WO2003024393A3 - Autologous t-cell vaccines materials and method - Google Patents

Autologous t-cell vaccines materials and method Download PDF

Info

Publication number
WO2003024393A3
WO2003024393A3 PCT/US2002/028874 US0228874W WO03024393A3 WO 2003024393 A3 WO2003024393 A3 WO 2003024393A3 US 0228874 W US0228874 W US 0228874W WO 03024393 A3 WO03024393 A3 WO 03024393A3
Authority
WO
WIPO (PCT)
Prior art keywords
autologous
cell vaccines
vaccines materials
cell
materials
Prior art date
Application number
PCT/US2002/028874
Other languages
French (fr)
Other versions
WO2003024393A2 (en
Inventor
Jingwu Zhang
Original Assignee
Opexa Pharmaceuticals Inc
Baylor College Medicine
Jingwu Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HU0401519A priority Critical patent/HUP0401519A3/en
Priority to NZ530762A priority patent/NZ530762A/en
Priority to JP2003528491A priority patent/JP2005502721A/en
Priority to CA2459969A priority patent/CA2459969C/en
Priority to MXPA04001862A priority patent/MXPA04001862A/en
Priority to BR0212504-8A priority patent/BR0212504A/en
Priority to EP02778249A priority patent/EP1416956B1/en
Priority to AU2002339914A priority patent/AU2002339914B2/en
Application filed by Opexa Pharmaceuticals Inc, Baylor College Medicine, Jingwu Zhang filed Critical Opexa Pharmaceuticals Inc
Priority to DE60226612T priority patent/DE60226612D1/en
Priority to KR10-2004-7002735A priority patent/KR20040066787A/en
Priority to DK02778249T priority patent/DK1416956T3/en
Priority to IL15999802A priority patent/IL159998A0/en
Publication of WO2003024393A2 publication Critical patent/WO2003024393A2/en
Publication of WO2003024393A3 publication Critical patent/WO2003024393A3/en
Priority to ZA2004/01502A priority patent/ZA200401502B/en
Priority to HK05104562A priority patent/HK1071698A1/en
Priority to IL196900A priority patent/IL196900A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46432—Nervous system antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule

Abstract

The present invention relates to improved autologous T cell vaccines and methods for their production. The invention is also directed to methods for treating T cell associated diseases such as multiple sclerosis are rheumatoid arthritis using autologous T cell vaccines.
PCT/US2002/028874 2001-09-14 2002-09-12 Autologous t-cell vaccines materials and method WO2003024393A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
DE60226612T DE60226612D1 (en) 2001-09-14 2002-09-12 AUTOLOGIC T-CELL VACCINE MATERIALS AND METHOD
NZ530762A NZ530762A (en) 2001-09-14 2002-09-12 Treatment for multiple sclerosis and rheumatoid arthritis with a vaccine comprising autologous T-cells comprising a myelin basic protein antigen
KR10-2004-7002735A KR20040066787A (en) 2001-09-14 2002-09-12 Autologous t-cell vaccines materials and methods
MXPA04001862A MXPA04001862A (en) 2001-09-14 2002-09-12 Autologous t-cell vaccines materials and method.
BR0212504-8A BR0212504A (en) 2001-09-14 2002-09-12 Materials and methods for autologous t-cell vaccine
EP02778249A EP1416956B1 (en) 2001-09-14 2002-09-12 Autologous t-cell vaccines materials and method
AU2002339914A AU2002339914B2 (en) 2001-09-14 2002-09-12 Autologous T-cell vaccines materials and method
HU0401519A HUP0401519A3 (en) 2001-09-14 2002-09-12 Autologous t-cell vaccines materials and method
JP2003528491A JP2005502721A (en) 2001-09-14 2002-09-12 Autologous T-cell vaccine material and method
CA2459969A CA2459969C (en) 2001-09-14 2002-09-12 Autologous t-cell vaccines materials and methods
DK02778249T DK1416956T3 (en) 2001-09-14 2002-09-12 Autologous T-cell vaccine materials and methods for their preparation
IL15999802A IL159998A0 (en) 2001-09-14 2002-09-12 Autologous t-cell vaccines materials and methods
ZA2004/01502A ZA200401502B (en) 2001-09-14 2004-02-24 Autologous t cell vaccines materials and method
HK05104562A HK1071698A1 (en) 2001-09-14 2005-05-31 Autologous t-cell vaccines materials and method
IL196900A IL196900A (en) 2001-09-14 2009-02-04 Autologous t-cell vaccine compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/952,532 US7658926B2 (en) 2001-09-14 2001-09-14 Autologous T-cell vaccines materials and methods
US09/952,532 2001-09-14

Publications (2)

Publication Number Publication Date
WO2003024393A2 WO2003024393A2 (en) 2003-03-27
WO2003024393A3 true WO2003024393A3 (en) 2003-11-06

Family

ID=25492995

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/028874 WO2003024393A2 (en) 2001-09-14 2002-09-12 Autologous t-cell vaccines materials and method

Country Status (22)

Country Link
US (2) US7658926B2 (en)
EP (3) EP1416956B1 (en)
JP (5) JP2005502721A (en)
KR (1) KR20040066787A (en)
CN (2) CN101229370B (en)
AT (1) ATE395076T1 (en)
AU (1) AU2002339914B2 (en)
BR (1) BR0212504A (en)
CA (1) CA2459969C (en)
DE (1) DE60226612D1 (en)
DK (2) DK1416956T3 (en)
ES (2) ES2418529T3 (en)
HK (1) HK1071698A1 (en)
HU (1) HUP0401519A3 (en)
IL (2) IL159998A0 (en)
MX (1) MXPA04001862A (en)
NZ (1) NZ530762A (en)
PL (1) PL210442B1 (en)
PT (2) PT2335720E (en)
RU (1) RU2302257C2 (en)
WO (1) WO2003024393A2 (en)
ZA (1) ZA200401502B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020009448A1 (en) * 1997-09-19 2002-01-24 Leslie P. Weiner T-cell vaccination for the treatment of multiple sclerosis
US7658926B2 (en) * 2001-09-14 2010-02-09 Opexa Pharmaceuticals, Inc. Autologous T-cell vaccines materials and methods
US7744893B2 (en) * 2002-06-05 2010-06-29 Baylor College Of Medicine T cell receptor CDR3 sequences associated with multiple sclerosis and compositions comprising same
EP1546719B1 (en) * 2002-08-08 2015-04-01 Baylor College Of Medicine Isolation and identification of t cells
AU2003299914A1 (en) * 2002-12-31 2004-07-29 Baylor College Of Medicine Isolation and identification of cross-reactive t cells
CN1893971A (en) * 2003-10-17 2007-01-10 贝勒医学院 A method for increasing CD8<+> cytotoxic T cell reponses and for treating multiple sclerosis
US20100003228A1 (en) * 2006-05-05 2010-01-07 Willimas Jim C T-cell vaccine
DK2318020T3 (en) * 2008-06-30 2015-11-30 Universitätsklinikum Heidelberg Immunosuppressive blood cells and methods of producing same
US20170246272A1 (en) * 2014-09-05 2017-08-31 Opexa Therapeutics, Inc. Compositions and methods for treating b cell mediated autoimmune disorders
CN109125717B (en) * 2017-09-08 2022-02-22 江苏苏博生物医学股份有限公司 Autologous whole cell vaccine formula for treating chronic diseases and preparation method thereof
US20210061875A1 (en) 2017-12-29 2021-03-04 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Compositions and methods for treating autoimmune disease

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5852225A (en) * 1981-09-22 1983-03-28 Mitsui Pharmaceut Inc Remedy for immune insufficiency
US5766920A (en) * 1982-08-11 1998-06-16 Cellcor, Inc. Ex vivo activation of immune cells
US4550086A (en) * 1983-02-16 1985-10-29 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that recognize human T cells
IL69686A (en) * 1983-09-11 1988-03-31 Yeda Res & Dev Compositions containing cell membrane proteins and process for their preparation
US4608365A (en) * 1984-03-30 1986-08-26 University Of Southern California Treatment of neurologic functions
US4677061A (en) * 1984-10-19 1987-06-30 Genetic Systems Corporation T-cell lymphocyte subset monitoring of immunologic disease
US4898856A (en) * 1984-10-29 1990-02-06 Chaovanee Aroonsakul Method for treating central nervous system diseases
US4897389A (en) * 1984-10-29 1990-01-30 Chaovanee Aroonsakul Treating central nervous system diseases
US4902680A (en) * 1984-10-29 1990-02-20 Chaovanee Aroonsakul Treating central nervous system diseases
US4898857A (en) * 1984-10-29 1990-02-06 Chaovanee Aroonsakul Treating control nervous system diseases
CA1296622C (en) * 1986-08-12 1992-03-03 Jeffrey E. Anderson Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system
US5849298A (en) * 1987-06-24 1998-12-15 Autoimmune Inc. Treatment of multiple sclerosis by oral administration of bovine myelin
US5039660A (en) * 1988-03-02 1991-08-13 Endocon, Inc. Partially fused peptide pellet
US5242687A (en) * 1989-03-15 1993-09-07 Tkb Associates Limited Partnership Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells
US5837246A (en) * 1989-03-21 1998-11-17 The Immune Response Corporation Vaccination and methods against diseases resulting from pathogenic responses by specific T cell populations
US6207645B1 (en) * 1989-03-21 2001-03-27 The Immune Response Corporation Vaccination and methods against diseases resulting from pathogenic responses by specific T cell populations
US5612035A (en) * 1989-03-21 1997-03-18 The Immune Response Corporation Vaccination against diseases resulting from pathogenic responses by specific T cell populations
US6007815A (en) * 1989-03-21 1999-12-28 The Immune Response Corporation Anti-idiotype vaccination against diseases resulting from pathogenic responses by specific T cell populations
US5861164A (en) * 1989-03-21 1999-01-19 The Immune Response Corporation Vaccination against diseases resulting from pathogenic responses by specific T cell populations
US6221352B1 (en) * 1989-03-21 2001-04-24 The Immune Response Corporation Method of preventing the proliferation of Vβ14 or Vβ17-Expressing T cells
US5776459A (en) * 1989-07-19 1998-07-07 Connetics Corporation TCR V beta 5 peptides
US5614192A (en) * 1989-07-19 1997-03-25 Connective Therapeutics, Inc. T cell receptor peptides as therapeutics for immune-related disease
US5298396A (en) * 1989-11-15 1994-03-29 National Jewish Center For Immunology And Respiratory Medicine Method for identifying T cells disease involved in autoimmune disease
IL165071A (en) 1990-03-30 2008-06-05 Autoimmune Inc Peptide capable of stimulating a subgroup of t-cells from multiple sclerosis patients
WO1992001044A1 (en) * 1990-07-06 1992-01-23 Allergene, Inc. Mouse/human heterohybrid cell line el41 and methods for the production of human monoclonal antibodies
US5668117A (en) * 1991-02-22 1997-09-16 Shapiro; Howard K. Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments
US5211952A (en) * 1991-04-12 1993-05-18 University Of Southern California Contraceptive methods and formulations for use therein
US6083503A (en) * 1991-08-28 2000-07-04 The United States Of America As Represented By The Department Of Health And Human Services Interleukin-2 stimulated T lymphocyte cell death for the treatment of autoimmune diseases, allergic responses, and graft rejection
US5480895A (en) * 1991-09-27 1996-01-02 New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery Method of producing antibodies to a restricted population of T lymphocytes, antibodies produced therefrom and methods of use thereof
US5298386A (en) * 1992-06-09 1994-03-29 Eastman Kodak Company In-line solvent incorporation for amorphous particle dispersions
US5545716A (en) * 1992-09-08 1996-08-13 University Of Florida Superantigen agonist and antagonist peptides
EP0688223A4 (en) * 1993-03-12 1998-05-13 Cellcor Inc -i(IN VITRO) ASSAY MEASURING DEGREE OF ACTIVATION OF IMMUNE CELLS
US5494899A (en) * 1993-04-07 1996-02-27 Oklahoma Medical Research Foundation Selective regulation of B lymphocyte precursors by hormones
IL108926A0 (en) 1993-05-14 1994-06-24 L Willems Instituut Dr Human t cell monoclone, process for its production and its use for the treatment and diagnosis of infectious diseases, autoimmune diseases, t-cell mediated allergies and cancer
IL110787A0 (en) * 1993-08-27 1994-11-11 Sandoz Ag Biodegradable polymer, its preparation and pharmaceutical composition containing it
US5552300A (en) * 1994-01-13 1996-09-03 T Cell Sciences, Inc. T cell antigen receptor V region proteins and methods of preparation thereof
US6410518B1 (en) * 1994-05-31 2002-06-25 Isis Pharmaceuticals, Inc. Antisense oligonucleotide inhibition of raf gene expression
US6033661A (en) * 1995-06-07 2000-03-07 Thomas Jefferson University Composition and method for allogenetic mononuclear cell immunotherapy
US5723503A (en) * 1994-09-28 1998-03-03 Thomas Jefferson University Biological treatment for rheumatoid arthritis
US5674487A (en) * 1994-09-28 1997-10-07 Univ Jefferson Method for treating autoimmune diseases
US6096314A (en) * 1994-10-07 2000-08-01 Yeda Research And Development Co. Ltd. Peptides and pharmaceutical compositions comprising them
AU721898B2 (en) * 1994-11-18 2000-07-20 Board Of Trustees Of The Leland Stanford Junior University Methods for treatment of multiple sclerosis using peptide analogues at position 91 of human myelin basic protein
FR2727117A1 (en) * 1994-11-18 1996-05-24 Geffard Michel USE OF POLYLYSIN CONJUGATES FOR THE PREPARATION OF MEDICAMENTS USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES AND DEGENERATIVE DISORDERS OF AUTOIMMUN CHARACTER
US6218166B1 (en) * 1994-12-09 2001-04-17 John Wayne Cancer Institute Adjuvant incorporation into antigen carrying cells: compositions and methods
US5874531A (en) * 1995-03-07 1999-02-23 President And Fellows Of Harvard College Identification of self and non-self antigens implicated autoimmune disease
US5869057A (en) * 1995-06-07 1999-02-09 Rock; Edwin P. Recombinant vaccines to break self-tolerance
SE9502921D0 (en) * 1995-08-23 1995-08-23 Astra Ab New compounds
US5739307A (en) * 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
US5750356A (en) * 1996-05-31 1998-05-12 Anergen, Inc. Method for monitoring T cell reactivity
US5849886A (en) * 1996-07-10 1998-12-15 Oy Aboatech Ab Extraction of myelin basic protein
US20010031253A1 (en) * 1996-07-24 2001-10-18 Gruenberg Micheal L. Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
US6130087A (en) * 1996-10-07 2000-10-10 Fordham University Methods for generating cytotoxic T cells in vitro
BR9712988A (en) * 1996-10-11 2000-10-24 Univ California Cancer immunotherapy using tumor cells combined with lymphocyte mixture
US6054292A (en) * 1997-07-18 2000-04-25 Incyte Pharmaceuticals, Inc. T-cell receptor protein
US20020009448A1 (en) 1997-09-19 2002-01-24 Leslie P. Weiner T-cell vaccination for the treatment of multiple sclerosis
US20020072493A1 (en) * 1998-05-19 2002-06-13 Yeda Research And Development Co. Ltd. Activated T cells, nervous system-specific antigens and their uses
AU5906099A (en) 1998-09-04 2000-03-27 Baylor College Of Medicine T cell peptides as therapeutics for immune-related disease
EP1159457B1 (en) * 1999-02-23 2010-11-03 Baylor College Of Medicine T cell receptor vbeta - dbeta - jbeta) sequence and methods for its detection
US6187750B1 (en) * 1999-08-25 2001-02-13 Everyoung Technologies, Inc. Method of hormone treatment for patients with symptoms consistent with multiple sclerosis
US6746670B2 (en) * 2000-08-15 2004-06-08 Schering Corporation Regulatory T cells; methods
PL364914A1 (en) 2000-08-22 2004-12-27 Baylor College Of Medicine T cell receptor vbeta-dbeta-jbeta sequence and methods for its detection
US7658926B2 (en) 2001-09-14 2010-02-09 Opexa Pharmaceuticals, Inc. Autologous T-cell vaccines materials and methods
US20030153073A1 (en) * 2001-11-07 2003-08-14 Paul Rogers Expansion of T cells in vitro and expanded T cell populations
DE10224223A1 (en) * 2002-05-31 2003-12-11 Mann & Hummel Filter Filter element, in particular for filtering liquids from a gas stream

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
MEDAER R. ET AL.: "Depletion of myelin-basic-protein autoreactive T cells by T-cell vaccination: pilot trial in multiple sclerosis", LANCET, vol. 346, no. 8973, 23 September 1995 (1995-09-23), pages 807 - 808, XP002966968 *
ZANG Y.C.Q. ET AL.: "Th2 immune regulation induced by T cell vaccination in patients with multiple sclerosis", EUR. J. IMMUNOL., vol. 30, no. 3, March 2000 (2000-03-01), pages 908 - 913, XP002966967 *
ZHANG J. ET AL.: "T cell vaccination in multiple sclerosis", MULTIPLE SCLEROSIS, vol. 1, no. 6, 1996, pages 353 - 356, XP002966966 *
ZHANG J. ET AL.: "Vaccination with myelin-reactive T cells: results of a clinical trial in patients with multiple sclerosis", NEUROLOGY, vol. 54, no. 7,SUPPL. 3, 11 April 2001 (2001-04-11), pages A23, XP002966964 *
ZHANG J.Z.: "T-cell vaccination in multiple sclerosis: immunoregulatory mechanism and prospects for therapy", CRIT. REV. IMMUNOL., vol. 21, no. 102, 2001, pages 41 - 55, XP002966965 *

Also Published As

Publication number Publication date
JP2005502721A (en) 2005-01-27
JP4889581B2 (en) 2012-03-07
CN100346824C (en) 2007-11-07
DK1416956T3 (en) 2008-09-01
BR0212504A (en) 2004-08-24
CN1553812A (en) 2004-12-08
HUP0401519A2 (en) 2004-11-29
ES2306792T3 (en) 2008-11-16
PL367306A1 (en) 2005-02-21
ZA200401502B (en) 2005-01-26
IL196900A (en) 2015-03-31
EP1416956B1 (en) 2008-05-14
US20050186192A1 (en) 2005-08-25
US7658926B2 (en) 2010-02-09
JP2015017129A (en) 2015-01-29
ATE395076T1 (en) 2008-05-15
EP1946767B1 (en) 2013-12-04
KR20040066787A (en) 2004-07-27
NZ530762A (en) 2005-10-28
RU2302257C2 (en) 2007-07-10
ES2418529T3 (en) 2013-08-14
CN101229370B (en) 2015-09-02
EP2335720A1 (en) 2011-06-22
CA2459969A1 (en) 2003-03-27
JP2016188238A (en) 2016-11-04
EP2335720B1 (en) 2013-04-03
RU2004103626A (en) 2005-03-27
US20030091578A1 (en) 2003-05-15
CA2459969C (en) 2014-12-02
MXPA04001862A (en) 2005-03-07
DK2335720T3 (en) 2013-07-08
JP2011168618A (en) 2011-09-01
EP1946767A3 (en) 2008-07-30
EP1946767A2 (en) 2008-07-23
AU2002339914B2 (en) 2005-03-24
IL159998A0 (en) 2004-06-20
HUP0401519A3 (en) 2009-04-28
DE60226612D1 (en) 2008-06-26
EP1416956A4 (en) 2004-10-13
JP2007254492A (en) 2007-10-04
IL196900A0 (en) 2011-07-31
PL210442B1 (en) 2012-01-31
PT2335720E (en) 2013-07-08
WO2003024393A2 (en) 2003-03-27
PT1416956E (en) 2008-08-26
HK1071698A1 (en) 2005-07-29
EP1416956A2 (en) 2004-05-12
CN101229370A (en) 2008-07-30

Similar Documents

Publication Publication Date Title
HK1071698A1 (en) Autologous t-cell vaccines materials and method
WO2004015070A3 (en) Isolation and identification of t cells
WO2001021766A8 (en) Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells
WO2004043407A3 (en) Methods and products for treating staphylococcal infections
AU2002310321A1 (en) Compositions and methods for high-level, large-scale production of recombinant proteins
PL345215A1 (en) Novel form of irbesartan, methods for obtaining said form and pharmaceutical compositions containing same
ATE322252T1 (en) METHOD FOR PRODUCING AND COLLECTING CRYSTALLINE PARTICLES
AU2002309932A1 (en) Method of fuel production from fischer-tropsch process
AU2001269445A1 (en) Method of culturing zooplankton, apparatus for culturing by the same, and culture obtained by the same
WO2004013294A3 (en) Method of producing non-recombinant bmp-2 and use thereof
AU2826801A (en) Surface modified supporting materials for binding biological materials, method for the production and use thereof
AU2003273521A1 (en) Production method of iturin a and its homologues
AU2002360583A1 (en) Method of isolating extract from the euphorbaciae obesa plant and methods for using the same
WO2003028666A3 (en) Isolated polypeptides and compositions from the venom of p. transvaalicus and methods of use
DE50203529D1 (en) PROCESS FOR THE PREPARATION OF DESCLARITHROMYCIN, AND INTERMEDIATE PRODUCTS
WO1998024894A3 (en) Pkd1 fragments with bonding areas for pkd1-specific antibodies
AU2003222771A1 (en) Ceramic mixture, relative method and production system and ceramic products obtained from said mixture
AU6709500A (en) Trehalose producing cells as vaccines
AU2002309356A1 (en) Method for production of materials aglomerated from biomass and materials so produced
AU2002333769A1 (en) Method for the production of 2-pyrrolidone
AU2003903223A0 (en) Method and composition for the treatment of rheumatoid arthritis and psoriatic arthritis
AU2002350701A1 (en) Method for inducing the production of stress proteins in plant material
AU2003221314A1 (en) Novel organosilicon compounds, process for production thereof, and optically active substances of the compounds
AUPR084900A0 (en) Process for the treatment of raw coal
AU2002216867A1 (en) Method for producing solid materials from plant material, material produced according to said method, use of the material in addition to a system for carrying out said method

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VC VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 159998

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 530762

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2002339914

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 266/DELNP/2004

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2003528491

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2002778249

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2004/01502

Country of ref document: ZA

Ref document number: 200401502

Country of ref document: ZA

Ref document number: 1020047002735

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: PA/a/2004/001862

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2459969

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 20028176723

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2002778249

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 2002339914

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 530762

Country of ref document: NZ

WWG Wipo information: grant in national office

Ref document number: 530762

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 196900

Country of ref document: IL