WO2003028535A2 - Apparatus and method for the repair of articular cartilage defects - Google Patents
Apparatus and method for the repair of articular cartilage defects Download PDFInfo
- Publication number
- WO2003028535A2 WO2003028535A2 PCT/US2002/031142 US0231142W WO03028535A2 WO 2003028535 A2 WO2003028535 A2 WO 2003028535A2 US 0231142 W US0231142 W US 0231142W WO 03028535 A2 WO03028535 A2 WO 03028535A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- leg
- encapsulation device
- bone
- accordance
- extending
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2/4618—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof of cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
- A61B17/0642—Surgical staples, i.e. penetrating the tissue for bones, e.g. for osteosynthesis or connecting tendon to bone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
- A61F2/30749—Fixation appliances for connecting prostheses to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
- A61B17/1635—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans for grafts, harvesting or transplants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
- A61B17/1655—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans for tapping
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0417—T-fasteners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
- A61B2017/0641—Surgical staples, i.e. penetrating the tissue having at least three legs as part of one single body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
- A61B2017/0646—Surgical staples, i.e. penetrating the tissue for insertion into cartillege, e.g. meniscus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
- A61B2017/0647—Surgical staples, i.e. penetrating the tissue having one single leg, e.g. tacks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30159—Concave polygonal shapes
- A61F2002/30181—Y-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/302—Three-dimensional shapes toroidal, e.g. rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
- A61F2/30749—Fixation appliances for connecting prostheses to the body
- A61F2002/30751—Fixation appliances for connecting prostheses to the body for attaching cartilage scaffolds to underlying bone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
- A61F2002/30761—Support means for artificial cartilage, e.g. cartilage defect covering membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30772—Apertures or holes, e.g. of circular cross section
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
- A61F2002/30891—Plurality of protrusions
- A61F2002/30892—Plurality of protrusions parallel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30904—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves serrated profile, i.e. saw-toothed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
- A61F2002/4625—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use
- A61F2002/4627—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use with linear motion along or rotating motion about the instrument axis or the implantation direction, e.g. telescopic, along a guiding rod, screwing inside the instrument
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/006—Y-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0065—Three-dimensional shapes toroidal, e.g. ring-shaped, doughnut-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
Definitions
- This invention relates to surgical apparatus and methods in general, and more particularly to surgical apparatus and methods for the repair of articular cartilage defects.
- chondroplasty and shaving are principally concerned with removing offending portions of the articular cartilage (e.g., loose flaps, rough edges, etc.) so as to prevent the enlargement of an existing articular cartilage defect. While
- microfracture and abrasion arthroplasty have proven helpful in preventing the spread of an existing articular cartilage defect, they do not actually repair the defect or effect articular cartilage healing.
- the basic idea behind microfracture and abrasion arthroplasty is to violate the subchondral plate, thereby allowing blood (preferably including marrow cells) to fill the defect and initiate an injury 5 repair. This may be done in a variety of ways well known in the art, e.g., with a rasp to abrade the defect, a pick to pick away the area of the defect, a drill to microdrill the area of the defect, an RF probe (or otherwise) to heat and thereby disrupt the region
- L5 properties of the articular cartilage is certainly better than bare bone.
- a common problem with this technique is that the blood (and marrow) cells do not tend to stay seeded in the defect, since they are commonly wiped away by joint motion and/or other
- osteocondral grafting a plug of healthy articular cartilage and underlying bone is harvested from a donor site and transplanted to the defect site. While this technique has proven effective, it typically causes serious damage to the donor site. In addition, it can be difficult to find donor sites with the proper surface profiles, and it can be difficult to properly align the layers (i.e., cartilage and underlying bone) of the graft plug with the layers of the defect site.
- one object of the present invention is to provide improved apparatus for the repair of articular cartilage defects, wherein the apparatus can be used with microfracture and abrasion arthroplasty.
- Another object of the present invention is to provide an improved method for the repair of articular cartilage defects, wherein the method can be used with microfracture and abrasion arthroplasty.
- Another object of the present invention is to provide improved apparatus for the repair of articular cartilage defects, wherein the apparatus can be used with autologous cell transplantation.
- Still another object of the present invention is to provide an improved method for the repair of articular cartilage defects, wherein the method can be used with autologous cell transplantation.
- the present invention which, in one form of the invention, comprises an encapsulation device adapted to encapsulate loose-bodied cells (e.g., blood and marrow cells, pluripotent stem cells, autologous cartilage cells, etc.) so as to facilitate the repair of articular cartilage defects.
- the encapsulation device is preferably formed out of bioabsorbable or bioremodelable materials, such that the encapsulation device will only be present at the surgical site for a limited period of time following surgery.
- an encapsulation device for the repair of articular cartilage defects.
- the device comprises a body for disposition adjacent a bone in an area of the cartilage defect, and elongated leg structure extending from the body for disposition in the bone in the area of the cartilage defect.
- the leg structure is provided with a length which is a plurality of magnitudes greater than a thickness of the body, and is of a generally conical configuration.
- a system for effecting articular cartilage defect repair includes an encapsulation device comprising a body for disposition adjacent a bone in an area of the cartilage defect, and elongated leg structure extending from a distal surface of the body for disposition in the bone in the area of the cartilage defect, wherein the elongated leg structure comprises one or more legs.
- Each leg of the leg structure is provided with a central opening therein extending from a proximal surface of the body.
- a pilot hole device comprising a head portion, at least one elongated foot extending distally from the head portion, and a handle portion extending proximally from the head portion, the pilot hole device elongated foot being adapted to form a pilot hole in the bone to receive a leg member of the leg structure.
- An insertion tool is provided comprising a head portion, at least one elongated foot extending from a distal end of the head portion, each elongated foot of the insertion tool head portion being adapted to be received by the central opening of one of the encapsulation device legs.
- the insertion tool head portion is adapted to engage a proximal surface of the encapsulation device.
- the encapsulation device is adapted to be mounted on the insertion tool, and the insertion tool may be manipulated to drive the encapsulation device leg structure into at least one hole in the bone, to place the encapsulation device distal surface adjacent the bone and in the area of the cartilage defect.
- a tool for in-bone placement of an encapsulation device for repair of an articular cartilage defect comprising a body portion and a cannulated leg extending distally from a center of a distal surface of the body portion.
- the tool comprises a head portion having a distal surface configured generally complementary to a proximal surface of the encapsulation device, a handle portion extending proximally from the head portion, the head portion and handle portion forming a bore extending axially of the head portion and handle portion, and an insertion spike extending through the bore and adapted to extend through the encapsulation device leg, with a pointed distal end of the spike extending distally from a distal end of the encapsulation device leg.
- the insertion spike is adapted to form a hole in the bone and the tool in adapted to push the encapsulation device leg into the hole and the encapsulation device body into engagement with the bone.
- a method for effecting a repair to an articular cartilage defect includes the steps of providing an encapsulation device comprising a body for disposition adjacent a bone in an area of the cartilage defect, and an elongated leg structure extending from the body for disposition in the bone in the area of the cartilage defect, wherein the elongated leg structure comprises at least one leg, producing a hole in the bone for each leg of the encapsulation device leg structure, and driving each leg of the leg structure of the encapsulation device into a hole m the bone to bring a distal surface of the encapsulation device body into adjacency with the bone.
- Fig. 1 is a schematic view of an encapsulation device formed in accordance with the present invention
- Fig. 2 is a schematic view of an insertion tool for deploying an encapsulation device of the type shown in Fig. 1
- Fig. 3 is a sectional view showing the encapsulation device of Fig. 1 about to be engaged by the insertion tool of Fig. 2;
- Fig. 4 is a sectional view showing the encapsulation device of Fig. 1 engaged by the insertion tool of Fig. 2;
- Fig. 5 is a schematic view of an articular cartilage defect
- Fig. 6 is a schematic view of a pilot hole device for forming pilot holes in the articular cartilage defect shown in Fig. 5;
- Fig. 7 is a sectional view showing the pilot hole device of Fig. 6 approaching the articular cartilage defect
- Fig. 8 is a sectional view showing the pilot hole device of Fig. 6 engaged with the articular cartilage defect
- Fig. 9 is a sectional view showing the articular cartilage defect after it has had pilot holes formed therein;
- Fig. 10 is a sectional view showing the encapsulation device of Fig. 1 about to be deployed in the articular cartilage defect by the insertion tool of Fig. 2;
- Fig. 11 is a sectional view showing the insertion tool of Fig. 2 deploying the encapsulation device of Fig. 1 in the articular cartilage defect;
- Fig. 12 is a sectional view showing the encapsulation device of Fig. 1 deployed in the articular cartilage defect, with the insertion tool of Fig. 2 having been removed from the surgical site;
- Fig. 13 is a schematic view of an alternative form of encapsulation device formed in accordance with the present invention.
- Fig. 14 is a schematic view of another alternative form of encapsulation device formed in accordance with the present invention.
- Fig. 15 is a schematic view showing still another alternative form of encapsulation device formed in accordance with the present invention, wherein the encapsulation device is adapted to have a piece of harvested periosteum secured thereto;
- Fig. 15A is a schematic view like that of Fig. 15, except showing the piece of harvested periosteum being secured to the encapsulation device
- Fig. 15B is a schematic view like those of Figs. 15 and 15A, except showing the piece of harvested periosteum secured to the encapsulation device;
- Figs. 16A and 16B are perspective views of an alternative embodiment of the encapsulation device
- Fig. 16C is a top plan view of the device of Figs. 16A and 16B;
- Fig. 16D is a sectional view taken along line XVI - XVI of Fig. 16C; Figs. 17A-17D are views similar to those of Figs.
- Figs. 18A-18D are views similar to those of Figs. 17A-17D, respectively, but illustrative of a further alternative embodiment
- Figs. 19A-19D are views similar to those of Figs. 18A-18D, respectively, but illustrative of a still further alternative embodiment
- Figs. 20A-20D are views similar to those of Figs. 19A-19D, respectively, but illustrative of a still further alternative embodiment
- Figs. 21A-21D are views similar to those of Figs. 20A-20D, respectively, but illustrative of a still further alternative embodiment
- Fig. 22 is a sectional view of the encapsulation device of Fig. 21 shown in conjunction with an inserter tool;
- Figs. 22A, 22B, 23 and 24 are sectional views illustrating steps in the use of the inserter tool of Fig. 22 to set the encapsulation device of Fig. 21 into bone.
- Encapsulation device 5 formed in accordance with the present invention.
- Encapsulation device 5 generally comprises a body 10 including a cover 14, and having a distal surface 15 (Fig. 3) and a proximal surface 20.
- At least one elongated leg 25 extends distally from the distal surface 15.
- the at least one leg 25 is of a length which is a plurality of magnitudes greater than a thickness of the body 10, to provide for secure anchoring of the body.
- the at least one leg 25 is preferably of a slightly conical configuration to aid in insertion of the leg into a bone, as described hereinbelow.
- the distal end of the at least one leg 25 may be pointed, and/or the shaft of the at least one leg 25 may be provided with locking 5 ribs, barbs, or other protrusions, 26, so as to enhance fixation.
- An opening 30 is formed in the at least one leg 25 and extends through, and opens on, the body's proximal surface 20.
- Encapsulation device 5 may be formed out of a
- Encapsulation device 5 is intended to encapsulate loose-bodied cells (e.g., blood and marrow cells, pluripotent stem cells, autologous cartilage cells,
- loose-bodied cells e.g., blood and marrow cells, pluripotent stem cells, autologous cartilage cells,
- encapsulation device 5 is preferably formed out of bioabsorbable or bioremodelable materials, such that the encapsulation device will only be present at the surgical site for a
- Insertion tool 35 generally comprises a head 40, at least one elongated foot 45 extending distally from head 40, and a shaft 50 extending proximally from head 40.
- Head 40 preferably has a distal end profile generally matching the proximal end profile of the encapsulation device's body 10.
- the insertion tool's at least one foot 45 has a configuration which matches the encapsulation device's at least one opening 30, whereby the at least one foot 45 may be received within the at least one opening 30.
- insertion tool 35 preferably has a plurality of feet 45, with feet 45 matching legs 25 and holes 30 in number and configuration.
- encapsulation device 5 may be mounted to head 40 of insertion tool 35 by passing the insertion tool's feet 45 into the encapsulation device's openings 30. See Figs. 3 and 4. This may be done during manufacture or at the time of use.
- Shaft 50 permits the insertion tool to be gripped by the user and have its head 40, and hence the encapsulation device 5, directed to the surgical site.
- Encapsulation device 5 may be used as follows.
- an articular cartilage defect 55 is first prepared by microfracture or abrasion arthroplasty.
- pilot hole 10 device 60 having a construction generally similar to insertion tool 35 (e.g., a head 65, at least one elongated and conically shaped foot 70 and a shaft 75) is pushed against articular cartilage defect 55 (Figs. 7 and 8) so as to create one or more pilot holes L5 80 (Fig. 9) .
- pilot hole device 60 is constructed so as to form a pattern of pilot holes 80 which conforms to the pattern of the encapsulation device's at least one leg 25.
- encapsulation device 5 is mounted to insertion tool 35 (Fig. 4), if it has not already been mounted to insertion tool 35, and then shaft 50.
- insertion tool 35 is manipulated (Figs. 10 and 11) so as to implant encapsulation device 5 directly over the treated lesion, with the encapsulation device's at least one leg 25 deployed in the at least one pilot hole 80 (Fig. 12), and with the encapsulation device's body 10 encapsulating the treated lesion, thus encouraging coagulation at the treated lesion and superior adhesion of regenerating fibrocartilage/Hyaline cartilage cells. As the cartilage cells are regenerated, encapsulation device 5 will be absorbed or remodeled, until only cartilage cells remain at the site of the original defect.
- the pluripotent stem cells are harvested by aspirating bone marrow from various regions of the body (e.g., the femoral notch, the iliac crest, the spine, etc.) and then depositing the bone marrow on the lesion site either before, or concurrently with, deployment of encapsulation device 5.
- the harvested bone marrow may be filtered prior to seeding so as to produce a more potent slurry of pluripotent stem cells.
- Autologous Ceil Transplantation It is also possible to seed the articular cartilage defect 55 with autologous articular cartilage cells prior to seating encapsulation device 5 at the defect site, whereby the encapsulation device will encapsulate the autologous articular cartilage cells at the defect site until the encapsulation device is absorbed or remodeled.
- autologous articular cartilage cells are harvested, prepared outside the body (e.g., isolated and/or enhanced with growth factors and/or multiplied, etc.) and then deposited at the defect site, either before, or concurrently with, deployment of encapsulation device 5.
- encapsulation device 5A which comprises an alternative form of the invention.
- Encapsulation device 5A is similar to the encapsulation device 5 described above, except that body 10A includes a matrix or mesh 85A at one or more locations within the body 10A, rather than the aforementioned cover 14.
- One or more legs 25A extend from the body 10A.
- Forming a body 10A with a matrix or mesh 85A can be advantageous over a solid body 10, e.g., in the case of microfracture and abrasion arthroplasty, it can provide a superior flow of nutrients to the site and a superior flow of waste products away from the site; or in the case of microfracture and abrasion arthroplasty with pluripotent stem cells, it can permit a slurry of such cells to be placed on the encapsulation device prior to deploying the encapsulation device at the defect site; or in the case of autologous cell transplantation, it can permit a slurry of graft articular cartilage cells to be placed on the encapsulation device prior to deploying the encapsulation device at the defect site.
- encapsulation device 5B which comprises another alternative form of the invention.
- Encapsulation device 5B is similar to encapsulation device 5 described above, except that body 10B thereof includes a collagen scaffold 90B for promoting the growth of replacement cartilage across the defect site.
- encapsulation device 5C which comprises still another alternative form of the invention.
- Encapsulation device 5C is similar to the encapsulation device 5 described above, except that body IOC thereof comprises an empty frame 12C into which a mass of harvested periosteum 95 may be secured, e.g., with sutures 100 (Figs. 15A and 15B) .
- body portion 10D includes a cover 14D which comprises a shell-like structure, and is provided with a distal surface 15D and a proximal surface 20D, with solid (i.e., non-cannulated) legs 25D extending distally from the distal surface 15D.
- the legs 25D may be provided with enlarged distal end portions 32D for increased retention properties.
- the enlarged end portions 32D include a proximal end 34 having a larger diameter than the adjacent portion of the leg 25D.
- the distal end 36 of the end portions 32D may be pointed or rounded, but are of reduced diameter.
- encapsulation device 5D is deployed by an insertion tool (not shown) lacking the elongated feet of insertion tool 35.
- an insertion tool preferably includes means (not shown) for releasably holding the encapsulation device to the distal end of the insertion tool (e.g., a mechanical coupler, a vacuum coupler, etc.).
- encapsulation device 5E generally similar to device 5D, but in which the body 10E comprises an open frame 12E, without a cover portion 14D or other similar component.
- Figs. 18A-18D Illustrated in Figs. 18A-18D is a further alternative embodiment of encapsulation device, 5F, in which the body 10F includes a cover portion 14F comprising a shell 16 provided with a distal surface 15F and a proximal surface 20F.
- a single central leg 25F extends from the distal surface 15F and is provided with an enlarged end portion 32F.
- the proximal surface 20F is provided with reinforcing struts 105.
- a further alternative embodiment features an encapsulation device 5G similar in appearance to device 5F, but in which the body 10G includes a substantially open frame 12G supporting only the reinforcing struts 105 from which depends a single central leg 25G having the enlarged distal end portion 32G.
- Figs. 20A-20D is generally similar to the embodiment shown in Figs. 19A-19D, but with a cannulated leg portion 25H depending from the struts 105. As shown in the drawings, the leg 25H may be provided with an increased diameter relative to the leg 25G to accommodate a desired central passageway 110 therethrough.
- FIGs. 21A-21D there is shown an alternative embodiment of encapsulation device, 51, which is similar to the device 5F shown in Figs. 18A-18D, but in which the single depending leg 251 is provided with the axial passageway 110 therethrough.
- FIG. 22 there is shown one preferred manner in which the cannulated encapsulation devices 5H and/or 51 may be deployed, the device 51 being shown for illustrative purposes.
- An insertion tool 35A includes a head portion 40A and a shaft 50A.
- the head portion 40A is provided with a distal end surface 116 which is generally complementary in configuration to the encapsulation device proximal surface 201.
- the insertion tool 35A is provided with a bore 115 in which is disposed an insertion spike 120.
- the encapsulation device axial passageway 110 receives the insertion tool insertion spike 120.
- the tool 35A may then be used as a combination pilot hole device and insertion tool, by punching a hole 80 and, simultaneously, introducing the device 51 into the hole. More particularly, insertion spike 120 is mounted in the insertion tool so that the distal end of the insertion spike protrudes from the distal end of the insertion tool (Fig. 22A) , encapsulation device 51 is mounted to insertion tool 35A and insertion spike 120 (Fig. 22), and the assembly is advanced into the defect site (Fig. 22B) . Thereafter, the insertion spike 120 is withdrawn from the device 51 (Fig. 23), and the insertion tool 35A is withdrawn from the device
- the encapsulation device of the present invention is ideal for full thickness defects, but it also has a role for chondromalacia, cartilage fissures, partial thickness tears, and abrasions. These lesions have a high potential for progressing into full thickness defects.
- the encapsulation device of the present invention with any of the techniques described above, can be used as a temporary patch, creating a microenvironment to aid in healing and regeneration.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2462256A CA2462256C (en) | 2001-10-01 | 2002-10-01 | Apparatus and method for the repair of articular cartilage defects |
JP2003531880A JP4330991B2 (en) | 2001-10-01 | 2002-10-01 | Apparatus and method for repairing articular cartilage defects |
AU2002330168A AU2002330168B2 (en) | 2001-10-01 | 2002-10-01 | Apparatus and method for the repair of articular cartilage defects |
DE60230306T DE60230306D1 (en) | 2001-10-01 | 2002-10-01 | DEVICE FOR REPAIRING CORROSION DEPARTMENTS |
EP02766431A EP1437960B1 (en) | 2001-10-01 | 2002-10-01 | Apparatus for the repair of articular cartilage defects |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32629301P | 2001-10-01 | 2001-10-01 | |
US60/326,293 | 2001-10-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003028535A2 true WO2003028535A2 (en) | 2003-04-10 |
WO2003028535A3 WO2003028535A3 (en) | 2003-11-20 |
Family
ID=23271614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/031142 WO2003028535A2 (en) | 2001-10-01 | 2002-10-01 | Apparatus and method for the repair of articular cartilage defects |
Country Status (9)
Country | Link |
---|---|
US (2) | US6712822B2 (en) |
EP (1) | EP1437960B1 (en) |
JP (2) | JP4330991B2 (en) |
AT (1) | ATE416682T1 (en) |
AU (1) | AU2002330168B2 (en) |
CA (1) | CA2462256C (en) |
DE (1) | DE60230306D1 (en) |
ES (1) | ES2318040T3 (en) |
WO (1) | WO2003028535A2 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008061216A2 (en) * | 2006-11-18 | 2008-05-22 | Smith & Nephew, Inc. | Annular ring implant |
JP2008521560A (en) * | 2004-11-30 | 2008-06-26 | オステオバイオロジクス・インコーポレーテッド | Implant and its delivery system for treating joint surface defects |
WO2009064509A1 (en) * | 2007-11-16 | 2009-05-22 | Smith & Nephew, Inc. | Annular ring implant |
EP2221014A1 (en) * | 2009-02-23 | 2010-08-25 | Inion Oy | Implant, implantation tool and kit |
EP2233113A1 (en) * | 2007-12-21 | 2010-09-29 | Iwamoto, Yukihide | Device for cell transplantation |
US7811223B2 (en) | 2005-04-05 | 2010-10-12 | Ams Research Corporation | Articles, devices, and methods for pelvic surgery |
EP2233114A3 (en) * | 2009-03-27 | 2011-01-19 | DePuy Mitek, Inc. | Methods and devices for delivering and affixing tissue scaffolds |
US8308814B2 (en) | 2009-03-27 | 2012-11-13 | Depuy Mitek, Inc. | Methods and devices for preparing and implanting tissue scaffolds |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040081704A1 (en) | 1998-02-13 | 2004-04-29 | Centerpulse Biologics Inc. | Implantable putty material |
EP1099443A1 (en) | 1999-11-11 | 2001-05-16 | Sulzer Orthopedics Ltd. | Transplant/implant device and method for its production |
DE60041670D1 (en) * | 1999-12-03 | 2009-04-09 | Univ Leeds | Restoration of damaged tissue |
US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
US7862831B2 (en) * | 2002-10-09 | 2011-01-04 | Synthasome, Inc. | Method and material for enhanced tissue-biomaterial integration |
US8673333B2 (en) * | 2002-09-25 | 2014-03-18 | The Johns Hopkins University | Cross-linked polymer matrices, and methods of making and using same |
US20050069572A1 (en) * | 2002-10-09 | 2005-03-31 | Jennifer Elisseeff | Multi-layered polymerizing hydrogels for tissue regeneration |
US20060147332A1 (en) | 2004-12-30 | 2006-07-06 | Howmedica Osteonics Corp. | Laser-produced porous structure |
US7537664B2 (en) * | 2002-11-08 | 2009-05-26 | Howmedica Osteonics Corp. | Laser-produced porous surface |
US8173162B2 (en) * | 2003-02-26 | 2012-05-08 | Zimmer Orthobiologics, Inc. | Preparation for repairing cartilage tissue, especially articular cartilage defects |
US7666230B2 (en) * | 2003-12-08 | 2010-02-23 | Depuy Products, Inc. | Implant device for cartilage regeneration in load bearing articulation regions |
JP2008515434A (en) * | 2004-10-08 | 2008-05-15 | ジョージア テック リサーチ コーポレイション | Microencapsulation of cells in hydrogels using electrostatic potential |
WO2006089119A2 (en) * | 2005-02-18 | 2006-08-24 | Cartilix, Inc. | Biological adhesive |
DE102005010989A1 (en) * | 2005-03-03 | 2006-09-14 | Karl Storz Gmbh & Co. Kg | Medical instrument for introducing microfractures into bone |
EP1764117A1 (en) | 2005-09-20 | 2007-03-21 | Zimmer GmbH | Implant for the repair of a cartilage defect and method for manufacturing the implant |
US8728387B2 (en) | 2005-12-06 | 2014-05-20 | Howmedica Osteonics Corp. | Laser-produced porous surface |
CA2572095C (en) * | 2005-12-30 | 2009-12-08 | Howmedica Osteonics Corp. | Laser-produced implants |
US20080015691A1 (en) * | 2006-06-15 | 2008-01-17 | Depuy Products, Inc. | Orthopaedic implants having bioresorbable posts |
US8147861B2 (en) * | 2006-08-15 | 2012-04-03 | Howmedica Osteonics Corp. | Antimicrobial implant |
US7718616B2 (en) * | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
WO2009014718A1 (en) | 2007-07-24 | 2009-01-29 | Porex Corporation | Porous laser sintered articles |
US8500759B2 (en) | 2007-09-26 | 2013-08-06 | Ethicon, Inc. | Hernia mesh support device |
US10172626B2 (en) * | 2008-04-15 | 2019-01-08 | The Lonnie and Shannon Paulos Trust | Tissue microfracture apparatus and methods of use |
US20100145451A1 (en) * | 2008-12-04 | 2010-06-10 | Derek Dee | Joint support and subchondral support system |
US10610364B2 (en) | 2008-12-04 | 2020-04-07 | Subchondral Solutions, Inc. | Method for ameliorating joint conditions and diseases and preventing bone hypertrophy |
US20100256765A1 (en) * | 2009-04-01 | 2010-10-07 | Butler Michael S | Spinal Implants and Deployment Instruments For Covering Traumatized Spinal Disc Areas |
US8911474B2 (en) | 2009-07-16 | 2014-12-16 | Howmedica Osteonics Corp. | Suture anchor implantation instrumentation system |
US9232954B2 (en) | 2009-08-20 | 2016-01-12 | Howmedica Osteonics Corp. | Flexible ACL instrumentation, kit and method |
JP2013542837A (en) | 2010-11-15 | 2013-11-28 | ジンマー オーソバイオロジクス,インコーポレイティド | Bone void filler |
AU2011332225B2 (en) * | 2010-11-23 | 2016-05-26 | Cc Innovation | Surgical implant |
US20130190873A1 (en) * | 2012-01-20 | 2013-07-25 | Kevin A. Mansmann | Rim anchoring systems for flexible surgical implants for replacing cartilage |
US9795398B2 (en) | 2011-04-13 | 2017-10-24 | Howmedica Osteonics Corp. | Flexible ACL instrumentation, kit and method |
US9445803B2 (en) | 2011-11-23 | 2016-09-20 | Howmedica Osteonics Corp. | Filamentary suture anchor |
US20130158588A1 (en) * | 2011-12-14 | 2013-06-20 | Innospan Enterprises, Inc. | Abdominoplasty Umbilicus Finder Device and Method |
US9364896B2 (en) | 2012-02-07 | 2016-06-14 | Medical Modeling Inc. | Fabrication of hybrid solid-porous medical implantable devices with electron beam melting technology |
EP2987458B1 (en) | 2012-03-09 | 2018-10-31 | George J. Sikora | Microfracture apparatuses |
US9180010B2 (en) | 2012-04-06 | 2015-11-10 | Howmedica Osteonics Corp. | Surface modified unit cell lattice structures for optimized secure freeform fabrication |
US9135374B2 (en) | 2012-04-06 | 2015-09-15 | Howmedica Osteonics Corp. | Surface modified unit cell lattice structures for optimized secure freeform fabrication |
US20140039552A1 (en) | 2012-08-03 | 2014-02-06 | Howmedica Osteonics Corp. | Soft tissue fixation devices and methods |
US9186380B2 (en) | 2012-11-15 | 2015-11-17 | Allosource | Minced cartilage systems and methods |
US9078740B2 (en) | 2013-01-21 | 2015-07-14 | Howmedica Osteonics Corp. | Instrumentation and method for positioning and securing a graft |
CA2894750C (en) | 2013-02-22 | 2021-12-14 | Allosource | Cartilage mosaic compositions and methods |
US9402620B2 (en) | 2013-03-04 | 2016-08-02 | Howmedica Osteonics Corp. | Knotless filamentary fixation devices, assemblies and systems and methods of assembly and use |
US9788826B2 (en) | 2013-03-11 | 2017-10-17 | Howmedica Osteonics Corp. | Filamentary fixation device and assembly and method of assembly, manufacture and use |
US9463013B2 (en) | 2013-03-13 | 2016-10-11 | Stryker Corporation | Adjustable continuous filament structure and method of manufacture and use |
KR102312720B1 (en) | 2013-03-15 | 2021-10-13 | 알로소스 | Cell repopulated collagen matrix for soft tissue repair and regeneration |
US9168140B2 (en) | 2013-03-15 | 2015-10-27 | Allosource | Perforated osteochondral allograft compositions |
WO2014176270A1 (en) | 2013-04-22 | 2014-10-30 | Pivot Medical, Inc. | Method and apparatus for attaching tissue to bone |
WO2015041888A1 (en) | 2013-09-23 | 2015-03-26 | Sikora George J | Microfracture apparatuses |
US9895519B2 (en) | 2013-10-07 | 2018-02-20 | Regentis Biomaterials Ltd. | Treatment of cavities in a human body |
US9872705B2 (en) | 2013-10-07 | 2018-01-23 | Regentis Biomaterials Ltd. | Treatment of cavities in a human body |
US10610211B2 (en) | 2013-12-12 | 2020-04-07 | Howmedica Osteonics Corp. | Filament engagement system and methods of use |
JP6307875B2 (en) * | 2013-12-26 | 2018-04-11 | 大日本印刷株式会社 | Cell sheet collection method and collection device |
US10702395B2 (en) | 2014-10-01 | 2020-07-07 | Arthrosurface, Inc. | Microfracture apparatuses and methods |
US10034742B2 (en) | 2014-10-23 | 2018-07-31 | Medos International Sarl | Biceps tenodesis implants and delivery tools |
US10751161B2 (en) | 2014-10-23 | 2020-08-25 | Medos International Sárl | Biceps tenodesis anchor implants |
US10076374B2 (en) | 2014-10-23 | 2018-09-18 | Medos International Sárl | Biceps tenodesis delivery tools |
US10729419B2 (en) | 2014-10-23 | 2020-08-04 | Medos International Sarl | Biceps tenodesis implants and delivery tools |
US10856966B2 (en) | 2014-10-23 | 2020-12-08 | Medos International Sarl | Biceps tenodesis implants and delivery tools |
US9986992B2 (en) | 2014-10-28 | 2018-06-05 | Stryker Corporation | Suture anchor and associated methods of use |
US10568616B2 (en) | 2014-12-17 | 2020-02-25 | Howmedica Osteonics Corp. | Instruments and methods of soft tissue fixation |
USD851250S1 (en) * | 2015-11-19 | 2019-06-11 | Orthovestments, Llc | Bone staple |
US9649108B2 (en) | 2015-02-24 | 2017-05-16 | Orthovestments, Llc | Orthopedic bone staple with polyaxial compression capability |
US9693856B2 (en) | 2015-04-22 | 2017-07-04 | DePuy Synthes Products, LLC | Biceps repair device |
US11039927B2 (en) | 2015-11-25 | 2021-06-22 | Subchondral Solutions, Inc. | Methods, systems and devices for repairing anatomical joint conditions |
ES2842295T3 (en) * | 2015-12-23 | 2021-07-13 | Inovedis Gmbh | Tendon fixation plate |
US10231824B2 (en) | 2016-04-08 | 2019-03-19 | Medos International Sárl | Tenodesis anchoring systems and tools |
US10231823B2 (en) | 2016-04-08 | 2019-03-19 | Medos International Sarl | Tenodesis implants and tools |
KR20170116680A (en) * | 2016-04-12 | 2017-10-20 | 가톨릭대학교 산학협력단 | The fixing device for articular cartilage damage |
US11298747B2 (en) | 2017-05-18 | 2022-04-12 | Howmedica Osteonics Corp. | High fatigue strength porous structure |
DE102017115404A1 (en) * | 2017-07-10 | 2019-01-10 | Karl Leibinger Medizintechnik Gmbh & Co. Kg | Bone augmentation piece and bone augmentation piece kit with inserted (dental) implant |
US10842603B1 (en) * | 2017-10-16 | 2020-11-24 | David Lee Street | Sutureless ventral hernia meshing system and method of fixation |
CN109966029A (en) * | 2017-12-28 | 2019-07-05 | 财团法人工业技术研究院 | Repair of cartilage carrier, the operational tool group arranged in pairs or groups and cartilage repair systems |
US10786370B2 (en) | 2017-12-28 | 2020-09-29 | Industrial Technology Research Institute | Cartilage repair implant, auxiliary surgical tool kit and cartilage repair system |
USD902405S1 (en) | 2018-02-22 | 2020-11-17 | Stryker Corporation | Self-punching bone anchor inserter |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4060089A (en) * | 1975-09-03 | 1977-11-29 | United States Surgical Corporation | Surgical fastening method and device therefor |
US4548202A (en) * | 1983-06-20 | 1985-10-22 | Ethicon, Inc. | Mesh tissue fasteners |
US4976715A (en) * | 1986-05-20 | 1990-12-11 | Concept, Inc. | Repair tack for bodily tissue |
US6179840B1 (en) * | 1999-07-23 | 2001-01-30 | Ethicon, Inc. | Graft fixation device and method |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4512038A (en) | 1979-04-27 | 1985-04-23 | University Of Medicine And Dentistry Of New Jersey | Bio-absorbable composite tissue scaffold |
US4932973A (en) | 1983-09-30 | 1990-06-12 | El Gendler | Cartilage and bone induction by artificially perforated organic bone matrix |
CH669724A5 (en) * | 1986-04-15 | 1989-04-14 | Sulzer Ag | |
US5139499A (en) * | 1989-02-06 | 1992-08-18 | American Cyanamid Company | Screw and driver |
US5258016A (en) * | 1990-07-13 | 1993-11-02 | American Cyanamid Company | Suture anchor and driver assembly |
CA2090000A1 (en) * | 1992-02-24 | 1993-08-25 | H. Jonathan Tovey | Articulating mesh deployment apparatus |
US5766246A (en) | 1992-05-20 | 1998-06-16 | C. R. Bard, Inc. | Implantable prosthesis and method and apparatus for loading and delivering an implantable prothesis |
US5632745A (en) * | 1995-02-07 | 1997-05-27 | R&D Biologicals, Inc. | Surgical implantation of cartilage repair unit |
US5769899A (en) | 1994-08-12 | 1998-06-23 | Matrix Biotechnologies, Inc. | Cartilage repair unit |
US5634926A (en) * | 1995-04-25 | 1997-06-03 | Jobe; Richard P. | Surgical bone fixation apparatus |
US5989269A (en) | 1996-08-30 | 1999-11-23 | Vts Holdings L.L.C. | Method, instruments and kit for autologous transplantation |
DE69838856T2 (en) * | 1997-02-11 | 2008-12-11 | Warsaw Orthopedic, Inc., Warsaw | Plate for the anterior cervical spine with fixation system for one screw |
ATE249175T1 (en) * | 1997-02-28 | 2003-09-15 | Synthes Ag | IMPLANT FOR OSTEOSYNTHESIS |
CA2311803A1 (en) * | 1997-10-24 | 1999-05-06 | Robert S. Bray, Jr. | Bone plate and bone screw guide mechanism |
US6251143B1 (en) * | 1999-06-04 | 2001-06-26 | Depuy Orthopaedics, Inc. | Cartilage repair unit |
US6533454B1 (en) * | 1999-09-30 | 2003-03-18 | Bionx Implants Oy | Surgical system for tissue fixation |
US6371958B1 (en) * | 2000-03-02 | 2002-04-16 | Ethicon, Inc. | Scaffold fixation device for use in articular cartilage repair |
-
2002
- 2002-10-01 WO PCT/US2002/031142 patent/WO2003028535A2/en active Application Filing
- 2002-10-01 CA CA2462256A patent/CA2462256C/en not_active Expired - Fee Related
- 2002-10-01 JP JP2003531880A patent/JP4330991B2/en not_active Expired - Fee Related
- 2002-10-01 AT AT02766431T patent/ATE416682T1/en not_active IP Right Cessation
- 2002-10-01 AU AU2002330168A patent/AU2002330168B2/en not_active Ceased
- 2002-10-01 EP EP02766431A patent/EP1437960B1/en not_active Expired - Lifetime
- 2002-10-01 DE DE60230306T patent/DE60230306D1/en not_active Expired - Lifetime
- 2002-10-01 ES ES02766431T patent/ES2318040T3/en not_active Expired - Lifetime
- 2002-10-01 US US10/261,899 patent/US6712822B2/en not_active Expired - Lifetime
-
2004
- 2004-03-30 US US10/812,609 patent/US8157805B2/en not_active Expired - Fee Related
-
2009
- 2009-05-07 JP JP2009112669A patent/JP4964272B2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4060089A (en) * | 1975-09-03 | 1977-11-29 | United States Surgical Corporation | Surgical fastening method and device therefor |
US4548202A (en) * | 1983-06-20 | 1985-10-22 | Ethicon, Inc. | Mesh tissue fasteners |
US4976715A (en) * | 1986-05-20 | 1990-12-11 | Concept, Inc. | Repair tack for bodily tissue |
US6179840B1 (en) * | 1999-07-23 | 2001-01-30 | Ethicon, Inc. | Graft fixation device and method |
Non-Patent Citations (1)
Title |
---|
See also references of EP1437960A2 * |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008521560A (en) * | 2004-11-30 | 2008-06-26 | オステオバイオロジクス・インコーポレーテッド | Implant and its delivery system for treating joint surface defects |
US7811223B2 (en) | 2005-04-05 | 2010-10-12 | Ams Research Corporation | Articles, devices, and methods for pelvic surgery |
US8801595B2 (en) | 2005-04-05 | 2014-08-12 | Ams Research Corporation | Articles, devices, and methods for pelvic surgery |
WO2008061216A2 (en) * | 2006-11-18 | 2008-05-22 | Smith & Nephew, Inc. | Annular ring implant |
WO2008061216A3 (en) * | 2006-11-18 | 2008-07-10 | Smith & Nephew Inc | Annular ring implant |
WO2009064509A1 (en) * | 2007-11-16 | 2009-05-22 | Smith & Nephew, Inc. | Annular ring implant |
EP2233113A1 (en) * | 2007-12-21 | 2010-09-29 | Iwamoto, Yukihide | Device for cell transplantation |
CN101969882A (en) * | 2007-12-21 | 2011-02-09 | 日本医疗器材有限公司 | Device for cell transplantation |
EP2233113A4 (en) * | 2007-12-21 | 2013-01-02 | Iwamoto Yukihide | Device for cell transplantation |
EP2221014A1 (en) * | 2009-02-23 | 2010-08-25 | Inion Oy | Implant, implantation tool and kit |
US10010351B2 (en) | 2009-02-23 | 2018-07-03 | Inion Oy | Implant, implantation tool, kit and method |
EP2221014B1 (en) | 2009-02-23 | 2015-05-20 | Inion Oy | Implant, implantation tool and kit |
US8308814B2 (en) | 2009-03-27 | 2012-11-13 | Depuy Mitek, Inc. | Methods and devices for preparing and implanting tissue scaffolds |
EP2974698A1 (en) * | 2009-03-27 | 2016-01-20 | DePuy Mitek, Inc. | Devices for delivering and affixing tissue scaffolds |
US8469980B2 (en) | 2009-03-27 | 2013-06-25 | Depuy Mitek, Llc | Methods and devices for preparing and implanting tissue scaffolds |
EP2377494A1 (en) * | 2009-03-27 | 2011-10-19 | DePuy Mitek, Inc. | Methods and devices for delivering and affixing tissue scaffolds |
CN101953698A (en) * | 2009-03-27 | 2011-01-26 | 德普伊米特克公司 | Be used to send method and apparatus with attached organization bracket |
AU2010200826B2 (en) * | 2009-03-27 | 2015-05-21 | Depuy Mitek, Inc. | Methods and devices for delivering and affixing tissue scaffolds |
US9149369B2 (en) | 2009-03-27 | 2015-10-06 | Depuy Mitek, Llc | Methods and devices for delivering and affixing tissue scaffolds |
US8241298B2 (en) | 2009-03-27 | 2012-08-14 | Depuy Mitek, Inc. | Methods and devices for delivering and affixing tissue scaffolds |
US9421082B2 (en) | 2009-03-27 | 2016-08-23 | Depuy Mitek, Llc | Methods and devices for preparing and implanting tissue scaffolds |
US9848999B2 (en) | 2009-03-27 | 2017-12-26 | Depuy Mitek, Llc | Methods and devices for delivering and affixing tissue scaffolds |
EP2233114A3 (en) * | 2009-03-27 | 2011-01-19 | DePuy Mitek, Inc. | Methods and devices for delivering and affixing tissue scaffolds |
US10449052B2 (en) | 2009-03-27 | 2019-10-22 | Depuy Synthes Products, Inc | Methods and devices for preparing and implanting tissue scaffolds |
US10821005B2 (en) | 2009-03-27 | 2020-11-03 | DePuy Synthes Products, Inc. | Methods and devices for delivering and affixing tissue scaffolds |
US11554028B2 (en) | 2009-03-27 | 2023-01-17 | DePuy Synthes Products, Inc. | Methods and devices for delivering and affixing tissue scaffolds |
US11589995B2 (en) | 2009-03-27 | 2023-02-28 | DePuy Synthes Products, Inc. | Methods and devices for preparing and implanting tissue scaffolds |
Also Published As
Publication number | Publication date |
---|---|
US20030083665A1 (en) | 2003-05-01 |
US8157805B2 (en) | 2012-04-17 |
JP2005528927A (en) | 2005-09-29 |
EP1437960A2 (en) | 2004-07-21 |
DE60230306D1 (en) | 2009-01-22 |
JP4964272B2 (en) | 2012-06-27 |
WO2003028535A3 (en) | 2003-11-20 |
EP1437960A4 (en) | 2006-04-12 |
CA2462256C (en) | 2010-06-01 |
US6712822B2 (en) | 2004-03-30 |
JP2009195732A (en) | 2009-09-03 |
ATE416682T1 (en) | 2008-12-15 |
CA2462256A1 (en) | 2003-04-10 |
US20040181232A1 (en) | 2004-09-16 |
EP1437960B1 (en) | 2008-12-10 |
JP4330991B2 (en) | 2009-09-16 |
AU2002330168B2 (en) | 2006-11-09 |
ES2318040T3 (en) | 2009-05-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1437960B1 (en) | Apparatus for the repair of articular cartilage defects | |
AU2002330168A1 (en) | Apparatus and method for the repair of articular cartilage defects | |
AU767246B2 (en) | Graft fixation device and method | |
US6364884B1 (en) | Method of securing a graft using a graft fixation device | |
JP4397622B2 (en) | Graft fixation device | |
EP1233707B1 (en) | Repair of damaged tissue | |
JP2003250808A (en) | Combination body of implant fixing device | |
US20050143826A1 (en) | Disk repair structures with anchors | |
US20020052628A1 (en) | Graft fixation device and method | |
US10155068B2 (en) | Connective tissue repair technology | |
AU1544002A (en) | Graft fixation device combination | |
US11684477B2 (en) | Repair of shoulder-joint lesions | |
EP1138263B1 (en) | Graft fixation system | |
JPH10504217A (en) | Surgical implantation of a cartilage repair unit | |
AU2007200564B2 (en) | Apparatus and method for the repair of articular cartilage defects | |
US20220087828A1 (en) | Partial glenoid arthroplasty | |
AU2815101A (en) | Method of securing a graft using a graft fixation device | |
AU771896B2 (en) | Graft fixation device combination | |
AU2005200675B2 (en) | Fixation technology | |
JP2001516618A (en) | Fusion transplantation device and method of using the same | |
AU2815301A (en) | Instrument for inserting graft fixation device | |
AU1544102A (en) | Method of securing a graft using a graft fixation device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ PL PT RO RU SE SG SI SK SL TJ TM TR TT TZ UA UZ VN YU ZA |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2462256 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003531880 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002330168 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002766431 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2002766431 Country of ref document: EP |