WO2003009774A3 - Ophthalmic drug delivery device - Google Patents

Ophthalmic drug delivery device Download PDF

Info

Publication number
WO2003009774A3
WO2003009774A3 PCT/US2002/023048 US0223048W WO03009774A3 WO 2003009774 A3 WO2003009774 A3 WO 2003009774A3 US 0223048 W US0223048 W US 0223048W WO 03009774 A3 WO03009774 A3 WO 03009774A3
Authority
WO
WIPO (PCT)
Prior art keywords
injection port
drug delivery
delivery device
ophthalmic drug
sclera
Prior art date
Application number
PCT/US2002/023048
Other languages
French (fr)
Other versions
WO2003009774A2 (en
Inventor
Yoseph Yaacobi
Original Assignee
Alcon Inc
Yoseph Yaacobi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE60217679T priority Critical patent/DE60217679T2/en
Application filed by Alcon Inc, Yoseph Yaacobi filed Critical Alcon Inc
Priority to MXPA03011609A priority patent/MXPA03011609A/en
Priority to DK02750196T priority patent/DK1409065T3/en
Priority to EP02750196A priority patent/EP1409065B1/en
Priority to CA002447802A priority patent/CA2447802C/en
Priority to JP2003515170A priority patent/JP4261343B2/en
Priority to PL368207A priority patent/PL204644B1/en
Priority to AU2002319596A priority patent/AU2002319596B2/en
Priority to BR0210494-6A priority patent/BR0210494A/en
Publication of WO2003009774A2 publication Critical patent/WO2003009774A2/en
Publication of WO2003009774A3 publication Critical patent/WO2003009774A3/en
Priority to US10/706,105 priority patent/US7094226B2/en
Priority to CY20071100160T priority patent/CY1105991T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts

Abstract

An ophthalmic drug delivery device (10) having a first end and a second end (Figure 3), an injection port (24), a reservoir, (22), and a sleeve (26) is disclosed. The injection port is for sealingly engaging a needle (102) of a syringe (100), which is for providing a fluid (104) comprising a pharmaceutically active agent. The reservoir is disposed within the device, is flui dly coupled to the injection port, and has an opening (25) for communicating the fluid to an outer surface of a sclera (58) of an eye (52). The sleeve is for engaging the device proximate overlapping portions of the first end and the second end for forming a generally ring-shaped three-dimensional geometry upon implantation of the device on the outer surface of the sclera. The device is useful for the treatment of a disease of the posterior segment (68) of the eye.
PCT/US2002/023048 2001-07-23 2002-07-22 Ophthalmic drug delivery device WO2003009774A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP2003515170A JP4261343B2 (en) 2001-07-23 2002-07-22 Ophthalmic drug administration device
MXPA03011609A MXPA03011609A (en) 2001-07-23 2002-07-22 Ophthalmic drug delivery device.
DK02750196T DK1409065T3 (en) 2001-07-23 2002-07-22 Ophthalmic drug delivery device
EP02750196A EP1409065B1 (en) 2001-07-23 2002-07-22 Ophthalmic drug delivery device
CA002447802A CA2447802C (en) 2001-07-23 2002-07-22 Ophthalmic drug delivery device
DE60217679T DE60217679T2 (en) 2001-07-23 2002-07-22 DEVICE FOR RELEASING AN OPHTHALMIC MEDICINAL PRODUCT
PL368207A PL204644B1 (en) 2001-07-23 2002-07-22 Ophthalmic drug delivery device
AU2002319596A AU2002319596B2 (en) 2001-07-23 2002-07-22 Ophthalmic drug delivery device
BR0210494-6A BR0210494A (en) 2001-07-23 2002-07-22 Ophthalmic drug delivery device
US10/706,105 US7094226B2 (en) 2001-07-23 2003-11-12 Ophthalmic drug delivery device
CY20071100160T CY1105991T1 (en) 2001-07-23 2007-02-06 EYE DRUG DISPENSING DEVICE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30728401P 2001-07-23 2001-07-23
US60/307,284 2001-07-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/706,105 Continuation US7094226B2 (en) 2001-07-23 2003-11-12 Ophthalmic drug delivery device

Publications (2)

Publication Number Publication Date
WO2003009774A2 WO2003009774A2 (en) 2003-02-06
WO2003009774A3 true WO2003009774A3 (en) 2003-08-21

Family

ID=23189050

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/023048 WO2003009774A2 (en) 2001-07-23 2002-07-22 Ophthalmic drug delivery device

Country Status (16)

Country Link
US (1) US7094226B2 (en)
EP (1) EP1409065B1 (en)
JP (1) JP4261343B2 (en)
CN (1) CN1203814C (en)
AU (1) AU2002319596B2 (en)
BR (1) BR0210494A (en)
CA (1) CA2447802C (en)
CY (1) CY1105991T1 (en)
DE (1) DE60217679T2 (en)
DK (1) DK1409065T3 (en)
ES (1) ES2278936T3 (en)
MX (1) MXPA03011609A (en)
PL (1) PL204644B1 (en)
PT (1) PT1409065E (en)
WO (1) WO2003009774A2 (en)
ZA (1) ZA200308993B (en)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
DE60239868D1 (en) 2001-06-12 2011-06-09 Univ Johns Hopkins Med RESERVOIR DEVICE FOR INTRAOCULAR DRUG DELIVERY
JP2005501602A (en) * 2001-08-29 2005-01-20 カルバーリョ、リカルド エイ．ピー． デ Sealable implantable device for unidirectional delivery of therapeutic agents to tissue
US20070027537A1 (en) * 2002-08-02 2007-02-01 David Castillejos Method and intra-sclera implant for treatment of glaucoma and presbyopia
US20060167435A1 (en) * 2003-02-18 2006-07-27 Adamis Anthony P Transscleral drug delivery device and related methods
EP1658109B1 (en) * 2003-08-26 2014-01-22 Vista Scientific LLC Ocular drug delivery device
WO2006039459A1 (en) * 2004-09-30 2006-04-13 Bausch & Lomb Incorporated Capsule for encasing tablets for surgical insertion into the human body
US20060233858A1 (en) * 2005-03-08 2006-10-19 Allergan, Inc. Systems and methods providing targeted intraocular drug delivery
ATE497797T1 (en) 2006-03-14 2011-02-15 Univ Southern California MEMS DEVICE FOR DRUG RELEASE
MX364408B (en) 2007-12-20 2019-04-25 Univ Southern California APPARATUS and METHODS FOR DELIVERING THERAPEUTIC AGENTS.
DK2240220T3 (en) 2008-01-03 2016-08-01 Univ Southern California Implantable devices for drug AND APPARATUS FOR refilling DEVICES
AU2015201289B2 (en) * 2008-03-14 2016-12-01 Institut National De La Sante Et De La Recherche Medicale Eye injection device
JP2011519695A (en) 2008-05-08 2011-07-14 リプレニッシュ パンプス， エルエルシー Implantable drug delivery device and apparatus and method for filling the device
CN102202708B (en) 2008-05-08 2015-01-21 迷你泵有限责任公司 Drug-delivery pumps and methods of manufacture
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
MX2010012213A (en) 2008-05-08 2011-05-03 Minipumps Llc Implantable pumps and cannulas therefor.
US10588855B2 (en) 2008-05-12 2020-03-17 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
EP2276439A4 (en) * 2008-05-12 2013-11-27 Univ Utah Res Found Intraocular drug delivery device and associated methods
US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9095404B2 (en) * 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
WO2010088548A1 (en) 2009-01-29 2010-08-05 Forsight Labs, Llc Posterior segment drug delivery
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
EP2437684B1 (en) 2009-06-03 2022-06-15 ForSight Vision5, Inc. Anterior segment drug delivery
MX2012002063A (en) 2009-08-18 2012-08-01 Minipumps Llc Electrolytic drug-delivery pump with adaptive control.
US9399102B2 (en) * 2010-06-25 2016-07-26 Euclid Systems Corporation Device and method for the controlled delivery of ophthalmic solutions
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US10617557B2 (en) 2010-08-05 2020-04-14 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
RS61601B1 (en) 2010-08-05 2021-04-29 Forsight Vision4 Inc Injector apparatus for drug delivery
US20140031769A1 (en) 2010-11-19 2014-01-30 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
EP2726016B1 (en) 2011-06-28 2023-07-19 ForSight Vision4, Inc. An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye
EP2739252A4 (en) 2011-08-05 2015-08-12 Forsight Vision4 Inc Small molecule delivery with implantable therapeutic device
WO2013040238A2 (en) 2011-09-13 2013-03-21 Vista Scientific Llc Sustained release ocular drug delivery devices and methods of manufacture
WO2013040426A2 (en) 2011-09-14 2013-03-21 Forsight Labs, Llc Ocular insert apparatus and methods
RS61758B1 (en) 2011-09-16 2021-05-31 Forsight Vision4 Inc Fluid exchange apparatus
US9381112B1 (en) 2011-10-06 2016-07-05 William Eric Sponsell Bleb drainage device, ophthalmological product and methods
US8632489B1 (en) 2011-12-22 2014-01-21 A. Mateen Ahmed Implantable medical assembly and methods
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
BR112014024041A2 (en) * 2012-03-27 2017-07-04 Duke Univ Empresa Americana elastomeric material, and methods for increasing the outflow of aqueous humor in the eye of an individual suffering from glaucoma, dispensing an ophthalmic agent, and inducing a glaucoma-like condition in an individual
DK2911623T3 (en) 2012-10-26 2019-10-28 Forsight Vision5 Inc Ophthalmic system for long-term release of drug into the eye
EP2968113B8 (en) 2013-03-14 2020-10-28 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
US9597227B2 (en) * 2013-03-15 2017-03-21 Abbott Medical Optics Inc. Trans-sclera portal for delivery of therapeutic agents
CA2907681C (en) 2013-03-28 2022-11-22 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9320645B2 (en) 2013-05-29 2016-04-26 Terry Glasser Approach to administering ocular medication
US20150342875A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
RU2695563C2 (en) 2014-07-15 2019-07-24 Форсайт Вижн4, Инк. Method and device for eye implant delivery
WO2016022750A1 (en) 2014-08-08 2016-02-11 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
JP7037360B2 (en) 2014-11-10 2022-03-16 フォーサイト・ビジョン フォー・インコーポレーテッド Expandable drug delivery device
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
WO2016187426A1 (en) 2015-05-19 2016-11-24 Amorphex Therapeutics Llc A device that delivers a sustained low-dose of a myopia-suppressing drug
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
WO2017087902A1 (en) 2015-11-20 2017-05-26 Forsight Vision4, Inc. Porous structures for extended release drug delivery devices
MX2018012021A (en) 2016-04-05 2019-01-24 Forsight Vision4 Inc Implantable ocular drug delivery devices.
US11318043B2 (en) 2016-04-20 2022-05-03 Dose Medical Corporation Bioresorbable ocular drug delivery device
WO2018143481A1 (en) * 2017-02-01 2018-08-09 国立大学法人東北大学 Sustained drug release device that can be reinjected with the drug, and injectable gel for refilling
US11523940B2 (en) * 2017-03-17 2022-12-13 W. L. Gore & Associates, Inc. Delivery aids for glaucoma shunts
WO2019023617A1 (en) 2017-07-27 2019-01-31 University Of Utah Research Foundation Therapeutic delivery device
BR112020010053A2 (en) 2017-11-21 2020-11-03 Forsight Vision4, Inc. fluid change device for expandable door release system and methods of using it
US20210267798A1 (en) * 2020-02-27 2021-09-02 Innfocus, Inc. Ocular implant

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5860994A (en) * 1996-07-30 1999-01-19 Yaacobi; Yoseph Remotely operable intraocular surgical instrument for automated capsulectomies
US6001088A (en) * 1994-12-02 1999-12-14 The University Of Queensland Iontophoresis method and apparatus
US6413540B1 (en) * 1999-10-21 2002-07-02 Alcon Universal Ltd. Drug delivery device

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3828777A (en) 1971-11-08 1974-08-13 Alza Corp Microporous ocular device
US3884232A (en) * 1974-06-05 1975-05-20 Ruth Braun Instrument for administering to the human eye
US4014335A (en) * 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4256108A (en) * 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4300557A (en) 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4624848A (en) 1984-05-10 1986-11-25 Ciba-Geigy Corporation Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
US5322691A (en) 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US5147647A (en) 1986-10-02 1992-09-15 Sohrab Darougar Ocular insert for the fornix
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
DE3905050A1 (en) 1989-02-18 1990-08-30 Lohmann Therapie Syst Lts THERAPEUTIC SYSTEM FOR DELAYED AND CONTROLLED TRANSDERMAL OR TRANSMUCOSAL ADMINISTRATION OF ACTIVE SUBSTANCES (II)
US4946450A (en) 1989-04-18 1990-08-07 Biosource Genetics Corporation Glucan/collagen therapeutic eye shields
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
DE4022553A1 (en) 1990-07-16 1992-01-23 Hund Helmut Gmbh Medical contact lens - with recess contg. therapeutically or diagnostically active substance
US5030214A (en) * 1990-11-01 1991-07-09 Larry Spector Ocular delivery system
US5290892A (en) 1990-11-07 1994-03-01 Nestle S.A. Flexible intraocular lenses made from high refractive index polymers
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5679666A (en) 1991-11-22 1997-10-21 Alcon Laboratories, Inc. Prevention and treatment of ocular neovascularization by treatment with angiostatic steroids
US5770592A (en) 1991-11-22 1998-06-23 Alcon Laboratories, Inc. Prevention and treatment of ocular neovascularization using angiostatic steroids
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
FR2690846B1 (en) 1992-05-05 1995-07-07 Aiache Jean Marc GALENIC FORM FOR EYE ADMINISTRATION AND METHOD OF PREPARATION.
WO1994005257A1 (en) 1992-09-08 1994-03-17 Allergan, Inc. Sustained release of ophthalmic drugs from a soluble polymer drug delivery vehicle
WO1995003009A1 (en) 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5516522A (en) 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
AU704591B2 (en) 1994-04-04 1999-04-29 William R. Freeman Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
US5710165A (en) 1994-07-06 1998-01-20 Synthelabo Use of polyamine antagonists for the treatment of glaucoma
AUPM897594A0 (en) 1994-10-25 1994-11-17 Daratech Pty Ltd Controlled release container
ATE232089T1 (en) 1994-11-10 2003-02-15 Univ Kentucky Res Found CONTROLLED RELEASE IMPLANTABLE REFILLABLE DEVICE FOR ADMINISTERING DRUGS IMMEDIATELY TO AN INTERNAL PART OF THE BODY
US5725493A (en) 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
CN1124164C (en) 1995-05-14 2003-10-15 奥普通诺尔有限公司 Intraocular implant, delivery device, and method of implantation
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
AUPN605795A0 (en) 1995-10-19 1995-11-09 F.H. Faulding & Co. Limited Analgesic pharmaceutical composition
US5743274A (en) 1996-03-18 1998-04-28 Peyman; Gholam A. Macular bandage for use in the treatment of subretinal neovascular members
US5824073A (en) 1996-03-18 1998-10-20 Peyman; Gholam A. Macular indentor for use in the treatment of subretinal neovascular membranes
US5904144A (en) 1996-03-22 1999-05-18 Cytotherapeutics, Inc. Method for treating ophthalmic diseases
JP3309175B2 (en) 1996-03-25 2002-07-29 参天製薬株式会社 Scleral plug containing proteinaceous drug
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US6120460A (en) * 1996-09-04 2000-09-19 Abreu; Marcio Marc Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
DE69816980T2 (en) 1997-03-31 2004-07-22 Alza Corp., Palo Alto IMPLANTABLE DIFFUSION DELIVERY SYSTEM
JP2001513369A (en) 1997-08-11 2001-09-04 アラーガン・セイルズ・インコーポレイテッド Sterile bioerodible implant devices and methods with improved biocompatibility
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6066671A (en) 1997-12-19 2000-05-23 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
JP2002506028A (en) 1998-03-13 2002-02-26 ジョンズ ホプキンズ ユニヴァーシティ スクール オヴ メディシン Use of a protein tyrosine inhibitor such as genistein in the treatment of diabetic retinopathy or ocular inflammation
US6378526B1 (en) 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
US6146366A (en) 1998-11-03 2000-11-14 Ras Holding Corp Device for the treatment of macular degeneration and other eye disorders
US6399655B1 (en) 1998-12-22 2002-06-04 Johns Hopkins University, School Of Medicine Method for the prophylactic treatment of cataracts
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6416777B1 (en) 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
US6413245B1 (en) 1999-10-21 2002-07-02 Alcon Universal Ltd. Sub-tenon drug delivery
RU2149615C1 (en) 1999-11-10 2000-05-27 Нестеров Аркадий Павлович Method for introducing drugs in treating posterior eye segment diseases
AUPQ496500A0 (en) 2000-01-06 2000-02-03 University Of Sydney, The Kit
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
DE60135352D1 (en) * 2000-08-30 2008-09-25 Univ Johns Hopkins DEVICE FOR INTRA-OCCULAR ACTIVE AGGREGATION
ES2294043T3 (en) * 2001-01-03 2008-04-01 BAUSCH & LOMB INCORPORATED PROLONGED RELEASE DEVICES OF MEDICINES THAT INCLUDE NUCLEOS COVERED MEDICINES.
US7181287B2 (en) 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6713081B2 (en) * 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
DE60239868D1 (en) 2001-06-12 2011-06-09 Univ Johns Hopkins Med RESERVOIR DEVICE FOR INTRAOCULAR DRUG DELIVERY

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001088A (en) * 1994-12-02 1999-12-14 The University Of Queensland Iontophoresis method and apparatus
US5860994A (en) * 1996-07-30 1999-01-19 Yaacobi; Yoseph Remotely operable intraocular surgical instrument for automated capsulectomies
US6413540B1 (en) * 1999-10-21 2002-07-02 Alcon Universal Ltd. Drug delivery device

Also Published As

Publication number Publication date
JP4261343B2 (en) 2009-04-30
CN1203814C (en) 2005-06-01
EP1409065B1 (en) 2007-01-17
EP1409065A4 (en) 2006-01-11
PL368207A1 (en) 2005-03-21
AU2002319596B2 (en) 2006-04-27
PT1409065E (en) 2007-03-30
JP2005521433A (en) 2005-07-21
CA2447802C (en) 2009-09-29
EP1409065A2 (en) 2004-04-21
US7094226B2 (en) 2006-08-22
DE60217679D1 (en) 2007-03-08
US20040106906A1 (en) 2004-06-03
DE60217679T2 (en) 2007-10-25
MXPA03011609A (en) 2004-07-01
DK1409065T3 (en) 2007-05-21
PL204644B1 (en) 2010-01-29
ES2278936T3 (en) 2007-08-16
CN1525872A (en) 2004-09-01
ZA200308993B (en) 2004-11-19
CY1105991T1 (en) 2011-04-06
CA2447802A1 (en) 2003-02-06
BR0210494A (en) 2004-06-22
WO2003009774A2 (en) 2003-02-06

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