredients such as, for example, co-
- solvents preservatives, emollients, humectants, anti-inflammatory agents, antioxidants, insect
- either of the first or second composition may contain one or more co-solvents, such as ethanol, acetone or propylene carbonate.
- a preservative can also be used in either or both of the first or second compositions.
- Preservatives suitable for use in connection with the present compositions include parabens, sorbates, benzyl alcohol, diazolidinyl urea and isothiazolinones.
- Preservatives can be present in an amount from about 0,001 wt. % to about 15 wt. % of the total composition.
- One or both of the first or second compositions can also be formulated to contain about 0.01 wt. % to about 30 wt. %, preferably about 1.0 wt. % to about 15 wt. % of the total composition, skin cooling compounds, such as menthol, methyl glycerol, asymmetrical carbonates, thiocarbonates and urethanes, substituted carboxamides, ureas or phosphine oxides as described in J. Cosmet. Chem., vol. 29, page 185 (1978) and incorporated herein by reference, methyl lactate and menthone glycerin acetal.
- skin cooling compounds such as menthol, methyl glycerol, asymmetrical carbonates, thiocarbonates and urethanes, substituted carboxamides, ureas or phosphine oxides as described in J. Cosmet. Chem., vol. 29, page 185 (1978) and incorporated herein by reference, methyl lac
- the first substantially and second compositions are stored in and dispensed from a multi- chamber dispenser.
- Dispensing systems that include pump means suited for simultaneously dosing two separately contained incompatible compounds are well known.
- the dispensing system schematically depicted in FIG. 1 (dispenser from Maplast, Tradate, Italy) is just one example out of a number of products which range from small, two-chambered single use pouches to tubes using different product compartments or tubes compartmentalized using extrudable, viscous and relatively inert materials to separate the incompatible compounds.
- the dispenser shown in FIG. 1 is able to simultaneously dose two compounds separately contained in A and B by pressing dosing head C.
- Pressing dosing head C activates two small pumps which subsequently dispense the two compounds in approximately equal volumes.
- the compounds can be dosed in two separate streams or in just one stream. If desired, a dispensing unit that is able to deliver The first and
- second substantially anhydrous compositions in a ratio such as, for example, 1 :2 can be used.
- Translated to a two-chambered single use pouch this would mean that the chamber containing the first substantially anhydrous composition contains at least half as much product volume as the other chamber.
- Translated to a two-compartment tube this would mean that under equal pressure the discharge orifice for the compartment containing the first substantially anhydrous composition allows the passage of at least twice as much product as the discharge orifice of the other compartment.
- Translated to a tube which is compartmentalized using extrudable material this would mean that first substantially anhydrous composition is present inside the tube in at least double the volume of the second substantially anhydrous composition.
- compositions suitable for use as the first composition I ⁇ IS erythromycin 2 2 - propylene glycol 96 71.5 96.0
- benzoyl peroxide-containing formulations are suitable for use as the second composition to be dispensed simultaneously with any of the anhydrous
- Lucidol 75% (Benzoyl Peroxide) 15.80 Ci 2 .i 5 Alkyl Benzoate 7.00 Triethanolamine 0.60
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Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2481754A CA2481754C (en) | 2002-04-12 | 2003-04-14 | Antibiotic/benzoyl peroxide dispenser |
AU2003226363A AU2003226363A1 (en) | 2002-04-12 | 2003-04-14 | Antibiotic/benzoyl peroxide dispenser |
EP03746745A EP1503769A4 (en) | 2002-04-12 | 2003-04-14 | Antibiotic/benzoyl peroxide dispenser |
JP2003583438A JP2005529636A (en) | 2002-04-12 | 2003-04-14 | Antibiotic / benzoyl peroxide dispenser |
MXPA04009941A MXPA04009941A (en) | 2002-04-12 | 2003-04-14 | Antibiotic/benzoyl peroxide dispenser. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/121,839 | 2002-04-12 | ||
US10/121,839 US7060732B2 (en) | 2000-12-12 | 2002-04-12 | Antibiotic/benzoyl peroxide dispenser |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003086419A1 true WO2003086419A1 (en) | 2003-10-23 |
Family
ID=29248309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/011363 WO2003086419A1 (en) | 2002-04-12 | 2003-04-14 | Antibiotic/benzoyl peroxide dispenser |
Country Status (7)
Country | Link |
---|---|
US (3) | US7060732B2 (en) |
EP (1) | EP1503769A4 (en) |
JP (1) | JP2005529636A (en) |
AU (1) | AU2003226363A1 (en) |
CA (1) | CA2481754C (en) |
MX (1) | MXPA04009941A (en) |
WO (1) | WO2003086419A1 (en) |
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US20020193321A1 (en) * | 2000-12-12 | 2002-12-19 | Mohan Vishnupad | Dual dispenser for aesthitically acceptable delivery of anhydrous skin treatment compositions |
US6399092B1 (en) * | 2000-12-27 | 2002-06-04 | Healthpoint, Ltd. | Anhydrous, hydrophilic absorbent wound dressing (tube) with antimicrobials or other pharmaceutically active agents |
US6899890B2 (en) * | 2002-03-20 | 2005-05-31 | Kv Pharmaceutical Company | Bioadhesive drug delivery system |
US20030215493A1 (en) * | 2002-04-30 | 2003-11-20 | Patel Pravin M. | Composition and method for dermatological treatment |
US20050255131A1 (en) * | 2004-05-11 | 2005-11-17 | Mohan Vishnupad | Clindamycin compositions and delivery system therefor |
-
2002
- 2002-04-12 US US10/121,839 patent/US7060732B2/en not_active Expired - Fee Related
-
2003
- 2003-04-14 EP EP03746745A patent/EP1503769A4/en not_active Withdrawn
- 2003-04-14 JP JP2003583438A patent/JP2005529636A/en active Pending
- 2003-04-14 AU AU2003226363A patent/AU2003226363A1/en not_active Abandoned
- 2003-04-14 CA CA2481754A patent/CA2481754C/en not_active Expired - Fee Related
- 2003-04-14 MX MXPA04009941A patent/MXPA04009941A/en active IP Right Grant
- 2003-04-14 WO PCT/US2003/011363 patent/WO2003086419A1/en active Application Filing
-
2006
- 2006-03-31 US US11/395,505 patent/US20060173076A1/en not_active Abandoned
- 2006-03-31 US US11/395,802 patent/US20060172955A1/en not_active Abandoned
Patent Citations (1)
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US4497794A (en) * | 1980-12-08 | 1985-02-05 | Dermik Laboratories, Inc. | Erythromycin/benzoyl peroxide composition for the treatment of acne |
Non-Patent Citations (1)
Title |
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See also references of EP1503769A4 * |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003099295A1 (en) | 2002-05-20 | 2003-12-04 | Imaginative Research Associates, Inc. | Dual dispenser for aesthetically acceptable delivery of anhydrous skin treatment compositions |
EP1505988A1 (en) * | 2002-05-20 | 2005-02-16 | Imaginative Research Associates, Inc. | Dual dispenser for aesthetically acceptable delivery of anhydrous skin treatment compositions |
EP1505988A4 (en) * | 2002-05-20 | 2007-11-07 | Imaginative Res Associates Inc | Dual dispenser for aesthetically acceptable delivery of anhydrous skin treatment compositions |
JP2008519764A (en) * | 2004-11-09 | 2008-06-12 | イマジナティブ リサーチ アソシエィツ インコーポレーテッド | Retinoid solutions and formulations made from them |
US9868103B2 (en) | 2005-08-02 | 2018-01-16 | Sol-Gel Technologies Ltd. | Metal oxide coating of water insoluble ingredients |
EP1813277A1 (en) * | 2006-01-25 | 2007-08-01 | Imaginative Research Associates, Inc. | Dispenser for dispensing two or more substances |
US8617580B2 (en) | 2007-02-01 | 2013-12-31 | Sol-Gel Technologies Ltd. | Compositions for topical application comprising a peroxide and retinoid |
US20110262506A1 (en) * | 2009-01-05 | 2011-10-27 | Sol-Gel Technologies Ltd. | Topical compositions containing coated active agents |
US9687465B2 (en) | 2012-11-27 | 2017-06-27 | Sol-Gel Technologies Ltd. | Compositions for the treatment of rosacea |
Also Published As
Publication number | Publication date |
---|---|
US7060732B2 (en) | 2006-06-13 |
US20060173076A1 (en) | 2006-08-03 |
US20030004118A1 (en) | 2003-01-02 |
AU2003226363A1 (en) | 2003-10-27 |
CA2481754C (en) | 2011-01-04 |
EP1503769A4 (en) | 2009-07-15 |
MXPA04009941A (en) | 2004-12-13 |
EP1503769A1 (en) | 2005-02-09 |
US20060172955A1 (en) | 2006-08-03 |
JP2005529636A (en) | 2005-10-06 |
CA2481754A1 (en) | 2003-10-23 |
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