WO2002087792A8 - Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles - Google Patents
Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particlesInfo
- Publication number
- WO2002087792A8 WO2002087792A8 PCT/US2001/051001 US0151001W WO02087792A8 WO 2002087792 A8 WO2002087792 A8 WO 2002087792A8 US 0151001 W US0151001 W US 0151001W WO 02087792 A8 WO02087792 A8 WO 02087792A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- forces
- particles
- sorting
- optical
- methods
- Prior art date
Links
- 230000003287 optical effect Effects 0.000 title abstract 5
- 239000002245 particle Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 238000012512 characterization method Methods 0.000 title 1
- 239000000975 dye Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 230000003245 working effect Effects 0.000 abstract 1
Classifications
-
- G01N15/1433—
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
- B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
- B07C5/34—Sorting according to other particular properties
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H3/00—Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
- H05H3/04—Acceleration by electromagnetic wave pressure
-
- G01N15/149—
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N2015/1486—Counting the particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002444783A CA2444783A1 (en) | 2001-04-27 | 2001-11-09 | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles |
AU2002241760A AU2002241760B2 (en) | 2001-04-27 | 2001-11-09 | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles |
EP01988455A EP1390160A4 (en) | 2001-04-27 | 2001-11-09 | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles |
JP2002585125A JP2004530877A (en) | 2001-04-27 | 2001-11-09 | Method and apparatus for using optical forces for particle identification, characterization and / or sorting |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/845,245 US20030007894A1 (en) | 2001-04-27 | 2001-04-27 | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles |
US09/845,245 | 2001-04-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002087792A1 WO2002087792A1 (en) | 2002-11-07 |
WO2002087792A8 true WO2002087792A8 (en) | 2003-11-20 |
Family
ID=25294755
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/051001 WO2002087792A1 (en) | 2001-04-27 | 2001-11-09 | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles |
Country Status (6)
Country | Link |
---|---|
US (4) | US20030007894A1 (en) |
EP (1) | EP1390160A4 (en) |
JP (1) | JP2004530877A (en) |
AU (1) | AU2002241760B2 (en) |
CA (1) | CA2444783A1 (en) |
WO (1) | WO2002087792A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9815058B2 (en) | 2003-05-08 | 2017-11-14 | The University Court Of The University Of St Andrews | Fractionation of particles |
US11965816B2 (en) | 2010-11-16 | 2024-04-23 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
Families Citing this family (194)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6797942B2 (en) * | 2001-09-13 | 2004-09-28 | University Of Chicago | Apparatus and process for the lateral deflection and separation of flowing particles by a static array of optical tweezers |
US6692952B1 (en) * | 1999-11-10 | 2004-02-17 | Massachusetts Institute Of Technology | Cell analysis and sorting apparatus for manipulation of cells |
US6537433B1 (en) * | 2000-03-10 | 2003-03-25 | Applera Corporation | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field |
US20020121443A1 (en) * | 2000-11-13 | 2002-09-05 | Genoptix | Methods for the combined electrical and optical identification, characterization and/or sorting of particles |
US20020160470A1 (en) * | 2000-11-13 | 2002-10-31 | Genoptix | Methods and apparatus for generating and utilizing linear moving optical gradients |
US6936811B2 (en) | 2000-11-13 | 2005-08-30 | Genoptix, Inc. | Method for separating micro-particles |
US20030007894A1 (en) * | 2001-04-27 | 2003-01-09 | Genoptix | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles |
US20020123112A1 (en) * | 2000-11-13 | 2002-09-05 | Genoptix | Methods for increasing detection sensitivity in optical dielectric sorting systems |
US6778724B2 (en) * | 2000-11-28 | 2004-08-17 | The Regents Of The University Of California | Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices |
US6913697B2 (en) | 2001-02-14 | 2005-07-05 | Science & Technology Corporation @ Unm | Nanostructured separation and analysis devices for biological membranes |
US20030194755A1 (en) * | 2001-04-27 | 2003-10-16 | Genoptix, Inc. | Early detection of apoptotic events and apoptosis using optophoretic analysis |
US20040023310A1 (en) * | 2001-04-27 | 2004-02-05 | Genoptix, Inc | Quantitative determination of protein kinase C activation using optophoretic analysis |
US20030124516A1 (en) * | 2001-04-27 | 2003-07-03 | Genoptix, Inc. | Method of using optical interrogation to determine a biological property of a cell or population of cells |
US6416190B1 (en) * | 2001-04-27 | 2002-07-09 | University Of Chicago | Apparatus for using optical tweezers to manipulate materials |
US6639208B2 (en) * | 2001-06-06 | 2003-10-28 | University Of Chicago | Optical peristaltic pumping with optical traps |
US20030055587A1 (en) * | 2001-09-17 | 2003-03-20 | Symyx Technologies, Inc. | Rapid throughput surface topographical analysis |
FR2833716B1 (en) * | 2001-12-13 | 2004-01-30 | Commissariat Energie Atomique | OPTICAL DEVICE AND OPTICAL METHOD FOR MOVING PARTICLES |
AU2003216175A1 (en) * | 2002-02-04 | 2003-09-02 | Colorado School Of Mines | Laminar flow-based separations of colloidal and cellular particles |
US20040033539A1 (en) * | 2002-05-01 | 2004-02-19 | Genoptix, Inc | Method of using optical interrogation to determine a biological property of a cell or population of cells |
US20030211461A1 (en) * | 2002-05-01 | 2003-11-13 | Genoptix, Inc | Optophoretic detection of durgs exhibiting inhibitory effect on Bcr-Abl positive tumor cells |
GB2389973B (en) * | 2002-06-18 | 2006-02-15 | Alstom | Improvements relating to electrical filters |
CN1774623B (en) | 2002-07-31 | 2012-02-01 | 阿尔利克斯公司 | System and method of sorting materials using holographic laser steering |
US7699767B2 (en) | 2002-07-31 | 2010-04-20 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
US7118676B2 (en) * | 2003-09-04 | 2006-10-10 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
US7150834B2 (en) * | 2003-07-31 | 2006-12-19 | Arryx, Inc. | Multiple laminar flow-based rate zonal or isopycnic separation with holographic optical trapping of blood cells and other static components |
US7109473B2 (en) * | 2002-09-16 | 2006-09-19 | University Of Chicago | Transverse optical accelerator and generalized optical vortices |
EP2359689B1 (en) | 2002-09-27 | 2015-08-26 | The General Hospital Corporation | Microfluidic device for cell separation and use thereof |
AU2003280704A1 (en) | 2002-11-01 | 2004-05-25 | Techno Network Shikoku Co., Ltd. | Method for sorting and recovering fine particle and apparatus for recovery |
US20040121474A1 (en) * | 2002-12-19 | 2004-06-24 | Genoptix, Inc | Detection and evaluation of chemically-mediated and ligand-mediated t-cell activation using optophoretic analysis |
US20040121307A1 (en) * | 2002-12-19 | 2004-06-24 | Genoptix, Inc | Early detection of cellular differentiation using optophoresis |
EP1604184A4 (en) * | 2003-02-27 | 2010-10-27 | Stephen A Lesko | Standardized evaluation of therapeutic efficacy based on cellular biomarkers |
DE10317669B4 (en) * | 2003-04-17 | 2017-03-09 | Leica Microsystems Cms Gmbh | Method for separating detection channels of a microscopic system |
JP2004325944A (en) * | 2003-04-25 | 2004-11-18 | Canon Inc | Micro object manipulation equipment |
WO2004104551A2 (en) * | 2003-05-16 | 2004-12-02 | University Of Chicago | Optical fractionation methods and apparatus |
CN100411497C (en) * | 2003-05-16 | 2008-08-13 | 芝加哥大学 | Optical fractionation methods and apparatus |
WO2005023391A2 (en) * | 2003-07-31 | 2005-03-17 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
CN1860363B (en) | 2003-08-28 | 2011-12-28 | 赛路拉公司 | Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network |
US20050067337A1 (en) * | 2003-09-30 | 2005-03-31 | Hart Sean J. | Laser optical separator and method for separating colloidal suspensions |
US7449679B2 (en) * | 2003-10-28 | 2008-11-11 | Arryx, Inc. | System and method for manipulating and processing materials using holographic optical trapping |
US20090108190A1 (en) * | 2004-03-17 | 2009-04-30 | Arryx, Inc. | System and method for manipulating and processing materials using holographic optical trapping |
CN101304781B (en) * | 2004-06-28 | 2012-08-01 | 美国血液技术公司 | Blood component separation system with stationary separation chamber |
ITBO20040420A1 (en) * | 2004-07-07 | 2004-10-07 | Type S R L | METAL CUTTING AND FORMING MACHINE |
US7259344B2 (en) * | 2004-10-01 | 2007-08-21 | Intel Corporation | Application of static light to a fluid of CNTs for purposes of sorting the CNTs |
US20060077361A1 (en) * | 2004-10-12 | 2006-04-13 | Michael Sogard | Means of removing particles from a membrane mask in a vacuum |
US20090002790A1 (en) * | 2004-10-28 | 2009-01-01 | Arryx, Inc. | System and method for manipulating and processing materials using holographic optical trapping |
US7473890B2 (en) * | 2004-11-23 | 2009-01-06 | New York University | Manipulation of objects in potential energy landscapes |
US20060171846A1 (en) * | 2005-01-10 | 2006-08-03 | Marr David W M | Microfluidic systems incorporating integrated optical waveguides |
US7586684B2 (en) * | 2005-01-21 | 2009-09-08 | New York University | Solute characterization by optoelectronkinetic potentiometry in an inclined array of optical traps |
US20070026415A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070026413A1 (en) * | 2005-07-29 | 2007-02-01 | Mehmet Toner | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070026417A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
US20070026414A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
KR20060111143A (en) * | 2005-04-22 | 2006-10-26 | 한국표준과학연구원 | Apparatus for separating particles using optical trapping |
US20070009909A1 (en) * | 2005-06-30 | 2007-01-11 | Lopez Herman A | Sorting of carbon nanotubes through arrays |
US7776478B2 (en) | 2005-07-15 | 2010-08-17 | Cymbet Corporation | Thin-film batteries with polymer and LiPON electrolyte layers and method |
KR101387855B1 (en) * | 2005-07-15 | 2014-04-22 | 사임베트 코퍼레이션 | Thin-film batteries with soft and hard electrolyte layers and method |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070059680A1 (en) * | 2005-09-15 | 2007-03-15 | Ravi Kapur | System for cell enrichment |
US20090181421A1 (en) * | 2005-07-29 | 2009-07-16 | Ravi Kapur | Diagnosis of fetal abnormalities using nucleated red blood cells |
US20070026416A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070059781A1 (en) * | 2005-09-15 | 2007-03-15 | Ravi Kapur | System for size based separation and analysis |
US20070059719A1 (en) * | 2005-09-15 | 2007-03-15 | Michael Grisham | Business methods for prenatal Diagnosis |
US20070059718A1 (en) * | 2005-09-15 | 2007-03-15 | Mehmet Toner | Systems and methods for enrichment of analytes |
US20070059683A1 (en) * | 2005-09-15 | 2007-03-15 | Tom Barber | Veterinary diagnostic system |
US20070059774A1 (en) * | 2005-09-15 | 2007-03-15 | Michael Grisham | Kits for Prenatal Testing |
WO2007038259A2 (en) | 2005-09-23 | 2007-04-05 | Massachusetts Institute Of Technology | Optical trapping with a semiconductor |
DE102005053669B4 (en) * | 2005-11-08 | 2007-12-13 | Kilper, Roland, Dr. | Sample manipulation device |
US9878326B2 (en) * | 2007-09-26 | 2018-01-30 | Colorado School Of Mines | Fiber-focused diode-bar optical trapping for microfluidic manipulation |
US8119976B2 (en) * | 2007-07-03 | 2012-02-21 | Colorado School Of Mines | Optical-based cell deformability |
US9487812B2 (en) | 2012-02-17 | 2016-11-08 | Colorado School Of Mines | Optical alignment deformation spectroscopy |
US9885644B2 (en) | 2006-01-10 | 2018-02-06 | Colorado School Of Mines | Dynamic viscoelasticity as a rapid single-cell biomarker |
US7718953B2 (en) * | 2006-04-12 | 2010-05-18 | University Of Delaware | Electromagnetic/optical tweezers using a full 3D negative-refraction flat lens |
JP2007313378A (en) * | 2006-05-23 | 2007-12-06 | Keio Gijuku | Optical substance operating device |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
WO2007147073A2 (en) * | 2006-06-14 | 2007-12-21 | Living Microsystems, Inc. | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
WO2007147074A2 (en) * | 2006-06-14 | 2007-12-21 | Living Microsystems, Inc. | Use of highly parallel snp genotyping for fetal diagnosis |
WO2007147018A1 (en) * | 2006-06-14 | 2007-12-21 | Cellpoint Diagnostics, Inc. | Analysis of rare cell-enriched samples |
US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
US20080007838A1 (en) * | 2006-07-07 | 2008-01-10 | Omnitech Partners, Inc. | Field-of-view indicator, and optical system and associated method employing the same |
WO2008088395A2 (en) * | 2006-08-31 | 2008-07-24 | Massachusetts Institute Ot Technology | Optofluidic-based particle sorting |
US8169600B2 (en) * | 2006-09-15 | 2012-05-01 | Arryx, Inc. | Surface mapping by optical manipulation of particles in relation to a functionalized surface |
GB0618605D0 (en) | 2006-09-21 | 2006-11-01 | Univ St Andrews | Optical sorting |
GB0618606D0 (en) * | 2006-09-21 | 2006-11-01 | Univ St Andrews | Optical sorting |
US7847238B2 (en) * | 2006-11-07 | 2010-12-07 | New York University | Holographic microfabrication and characterization system for soft matter and biological systems |
TWI322280B (en) * | 2007-01-24 | 2010-03-21 | Raydium Semiconductor Corp | Apparatus capable of providing optical tweezers with momentum and method thereof |
US7978303B2 (en) * | 2007-03-27 | 2011-07-12 | United Microelectronics Corp. | Method for removing micro-bubbles and/or particles from liquid, liquid supply apparatus and immersion exposure apparatus |
CN101281375B (en) * | 2007-04-04 | 2011-02-09 | 联华电子股份有限公司 | Method for removing micro-air blister / particulate in liquid, liquid supplier and uses thereof |
US8691164B2 (en) * | 2007-04-20 | 2014-04-08 | Celula, Inc. | Cell sorting system and methods |
US7746466B2 (en) * | 2007-05-14 | 2010-06-29 | The Regents Of The University Of California | System and method for flow cytometry |
CN104307581B (en) * | 2007-08-09 | 2017-04-12 | 诺思可有限公司 | Methods and devices for correlated, multi-parameter single cell measurements and recovery of remnant biological material |
US20090062828A1 (en) * | 2007-09-04 | 2009-03-05 | Colorado School Of Mines | Magnetic field-based colloidal atherectomy |
US10722250B2 (en) | 2007-09-04 | 2020-07-28 | Colorado School Of Mines | Magnetic-field driven colloidal microbots, methods for forming and using the same |
US8368008B2 (en) * | 2007-09-23 | 2013-02-05 | President And Fellows Of Harvard College | Optical trapping methods and apparatus employing one or more Fresnel zone plates |
US9594071B2 (en) * | 2007-12-21 | 2017-03-14 | Colin G. Hebert | Device and method for laser analysis and separation (LAS) of particles |
US10281385B2 (en) * | 2007-12-21 | 2019-05-07 | The United States Of America, As Represented By The Secretary Of The Navy | Device for laser analysis and separation (LAS) of particles |
US8585916B2 (en) * | 2008-01-24 | 2013-11-19 | Sandia Corporation | Micropores and methods of making and using thereof |
US8174742B2 (en) | 2008-03-14 | 2012-05-08 | New York University | System for applying optical forces from phase gradients |
CA2737643C (en) * | 2008-09-20 | 2020-10-06 | Hei-Mun Fan | Noninvasive diagnosis of fetal aneuploidy by sequencing |
WO2010053796A2 (en) * | 2008-10-28 | 2010-05-14 | The Regents Of The University Of Colorado, A Body Corporate | Microfluidic cell sorter utilizing broadband coherent anti-stokes raman scattering |
WO2010101671A1 (en) | 2009-01-16 | 2010-09-10 | New York University | Automated real-time particle characterization and three-dimensional velocimetry with holographic video microscopy |
DE102008060332B4 (en) * | 2008-12-03 | 2013-01-10 | Albert-Ludwigs-Universität Freiburg | Method for sorting at least one particle with a microfluidic sorting device with optical tweezers |
US8162149B1 (en) | 2009-01-21 | 2012-04-24 | Sandia Corporation | Particle sorter comprising a fluid displacer in a closed-loop fluid circuit |
US9134221B2 (en) | 2009-03-10 | 2015-09-15 | The Regents Of The University Of California | Fluidic flow cytometry devices and particle sensing based on signal-encoding |
US9645010B2 (en) | 2009-03-10 | 2017-05-09 | The Regents Of The University Of California | Fluidic flow cytometry devices and methods |
AU2010257118B2 (en) | 2009-06-04 | 2014-08-28 | Lockheed Martin Corporation | Multiple-sample microfluidic chip for DNA analysis |
WO2011079139A2 (en) * | 2009-12-22 | 2011-06-30 | New York University | Sorting colloidal particles into multiple channels with optical forces: prismatic optical fractionation |
US20110312503A1 (en) | 2010-01-23 | 2011-12-22 | Artemis Health, Inc. | Methods of fetal abnormality detection |
US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
JP2013533469A (en) * | 2010-05-25 | 2013-08-22 | アリックス インク | Methods and apparatus for detection of particle positional freedom in biological and chemical analysis and applications in immunodiagnostics |
US20130095512A1 (en) * | 2010-06-18 | 2013-04-18 | Cornell University | Device for sorting, classifying, and assaying partition behavior of cell membrane biomolecules and methods based thereon |
CA2814720C (en) | 2010-10-15 | 2016-12-13 | Lockheed Martin Corporation | Micro fluidic optic design |
KR101885936B1 (en) | 2010-10-21 | 2018-09-10 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Microfluidics with Wirelessly Powered Electronic Circuits |
US8476004B2 (en) | 2011-06-27 | 2013-07-02 | United Microelectronics Corp. | Method for forming photoresist patterns |
US11527774B2 (en) | 2011-06-29 | 2022-12-13 | Space Charge, LLC | Electrochemical energy storage devices |
US10601074B2 (en) | 2011-06-29 | 2020-03-24 | Space Charge, LLC | Rugged, gel-free, lithium-free, high energy density solid-state electrochemical energy storage devices |
US9853325B2 (en) | 2011-06-29 | 2017-12-26 | Space Charge, LLC | Rugged, gel-free, lithium-free, high energy density solid-state electrochemical energy storage devices |
US9841367B2 (en) * | 2011-09-16 | 2017-12-12 | The University Of North Carolina At Charlotte | Methods and devices for optical sorting of microspheres based on their resonant optical properties |
US9242248B2 (en) * | 2011-09-16 | 2016-01-26 | The University Of North Carolina At Charlotte | Methods and devices for optical sorting of microspheres based on their resonant optical properties |
DE102011055367B4 (en) * | 2011-11-15 | 2017-02-09 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Method and device for tracking a movement of a particle, in particular a single molecule, in a sample |
US9291562B2 (en) | 2011-11-15 | 2016-03-22 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Method and apparatus for tracking a particle, particularly a single molecule, in a sample |
US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
EP2877832B1 (en) | 2012-07-27 | 2020-10-28 | Engender Technologies Limited | System for microfluidic orientation and sorting of particles |
US9194786B2 (en) * | 2012-08-01 | 2015-11-24 | Owl biomedical, Inc. | Particle manipulation system with cytometric capability |
US9731293B2 (en) | 2012-10-03 | 2017-08-15 | The United States Of America, As Represented By The Secretary Of The Navy | Paired laser and electrokinetic separation, manipulation, and analysis device |
CN110579435B (en) | 2012-10-15 | 2023-09-26 | 纳诺赛莱克特生物医药股份有限公司 | System, apparatus and method for particle sorting |
US9857333B2 (en) | 2012-10-31 | 2018-01-02 | Berkeley Lights, Inc. | Pens for biological micro-objects |
TWI498593B (en) | 2012-11-06 | 2015-09-01 | Ind Tech Res Inst | Projection lens, projection device and optically-induced microparticle device |
US8701052B1 (en) | 2013-01-23 | 2014-04-15 | United Microelectronics Corp. | Method of optical proximity correction in combination with double patterning technique |
US8627242B1 (en) | 2013-01-30 | 2014-01-07 | United Microelectronics Corp. | Method for making photomask layout |
US10502666B2 (en) * | 2013-02-06 | 2019-12-10 | Alentic Microscience Inc. | Sample processing improvements for quantitative microscopy |
CN103234880A (en) * | 2013-03-30 | 2013-08-07 | 成都佳锂科技有限公司 | Portable bluetooth fine particle detection instrument |
US9372143B2 (en) | 2013-05-15 | 2016-06-21 | Captl Llc | Scanning image flow cytometer |
US9230812B2 (en) | 2013-05-22 | 2016-01-05 | United Microelectronics Corp. | Method for forming semiconductor structure having opening |
US9539619B2 (en) * | 2013-05-24 | 2017-01-10 | Gii Acquisition, Llc | High speed method and system for inspecting a stream of parts at a pair of inspection stations |
US10207297B2 (en) | 2013-05-24 | 2019-02-19 | GII Inspection, LLC | Method and system for inspecting a manufactured part at an inspection station |
EP3014330B1 (en) | 2013-06-26 | 2024-01-03 | Alentic Microscience Inc. | Sample processing improvements for microscopy |
US8961904B2 (en) | 2013-07-16 | 2015-02-24 | Premium Genetics (Uk) Ltd. | Microfluidic chip |
SG10202002543UA (en) | 2013-10-22 | 2020-05-28 | Berkeley Lights Inc | Micro-fluidic devices for assaying biological activity |
IL283153B2 (en) | 2013-10-22 | 2023-04-01 | Berkeley Lights Inc | Microfluidic devices having isolation pens and methods of testing biological micro-objects with same |
US9889445B2 (en) | 2013-10-22 | 2018-02-13 | Berkeley Lights, Inc. | Micro-fluidic devices for assaying biological activity |
US11796449B2 (en) | 2013-10-30 | 2023-10-24 | Abs Global, Inc. | Microfluidic system and method with focused energy apparatus |
US8820538B1 (en) * | 2014-03-17 | 2014-09-02 | Namocell LLC | Method and apparatus for particle sorting |
US11192107B2 (en) | 2014-04-25 | 2021-12-07 | Berkeley Lights, Inc. | DEP force control and electrowetting control in different sections of the same microfluidic apparatus |
US20150306599A1 (en) | 2014-04-25 | 2015-10-29 | Berkeley Lights, Inc. | Providing DEP Manipulation Devices And Controllable Electrowetting Devices In The Same Microfluidic Apparatus |
US10300510B2 (en) | 2014-08-01 | 2019-05-28 | General Inspection Llc | High speed method and system for inspecting a stream of parts |
SG11201704558QA (en) | 2014-12-08 | 2017-07-28 | Berkeley Lights Inc | Microfluidic device comprising lateral/vertical transistor structures and process of making and using same |
CN107249742B (en) | 2014-12-08 | 2019-12-06 | 伯克利之光生命科技公司 | Directional flow actuated microfluidic structures in microfluidic devices and methods of using the same |
US9996920B2 (en) | 2014-12-09 | 2018-06-12 | Berkeley Lights, Inc. | Automated detection and repositioning of micro-objects in microfluidic devices |
EP3230718B1 (en) | 2014-12-09 | 2022-03-02 | Berkeley Lights, Inc. | Automated detection of assay-positive areas or of analyte quantities in microfluidic devices |
SG11201704659PA (en) | 2014-12-10 | 2017-07-28 | Berkeley Lights Inc | Systems for operating electrokinetic devices |
WO2016094715A2 (en) | 2014-12-10 | 2016-06-16 | Berkeley Lights, Inc. | Movement and selection of micro-objects in a microfluidic apparatus |
US10900885B2 (en) | 2014-12-19 | 2021-01-26 | Captl Llc | Flow cytometry using hydrodynamically planar flow |
WO2016132222A2 (en) | 2015-02-19 | 2016-08-25 | Premium Genetics (Uk) Ltd. | Scanning infrared measurement system |
US9734927B2 (en) | 2015-04-09 | 2017-08-15 | International Business Machines Corporation | Optical capture and isolation of circulating tumor cells in a micro-fluidic device utilizing size selective trapping with optical cogwheel tweezers |
US10101250B2 (en) | 2015-04-22 | 2018-10-16 | Berkeley Lights, Inc. | Manipulation of cell nuclei in a micro-fluidic device |
CA3176115A1 (en) | 2015-04-22 | 2016-10-27 | Berkeley Lights, Inc. | Microfluidic device for culturing biological cells and methods of use thereof |
US10751715B1 (en) | 2015-04-22 | 2020-08-25 | Berkeley Lights, Inc. | Microfluidic reporter cell assay methods and kits thereof |
KR102334118B1 (en) | 2015-04-22 | 2021-12-01 | 버클리 라잇츠, 인크. | Freezing and archiving cells on a microfluidic device |
US10036698B2 (en) | 2015-06-19 | 2018-07-31 | Captl Llc | Time-sequential cytometry |
CN105137585B (en) * | 2015-07-21 | 2022-11-18 | 大连理工大学 | Method for generating tunable non-gradient optical force on chalcogenide metal multilayer core-shell surface by linearly polarized non-planar optical waves |
CN105182518B (en) * | 2015-07-21 | 2023-01-06 | 大连理工大学 | Method for tunable capture and screening of particles above vanadium dioxide substrate by linear polarization plane light waves |
CN105116533A (en) * | 2015-07-21 | 2015-12-02 | 大连理工大学 | Tunable capturing and screening method of linear polarization planar optical waves for liquid crystal material particle above substrate |
CN105116532A (en) * | 2015-07-21 | 2015-12-02 | 大连理工大学 | Method for generating tunable non-gradient optical force by linear polarization non-planar optical waves at surface of vanadium dioxide/metal multilayer core-shell |
CN105137586B (en) * | 2015-07-21 | 2022-11-18 | 大连理工大学 | Method for tunable capture and screening of particles above graphene substrate by linear polarization plane light waves |
CN105137587B (en) * | 2015-07-21 | 2022-11-18 | 大连理工大学 | Method for generating tunable non-gradient optical force on particles wrapping graphene thin layer by linear polarization non-planar light waves |
US10799865B2 (en) | 2015-10-27 | 2020-10-13 | Berkeley Lights, Inc. | Microfluidic apparatus having an optimized electrowetting surface and related systems and methods |
WO2017091601A1 (en) | 2015-11-23 | 2017-06-01 | Berkeley Lights, Inc. | In situ-generated microfluidic isolation structures, kits and methods of use thereof |
SG11201804275TA (en) | 2015-12-08 | 2018-06-28 | Berkeley Lights Inc | Microfluidic devices and kits and methods for use thereof |
CN108698814A (en) | 2015-12-30 | 2018-10-23 | 伯克利之光生命科技公司 | Microfluidic device, kit and its method of convection current and displacement for optical drive |
WO2017117521A1 (en) | 2015-12-31 | 2017-07-06 | Berkeley Lights, Inc. | Tumor infilitrating cells engineered to express a pro-inflammatory polypeptide |
KR102512608B1 (en) | 2016-01-15 | 2023-03-22 | 버클리 라잇츠, 인크. | Method for manufacturing patient-specific anti-cancer treatment and treatment method therefor |
DK3414517T3 (en) | 2016-02-08 | 2021-12-13 | Univ New York | HOLOGRAPHIC CHARACTERIZATION OF PROTEIN UNITS |
CN109922885B (en) | 2016-03-16 | 2022-05-10 | 伯克利之光生命科技公司 | Methods, systems and apparatus for selection and generation of genome editing clones |
AU2017248822B2 (en) | 2016-04-15 | 2022-09-15 | Berkeley Lights, Inc. | Methods, systems and kits for in-pen assays |
US10675625B2 (en) | 2016-04-15 | 2020-06-09 | Berkeley Lights, Inc | Light sequencing and patterns for dielectrophoretic transport |
SG11201809539RA (en) | 2016-05-26 | 2018-12-28 | Berkeley Lights Inc | Covalently modified surfaces, kits, and methods of preparation and use |
US10073026B2 (en) * | 2016-07-05 | 2018-09-11 | The United States Of America, As Represented By The Secretary Of Commerce | Optical particle sorter |
JP7038100B2 (en) | 2016-07-21 | 2022-03-17 | バークレー ライツ,インコーポレイテッド | Sorting of T lymphocytes with a microfluidic device |
CN110546495B (en) | 2016-12-30 | 2022-11-01 | 加利福尼亚州立大学董事会 | Methods for selection and passage of genome editing T cells |
WO2019075476A2 (en) | 2017-10-15 | 2019-04-18 | Berkeley Lights, Inc. | Methods, systems and kits for in-pen assays |
JP2019082336A (en) * | 2017-10-27 | 2019-05-30 | シャープ株式会社 | Particulate detection sensor |
EP3762989A4 (en) | 2018-03-07 | 2021-12-15 | Space Charge, LLC | Thin-film solid-state energy-storage devices |
EP3796998A1 (en) | 2018-05-23 | 2021-03-31 | ABS Global, Inc. | Systems and methods for particle focusing in microchannels |
EP4245140A3 (en) | 2019-04-18 | 2024-01-17 | ABS Global, Inc. | System and process for continuous addition of cryoprotectant |
EP3962652A4 (en) | 2019-04-30 | 2023-01-18 | Berkeley Lights, Inc. | Methods for encapsulating and assaying cells |
CN111906053A (en) * | 2019-05-07 | 2020-11-10 | 矽电半导体设备(深圳)股份有限公司 | Core particle sorting method and core particle sorting structure |
US11543338B2 (en) | 2019-10-25 | 2023-01-03 | New York University | Holographic characterization of irregular particles |
US11628439B2 (en) | 2020-01-13 | 2023-04-18 | Abs Global, Inc. | Single-sheath microfluidic chip |
US11948302B2 (en) | 2020-03-09 | 2024-04-02 | New York University | Automated holographic video microscopy assay |
CN113318996A (en) * | 2021-05-26 | 2021-08-31 | 河源职业技术学院 | Automatic patch detection device for glasses box |
IT202100013715A1 (en) * | 2021-05-26 | 2022-11-26 | Menarini Silicon Biosystems Spa | MICROFLUIDIC METHOD AND SYSTEM FOR THE ISOLATION OF PARTICLES |
Family Cites Families (167)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US47676A (en) * | 1865-05-09 | Improvement in the manufacture of blacking-boxes | ||
US58332A (en) * | 1866-09-25 | Improvement in buttons | ||
US332204A (en) * | 1885-12-08 | John keehbiel | ||
US3638139A (en) | 1964-09-29 | 1972-01-25 | Bell Telephone Labor Inc | Frequency-selective laser devices |
US3558877A (en) | 1966-12-19 | 1971-01-26 | Gca Corp | Method and apparatus for mass separation by selective light absorption |
US3628182A (en) | 1969-03-20 | 1971-12-14 | Bell Telephone Labor Inc | Ring-type parametric oscillator |
US3826899A (en) * | 1969-08-15 | 1974-07-30 | Nuclear Res Ass Inc | Biological cell analyzing system |
US3778612A (en) | 1969-12-15 | 1973-12-11 | A Ashkin | Neutral particle beam separator and velocity analyzer using radiation pressure |
US3808550A (en) | 1969-12-15 | 1974-04-30 | Bell Telephone Labor Inc | Apparatuses for trapping and accelerating neutral particles |
US3710279A (en) | 1969-12-15 | 1973-01-09 | Bell Telephone Labor Inc | Apparatuses for trapping and accelerating neutral particles |
CA944466A (en) | 1970-01-26 | 1974-03-26 | Western Electric Company, Incorporated | Guided raman devices |
US3687331A (en) * | 1970-04-01 | 1972-08-29 | Nick S Racz | Cook ware container cover |
US3808432A (en) | 1970-06-04 | 1974-04-30 | Bell Telephone Labor Inc | Neutral particle accelerator utilizing radiation pressure |
US3662183A (en) | 1970-12-28 | 1972-05-09 | Bell Telephone Labor Inc | Continuously tunable optical parametric oscillator |
US3725810A (en) | 1971-04-23 | 1973-04-03 | Bell Telephone Labor Inc | Optical stimulated emission devices employing split optical guides |
US3761721A (en) | 1972-07-06 | 1973-09-25 | Trw Inc | Matter wave interferometric apparatus |
US4127329A (en) | 1976-12-21 | 1978-11-28 | Northeast Utilities Service Company | Raman scattering system and method for aerosol monitoring |
US4092535A (en) | 1977-04-22 | 1978-05-30 | Bell Telephone Laboratories, Incorporated | Damping of optically levitated particles by feedback and beam shaping |
US4063106A (en) | 1977-04-25 | 1977-12-13 | Bell Telephone Laboratories, Incorporated | Optical fiber Raman oscillator |
US4247815A (en) | 1979-05-22 | 1981-01-27 | The United States Of America As Represented By The Secretary Of The Army | Method and apparatus for physiologic facsimile imaging of biologic targets based on complex permittivity measurements using remote microwave interrogation |
US4253846A (en) | 1979-11-21 | 1981-03-03 | Technicon Instruments Corporation | Method and apparatus for automated analysis of fluid samples |
US4327288A (en) | 1980-09-29 | 1982-04-27 | Bell Telephone Laboratories, Incorporated | Method for focusing neutral atoms, molecules and ions |
US4386274A (en) | 1980-11-10 | 1983-05-31 | Saul Altshuler | Isotope separation by standing waves |
US4453805A (en) | 1981-02-19 | 1984-06-12 | Bell Telephone Laboratories, Incorporated | Optical grating using a liquid suspension of dielectric particles |
FR2506530A1 (en) | 1981-05-22 | 1982-11-26 | Thomson Csf | COHERENT RADIATION SOURCE GENERATING AN ADJUSTABLE SPREAD DIRECTION BEAM |
US4390403A (en) | 1981-07-24 | 1983-06-28 | Batchelder J Samuel | Method and apparatus for dielectrophoretic manipulation of chemical species |
FR2519777A1 (en) | 1982-01-12 | 1983-07-18 | Thomson Csf | METHOD FOR MANUFACTURING DIFFRACTANT PHASE STRUCTURES |
US4440638A (en) | 1982-02-16 | 1984-04-03 | U.T. Board Of Regents | Surface field-effect device for manipulation of charged species |
FR2537768A1 (en) | 1982-12-08 | 1984-06-15 | Commissariat Energie Atomique | METHOD AND DEVICE FOR OBTAINING SPATIALLY MODULATED DENSITY PARTICLE BEAMS, APPLICATION TO ION ETCHING AND IMPLANTATION |
US4627689A (en) | 1983-12-08 | 1986-12-09 | University Of Pittsburgh | Crystalline colloidal narrow band radiation filter |
US4632517A (en) | 1983-12-08 | 1986-12-30 | University Of Pittsburgh | Crystalline colloidal narrow band radiation filter |
ATE48477T1 (en) | 1984-09-11 | 1989-12-15 | Partec Ag | METHOD AND DEVICE FOR SORTING MICROSCOPIC PARTICLES. |
GB8623072D0 (en) | 1986-09-25 | 1986-10-29 | Amersham Int Plc | Particle analysis |
US4827125A (en) | 1987-04-29 | 1989-05-02 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Confocal scanning laser microscope having no moving parts |
US4939081A (en) * | 1987-05-27 | 1990-07-03 | The Netherlands Cancer Institute | Cell-separation |
US4893886A (en) | 1987-09-17 | 1990-01-16 | American Telephone And Telegraph Company | Non-destructive optical trap for biological particles and method of doing same |
US4887721A (en) | 1987-11-30 | 1989-12-19 | The United States Of America As Represented By The United States Department Of Energy | Laser particle sorter |
US4908112A (en) | 1988-06-16 | 1990-03-13 | E. I. Du Pont De Nemours & Co. | Silicon semiconductor wafer for analyzing micronic biological samples |
US5100627A (en) | 1989-11-30 | 1992-03-31 | The Regents Of The University Of California | Chamber for the optical manipulation of microscopic particles |
FR2655435B1 (en) | 1989-12-01 | 1992-02-21 | Thomson Csf | COHERENT ADDITION DEVICE OF LASER BEAMS. |
CA2031716C (en) | 1989-12-07 | 1996-06-18 | Hiroaki Misawa | Laser microprocessing and the device therefor |
US5795457A (en) | 1990-01-30 | 1998-08-18 | British Technology Group Ltd. | Manipulation of solid, semi-solid or liquid materials |
US5029791A (en) | 1990-03-08 | 1991-07-09 | Candela Laser Corporation | Optics X-Y positioner |
US5198369A (en) | 1990-04-25 | 1993-03-30 | Canon Kabushiki Kaisha | Sample measuring method using agglomeration reaction of microcarriers |
US5079169A (en) | 1990-05-22 | 1992-01-07 | The Regents Of The Stanford Leland Junior University | Method for optically manipulating polymer filaments |
US5338930A (en) | 1990-06-01 | 1994-08-16 | Research Corporation Technologies | Frequency standard using an atomic fountain of optically trapped atoms |
US5245466A (en) | 1990-08-15 | 1993-09-14 | President And Fellows Of Harvard University And Rowland Institute | Optical matter |
US5113286A (en) | 1990-09-27 | 1992-05-12 | At&T Bell Laboratories | Diffraction grating apparatus and method of forming a surface relief pattern in diffraction grating apparatus |
US6149789A (en) | 1990-10-31 | 2000-11-21 | Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Process for manipulating microscopic, dielectric particles and a device therefor |
US5170890A (en) * | 1990-12-05 | 1992-12-15 | Wilson Steven D | Particle trap |
CA2057506C (en) | 1990-12-13 | 2003-05-13 | Keiji Sasaki | Laser trapping and method for applications thereof |
JP3129471B2 (en) | 1991-06-01 | 2001-01-29 | 科学技術振興事業団 | Multi-beam particle operation method |
US5206504A (en) | 1991-11-01 | 1993-04-27 | The United States Of America As Represented By The Administrator, National Aeronautics And Space Administration | Sample positioning in microgravity |
JP3018687B2 (en) | 1991-12-12 | 2000-03-13 | 松下電器産業株式会社 | Scanning laser microscope |
JPH05203878A (en) | 1992-01-27 | 1993-08-13 | Jeol Ltd | Scanning type laser microscope |
DE69321748T2 (en) * | 1992-02-20 | 1999-06-17 | Canon Kk | Method and measuring apparatus for handling particles |
US5495105A (en) * | 1992-02-20 | 1996-02-27 | Canon Kabushiki Kaisha | Method and apparatus for particle manipulation, and measuring apparatus utilizing the same |
US5274231A (en) | 1992-04-14 | 1993-12-28 | Board Of Trustees, Leland Stanford Jr. University | Method and apparatus for manipulating atoms, ions or molecules and for measuring physical quantities using stimulated Raman transitions |
JP3101419B2 (en) | 1992-05-27 | 2000-10-23 | 株式会社竹中工務店 | Office lighting equipment |
JPH0693038B2 (en) | 1992-06-11 | 1994-11-16 | 東京工業大学長 | Method and apparatus for controlling the motion of a small number of neutral atoms |
US5189294A (en) | 1992-07-08 | 1993-02-23 | The United States Of America As Represented By The Secretary Of The Air Force | Transform lens with a plurality of sliced lens segments |
US5374556A (en) * | 1992-07-23 | 1994-12-20 | Cell Robotics, Inc. | Flexure structure for stage positioning |
US5364744A (en) | 1992-07-23 | 1994-11-15 | Cell Robotics, Inc. | Method for the manufacture of an optical manipulation chamber |
JP3292515B2 (en) * | 1992-09-07 | 2002-06-17 | オリンパス光学工業株式会社 | Fine adjustment method and fine adjustment device for microscope observation |
US6399397B1 (en) | 1992-09-14 | 2002-06-04 | Sri International | Up-converting reporters for biological and other assays using laser excitation techniques |
GB9220564D0 (en) * | 1992-09-29 | 1992-11-11 | Univ London | The method of rheological investigation |
LU88184A1 (en) | 1992-10-28 | 1994-09-09 | Europ Communities | Optical modulator |
US5452123A (en) | 1992-12-30 | 1995-09-19 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of making an optically nonlinear switched optical device and related devices |
DE4300698A1 (en) | 1993-01-13 | 1994-07-14 | Raimund Schuetze | Device and method for handling, processing and observing small particles, in particular biological particles |
US5327515A (en) | 1993-01-14 | 1994-07-05 | At&T Laboratories | Method for forming a Bragg grating in an optical medium |
GB9301122D0 (en) | 1993-01-21 | 1993-03-10 | Scient Generics Ltd | Method of analysis/separation |
US5374566A (en) | 1993-01-27 | 1994-12-20 | National Semiconductor Corporation | Method of fabricating a BiCMOS structure |
US5360764A (en) | 1993-02-16 | 1994-11-01 | The United States Of America, As Represented By The Secretary Of Commerce | Method of fabricating laser controlled nanolithography |
GB9306729D0 (en) | 1993-03-31 | 1993-05-26 | British Tech Group | Improvements in separators |
US5473471A (en) | 1993-04-16 | 1995-12-05 | Matsushita Electric Industrial Co., Ltd. | Complex lens with diffraction grating |
US5366559A (en) * | 1993-05-27 | 1994-11-22 | Research Triangle Institute | Method for protecting a substrate surface from contamination using the photophoretic effect |
EP0635994B1 (en) * | 1993-07-08 | 1998-09-23 | Canon Kabushiki Kaisha | Method and apparatus for separating particles |
EP0710370B1 (en) | 1993-07-22 | 1998-12-02 | Btg International Limited | Intelligent sensor for near field optical device |
CA2168107C (en) | 1993-07-27 | 2001-02-13 | Joel Petersen | Light source destructuring and shaping device |
DE4326181A1 (en) | 1993-08-04 | 1995-02-09 | Europ Lab Molekularbiolog | Method and device for luminescence spectroscopy and material microprocessing of fixed and moving molecules, particles and objects |
AU679556B2 (en) * | 1993-08-25 | 1997-07-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel tyrosine kinase |
US5445011A (en) | 1993-09-21 | 1995-08-29 | Ghislain; Lucien P. | Scanning force microscope using an optical trap |
US5900160A (en) | 1993-10-04 | 1999-05-04 | President And Fellows Of Harvard College | Methods of etching articles via microcontact printing |
US5512745A (en) | 1994-03-09 | 1996-04-30 | Board Of Trustees Of The Leland Stanford Jr. University | Optical trap system and method |
JP3355021B2 (en) | 1994-03-26 | 2002-12-09 | 科学技術振興事業団 | Micro memory and micro sensor |
DE4411268C2 (en) | 1994-03-31 | 2001-02-01 | Danfoss As | Analysis method and device |
US6071394A (en) | 1996-09-06 | 2000-06-06 | Nanogen, Inc. | Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis |
US5637458A (en) | 1994-07-20 | 1997-06-10 | Sios, Inc. | Apparatus and method for the detection and assay of organic molecules |
US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
JP3474652B2 (en) | 1994-11-11 | 2003-12-08 | 株式会社モリテックス | Multi-point laser trapping apparatus and method |
US5629802A (en) | 1995-01-05 | 1997-05-13 | The United States Of America As Represented By The Secretary Of The Air Force | Spatially multiplexed optical signal processor |
US5795782A (en) | 1995-03-17 | 1998-08-18 | President & Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US5608519A (en) | 1995-03-20 | 1997-03-04 | Gourley; Paul L. | Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells |
US5793485A (en) | 1995-03-20 | 1998-08-11 | Sandia Corporation | Resonant-cavity apparatus for cytometry or particle analysis |
US5953166A (en) | 1995-03-22 | 1999-09-14 | Moritex Corporation | Laser trapping apparatus |
US5677286A (en) * | 1995-04-27 | 1997-10-14 | The University Of Michigan | Glycosylated analogs of camptothecin |
US6797942B2 (en) * | 2001-09-13 | 2004-09-28 | University Of Chicago | Apparatus and process for the lateral deflection and separation of flowing particles by a static array of optical tweezers |
US5631141A (en) | 1995-05-05 | 1997-05-20 | The Regents Of The University Of California | High resolution biosensor for in-situ microthermometry |
US5776674A (en) | 1995-06-05 | 1998-07-07 | Seq, Ltd | Chemical biochemical and biological processing in thin films |
US5659561A (en) | 1995-06-06 | 1997-08-19 | University Of Central Florida | Spatial solitary waves in bulk quadratic nonlinear materials and their applications |
US5620857A (en) | 1995-06-07 | 1997-04-15 | United States Of America, As Represented By The Secretary Of Commerce | Optical trap for detection and quantitation of subzeptomolar quantities of analytes |
US5950071A (en) * | 1995-11-17 | 1999-09-07 | Lightforce Technology, Inc. | Detachment and removal of microscopic surface contaminants using a pulsed detach light |
US6641708B1 (en) * | 1996-01-31 | 2003-11-04 | Board Of Regents, The University Of Texas System | Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation |
US5993630A (en) | 1996-01-31 | 1999-11-30 | Board Of Regents The University Of Texas System | Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation |
US5888370A (en) | 1996-02-23 | 1999-03-30 | Board Of Regents, The University Of Texas System | Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation |
NZ331865A (en) | 1996-03-18 | 1999-04-29 | Univ Wales Bangor Change Of Na | Apparatus with electrode arrays for carrying out chemical, physical or physico-chemical reactions |
US6078681A (en) | 1996-03-18 | 2000-06-20 | Marine Biological Laboratory | Analytical imaging system and process |
US5942443A (en) | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US5760395A (en) | 1996-04-18 | 1998-06-02 | Universities Research Assoc., Inc. | Method and apparatus for laser-controlled proton beam radiology |
US5694216A (en) | 1996-04-25 | 1997-12-02 | University Of Central Florida | Scanning heterodyne acousto-optical interferometers |
US5752606A (en) * | 1996-05-23 | 1998-05-19 | Wilson; Steve D. | Method for trapping, manipulating, and separating cells and cellular components utilizing a particle trap |
US5952651A (en) | 1996-06-10 | 1999-09-14 | Moritex Corporation | Laser manipulation apparatus and cell plate used therefor |
US6280967B1 (en) | 1996-08-02 | 2001-08-28 | Axiom Biotechnologies, Inc. | Cell flow apparatus and method for real-time of cellular responses |
US5804436A (en) | 1996-08-02 | 1998-09-08 | Axiom Biotechnologies, Inc. | Apparatus and method for real-time measurement of cellular response |
US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US5858192A (en) | 1996-10-18 | 1999-01-12 | Board Of Regents, The University Of Texas System | Method and apparatus for manipulation using spiral electrodes |
US6008010A (en) * | 1996-11-01 | 1999-12-28 | University Of Pittsburgh | Method and apparatus for holding cells |
DE19649048C1 (en) | 1996-11-27 | 1998-04-09 | Evotec Biosystems Gmbh | Particle identification method for enzyme-linked immunoassay using fast Fourier transform |
US6534308B1 (en) * | 1997-03-27 | 2003-03-18 | Oncosis, Llc | Method and apparatus for selectively targeting specific cells within a mixed cell population |
US5874266A (en) * | 1997-03-27 | 1999-02-23 | Palsson; Bernhard O. | Targeted system for removing tumor cells from cell populations |
US5939716A (en) | 1997-04-02 | 1999-08-17 | Sandia Corporation | Three-dimensional light trap for reflective particles |
US6215134B1 (en) | 1997-05-09 | 2001-04-10 | California Institute Of Technology | Semiconductor surface lenses and shaped structures |
GB2326229A (en) * | 1997-06-13 | 1998-12-16 | Robert Jeffrey Geddes Carr | Detecting and analysing submicron particles |
US6111398A (en) | 1997-07-03 | 2000-08-29 | Coulter International Corp. | Method and apparatus for sensing and characterizing particles |
US6143558A (en) | 1997-07-08 | 2000-11-07 | The Regents Of The University Of Michigan | Optical fiberless sensors for analyzing cellular analytes |
US6540895B1 (en) * | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
US6121603A (en) | 1997-12-01 | 2000-09-19 | Hang; Zhijiang | Optical confocal device having a common light directing means |
EP1714699B1 (en) * | 1998-01-12 | 2010-08-18 | Massachusetts Institute of Technology | System for analyzing a plurality of samples |
DE19801139B4 (en) | 1998-01-14 | 2016-05-12 | Till Photonics Gmbh | Point Scanning Luminescence Microscope |
US6485905B2 (en) * | 1998-02-02 | 2002-11-26 | Signature Bioscience, Inc. | Bio-assay device |
US6287776B1 (en) | 1998-02-02 | 2001-09-11 | Signature Bioscience, Inc. | Method for detecting and classifying nucleic acid hybridization |
US6287874B1 (en) | 1998-02-02 | 2001-09-11 | Signature Bioscience, Inc. | Methods for analyzing protein binding events |
US6338968B1 (en) * | 1998-02-02 | 2002-01-15 | Signature Bioscience, Inc. | Method and apparatus for detecting molecular binding events |
US6395480B1 (en) * | 1999-02-01 | 2002-05-28 | Signature Bioscience, Inc. | Computer program and database structure for detecting molecular binding events |
US6055106A (en) * | 1998-02-03 | 2000-04-25 | Arch Development Corporation | Apparatus for applying optical gradient forces |
US6082205A (en) | 1998-02-06 | 2000-07-04 | Ohio State University | System and device for determining particle characteristics |
US5974901A (en) | 1998-02-06 | 1999-11-02 | The Cleveland Clinic Foundation | Method for determining particle characteristics |
US6740497B2 (en) * | 1998-03-06 | 2004-05-25 | The Regents Of The University Of California | Method and apparatus for detecting cancerous cells using molecules that change electrophoretic mobility |
US5998152A (en) * | 1998-03-09 | 1999-12-07 | Tularik Inc. | High-throughput screening assays for modulators of nucleic acid topoisomerases |
US6088376A (en) | 1998-03-16 | 2000-07-11 | California Institute Of Technology | Vertical-cavity-surface-emitting semiconductor devices with fiber-coupled optical cavity |
US6642018B1 (en) | 1998-03-27 | 2003-11-04 | Oncosis Llc | Method for inducing a response in one or more targeted cells |
US6139831A (en) | 1998-05-28 | 2000-10-31 | The Rockfeller University | Apparatus and method for immobilizing molecules onto a substrate |
AU2842200A (en) * | 1998-09-30 | 2000-05-08 | Board Of Control Of Michigan Technological University | Laser-guided manipulation of non-atomic particles |
EP1161178A2 (en) * | 1998-12-23 | 2001-12-12 | Medispectra Inc. | Systems and methods for optical examination of samples |
US6294063B1 (en) | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing |
US6507400B1 (en) * | 1999-02-27 | 2003-01-14 | Mwi, Inc. | Optical system for multi-part differential particle discrimination and an apparatus using the same |
US6067859A (en) | 1999-03-04 | 2000-05-30 | The Board Of Regents, The University Of Texas System | Optical stretcher |
CN1185492C (en) * | 1999-03-15 | 2005-01-19 | 清华大学 | Single-point strobed micro electromagnetic units array chip or electromagnetic biologic chip and application thereof |
FR2792410B1 (en) * | 1999-04-14 | 2001-06-22 | Schlumberger Services Petrol | MANOMETER PRESSURE MEASUREMENT METHOD WITH RESONANT ELEMENT |
US6518056B2 (en) * | 1999-04-27 | 2003-02-11 | Agilent Technologies Inc. | Apparatus, systems and method for assaying biological materials using an annular format |
US6485690B1 (en) * | 1999-05-27 | 2002-11-26 | Orchid Biosciences, Inc. | Multiple fluid sample processor and system |
US6818395B1 (en) * | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US7601270B1 (en) * | 1999-06-28 | 2009-10-13 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
GB9916848D0 (en) * | 1999-07-20 | 1999-09-22 | Univ Wales Bangor | Travelling wave dielectrophoretic apparatus and method |
WO2001040454A1 (en) | 1999-11-30 | 2001-06-07 | Oncosis | Method and apparatus for selectively targeting specific cells within a cell population |
US6287758B1 (en) | 2000-03-23 | 2001-09-11 | Axiom Biotechnologies, Inc. | Methods of registering trans-membrane electric potentials |
WO2002022774A1 (en) | 2000-09-12 | 2002-03-21 | Oncosis Llc | Chamber for laser-based processing |
WO2002023163A1 (en) | 2000-09-15 | 2002-03-21 | California Institute Of Technology | Microfabricated crossflow devices and methods |
US6784420B2 (en) * | 2000-11-13 | 2004-08-31 | Genoptix, Inc. | Method of separating particles using an optical gradient |
US6936811B2 (en) * | 2000-11-13 | 2005-08-30 | Genoptix, Inc. | Method for separating micro-particles |
US20030007894A1 (en) * | 2001-04-27 | 2003-01-09 | Genoptix | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles |
US6744038B2 (en) * | 2000-11-13 | 2004-06-01 | Genoptix, Inc. | Methods of separating particles using an optical gradient |
US6833542B2 (en) * | 2000-11-13 | 2004-12-21 | Genoptix, Inc. | Method for sorting particles |
US6778724B2 (en) * | 2000-11-28 | 2004-08-17 | The Regents Of The University Of California | Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices |
WO2002044689A2 (en) * | 2000-11-28 | 2002-06-06 | The Regents Of The University Of California | Storing microparticles in optical switch which is transported by micro-fluidic device |
EP1421365A1 (en) | 2001-07-19 | 2004-05-26 | Tufts University | Optical array device and methods of use thereof for screening, analysis and manipulation of particles |
AU2003216175A1 (en) * | 2002-02-04 | 2003-09-02 | Colorado School Of Mines | Laminar flow-based separations of colloidal and cellular particles |
-
2001
- 2001-04-27 US US09/845,245 patent/US20030007894A1/en not_active Abandoned
- 2001-11-09 JP JP2002585125A patent/JP2004530877A/en active Pending
- 2001-11-09 WO PCT/US2001/051001 patent/WO2002087792A1/en active Application Filing
- 2001-11-09 CA CA002444783A patent/CA2444783A1/en not_active Abandoned
- 2001-11-09 EP EP01988455A patent/EP1390160A4/en not_active Withdrawn
- 2001-11-09 AU AU2002241760A patent/AU2002241760B2/en not_active Ceased
- 2001-11-14 US US09/993,318 patent/US6815664B2/en not_active Expired - Lifetime
-
2005
- 2005-11-11 US US11/272,593 patent/US20060060767A1/en not_active Abandoned
-
2009
- 2009-08-21 US US12/545,624 patent/US20100108577A1/en not_active Abandoned
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9815058B2 (en) | 2003-05-08 | 2017-11-14 | The University Court Of The University Of St Andrews | Fractionation of particles |
US11965816B2 (en) | 2010-11-16 | 2024-04-23 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
Also Published As
Publication number | Publication date |
---|---|
US20100108577A1 (en) | 2010-05-06 |
US20030008364A1 (en) | 2003-01-09 |
US20030007894A1 (en) | 2003-01-09 |
EP1390160A1 (en) | 2004-02-25 |
AU2002241760B2 (en) | 2006-08-24 |
JP2004530877A (en) | 2004-10-07 |
US20060060767A1 (en) | 2006-03-23 |
CA2444783A1 (en) | 2002-11-07 |
EP1390160A4 (en) | 2008-08-20 |
WO2002087792A1 (en) | 2002-11-07 |
US6815664B2 (en) | 2004-11-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2002087792A8 (en) | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles | |
Yang et al. | Cell separation on microfabricated electrodes using dielectrophoretic/gravitational field-flow fractionation | |
Ying et al. | Programmable delivery of DNA through a nanopipet | |
WO2003062867A3 (en) | Methods and apparatus for generating and utilizing linear moving optical gradients | |
GB2430740A (en) | System and method for tracking and quatitating chemical entites | |
WO2000049385A3 (en) | Method and apparatus for analyzing cells in a whole blood sample | |
WO2006084283A3 (en) | Methods and devices for characterizing particles in clear and turbid media | |
WO2005029046A3 (en) | A multi-spectral optical method and system for detecting and classifying biological and non-biological particles | |
DE69907630D1 (en) | MICROPARTICLE WITH MULTIPLE FLUORESCENCE SIGNALS | |
DE60040603D1 (en) | METHOD FOR ANALYZING A MULTIPLE OF SAMPLES OF VARIOUS ORIGIN ON AN ANALYTE | |
BR0010068A (en) | Identification system of the phenotypic and biological marker | |
WO2006047502A3 (en) | Automated segmentation, classification and tracking of cell nuclei in time-lapse microscopy | |
WO2006098752A3 (en) | Ultrasensitive sensor and rapid detection of analytes | |
WO2006119087A3 (en) | Photoluminescent silica-based sensors and methods of use | |
AR053251A1 (en) | NEW LABELING STRATEGIES FOR THE SENSITIVE DETECTION OF ANALYTES | |
WO2008070865A3 (en) | Materials and methods for efficient and accurate detection of analytes | |
CY1112359T1 (en) | METHOD FOR IDENTIFICATION OF A SUBJECT THREATENING TO PRESENT CARDIAC DEFICIENCY THROUGH 2-Tier Level 2 GALAXY DETERMINATION | |
WO2006087603A3 (en) | Isoelectric particles and uses as electrophoretic tags for multiple analyte detection using capillary isoelectric focusing | |
Suzuki et al. | Mechanical low-pass filtering of cells for detection of circulating tumor cells in whole blood | |
Hu et al. | Manipulating cell adhesions with optical tweezers for study of cell-to-cell interactions | |
Rajauria et al. | High-speed discrimination and sorting of submicron particles using a microfluidic device | |
Kontomaris et al. | A simplified approach for the determination of fitting constants in Oliver–Pharr method regarding biological samples | |
US20150212070A1 (en) | Low-Cost Portable Microfluidic System for Cell Migration | |
WO2004106535A3 (en) | Enhanced cellular assay method for use in flow cytometry or similar instruments using optically resonant particles | |
DE60142634D1 (en) | RECOGNITION OF TUMOR-SPECIFIC GENE PRODUCTS IN CANCER |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2444783 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002241760 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002585125 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001988455 Country of ref document: EP |
|
CFP | Corrected version of a pamphlet front page | ||
CR1 | Correction of entry in section i |
Free format text: IN PCT GAZETTE 45/2002 UNDER (72, 75) APPLICANTS AND INVENTORS "NOVA, TINA, S., LYKSTAD, KRISTIE, L., HALL, JEFFREY, M., AND BUTLER, WILLIAM, F." ADDED Free format text: IN PCT GAZETTE 45/2002 UNDER (72, 75) APPLICANTS AND INVENTORS "NOVA, TINA, S., LYKSTAD, KRISTIE, L., HALL, JEFFREY, M., AND BUTLER, WILLIAM, F." ADDED |
|
WWP | Wipo information: published in national office |
Ref document number: 2001988455 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |