WO2002079232A3 - Reducing the immunogenicity of fusion proteins - Google Patents
Reducing the immunogenicity of fusion proteins Download PDFInfo
- Publication number
- WO2002079232A3 WO2002079232A3 PCT/US2002/009815 US0209815W WO02079232A3 WO 2002079232 A3 WO2002079232 A3 WO 2002079232A3 US 0209815 W US0209815 W US 0209815W WO 02079232 A3 WO02079232 A3 WO 02079232A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fusion proteins
- methods
- reducing
- immunogenicity
- compositions
- Prior art date
Links
- 108020001507 fusion proteins Proteins 0.000 title abstract 4
- 102000037865 fusion proteins Human genes 0.000 title abstract 4
- 230000005847 immunogenicity Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- 108091008874 T cell receptors Proteins 0.000 abstract 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000043131 MHC class II family Human genes 0.000 abstract 1
- 108091054438 MHC class II family Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/809—Drug, bio-affecting and body treating compositions involving immunoglobulin or antibody fragment, e.g. fab', fv, fc, heavy chain or light chain
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Abstract
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02757870A EP1373301B1 (en) | 2001-03-30 | 2002-03-30 | Reducing the immunogenicity of fusion proteins |
DE60238472T DE60238472D1 (en) | 2001-03-30 | 2002-03-30 | WEAKNESS OF IMMUNOGENICITY OF FUSION PROTEINS |
HU0303753A HUP0303753A2 (en) | 2001-03-30 | 2002-03-30 | Reducing the immunogenicity of fusion proteins |
CA2442363A CA2442363C (en) | 2001-03-30 | 2002-03-30 | Reducing the immunogenicity of fusion proteins |
DK02757870.7T DK1373301T3 (en) | 2001-03-30 | 2002-03-30 | Reduction of the immunogenicity of fusion proteins |
JP2002577856A JP4638129B2 (en) | 2001-03-30 | 2002-03-30 | Reduce immunogenicity of fusion proteins |
MXPA03008715A MXPA03008715A (en) | 2001-03-30 | 2002-03-30 | Reducing the immunogenicity of fusion proteins. |
BR0208207-1A BR0208207A (en) | 2001-03-30 | 2002-03-30 | Reduction of fusion protein immunogenicity |
AU2002306976A AU2002306976B2 (en) | 2001-03-30 | 2002-03-30 | Reducing the immunogenicity of fusion proteins |
KR10-2003-7012819A KR20030087040A (en) | 2001-03-30 | 2002-03-30 | Reducing the immunogenicity of fusion proteins |
AT02757870T ATE490262T1 (en) | 2001-03-30 | 2002-03-30 | ATTENUATION OF THE IMMUNOGENICITY OF FUSION PROTEINS |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28062501P | 2001-03-30 | 2001-03-30 | |
US60/280,625 | 2001-03-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002079232A2 WO2002079232A2 (en) | 2002-10-10 |
WO2002079232A3 true WO2002079232A3 (en) | 2002-12-12 |
Family
ID=23073904
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/009650 WO2002079415A2 (en) | 2001-03-30 | 2002-03-29 | Reducing the immunogenicity of fusion proteins |
PCT/US2002/009815 WO2002079232A2 (en) | 2001-03-30 | 2002-03-30 | Reducing the immunogenicity of fusion proteins |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/009650 WO2002079415A2 (en) | 2001-03-30 | 2002-03-29 | Reducing the immunogenicity of fusion proteins |
Country Status (19)
Country | Link |
---|---|
US (5) | US6992174B2 (en) |
EP (2) | EP1373301B1 (en) |
JP (2) | JP4638129B2 (en) |
KR (1) | KR20030087040A (en) |
CN (1) | CN100488984C (en) |
AT (1) | ATE490262T1 (en) |
AU (1) | AU2002306976B2 (en) |
BR (1) | BR0208207A (en) |
CA (1) | CA2442363C (en) |
DE (1) | DE60238472D1 (en) |
DK (1) | DK1373301T3 (en) |
ES (1) | ES2356620T3 (en) |
HU (1) | HUP0303753A2 (en) |
MX (1) | MXPA03008715A (en) |
PL (1) | PL209110B1 (en) |
PT (1) | PT1373301E (en) |
RU (1) | RU2333919C2 (en) |
WO (2) | WO2002079415A2 (en) |
ZA (1) | ZA200308430B (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8691952B2 (en) | 2005-12-30 | 2014-04-08 | Merck Patent Gmbh | Anti-CD19 antibodies with reduced immunogenicity |
US8835606B2 (en) | 2004-01-22 | 2014-09-16 | Merck Patent Gmbh | Anti-cancer antibodies with reduced complement fixation |
US8907066B2 (en) | 2009-04-22 | 2014-12-09 | Merck Patent Gmbh | Antibody fusion proteins with a modified FcRn binding site |
US8937158B2 (en) | 2003-03-03 | 2015-01-20 | Xencor, Inc. | Fc variants with increased affinity for FcγRIIc |
US9371369B2 (en) | 2009-02-03 | 2016-06-21 | Amunix Operating Inc. | Extended recombinant polypeptides and compositions comprising same |
Families Citing this family (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1037927B1 (en) | 1997-12-08 | 2004-05-19 | Lexigen Pharmaceuticals Corp. | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
JP2002511432A (en) * | 1998-04-15 | 2002-04-16 | レキシジェン ファーマシューティカルズ コーポレイション | Enhancement of antibody-cytokine fusion protein-mediated immune response by co-administration of an angiogenesis inhibitor |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
MXPA02001417A (en) * | 1999-08-09 | 2002-08-12 | Lexigen Pharm Corp | Multiple cytokine-antibody complexes. |
US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
AU4314801A (en) | 2000-02-11 | 2001-08-20 | Lexigen Pharm Corp | Enhancing the circulating half-life of antibody-based fusion proteins |
CN1270775C (en) * | 2000-06-29 | 2006-08-23 | 默克专利有限公司 | Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enbancing agents |
KR100900176B1 (en) * | 2001-03-07 | 2009-06-02 | 메르크 파텐트 게엠베하 | Expression technology for proteins containing a hybrid isotype antibody moiety |
US6992174B2 (en) * | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
US20120148585A1 (en) * | 2001-05-01 | 2012-06-14 | Andrew Saxon | Fusion molecules and methods for treatment of immune diseases |
DK1383785T3 (en) * | 2001-05-03 | 2011-05-23 | Merck Patent Gmbh | Recombinant tumor-specific antibody and its use |
DE10122140A1 (en) * | 2001-05-08 | 2002-11-28 | Apotech Res & Dev Ltd | Recombinant fusion proteins and their trimers |
AU2002357784B2 (en) | 2001-12-04 | 2008-07-31 | Merck Patent Gmbh | Immunocytokines with modulated selectivity |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
US7657380B2 (en) | 2003-12-04 | 2010-02-02 | Xencor, Inc. | Methods of generating variant antibodies with increased host string content |
US8093357B2 (en) | 2002-03-01 | 2012-01-10 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
ATE466085T1 (en) * | 2002-09-09 | 2010-05-15 | Hanall Pharmaceutical Co Ltd | PROTEASE-RESISTANT MODIFIED INTERFERON ALPHA POLYPEPTIDES |
WO2004045583A1 (en) * | 2002-11-15 | 2004-06-03 | Nipro Corporation | Liposome |
PT1572748E (en) | 2002-12-17 | 2010-09-28 | Merck Patent Gmbh | Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2 |
US8388955B2 (en) | 2003-03-03 | 2013-03-05 | Xencor, Inc. | Fc variants |
CA2520138C (en) * | 2003-03-26 | 2017-05-23 | Apogenix Gmbh | Improved fc fusion proteins |
US20070161087A1 (en) * | 2003-05-29 | 2007-07-12 | Wolfgang Glaesner | Glp-1 fusion proteins |
EA008831B1 (en) * | 2003-06-12 | 2007-08-31 | Эли Лилли Энд Компани | Glp-1 analog fusion proteins |
CA2536408A1 (en) | 2003-08-22 | 2005-03-03 | Biogen Idec Ma Inc. | Improved antibodies having altered effector function and methods for making the same |
US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
US8101720B2 (en) | 2004-10-21 | 2012-01-24 | Xencor, Inc. | Immunoglobulin insertions, deletions and substitutions |
US9714282B2 (en) | 2003-09-26 | 2017-07-25 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
BRPI0415457A (en) | 2003-10-16 | 2006-12-05 | Micromet Ag | cytotoxically active cd3 specific binding construct, its production process, composition comprising the same, nucleic acid sequence, vector, host, its uses in the preparation of a pharmaceutical composition and kit comprising the same |
US20050142133A1 (en) * | 2003-12-03 | 2005-06-30 | Xencor, Inc. | Optimized proteins that target the epidermal growth factor receptor |
CN100427599C (en) * | 2003-12-26 | 2008-10-22 | 吉林大学第一医院 | ALBSIN/IL-18MAT hybridization cytokine |
BRPI0418286A (en) * | 2003-12-30 | 2007-05-02 | Merck Patent Gmbh | il-7 fusion proteins |
CA2551916C (en) * | 2003-12-31 | 2014-04-29 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Fc-erythropoietin fusion protein with improved pharmacokinetics |
AU2005203962C1 (en) * | 2004-01-05 | 2012-11-08 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
DK1737961T3 (en) | 2004-03-19 | 2013-08-05 | Merck Patent Gmbh | MODIFIED BOUGANINE PROTEINS, CYTOTOXINES AND PROCEDURES AND APPLICATIONS THEREOF |
EP2053062A1 (en) | 2004-03-24 | 2009-04-29 | Xencor, Inc. | Immunoglobin variants outside the Fc region |
US8642743B2 (en) * | 2004-04-06 | 2014-02-04 | Affibody Ab | Method for reducing the immune response to a biologically active protein |
US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
AU2005272993B2 (en) | 2004-07-15 | 2010-02-11 | Xencor, Inc | Optimized Fc variants |
EP1864998B2 (en) * | 2004-07-22 | 2022-06-22 | Erasmus University Medical Center Rotterdam | Binding molecules |
KR20070047327A (en) | 2004-07-26 | 2007-05-04 | 비오겐 아이덱 엠에이 아이엔씨. | Anti-cd154 antibodies |
AU2005286662B2 (en) | 2004-09-23 | 2011-10-06 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
WO2006053301A2 (en) | 2004-11-12 | 2006-05-18 | Xencor, Inc. | Fc variants with altered binding to fcrn |
US8802820B2 (en) | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
EP1819728B1 (en) * | 2004-12-09 | 2010-04-21 | MERCK PATENT GmbH | Il-7 variants with reduced immunogenicity |
PT1831252E (en) * | 2004-12-22 | 2009-09-17 | Lilly Co Eli | Glp-1 analog fusion protein formulations |
WO2006076594A2 (en) * | 2005-01-12 | 2006-07-20 | Xencor, Inc. | Antibodies and fc fusion proteins with altered immunogenicity |
EP1920061A4 (en) * | 2005-07-27 | 2009-05-13 | Wang Qinghua | GLP/1/EXENDIN 4 IgG Fc FUSION CONSTRUCTS FOR TREATMENT OF DIABETES |
US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
DK1931709T3 (en) | 2005-10-03 | 2017-03-13 | Xencor Inc | FC VARIETIES WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES |
DK1940881T3 (en) | 2005-10-11 | 2017-02-20 | Amgen Res (Munich) Gmbh | COMPOSITIONS WITH ARTICLE CROSS-SPECIFIC ANTIBODIES AND APPLICATIONS THEREOF |
PL1976880T3 (en) | 2005-12-21 | 2017-01-31 | Amgen Research (Munich) Gmbh | Pharmaceutical compositions with resistance to soluble cea |
CN101351475B (en) * | 2005-12-30 | 2013-05-15 | 默克专利有限公司 | Interleukin-12p40 variants with improved stability |
US20100047171A1 (en) * | 2006-01-24 | 2010-02-25 | Roland Beckmann | Fusion Proteins That Contain Natural Junctions |
US7625564B2 (en) * | 2006-01-27 | 2009-12-01 | Novagen Holding Corporation | Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo |
WO2008003473A2 (en) * | 2006-07-06 | 2008-01-10 | Merck Patent Gmbh | Compositions and methods for enhancing the efficacy of il-2 mediated immune responses |
WO2008045380A2 (en) * | 2006-10-04 | 2008-04-17 | Codon Devices, Inc. | Nucleic acid libraries and their design and assembly |
EP2120998B1 (en) | 2006-11-28 | 2013-08-07 | HanAll Biopharma Co., Ltd. | Modified erythropoietin polypeptides and uses thereof for treatment |
EP2450371B1 (en) | 2007-01-30 | 2015-04-29 | Epivax, Inc. | Regulatory t cell epitopes, compositions and uses thereof |
JP2010525821A (en) | 2007-05-02 | 2010-07-29 | アンブルックス,インコーポレイテッド | Modified IFN beta polypeptides and their use |
US8252897B2 (en) * | 2007-06-21 | 2012-08-28 | Angelica Therapeutics, Inc. | Modified toxins |
US8137979B2 (en) * | 2007-06-25 | 2012-03-20 | Qinetiq Limited | Preconcentrator device |
WO2009012600A1 (en) | 2007-07-26 | 2009-01-29 | Novagen Holding Corporation | Fusion proteins |
EP3492488A1 (en) | 2007-08-22 | 2019-06-05 | The Regents of The University of California | Activatable binding polypeptides and methods of identification and use thereof |
SI2808343T1 (en) | 2007-12-26 | 2019-10-30 | Xencor Inc | Fc variants with altered binding to FcRn |
WO2009110944A1 (en) * | 2008-02-29 | 2009-09-11 | Angelica Therapeutics, Inc. | Modified toxins |
EP2376105B1 (en) | 2008-12-18 | 2015-07-29 | Dana-Farber Cancer Institute, Inc. | Nkg2d-fc for immunotherapy |
BRPI1006141B8 (en) * | 2009-01-12 | 2021-05-25 | Cytomx Therapeutics Llc | modified antibody compositions, methods of making and using the same |
CA2753294A1 (en) | 2009-02-23 | 2010-08-26 | Cytomx Therapeutics, Inc. | Proproteins and methods of use thereof |
NZ596787A (en) | 2009-06-08 | 2014-03-28 | Amunix Operating Inc | Growth hormone polypeptides and methods of making and using same |
AU2010258898B8 (en) | 2009-06-08 | 2015-02-05 | Amunix Operating Inc. | Glucose-regulating polypeptides and methods of making and using same |
CA2797480A1 (en) | 2009-06-15 | 2010-12-23 | 4S3 Bioscience Inc. | Methods and compositions for treatment of myotubular myopathy using chimeric polypeptides comprising myotubularin 1 (mtm1) polypeptides |
JP5813641B2 (en) | 2009-08-24 | 2015-11-17 | アムニクス オペレーティング インコーポレイテッド | Coagulation factor IX composition and methods of making and using the same |
WO2011028952A1 (en) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
US8932588B2 (en) | 2009-11-05 | 2015-01-13 | Teva Pharmaceuticals Australia Pty. Ltd. | Treatment of cancer involving mutated KRAS or BRAF genes |
WO2011091078A2 (en) | 2010-01-19 | 2011-07-28 | Xencor, Inc. | Antibody fc variants with enhanced complement activity |
CN102781960B (en) | 2010-02-16 | 2014-12-10 | 米迪缪尼有限公司 | HSA-related compositions and methods of use |
WO2012119989A2 (en) | 2011-03-04 | 2012-09-13 | Oryzon Genomics, S.A. | Methods and antibodies for the diagnosis and treatment of cancer |
ES2876421T3 (en) * | 2011-04-13 | 2021-11-12 | Bristol Myers Squibb Co | Fc fusion proteins comprising new linkers or arrangements |
GB2491006A (en) * | 2011-05-05 | 2012-11-21 | Novozymes Biopharma Uk Ltd | Albumin variants |
CN102222177A (en) * | 2011-07-08 | 2011-10-19 | 上海生物信息技术研究中心 | Auxiliary prediction method for molecular modification of antibody protein |
EP2793944A4 (en) | 2011-12-23 | 2015-09-02 | Nicholas B Lydon | Immunoglobulins and variants directed against pathogenic microbes |
US9988439B2 (en) | 2011-12-23 | 2018-06-05 | Nicholas B. Lydon | Immunoglobulins and variants directed against pathogenic microbes |
PL3564260T3 (en) | 2012-02-15 | 2023-03-06 | Bioverativ Therapeutics Inc. | Factor viii compositions and methods of making and using same |
HUE043537T2 (en) | 2012-02-15 | 2019-08-28 | Bioverativ Therapeutics Inc | Recombinant factor viii proteins |
US10172953B2 (en) | 2012-02-27 | 2019-01-08 | Amunix Operating Inc. | XTEN conjugate compositions and methods of making same |
BR112014030404A2 (en) | 2012-06-05 | 2017-06-27 | Amunix Operating Inc | hgh-xten fusion protein and its use in the treatment of growth hormone deficiency |
ES2773107T3 (en) * | 2012-10-05 | 2020-07-09 | Kyowa Kirin Co Ltd | Heterodimeric protein composition |
JP2016514096A (en) | 2013-02-20 | 2016-05-19 | バレリオン セラピューティクス, エルエルシー | Methods and compositions for the treatment of Pompe disease |
EP2968450A4 (en) | 2013-03-15 | 2016-10-26 | Angelica Therapeutics Inc | Modified toxins |
WO2014141192A1 (en) | 2013-03-15 | 2014-09-18 | Erasmus University Medical Center | Generation of heavy chain-only antibodies |
TW202003554A (en) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | Factor VIII-XTEN fusions and uses thereof |
EP3077048B1 (en) | 2013-12-07 | 2019-07-17 | Case Western Reserve University | Compositions and methods of treating thrombosis |
EP3954714A1 (en) | 2014-01-08 | 2022-02-16 | Prosit Sole Biotechnology (Beijing) Co. Ltd | Fusion polypeptides and methods of use |
AU2015204446A1 (en) | 2014-01-13 | 2016-07-14 | Valerion Therapeutics, Llc | Internalizing moieties |
CN106103488B (en) | 2014-02-10 | 2021-07-30 | 默克专利有限公司 | Targeted TGF-beta inhibition |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
WO2015188132A1 (en) * | 2014-06-06 | 2015-12-10 | The California Institute For Biomedical Research | Methods of constructing amino terminal immunoglobulin fusion proteins and compositions thereof |
WO2016022597A1 (en) | 2014-08-04 | 2016-02-11 | Case Western Reserve University | Targeting peptides and methods of use |
CN117442748A (en) | 2014-10-02 | 2024-01-26 | 希望之城公司 | Multivalent mimotopes, mimotope binding antibodies and uses thereof |
EP3227341A1 (en) | 2014-12-02 | 2017-10-11 | CeMM - Forschungszentrum für Molekulare Medizin GmbH | Anti-mutant calreticulin antibodies and their use in the diagnosis and therapy of myeloid malignancies |
CN107530410B (en) * | 2015-03-18 | 2021-11-09 | 欧姆尼赛特有限公司 | Fusion proteins comprising modified alphavirus surface glycoproteins and tumor-associated antigens and methods thereof |
WO2017008758A1 (en) | 2015-07-15 | 2017-01-19 | Prosit Sole Biotechnology (Beijing) Co., Ltd | Fusion polypeptides and methods of use |
BR112018002150A2 (en) | 2015-08-03 | 2018-09-18 | Bioverativ Therapeutics Inc | factor ix fusion proteins and methods of manufacturing and using them |
CA3004148A1 (en) | 2015-11-13 | 2017-05-18 | Dana-Farber Cancer Institute, Inc. | An nkg2d-ig fusion protein for cancer immunotherapy |
EP4011919A3 (en) | 2015-12-09 | 2022-10-12 | The Scripps Research Institute | Relaxin immunoglobulin fusion proteins and methods of use |
US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
US20180118832A1 (en) | 2016-08-12 | 2018-05-03 | Merck Patent Gmbh | Combination therapy for cancer |
US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
WO2018102777A1 (en) * | 2016-12-01 | 2018-06-07 | University Of South Florida | Peptibodies, compositions thereof, and methods of treating atrial fibrillation |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
AU2019371457A1 (en) | 2018-11-01 | 2021-05-20 | Merck Patent Gmbh | Anti-TIM-3 antibodies |
CA3117371A1 (en) | 2018-11-01 | 2020-05-07 | Merck Patent Gmbh | Methods of administering anti-tim-3 antibodies |
EP4010371A1 (en) * | 2019-08-08 | 2022-06-15 | Regeneron Pharmaceuticals, Inc. | Novel antigen binding molecule formats |
BR112022009217A2 (en) | 2019-11-13 | 2022-08-02 | Amunix Pharmaceuticals Inc | BAR-CODE XTEN POLYPEPTIDES AND COMPOSITIONS THEREOF, AND METHODS FOR PRODUCING AND USING THEM |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998059244A1 (en) * | 1997-06-20 | 1998-12-30 | Eclagen Limited | Identification of mhc binding peptides |
WO1999002709A1 (en) * | 1997-07-10 | 1999-01-21 | Beth Israel Deaconess Medical Center | Recombinant erythropoietin / immunoglobulin fusion proteins |
WO1999003887A1 (en) * | 1997-07-14 | 1999-01-28 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
WO2000034317A2 (en) * | 1998-12-08 | 2000-06-15 | Biovation Limited | Method for reducing immunogenicity of proteins |
Family Cites Families (239)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US12789A (en) * | 1855-05-01 | Office | ||
US147311A (en) * | 1874-02-10 | Improvement in electric telegraphs | ||
US142374A (en) * | 1873-09-02 | Improvement in stopping mechanisms for doubling and twisting machines | ||
US49227A (en) * | 1865-08-08 | Improvement in construction of railway trains and cars | ||
US105294A (en) * | 1870-07-12 | Erasmus w | ||
US166877A (en) * | 1875-08-17 | Improvement in electric lights | ||
US192222A (en) * | 1877-06-19 | Improvement in watches | ||
US166163A (en) * | 1875-07-27 | Improvement in bee-hives | ||
US193570A (en) * | 1877-07-24 | Improvement in washing-boards | ||
US3529A (en) * | 1844-04-10 | yvolfe | ||
US44423A (en) * | 1864-09-27 | Improved screw for music-stools | ||
US348237A (en) * | 1886-08-31 | richards | ||
US81664A (en) * | 1868-09-01 | Island | ||
US53539A (en) * | 1866-03-27 | Improvement in revolving fire-arms | ||
US1803686A (en) * | 1923-11-23 | 1931-05-05 | Herman A Brassert | Gas production |
US4196265A (en) | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4469797A (en) | 1982-09-23 | 1984-09-04 | Miles Laboratories, Inc. | Digoxigenin immunogens, antibodies, labeled conjugates, and related derivatives |
US4737462A (en) | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
US4966843A (en) | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
KR850004274A (en) | 1983-12-13 | 1985-07-11 | 원본미기재 | Method for preparing erythropoietin |
US5082658A (en) | 1984-01-16 | 1992-01-21 | Genentech, Inc. | Gamma interferon-interleukin-2 synergism |
EP0158198A1 (en) | 1984-03-29 | 1985-10-16 | Takeda Chemical Industries, Ltd. | DNA and use thereof |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
US4667016A (en) | 1985-06-20 | 1987-05-19 | Kirin-Amgen, Inc. | Erythropoietin purification |
US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
US5679543A (en) | 1985-08-29 | 1997-10-21 | Genencor International, Inc. | DNA sequences, vectors and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi |
US5643565A (en) | 1985-09-20 | 1997-07-01 | Chiron Corporation | Human IL-2 as a vaccine adjuvant |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
US5359035A (en) | 1985-12-21 | 1994-10-25 | Hoechst Aktiengesellschaft | Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF) |
DE3712985A1 (en) | 1987-04-16 | 1988-11-03 | Hoechst Ag | BIFUNCTIONAL PROTEINS |
JPS63267278A (en) | 1986-03-14 | 1988-11-04 | Toray Ind Inc | Base sequence coding bonded interferon |
EP0237019A3 (en) | 1986-03-14 | 1988-03-09 | Toray Industries, Inc. | Interferon conjugate and production thereof using recombinant gene |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
DK173067B1 (en) | 1986-06-27 | 1999-12-13 | Univ Washington | Human erythropoietin gene, method of expression thereof in transfected cell lines, the transfected cell lines |
US4954617A (en) | 1986-07-07 | 1990-09-04 | Trustees Of Dartmouth College | Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes |
US4894227A (en) | 1986-08-01 | 1990-01-16 | Cetus Corporation | Composition of immunotoxins with interleukin-2 |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5508031A (en) | 1986-11-21 | 1996-04-16 | Cetus Oncology Corporation | Method for treating biological damage using a free-radial scavenger and interleukin-2 |
US4732683A (en) | 1986-12-02 | 1988-03-22 | Biospectrum, Inc. | Purification method for alpha interferon |
US5019368A (en) | 1989-02-23 | 1991-05-28 | Cancer Biologics, Inc. | Detection of necrotic malignant tissue and associated therapy |
EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
DE3856559T2 (en) | 1987-05-21 | 2004-04-29 | Micromet Ag | Multifunctional proteins with predetermined objectives |
US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
DE3853740T2 (en) | 1987-06-10 | 1995-11-09 | Dana Farber Cancer Inst Inc | Bifunctional antibody designs and methods for the selective killing of cell populations. |
US5064646A (en) | 1988-08-02 | 1991-11-12 | The University Of Maryland | Novel infectious bursal disease virus |
ATE88900T1 (en) | 1987-09-02 | 1993-05-15 | Ciba Geigy Ag | INTERFERON ALPHA CONJUGATES WITH IMMUNOGLOBULINS. |
NZ226414A (en) | 1987-10-02 | 1992-07-28 | Genentech Inc | Cd4 peptide adhesion variants and their preparation and use |
PT89121A (en) | 1987-12-04 | 1989-12-29 | Du Pont | PROCESS FOR THE PREPARATION OF INTERLEUQUIN-2 FIXED AND INTERLEUKIN-2 CONTAINING AN EXTENSION IN THE TERMINAL-CARBOXYL WITH ACTIVITY OF INTERLEUQUIN-2 NATURAL |
WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
CA1341588C (en) | 1988-01-26 | 2009-01-06 | Michel Revel | Human ifn-beta2/i1-6, its purification and use |
US5120525A (en) | 1988-03-29 | 1992-06-09 | Immunomedics, Inc. | Radiolabeled antibody cytotoxic therapy of cancer |
DE3812605A1 (en) | 1988-04-15 | 1990-06-07 | Leskovar Peter Dipl Ing Dr Hab | IMMUNEGULATIVE SUBSTANCES AND SUBSTANCE MIXTURES FOR ACTIVE INFLUENCING OF THE DISEASE PROCESS |
US4975369A (en) | 1988-04-21 | 1990-12-04 | Eli Lilly And Company | Recombinant and chimeric KS1/4 antibodies directed against a human adenocarcinoma antigen |
IE62463B1 (en) | 1988-07-07 | 1995-02-08 | Res Dev Foundation | Immunoconjugates for cancer diagnosis and therapy |
US5601819A (en) | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
IL91933A (en) | 1988-10-11 | 1994-12-29 | Univ Southern California | Vasoactive immunoconjugates useful for increasing the vascular permeability or the blood supply to neoplastic or otherwise diseased tissues |
US5457038A (en) | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
US5242824A (en) | 1988-12-22 | 1993-09-07 | Oncogen | Monoclonal antibody to human carcinomas |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US6750329B1 (en) | 1989-05-05 | 2004-06-15 | Research Development Foundation | Antibody delivery system for biological response modifiers |
IE63847B1 (en) | 1989-05-05 | 1995-06-14 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
DK0479909T3 (en) | 1989-06-29 | 1997-04-07 | Medarex Inc | Bispecific reagents for AIDS treatment |
EP0406857B1 (en) | 1989-07-07 | 1995-05-24 | Takeda Chemical Industries, Ltd. | Proteins and production thereof |
US5073627A (en) | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
DK0765937T3 (en) | 1989-09-20 | 2003-03-24 | Abbott Lab | Process for Preparation of Fusion Proteins |
WO1991005867A1 (en) | 1989-10-13 | 1991-05-02 | Amgen Inc. | Erythropoietin isoforms |
US5856298A (en) | 1989-10-13 | 1999-01-05 | Amgen Inc. | Erythropoietin isoforms |
EP0433827B1 (en) | 1989-12-22 | 1998-03-04 | F. Hoffmann-La Roche Ag | Cytotoxic lymphocyte maturation factor |
US5314995A (en) | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
JPH07507440A (en) | 1990-03-02 | 1995-08-24 | レプリゲン・コーポレーション | Antibody constructs with increased binding affinity |
EP0521985B1 (en) | 1990-03-20 | 1997-09-24 | The Trustees Of Columbia University In The City Of New York | Chimeric antibodies with receptor binding ligands in place of their constant region |
US5349053A (en) | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
US7253264B1 (en) | 1990-06-28 | 2007-08-07 | Sanofi-Arentideutschland GmbH | Immunoglobulin fusion proteins, their production and use |
EP0541716A1 (en) | 1990-07-27 | 1993-05-19 | Repligen Corporation | Novel methods and compositions for treatment of angiogenic diseases |
US5650150A (en) | 1990-11-09 | 1997-07-22 | Gillies; Stephen D. | Recombinant antibody cytokine fusion proteins |
CA2095842A1 (en) | 1990-11-09 | 1992-05-10 | Stephen D. Gillies | Bridging antibody fusion constructs |
DK0574395T3 (en) | 1990-11-09 | 2002-10-07 | Stephen D Gillies | Cytokine immunoconjugates |
EP0561907B1 (en) | 1990-12-05 | 1998-09-02 | Novo Nordisk A/S | Proteins with changed epitopes and methods for the production thereof |
US5709859A (en) | 1991-01-24 | 1998-01-20 | Bristol-Myers Squibb Company | Mixed specificity fusion proteins |
GB9105245D0 (en) | 1991-03-12 | 1991-04-24 | Lynxvale Ltd | Binding molecules |
US6072039A (en) | 1991-04-19 | 2000-06-06 | Rohm And Haas Company | Hybrid polypeptide comparing a biotinylated avidin binding polypeptide fused to a polypeptide of interest |
EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
US5199942A (en) | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
WO1993003157A1 (en) | 1991-07-29 | 1993-02-18 | Dana Farber Cancer Institute | Plasmids for the rapid preparation of modified proteins |
US20020037558A1 (en) * | 1991-10-23 | 2002-03-28 | Kin-Ming Lo | E.coli produced immunoglobulin constructs |
US5376367A (en) | 1991-11-22 | 1994-12-27 | Immunex Corporation | Fusion proteins comprising MGF and IL-3 |
US6627615B1 (en) | 1991-12-17 | 2003-09-30 | The Regents Of The University Of California | Methods and compositions for in vivo gene therapy |
ATE260971T1 (en) | 1992-04-01 | 2004-03-15 | Univ Rockefeller | METHOD FOR THE IN VITRO CULTIVATION OF DENDRITIC PRECURSOR CELLS AND THEIR USE FOR IMMUNOGENIC PRODUCTION |
WO1993020185A1 (en) | 1992-04-01 | 1993-10-14 | Steinman Ralph M | Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens |
WO1993024135A1 (en) | 1992-05-26 | 1993-12-09 | Immunex Corporation | Novel cytokine that binds cd30 |
WO1993024640A2 (en) | 1992-06-04 | 1993-12-09 | The Regents Of The University Of California | Methods and compositions for in vivo gene therapy |
US5614184A (en) | 1992-07-28 | 1997-03-25 | New England Deaconess Hospital | Recombinant human erythropoietin mutants and therapeutic methods employing them |
EP0671926B1 (en) | 1992-08-11 | 2002-11-13 | President And Fellows Of Harvard College | Immunomodulatory peptides |
US5429199A (en) * | 1992-08-26 | 1995-07-04 | Kennametal Inc. | Cutting bit and cutting insert |
DE4228839A1 (en) | 1992-08-29 | 1994-03-03 | Behringwerke Ag | Methods for the detection and determination of mediators |
US5837821A (en) | 1992-11-04 | 1998-11-17 | City Of Hope | Antibody construct |
WO1994009820A1 (en) | 1992-11-05 | 1994-05-11 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
US5738849A (en) | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
US5543297A (en) | 1992-12-22 | 1996-08-06 | Merck Frosst Canada, Inc. | Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity |
US6096331A (en) * | 1993-02-22 | 2000-08-01 | Vivorx Pharmaceuticals, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
KR960701988A (en) | 1993-04-20 | 1996-03-28 | 윌리엄 에스. 로빈슨 | METHODS AND MATERIALS FOR TREATMENT OF INDIVIDUALS INFECTED WITH INTRACELLULAR IN-FECTIOUS AGENTS |
AU6709794A (en) | 1993-04-21 | 1994-11-08 | Brigham And Women's Hospital | Erythropoietin muteins with enhanced activity |
US5759551A (en) | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
WO1994025609A1 (en) | 1993-04-28 | 1994-11-10 | Hybritech Incorporated | Method for creating optimized regulatory regions affecting protein expression and protein trafficking |
CA2161651A1 (en) | 1993-04-29 | 1994-11-10 | Gregory F. Okasinski | Erythropoietin analog compositions and methods |
US5554512A (en) | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
CA2125763C (en) | 1993-07-02 | 2007-08-28 | Maurice Kent Gately | P40 homodimer of interleukin-12 |
GB9316989D0 (en) | 1993-08-16 | 1993-09-29 | Lynxvale Ltd | Binding molecules |
IL192290A0 (en) | 1993-08-17 | 2008-12-29 | Kirin Amgen Inc | Erythropoietin analogs |
JPH09509054A (en) | 1994-02-01 | 1997-09-16 | アメリカ合衆国 | Fusion protein containing antibody portion and non-antibody portion |
WO1995028427A1 (en) | 1994-04-15 | 1995-10-26 | Imclone Systems Incorporated | Chimeric interleukin-3/mutein interleukin-6 lymphokine |
US5639725A (en) | 1994-04-26 | 1997-06-17 | Children's Hospital Medical Center Corp. | Angiostatin protein |
US5837682A (en) | 1996-03-08 | 1998-11-17 | The Children's Medical Center Corporation | Angiostatin fragments and method of use |
EP0758390B1 (en) | 1994-04-26 | 2007-02-28 | The Children's Medical Center Corporation | Angiostatin and method of use for inhibition of angiogenesis |
ES2162917T3 (en) | 1994-05-13 | 2002-01-16 | Biovation Ltd | IMPROVEMENTS IN OR RELATING TO THE SUPPLY OF PEPTIDES. |
CU22615A1 (en) | 1994-06-30 | 2000-02-10 | Centro Inmunologia Molecular | PROCEDURE FOR OBTAINING LESS IMMUNOGENIC MONOCLONAL ANTIBODIES. MONOCLONAL ANTIBODIES OBTAINED |
US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
CN1117155C (en) | 1994-07-29 | 2003-08-06 | 史密丝克莱恩比彻姆有限公司 | Novel compounds |
US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
US5888773A (en) * | 1994-08-17 | 1999-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Method of producing single-chain Fv molecules |
US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
EP0706799B1 (en) | 1994-09-16 | 2001-11-14 | MERCK PATENT GmbH | Immunoconjugates II |
WO1996018412A1 (en) | 1994-12-12 | 1996-06-20 | Beth Israel Hospital Association | Chimeric cytokines and uses thereof |
US6086875A (en) | 1995-01-17 | 2000-07-11 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of immunogens |
US6485726B1 (en) | 1995-01-17 | 2002-11-26 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
US5552524A (en) | 1995-01-31 | 1996-09-03 | Eli Lilly And Company | Anti-obesity proteins |
US5691309A (en) | 1995-01-31 | 1997-11-25 | Eli Lilly And Company | Anti-obesity proteins |
US5891680A (en) | 1995-02-08 | 1999-04-06 | Whitehead Institute For Biomedical Research | Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12 |
AU712585B2 (en) | 1995-03-10 | 1999-11-11 | Genentech Inc. | Receptor activation by gas6 |
US5719266A (en) | 1995-03-17 | 1998-02-17 | Eli Lilly And Company | Anti-obesity proteins |
WO1996031526A1 (en) | 1995-04-06 | 1996-10-10 | Amylin Pharmaceuticals, Inc. | Anti-obesity agents |
US6281010B1 (en) | 1995-06-05 | 2001-08-28 | The Trustees Of The University Of Pennsylvania | Adenovirus gene therapy vehicle and cell line |
AU5893796A (en) | 1995-06-07 | 1996-12-30 | Novo Nordisk A/S | Modification of polypeptides |
WO1997000317A1 (en) | 1995-06-07 | 1997-01-03 | Osteosa Inc. | Osteoclast growth regulatory factor |
GB9511935D0 (en) | 1995-06-13 | 1995-08-09 | Smithkline Beecham Plc | Novel compound |
NL1000614C2 (en) * | 1995-06-20 | 1996-12-23 | Leer Koninklijke Emballage | Method for manufacturing a laminated product. |
US5736852A (en) * | 1995-06-21 | 1998-04-07 | Alliedsignal Truck Brake Systems Co. | Circuit and method for conditioning a wheel speed sensor signal |
PL324284A1 (en) | 1995-06-30 | 1998-05-11 | Lilly Co Eli | Methods of treating diabetes |
US6406689B1 (en) | 1995-10-03 | 2002-06-18 | Frank W. Falkenberg | Compositions and methods for treatment of tumors and metastatic diseases |
US5854205A (en) | 1995-10-23 | 1998-12-29 | The Children's Medical Center Corporation | Therapeutic antiangiogenic compositions and methods |
WO1997015666A1 (en) | 1995-10-23 | 1997-05-01 | The Children's Medical Center Corporation | Therapeutic antiangiogenic compositions and methods |
WO1997020062A1 (en) | 1995-12-01 | 1997-06-05 | University Of Massachusetts | Il-12 p40 subunit fusion polypeptides and uses thereof |
IL124831A0 (en) | 1995-12-27 | 1999-01-26 | Genentech Inc | Ob protein derivatives having prolonged half-life |
US6080409A (en) | 1995-12-28 | 2000-06-27 | Dendreon Corporation | Immunostimulatory method |
US5723125A (en) | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
US7063958B1 (en) | 1996-01-16 | 2006-06-20 | The Rockefeller University | Nucleic acids db, the receptor for leptin |
US6750334B1 (en) | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
AU1952497A (en) | 1996-02-13 | 1997-09-02 | Regents Of The University Of California, The | Novel antibody-cytokine fusion protein, and methods of making and using the same |
US5756541A (en) | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
US6046310A (en) | 1996-03-13 | 2000-04-04 | Protein Design Labs., Inc. | FAS ligand fusion proteins and their uses |
DE69731289D1 (en) | 1996-03-18 | 2004-11-25 | Univ Texas | IMMUNGLOBULIN-LIKE DOMAIN WITH INCREASED HALF-VALUE TIMES |
WO1997043316A1 (en) | 1996-05-10 | 1997-11-20 | Beth Israel Deaconess Medical Center, Inc. | Physiologically active molecules with extended half-lives and methods of using same |
CN1136197C (en) | 1996-05-30 | 2004-01-28 | 霍夫曼-拉罗奇有限公司 | Novel pyridajinone derivatives |
US5922685A (en) | 1996-06-05 | 1999-07-13 | Powderject Vaccines, Inc. | IL-12 gene therapy of tumors |
EP0927033A1 (en) | 1996-07-02 | 1999-07-07 | Bar-Ilan University | Retinoyloxy(substituted)alkylene butyrates useful for the treatment of cancer and other proliferative diseases |
WO1998006752A1 (en) | 1996-08-16 | 1998-02-19 | The Rockefeller University | A leptin binding protein and its use in methods for diagnosing and treating abnormalities of the endogenous leptin pathway |
EP0826696B1 (en) * | 1996-09-03 | 2002-05-29 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Use of bi-and trispecific antibodies for inducing tumor immunity |
US5994104A (en) | 1996-11-08 | 1999-11-30 | Royal Free Hospital School Of Medicine | Interleukin-12 fusion protein |
DK0954588T3 (en) | 1996-12-20 | 2007-05-14 | Amgen Inc | OB fusion protein compositions and methods |
US6737057B1 (en) | 1997-01-07 | 2004-05-18 | The University Of Tennessee Research Corporation | Compounds, compositions and methods for the endocytic presentation of immunosuppressive factors |
US6100387A (en) | 1997-02-28 | 2000-08-08 | Genetics Institute, Inc. | Chimeric polypeptides containing chemokine domains |
US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
WO1998046264A1 (en) | 1997-04-11 | 1998-10-22 | G.D. Searle & Co. | Antagonistic anti-avb3 integrin antibodies |
ATE223229T1 (en) | 1997-04-17 | 2002-09-15 | Amgen Inc | COMPOSITIONS OF CONJUGATES OF THE STABLE, ACTIVE, HUMAN OB PROTEIN WITH THE FC CHAIN OF IMMUNOGLOBULINS AND RELATED METHODS |
DE69833755T2 (en) * | 1997-05-21 | 2006-12-28 | Biovation Ltd. | METHOD FOR PRODUCING NON-IMMUNOGENOUS PROTEINS |
EP1037927B1 (en) | 1997-12-08 | 2004-05-19 | Lexigen Pharmaceuticals Corp. | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
US20030105294A1 (en) | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
JP2002505086A (en) | 1998-02-25 | 2002-02-19 | レキシジェン ファーマシューティカルズ コーポレイション | Enhanced circulating half-life of antibody-based fusion proteins |
JP2002511432A (en) | 1998-04-15 | 2002-04-16 | レキシジェン ファーマシューティカルズ コーポレイション | Enhancement of antibody-cytokine fusion protein-mediated immune response by co-administration of an angiogenesis inhibitor |
EP1071469A2 (en) * | 1998-04-17 | 2001-01-31 | Lexigen Pharmaceuticals Corp. | Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with prostaglandin inhibitor |
US6284536B1 (en) | 1998-04-20 | 2001-09-04 | The Regents Of The University Of California | Modified immunoglobin molecules and methods for use thereof |
WO1999058662A1 (en) | 1998-05-14 | 1999-11-18 | Merck Patent Gmbh | Fused protein |
DZ2788A1 (en) | 1998-05-15 | 2003-12-01 | Bayer Ag | Selective IL-2 agonists and antagonists. |
US6620382B1 (en) | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
KR20010052566A (en) | 1998-06-03 | 2001-06-25 | 윌리엄 뉴 | Protein oligomer compositions comprising endostatin protein and methods of using the same |
CA2330527A1 (en) | 1998-06-15 | 1999-12-23 | Genzyme Transgenics Corporation | Erythropoietin analog-human serum albumin fusion |
GB9814383D0 (en) | 1998-07-02 | 1998-09-02 | Cambridge Antibody Tech | Improvements relating to antibodies |
AU770555B2 (en) | 1998-08-17 | 2004-02-26 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
BR9913331A (en) | 1998-08-25 | 2001-05-15 | Lexigen Pharm Corp | Expression and export of angiogenesis inhibitors as immunofusins |
US6646113B1 (en) | 1998-09-17 | 2003-11-11 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecule encoding human survival of motor neuron-interacting protein 1 (SIP1) deletion mutants |
US6335176B1 (en) | 1998-10-16 | 2002-01-01 | Pharmacopeia, Inc. | Incorporation of phosphorylation sites |
ES2283139T5 (en) | 1998-10-23 | 2018-03-05 | Amgen Inc. | Methods and compositions for the prevention and treatment of anemia |
KR20020007287A (en) * | 1999-01-07 | 2002-01-26 | 추후보정 | EXPRESSION AND EXPORT OF ANTI-OBESITY PROTEINS AS Fc FUSION PROTEINS |
CA2359840C (en) * | 1999-02-12 | 2012-10-23 | Amgen Inc. | Glycosylated leptin compositions and related methods |
DE60041183D1 (en) | 1999-05-06 | 2009-02-05 | Univ Wake Forest | COMPOSITIONS AND METHODS FOR IDENTIFYING ANTIGENES WHICH CAUSE AN IMMUNE RESPONSE |
JP3660880B2 (en) | 1999-05-07 | 2005-06-15 | ジェネンテック・インコーポレーテッド | Novel chimpanzee erythropoietin (CHEPO) polypeptide and nucleic acid encoding the same |
US6348192B1 (en) | 1999-05-11 | 2002-02-19 | Bayer Corporation | Interleukin-2 mutein expressed from mammalian cells |
PT1187852E (en) | 1999-05-19 | 2007-11-14 | Merck Patent Gmbh | Expression and export of interferon-alpha proteins as fc fusion proteins |
WO2000078334A1 (en) | 1999-06-17 | 2000-12-28 | University Of Maryland Biotechnology Institute | Chimeric chemokine-antigen polypeptides and uses therefor |
CZ299516B6 (en) * | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Erythropoietin glycoprotein conjugate, process for its preparation and use and pharmaceutical composition containing thereof |
JO2291B1 (en) | 1999-07-02 | 2005-09-12 | اف . هوفمان لاروش ايه جي | Erythopintin derivatives |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
MXPA02001417A (en) * | 1999-08-09 | 2002-08-12 | Lexigen Pharm Corp | Multiple cytokine-antibody complexes. |
WO2001036489A2 (en) | 1999-11-12 | 2001-05-25 | Merck Patent Gmbh | Erythropoietin forms with improved properties |
US20050202538A1 (en) | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
AU4314801A (en) | 2000-02-11 | 2001-08-20 | Lexigen Pharm Corp | Enhancing the circulating half-life of antibody-based fusion proteins |
ES2269361T3 (en) * | 2000-02-24 | 2007-04-01 | Philogen S.P.A. | COMPOSITIONS AND METHODS FOR TREATMENT OF ANGIOGENESIS IN PATHOLOGICAL INJURIES. |
US6586398B1 (en) * | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
US6946134B1 (en) * | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
HUP0302299A2 (en) * | 2000-05-12 | 2003-10-28 | Neose Technologies, Inc. | In vitro fucosylation recombinant glycopeptides |
CN1270775C (en) * | 2000-06-29 | 2006-08-23 | 默克专利有限公司 | Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enbancing agents |
KR20030067755A (en) * | 2001-01-18 | 2003-08-14 | 메르크 파텐트 게엠베하 | Bifunctional fusion proteins with glucocerebrosidase activity |
US7430476B2 (en) | 2001-02-19 | 2008-09-30 | Merck Patent Gmbh | Method for identification of t-cell epitopes and use for preparing molecules with reduced immunogenicity |
KR20040074587A (en) * | 2001-02-19 | 2004-08-25 | 메르크 파텐트 게엠베하 | Artificial proteins with reduced immunogenicity |
KR100900176B1 (en) * | 2001-03-07 | 2009-06-02 | 메르크 파텐트 게엠베하 | Expression technology for proteins containing a hybrid isotype antibody moiety |
US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
DK1383785T3 (en) | 2001-05-03 | 2011-05-23 | Merck Patent Gmbh | Recombinant tumor-specific antibody and its use |
EP1476180A4 (en) | 2001-08-13 | 2005-04-20 | Univ Southern California | Interleukin-2 mutants with reduced toxicity |
AU2002357784B2 (en) | 2001-12-04 | 2008-07-31 | Merck Patent Gmbh | Immunocytokines with modulated selectivity |
WO2003077834A2 (en) | 2002-03-15 | 2003-09-25 | The Brigham And Women's Hospital, Inc. | Central airway administration for systemic delivery of therapeutics |
US6996009B2 (en) * | 2002-06-21 | 2006-02-07 | Micron Technology, Inc. | NOR flash memory cell with high storage density |
PT1572748E (en) | 2002-12-17 | 2010-09-28 | Merck Patent Gmbh | Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2 |
US20050069521A1 (en) | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
BRPI0418286A (en) | 2003-12-30 | 2007-05-02 | Merck Patent Gmbh | il-7 fusion proteins |
CA2551916C (en) | 2003-12-31 | 2014-04-29 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Fc-erythropoietin fusion protein with improved pharmacokinetics |
CA2553883C (en) | 2004-01-22 | 2013-04-02 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Anti-cancer antibodies with reduced complement fixation |
US7670595B2 (en) | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
EP1819728B1 (en) | 2004-12-09 | 2010-04-21 | MERCK PATENT GmbH | Il-7 variants with reduced immunogenicity |
US20070104689A1 (en) | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
CN101351475B (en) | 2005-12-30 | 2013-05-15 | 默克专利有限公司 | Interleukin-12p40 variants with improved stability |
PT1966244E (en) | 2005-12-30 | 2012-05-17 | Merck Patent Gmbh | Anti-il-6 antibodies preventing the binding of il-6 complexed with il-6ralpha to gp130 |
EP1966245B1 (en) | 2005-12-30 | 2011-05-18 | Merck Patent GmbH | Anti-cd19 antibodies with reduced immunogenicity |
AU2007229698B9 (en) | 2006-03-24 | 2012-11-08 | Merck Patent Gmbh | Engineered heterodimeric protein domains |
WO2008003473A2 (en) | 2006-07-06 | 2008-01-10 | Merck Patent Gmbh | Compositions and methods for enhancing the efficacy of il-2 mediated immune responses |
-
2002
- 2002-03-29 US US10/112,582 patent/US6992174B2/en not_active Expired - Lifetime
- 2002-03-29 WO PCT/US2002/009650 patent/WO2002079415A2/en not_active Application Discontinuation
- 2002-03-30 EP EP02757870A patent/EP1373301B1/en not_active Expired - Lifetime
- 2002-03-30 AT AT02757870T patent/ATE490262T1/en active
- 2002-03-30 KR KR10-2003-7012819A patent/KR20030087040A/en not_active Application Discontinuation
- 2002-03-30 CA CA2442363A patent/CA2442363C/en not_active Expired - Lifetime
- 2002-03-30 AU AU2002306976A patent/AU2002306976B2/en not_active Expired
- 2002-03-30 DK DK02757870.7T patent/DK1373301T3/en active
- 2002-03-30 JP JP2002577856A patent/JP4638129B2/en not_active Expired - Fee Related
- 2002-03-30 EP EP10010015A patent/EP2311882A1/en not_active Withdrawn
- 2002-03-30 PL PL366826A patent/PL209110B1/en unknown
- 2002-03-30 HU HU0303753A patent/HUP0303753A2/en unknown
- 2002-03-30 MX MXPA03008715A patent/MXPA03008715A/en active IP Right Grant
- 2002-03-30 ES ES02757870T patent/ES2356620T3/en not_active Expired - Lifetime
- 2002-03-30 PT PT02757870T patent/PT1373301E/en unknown
- 2002-03-30 CN CNB028075056A patent/CN100488984C/en not_active Expired - Lifetime
- 2002-03-30 RU RU2003129523/13A patent/RU2333919C2/en not_active IP Right Cessation
- 2002-03-30 DE DE60238472T patent/DE60238472D1/en not_active Expired - Lifetime
- 2002-03-30 WO PCT/US2002/009815 patent/WO2002079232A2/en active Application Filing
- 2002-03-30 BR BR0208207-1A patent/BR0208207A/en not_active IP Right Cessation
-
2003
- 2003-10-29 ZA ZA200308430A patent/ZA200308430B/en unknown
-
2005
- 2005-09-23 US US11/233,683 patent/US7601814B2/en not_active Expired - Fee Related
-
2009
- 2009-09-01 US US12/552,076 patent/US7973150B2/en not_active Expired - Fee Related
-
2010
- 2010-07-02 JP JP2010151743A patent/JP5291671B2/en not_active Expired - Fee Related
-
2011
- 2011-05-26 US US13/116,830 patent/US8926973B2/en not_active Expired - Fee Related
-
2015
- 2015-01-02 US US14/588,702 patent/US20150141626A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998059244A1 (en) * | 1997-06-20 | 1998-12-30 | Eclagen Limited | Identification of mhc binding peptides |
WO1999002709A1 (en) * | 1997-07-10 | 1999-01-21 | Beth Israel Deaconess Medical Center | Recombinant erythropoietin / immunoglobulin fusion proteins |
WO1999003887A1 (en) * | 1997-07-14 | 1999-01-28 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
WO2000034317A2 (en) * | 1998-12-08 | 2000-06-15 | Biovation Limited | Method for reducing immunogenicity of proteins |
Non-Patent Citations (2)
Title |
---|
LODE ET AL.: "Amplification of T cell mediated immune responses by antibody-cytokine fusion proteins", IMMUNOL. INVEST., vol. 29, no. 2, 2000, pages 117 - 120, XP002956103 * |
REISFELD ET AL.: "Immunocytokines: a new approach to immunotherapy of melanoma", MELANOMA RES., vol. 7, no. SUPPL. 2, 1997, pages S99 - S106, XP002955740 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8937158B2 (en) | 2003-03-03 | 2015-01-20 | Xencor, Inc. | Fc variants with increased affinity for FcγRIIc |
US8835606B2 (en) | 2004-01-22 | 2014-09-16 | Merck Patent Gmbh | Anti-cancer antibodies with reduced complement fixation |
US8691952B2 (en) | 2005-12-30 | 2014-04-08 | Merck Patent Gmbh | Anti-CD19 antibodies with reduced immunogenicity |
US8957195B2 (en) | 2005-12-30 | 2015-02-17 | Merck Patent Gmbh | Anti-CD19 antibodies with reduced immunogenicity |
US9371369B2 (en) | 2009-02-03 | 2016-06-21 | Amunix Operating Inc. | Extended recombinant polypeptides and compositions comprising same |
US8907066B2 (en) | 2009-04-22 | 2014-12-09 | Merck Patent Gmbh | Antibody fusion proteins with a modified FcRn binding site |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2002079232A3 (en) | Reducing the immunogenicity of fusion proteins | |
WO2004020404A3 (en) | Modified transferin-antibody fusion proteins | |
BR0212256A (en) | Modified transferrin fusion proteins | |
WO2004020405A3 (en) | Modified transferrin fusion proteins | |
WO1999057280A3 (en) | Neisseria meningitidis antigens and compositions | |
EP1724282A3 (en) | Method for the production of non-immunogenic proteins | |
WO2001070984A3 (en) | Anti-tissue factor antibodies with enhanced anticoagulant potency | |
AU2002217010A1 (en) | Peptides, the production and use thereof for binding immunoglobulins | |
WO2002074795A3 (en) | Oligomeric complexes of chimeric proteins with enhanced immunogenic potential | |
WO2003072746A3 (en) | Subtilisin carlsberg proteins with reduced immunogenicity | |
WO2001059130A3 (en) | Proteins producing an altered immunogenic response and methods of making and using the same | |
AU2002354806A1 (en) | Parathyroid hormone antibodies and related methods | |
WO2001094949A3 (en) | Soluble cd1 compositions and uses thereof | |
WO2004020588A3 (en) | Transferrin fusion protein libraries | |
AU2002365269A1 (en) | Mut-il-18 or mut-il-18r proteins, antibodies, compositions, methods and uses | |
WO2001002429A3 (en) | Angiopoietin-6 and uses thereof | |
BR0311308A (en) | Reduced immunogenicity modified brodine 1 | |
AU2002250254A1 (en) | Nucleic acids, proteins, and antibodies | |
WO1999001475A3 (en) | Human antibody against a fusion (poly) peptide or protein presenting a part having at least six histidines | |
AU2003226907A1 (en) | Method for the preparation of recombinant mammalian heparin-binding protein (hbp) | |
AU2002257052A1 (en) | Reg-like protein immunoglobulin derived proteins, compositions, methods and uses | |
WO1999055876A3 (en) | Polypeptide with immunogenic properties and with a protein with modified biological functions | |
AU2002325299A1 (en) | Novel t-cell proteins, peptides and antibodies derived therefrom and uses thereof | |
WO1999019358A3 (en) | Antibody against baculoviruses | |
PL362413A1 (en) | Modified anti-egfr antibodies with reduced immunogenicity |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2002757870 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002306976 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2003/008715 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2442363 Country of ref document: CA Ref document number: 2002577856 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 028075056 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020037012819 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003/08430 Country of ref document: ZA Ref document number: 200308430 Country of ref document: ZA |
|
WWP | Wipo information: published in national office |
Ref document number: 2002757870 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
ENP | Entry into the national phase |
Ref document number: 2002306976 Country of ref document: AU Date of ref document: 20020330 Kind code of ref document: B |