WO2003083434A3 - Characterization of moving objects in a stationary background - Google Patents

Characterization of moving objects in a stationary background Download PDF

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Publication number
WO2003083434A3
WO2003083434A3 PCT/IL2003/000275 IL0300275W WO03083434A3 WO 2003083434 A3 WO2003083434 A3 WO 2003083434A3 IL 0300275 W IL0300275 W IL 0300275W WO 03083434 A3 WO03083434 A3 WO 03083434A3
Authority
WO
WIPO (PCT)
Prior art keywords
moving objects
chromophores
attached
stationary
objects
Prior art date
Application number
PCT/IL2003/000275
Other languages
French (fr)
Other versions
WO2003083434A2 (en
Inventor
Amiram Grinvald
Darin Nelson
Ivo Vanzetta
Original Assignee
Yeda Res & Dev
Amiram Grinvald
Darin Nelson
Ivo Vanzetta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28675581&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003083434(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yeda Res & Dev, Amiram Grinvald, Darin Nelson, Ivo Vanzetta filed Critical Yeda Res & Dev
Priority to AU2003227315A priority Critical patent/AU2003227315A1/en
Priority to AT03745392T priority patent/ATE517573T1/en
Priority to JP2003580824A priority patent/JP4615865B2/en
Priority to IL16436203A priority patent/IL164362A0/en
Priority to EP03745392A priority patent/EP1494579B1/en
Priority to DK03745392.5T priority patent/DK1494579T3/en
Publication of WO2003083434A2 publication Critical patent/WO2003083434A2/en
Publication of WO2003083434A3 publication Critical patent/WO2003083434A3/en
Priority to US10/954,014 priority patent/US7912534B2/en
Priority to HK05105950.2A priority patent/HK1074375A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14555—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for the eye fundus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • A61B3/1241—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter

Abstract

A method and system for determination and mapping the quantity of chromophores having a distinct spectrum attached to moving objects in an spectrally rich environment that may include multiple chromophores attached to stationary objects. An area of interest is imaged at different times and different wavelengths, and the spectral properties of one or more chromophores attached to the moving objects are separated from the stationary spectral properties of the background, followed by spectral analysis of the moving objects to determine their quantity. Application to the retinal vasculature is illustrated, showing the imaging, analyzing and quantifying of the oxygen saturation of retinal blood, resolved for the different vascular compartments - capillaries, arterioles, venules, arteries, and veins. Changes in the structure of the vascular environment are also determined, whether growth of new vessels or the elimination of existing ones, by the generation of path maps based on analysis of differential images taken at a single wavelength of the moving components in the blood flow.49
PCT/IL2003/000275 2002-04-02 2003-04-02 Characterization of moving objects in a stationary background WO2003083434A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2003227315A AU2003227315A1 (en) 2002-04-02 2003-04-02 Characterization of moving objects in a stationary background
AT03745392T ATE517573T1 (en) 2002-04-02 2003-04-02 CHARACTERIZATION OF MOVING OBJECTS IN A STATIONARY BACKGROUND
JP2003580824A JP4615865B2 (en) 2002-04-02 2003-04-02 Characterization of moving substances in a stationary background
IL16436203A IL164362A0 (en) 2002-04-02 2003-04-02 Characterization of moving objects in a stationarybackground
EP03745392A EP1494579B1 (en) 2002-04-02 2003-04-02 Characterization of moving objects in a stationary background
DK03745392.5T DK1494579T3 (en) 2002-04-02 2003-04-02 Characterization of moving objects in a stationary background
US10/954,014 US7912534B2 (en) 2002-04-02 2004-09-29 Characterization of moving objects in a stationary background
HK05105950.2A HK1074375A1 (en) 2002-04-02 2005-07-12 Characterization of moving objects in a stationary background

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36965802P 2002-04-02 2002-04-02
US60/369,658 2002-04-02

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/954,014 Continuation US7912534B2 (en) 2002-04-02 2004-09-29 Characterization of moving objects in a stationary background

Publications (2)

Publication Number Publication Date
WO2003083434A2 WO2003083434A2 (en) 2003-10-09
WO2003083434A3 true WO2003083434A3 (en) 2004-03-18

Family

ID=28675581

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2003/000275 WO2003083434A2 (en) 2002-04-02 2003-04-02 Characterization of moving objects in a stationary background

Country Status (10)

Country Link
US (1) US7912534B2 (en)
EP (1) EP1494579B1 (en)
JP (1) JP4615865B2 (en)
CN (1) CN100571611C (en)
AT (1) ATE517573T1 (en)
AU (1) AU2003227315A1 (en)
DK (1) DK1494579T3 (en)
HK (1) HK1074375A1 (en)
IL (1) IL164362A0 (en)
WO (1) WO2003083434A2 (en)

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Also Published As

Publication number Publication date
AU2003227315A8 (en) 2003-10-13
JP2005521499A (en) 2005-07-21
DK1494579T3 (en) 2011-11-14
AU2003227315A1 (en) 2003-10-13
JP4615865B2 (en) 2011-01-19
EP1494579B1 (en) 2011-07-27
EP1494579A2 (en) 2005-01-12
WO2003083434A2 (en) 2003-10-09
US7912534B2 (en) 2011-03-22
US20050131284A1 (en) 2005-06-16
ATE517573T1 (en) 2011-08-15
CN1658788A (en) 2005-08-24
CN100571611C (en) 2009-12-23
HK1074375A1 (en) 2005-11-11
IL164362A0 (en) 2005-12-18

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