WO2002081628A3 - Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies - Google Patents
Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies Download PDFInfo
- Publication number
- WO2002081628A3 WO2002081628A3 PCT/US2002/010512 US0210512W WO02081628A3 WO 2002081628 A3 WO2002081628 A3 WO 2002081628A3 US 0210512 W US0210512 W US 0210512W WO 02081628 A3 WO02081628 A3 WO 02081628A3
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- WIPO (PCT)
- Prior art keywords
- nucleic acid
- proliferation
- inflammation
- modulation
- gene expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/13—Decoys
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/332—Abasic residue
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- C—CHEMISTRY; METALLURGY
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02763926A EP1386004A4 (en) | 2001-04-05 | 2002-04-03 | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
AU2002307099A AU2002307099A1 (en) | 2001-04-05 | 2002-04-03 | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
US10/471,271 US20070026394A1 (en) | 2000-02-11 | 2002-04-03 | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies |
US10/206,693 US20050261212A1 (en) | 2000-02-11 | 2002-07-26 | RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering RNA |
US10/430,882 US20030203870A1 (en) | 2000-02-11 | 2003-05-06 | Method and reagent for the inhibition of NOGO and NOGO receptor genes |
US10/923,142 US20050182008A1 (en) | 2000-02-11 | 2004-08-20 | RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering nucleic acid (siNA) |
US11/255,139 US20060154271A1 (en) | 2001-04-05 | 2005-10-20 | Enzymatic nucleic acid treatment of diseases or conditions related to levels of IKK-gamma and PKR |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/827,395 US20030113891A1 (en) | 2000-02-11 | 2001-04-05 | Method and reagent for the inhibition of NOGO and NOGO receptor genes |
US09/827,395 | 2001-04-05 | ||
US29441201P | 2001-05-29 | 2001-05-29 | |
US60/294,412 | 2001-05-29 | ||
US31531501P | 2001-08-28 | 2001-08-28 | |
US60/315,315 | 2001-08-28 |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/827,395 Continuation-In-Part US20030113891A1 (en) | 2000-02-11 | 2001-04-05 | Method and reagent for the inhibition of NOGO and NOGO receptor genes |
US29441201P Continuation | 2000-02-11 | 2001-05-29 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/156,306 Continuation-In-Part US7022828B2 (en) | 2001-04-05 | 2002-05-28 | siRNA treatment of diseases or conditions related to levels of IKK-gamma |
US10/206,693 Continuation-In-Part US20050261212A1 (en) | 2000-02-11 | 2002-07-26 | RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering RNA |
US10/430,882 Continuation-In-Part US20030203870A1 (en) | 2000-02-11 | 2003-05-06 | Method and reagent for the inhibition of NOGO and NOGO receptor genes |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2002081628A2 WO2002081628A2 (en) | 2002-10-17 |
WO2002081628A3 true WO2002081628A3 (en) | 2003-02-20 |
WO2002081628A8 WO2002081628A8 (en) | 2003-08-28 |
Family
ID=40293860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/010512 WO2002081628A2 (en) | 2000-02-11 | 2002-04-03 | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
Country Status (3)
Country | Link |
---|---|
US (7) | US20070026394A1 (en) |
EP (1) | EP1386004A4 (en) |
WO (1) | WO2002081628A2 (en) |
Families Citing this family (563)
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WO2002081628A2 (en) | 2002-10-17 |
US7022828B2 (en) | 2006-04-04 |
US20060154271A1 (en) | 2006-07-13 |
US20030191077A1 (en) | 2003-10-09 |
US20030119017A1 (en) | 2003-06-26 |
EP1386004A4 (en) | 2005-02-16 |
WO2002081628A8 (en) | 2003-08-28 |
US20030148507A1 (en) | 2003-08-07 |
US20050261212A1 (en) | 2005-11-24 |
US20070026394A1 (en) | 2007-02-01 |
US20030143732A1 (en) | 2003-07-31 |
EP1386004A2 (en) | 2004-02-04 |
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