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Publication numberWO2002087438 A3
Publication typeApplication
Application numberPCT/US2002/010995
Publication date27 Nov 2003
Filing date5 Apr 2002
Priority date27 Apr 2001
Also published asDE60204451D1, DE60204451T2, EP1385426A2, EP1385426B1, US6671555, US7006872, US20020188330, US20030181955, WO2002087438A2
Publication numberPCT/2002/10995, PCT/US/2/010995, PCT/US/2/10995, PCT/US/2002/010995, PCT/US/2002/10995, PCT/US2/010995, PCT/US2/10995, PCT/US2002/010995, PCT/US2002/10995, PCT/US2002010995, PCT/US200210995, PCT/US2010995, PCT/US210995, WO 02087438 A3, WO 02087438A3, WO 2002/087438 A3, WO 2002087438 A3, WO 2002087438A3, WO-A3-02087438, WO-A3-2002087438, WO02087438 A3, WO02087438A3, WO2002/087438A3, WO2002087438 A3, WO2002087438A3
InventorsWytse Wadman, Frans L H Gielen
ApplicantMedtronic Inc
Export CitationBiBTeX, EndNote, RefMan
External Links: Patentscope, Espacenet
Closed loop neuromodulation for supperssion of epileptic activity
WO 2002087438 A3
A system and method for predicting the likelihood of occurrence of an impending neurological episode. Electrical stimuli are delivered to a structure of the brain. Response field potentials evoked by the stimuli are sensed. Analysis of these field potentials allows for predictions as to the occurrence of an impending, but not yet occurring, neurological disorder. In one example, a measurement of change in response pulses is used to determine a level of interconnectivity in the structures of the brain. The level of functional interconnectivity is used in predicting the occurrence of the neurological event. An example of such a neurological event includes an epileptic seizure.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US6018682 *30 Apr 199825 Jan 2000Medtronic, Inc.Implantable seizure warning system
US6128538 *29 Nov 19993 Oct 2000Neuropace, Inc.Means and method for the treatment of neurological disorders
Non-Patent Citations
1 *HAO QU ET AL.: "A Patient-Specific Algorithm for the Detection of Seizure Onset in Long-Term EEG Monitoring: Possible USe as a Warning Device", IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, IEEE INC., vol. 44, no. 2, - 1 February 1997 (1997-02-01), New York, US, pages 115 - 122, XP000658735
2 *LOPES DA SILVA F. H. ET AL.: "Dynamics of local neuronal networks: control parameters and state bifurcations in epileptogenesis", PROGRESS IN BRAIN RESEARCH, vol. 102, - 1994, Amsterdam, NL, pages 359 - 370, XP001090895
3 *MARCOS VELASCO ET AL.: "Acute and Chronic Electrical Stimulation of the Centromedian Thalamic Nucleus: Modulation of Reticulo-Cortical Systems and Predictor Factors for Generalized Seizure Control", ELSEVIER, ARCHIVES OF MEDICAL RESEARCH, no. 31, 2000, USA, pages 304 - 315, XP002228561
4 *OSORIO ET AL.: "Real-Time Automated Detection and Quantitative Analysis of Seizure and Short-Term Prediction of Clinical Onset", EPILEPSIA, vol. 39, no. 6, June 1998 (1998-06-01), USA, pages 615 - 627, XP001090899
5 *WILSON C. L. ET AL: "Paired pulse suppression and facilitation in human epileptogenic hippocampal formation", EPILEPSY RESEARCH, vol. 31, no. 3, - August 1998 (1998-08-01), pages 211 - 230, XP002228562
International ClassificationA61N1/36, A61B5/0484
Cooperative ClassificationA61B5/4094, A61N1/36082, A61B5/0484
European ClassificationA61B5/0484
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