WO2002085386A3 - Medicament containing a metal such as silver, gold, platinum or palladium as an antimicrobial agent and their use to induce apoptosis in cancerous tissue - Google Patents

Medicament containing a metal such as silver, gold, platinum or palladium as an antimicrobial agent and their use to induce apoptosis in cancerous tissue Download PDF

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Publication number
WO2002085386A3
WO2002085386A3 PCT/CA2002/000548 CA0200548W WO02085386A3 WO 2002085386 A3 WO2002085386 A3 WO 2002085386A3 CA 0200548 W CA0200548 W CA 0200548W WO 02085386 A3 WO02085386 A3 WO 02085386A3
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WO
WIPO (PCT)
Prior art keywords
nanocrystalline
metal
induce apoptosis
palladium
platinum
Prior art date
Application number
PCT/CA2002/000548
Other languages
French (fr)
Other versions
WO2002085386A2 (en
Inventor
Robert Edward Burrell
John Barrymore Wright
Kan Lam
Original Assignee
Nucryst Pharm Corp
Robert Edward Burrell
John Barrymore Wright
Kan Lam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/840,637 external-priority patent/US7008647B2/en
Application filed by Nucryst Pharm Corp, Robert Edward Burrell, John Barrymore Wright, Kan Lam filed Critical Nucryst Pharm Corp
Priority to EP20020721903 priority Critical patent/EP1383521A2/en
Priority to JP2002582959A priority patent/JP2004529929A/en
Priority to CA002445734A priority patent/CA2445734A1/en
Publication of WO2002085386A2 publication Critical patent/WO2002085386A2/en
Publication of WO2002085386A3 publication Critical patent/WO2002085386A3/en

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    • Y10T428/31855—Of addition polymer from unsaturated monomers

Abstract

The invention relates to a method to induce apoptosis and to inhibit matrix metalloproteinases in a disease condition in a human or animal by contacting hyperplastic tissue, tumor tissue, or a cancerous lesion with one or more antimicrobial metals, preferably formed with atomic disorder, and preferably in a nanocrystalline form. The nanocrystalline antimicrobial metal of choise may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals , or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals .
PCT/CA2002/000548 2001-04-23 2002-04-23 Medicament containing a metal such as silver, gold, platinum or palladium as an antimicrobial agent and their use to induce apoptosis in cancerous tissue WO2002085386A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP20020721903 EP1383521A2 (en) 2001-04-23 2002-04-23 Medicament containing a metal such as silver, gold, platinum or palladium as an antimicrobial agent and their use to induce apoptosis in cancerous tissue
JP2002582959A JP2004529929A (en) 2001-04-23 2002-04-23 Use of metals for induction of apoptosis and inhibition of matrix metalloproteinases
CA002445734A CA2445734A1 (en) 2001-04-23 2002-04-23 Medicament containing a metal such as silver, gold, platinum or palladium as an antimicrobial agent and their use to induce apoptosis in cancerous tissue

Applications Claiming Priority (4)

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US28588401P 2001-04-23 2001-04-23
US09/840,637 US7008647B2 (en) 2001-04-23 2001-04-23 Treatment of acne
US09/840,637 2001-04-23
US60/285,884 2001-04-23

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WO2002085386A2 WO2002085386A2 (en) 2002-10-31
WO2002085386A3 true WO2002085386A3 (en) 2003-01-16

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PCT/CA2002/000547 WO2002085385A2 (en) 2001-04-23 2002-04-23 Medicament containing a metal such as silver, gold, platinum or palladium as an antimicrobial agent and their use in the treatment of diseases of the mucosa
PCT/US2002/012690 WO2002085299A2 (en) 2001-04-23 2002-04-23 Therapeutic treatments using the direct application of antimicrobial metal compositions
PCT/CA2002/000546 WO2002085384A2 (en) 2001-04-23 2002-04-23 Lubricious coatings for substrates
PCT/CA2002/000549 WO2002085387A2 (en) 2001-04-23 2002-04-23 A medicament or a dressing containing a metal such as silver, gold, platinum or palladium as an antimicrobial agent ans their use in the treatment of inflammatory skin conditions
PCT/CA2002/000548 WO2002085386A2 (en) 2001-04-23 2002-04-23 Medicament containing a metal such as silver, gold, platinum or palladium as an antimicrobial agent and their use to induce apoptosis in cancerous tissue

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PCT/CA2002/000547 WO2002085385A2 (en) 2001-04-23 2002-04-23 Medicament containing a metal such as silver, gold, platinum or palladium as an antimicrobial agent and their use in the treatment of diseases of the mucosa
PCT/US2002/012690 WO2002085299A2 (en) 2001-04-23 2002-04-23 Therapeutic treatments using the direct application of antimicrobial metal compositions
PCT/CA2002/000546 WO2002085384A2 (en) 2001-04-23 2002-04-23 Lubricious coatings for substrates
PCT/CA2002/000549 WO2002085387A2 (en) 2001-04-23 2002-04-23 A medicament or a dressing containing a metal such as silver, gold, platinum or palladium as an antimicrobial agent ans their use in the treatment of inflammatory skin conditions

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US (9) US6989156B2 (en)
EP (4) EP1383522B1 (en)
JP (4) JP2004529929A (en)
AT (1) ATE322274T1 (en)
AU (4) AU2002252879B2 (en)
CA (4) CA2445729C (en)
DE (1) DE60210441T2 (en)
ES (1) ES2261659T3 (en)
WO (5) WO2002085385A2 (en)

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